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Sin Tiong Ong

Associate Professor of Medicine
Medicine, Medical Oncology
406 Seeley Mudd Bldg, Box 3406, Durham, NC 27710

Current Appointments & Affiliations


Associate Professor of Medicine · 2021 - Present Medicine, Medical Oncology, Medicine

Recent Publications


Chronic inflammation deters natural killer cell fitness and cytotoxicity in myeloid leukemia.

Journal Article Blood Adv · February 25, 2025 Natural killer (NK) cells play an integral role in immunosurveillance against myeloid malignancies, with their mature phenotype and abundance linked to prolonged treatment-free remission in chronic myeloid leukemia (CML). However, NK cell function is suppr ... Full text Link to item Cite

The BIM deletion polymorphism potentiates the survival of leukemia stem and progenitor cells and impairs response to targeted therapies.

Journal Article Leukemia · January 2025 One sixth of human cancers harbor pathogenic germline variants, but few studies have established their functional contribution to cancer outcomes. Here, we developed a humanized mouse model harboring a common East Asian polymorphism, the BIM deletion polym ... Full text Link to item Cite

Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche

Conference Blood · November 2, 2023 These authors contributed equally to this work: Martha M. Zarou & Amy DawsonMacrophages are fundamental cells of the innate immune system. Bone marrow (BM) resident macrophages are i ... Full text Cite
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Education, Training & Certifications


University of Cambridge (United Kingdom) · 1987 M.B.B.Ch.