Sid Madhavan

Journal Article Cell chemical biology · January 2025 Loss of proteostasis is a hallmark of aging and Alzheimer disease (AD). We identify β-hydroxybutyrate (βHB), a ketone body, as a regulator of protein solubility. βHB primarily provides ATP substrate during periods of reduced glucose availability, and regul ... Full text Cite

A ketogenic diet reduces age-induced chronic neuroinflammation in mice Running title: ketogenic diet and brain inflammaging.

Preprint · December 4, 2023 Full text Link to item Cite

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

Preprint · July 3, 2023 Full text Cite

Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains.

Journal Article Pathogens (Basel, Switzerland) · December 2022 Tau aggregation associates with multiple neurodegenerative diseases including Alzheimer's disease and rare tauopathies such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration. The molecular and structural basis of tau aggregat ... Full text Cite