Overview
Dr. Gospe held the Herman and Faye Sarkowsky Endowed Chair of Child Neurology at the University of Washington and directed the Division of Neurology at Seattle Children's Hospital from 2000-2017. He joined the Duke faculty as Adjunct Professor of Pediatrics in 2017. Dr. Gospe's research focuses on the natural history, genetics and management of pyridoxine-dependent epilepsy.
Current Appointments & Affiliations
Adjunct Professor in the Department of Pediatrics
·
2018 - Present
Pediatrics, Neurology,
Pediatrics
Recent Publications
Hepatocellular Carcinoma: A Critical Complication in Patients Treated with Pyridoxal Phosphate.
Journal Article Neuropediatrics · January 6, 2026 Pyridoxal-5'-phosphate (PLP) is in most patients the effective treatment for pyridox(am)ine-5'-phosphate oxidase (PNPO) deficiency, a rare autosomal recessive cause of neonatal-onset developmental and epileptic encephalopathy. Although generally considered ... Full text Link to item CiteCharacterization of severe COL6-related dystrophy due to the recurrent variant COL6A1 c.930+189C>T.
Journal Article Brain · September 3, 2025 Collagen VI-related dystrophies manifest with a spectrum of clinical phenotypes, ranging from Ullrich congenital muscular dystrophy (UCMD), presenting with prominent congenital symptoms and characterized by progressive muscle weakness, joint contractures a ... Full text Open Access Link to item CiteManganese Neurotoxicity and Familial Disorders of Manganese Transport
Journal Article Annals of the Child Neurology Society · September 2025 ABSTRACTManganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is requ ... Full text Open Access CiteEducation, Training & Certifications
Duke University, School of Medicine ·
1981
M.D.
Duke University ·
1980
Ph.D.