Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Medicine, University of California - Irvine 1997 - 1999
  • Fellow, Hematology, Oncology, The University of Chicago 1993 - 1997
  • Resident, National University Hospital (Singapore) 1991 - 1993
  • M.B.B.Ch., University of Cambridge (United Kingdom) 1987
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Medical Oncology, Medicine 2010 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ko, Tun Kiat, Asif Javed, Kian Leong Lee, Thushangi N. Pathiraja, Xingliang Liu, Simeen Malik, Sheila Xinxuan Soh, et al. “An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia.” Blood 135, no. 26 (June 25, 2020): 2337–53. https://doi.org/10.1182/blood.2020004834.
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    • Arai, Sachiko, Shinji Takeuchi, Koji Fukuda, Azusa Tanimoto, Akihiro Nishiyama, Hiroaki Konishi, Akimitsu Takagi, Hiroyuki Takahashi, S Tiong Ong, and Seiji Yano. “Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism.” J Med Invest 67, no. 3.4 (2020): 343–50. https://doi.org/10.2152/jmi.67.343.
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    • Branford, Susan, Dennis Dong Hwan Kim, Jane F. Apperley, Christopher A. Eide, Satu Mustjoki, S Tiong Ong, Georgios Nteliopoulos, et al. “Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia.” Leukemia 33, no. 8 (August 2019): 1835–50. https://doi.org/10.1038/s41375-019-0512-y.
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    • Than, Hein, Weng K. Lye, Colin Sng, John C. Allen, S Tiong Ong, and Charles Chuah. “BIM deletion polymorphism profiling complements prognostic values of risk scores in imatinib-treated Asian chronic myeloid leukemia patients.” Leuk Lymphoma 60, no. 1 (January 2019): 234–37. https://doi.org/10.1080/10428194.2018.1461863.
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    • Leidy-Davis, Tiffany, Kai Cheng, Leslie O. Goodwin, Judith L. Morgan, Wen Chun Juan, Xavier Roca, S Tiong Ong, and David E. Bergstrom. “Viable Mice with Extensive Gene Humanization (25-kbp) Created Using Embryonic Stem Cell/Blastocyst and CRISPR/Zygote Injection Approaches.” Sci Rep 8, no. 1 (October 9, 2018): 15028. https://doi.org/10.1038/s41598-018-33408-9.
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    • Ng, King Pan, Aditi Manjeri, Lin Ming Lee, Zhu En Chan, Chin Yee Tan, Qiancheng Darren Tan, A’Qilah Majeed, et al. “The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target.” Plos One 13, no. 10 (2018): e0205254. https://doi.org/10.1371/journal.pone.0205254.
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    • Liu, Jun, Malini Bhadra, Joanna Rajeswary Sinnakannu, Wan Lin Yue, Cheryl Weiqi Tan, Frank Rigo, S Tiong Ong, and Xavier Roca. “Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides.” Oncotarget 8, no. 44 (September 29, 2017): 77567–85. https://doi.org/10.18632/oncotarget.20658.
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    • Soh, Sheila X., Fahad J. Siddiqui, John C. Allen, Go Woon Kim, Jae Cheol Lee, Yasushi Yatabe, Manabu Soda, et al. “A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer.” Oncotarget 8, no. 25 (June 20, 2017): 41474–86. https://doi.org/10.18632/oncotarget.17102.
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    • Tanimoto, Azusa, Shinji Takeuchi, Sachiko Arai, Koji Fukuda, Tadaaki Yamada, Xavier Roca, S Tiong Ong, and Seiji Yano. “Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer.” Clin Cancer Res 23, no. 12 (June 15, 2017): 3139–49. https://doi.org/10.1158/1078-0432.CCR-16-2271.
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    • Rauzan, Muhammad, Charles T. H. Chuah, Tun Kiat Ko, and S Tiong Ong. “The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia.” Plos One 12, no. 3 (2017): e0174107. https://doi.org/10.1371/journal.pone.0174107.
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    • Cherian, Joseph, Kassoum Nacro, Zhi Ying Poh, Samantha Guo, Duraiswamy A. Jeyaraj, Yun Xuan Wong, Melvyn Ho, et al. “Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.” J Med Chem 59, no. 7 (April 14, 2016): 3063–78. https://doi.org/10.1021/acs.jmedchem.5b01712.
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    • Ko, Tun Kiat, Hui San Chin, Charles T. H. Chuah, John W. J. Huang, King-Pan Ng, Seong Lin Khaw, David C. S. Huang, and S Tiong Ong. “The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.” Oncotarget 7, no. 3 (January 19, 2016): 2721–33. https://doi.org/10.18632/oncotarget.5436.
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    • Yano, Seiji, Azusa Tanimoto, Shoko Arai, Koji Fukuda, Sin T. Ong, and Shinji Takeuchi. “HDAC Inhibitors Overcome New Generation EGFR-TKI-Resistance Caused by Homozygous BIM Polymorphism in EGFR Mutant Lung Cancer.” Journal of Thoracic Oncology 10, no. 9 (September 1, 2015): S296–97.
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    • Tsai, Becky Pinjou, Judith Jimenez, Sharon Lim, Kerry D. Fitzgerald, Min Zhang, Charles T. H. Chuah, Haley Axelrod, et al. “A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.” Open Biol 4, no. 11 (November 2014): 140180. https://doi.org/10.1098/rsob.140180.
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    • Ko, Tun Kiat, Charles T. H. Chuah, John W. J. Huang, King-Pan Ng, and S Tiong Ong. “The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors.” Oncotarget 5, no. 19 (October 15, 2014): 9033–38. https://doi.org/10.18632/oncotarget.1925.
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    • Ong, S Tiong, Charles T. H. Chuah, Tun Kiat Ko, Axel M. Hillmer, and Wan-Teck Lim. “Reply: the BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia.” Nat Med 20, no. 10 (October 2014): 1090–91. https://doi.org/10.1038/nm.3652.
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    • Ong, S Tiong. “Heritable resistance to tyrosine kinase inhibitors.” Clin Adv Hematol Oncol 12, no. 7 (July 2014): 454–57.
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    • Juan, Wen Chun, Xavier Roca, and S Tiong Ong. “Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.” Plos One 9, no. 4 (2014): e95210. https://doi.org/10.1371/journal.pone.0095210.
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    • Soh, Sheila Xinxuan, Joshua Yew Suang Lim, John W. J. Huang, Nan Jiang, Allen Eng Juh Yeoh, and S Tiong Ong. “Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia.” Plos One 9, no. 8 (2014): e103435. https://doi.org/10.1371/journal.pone.0103435.
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    • Soh, Sheila, and S Tiong Ong. “A novel BIM deletion polymorphism: implications and lessons for cancer targeted therapies.” Rinsho Ketsueki 54, no. 10 (October 2013): 1714–19.
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    • Lim, Sharon, Tzuen Yih Saw, Min Zhang, Matthew R. Janes, Kassoum Nacro, Jeffrey Hill, An Qi Lim, et al. “Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function.” Proc Natl Acad Sci U S A 110, no. 25 (June 18, 2013): E2298–2307. https://doi.org/10.1073/pnas.1301838110.
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    • Juan, Wen Chun, Tun Kiat Ko, Xavier Roca, and Sin Tiong Ong. “Abstract 4958: Identification of cis-regulatory elements in a BIM deletion polymorphism that regulate splicing and generation of non-apoptotic BIM isoforms.” Molecular and Cellular Biology, April 15, 2012. https://doi.org/10.1158/1538-7445.am2012-4958.
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    • Ng, King Pan, Axel M. Hillmer, Charles T. H. Chuah, Wen Chun Juan, Tun Kiat Ko, Audrey S. M. Teo, Pramila N. Ariyaratne, et al. “A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.” Nat Med 18, no. 4 (March 18, 2012): 521–28. https://doi.org/10.1038/nm.2713.
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    • Juan, Wen Chun, and S Tiong Ong. “The role of protein phosphorylation in therapy resistance and disease progression in chronic myelogenous leukemia.” Prog Mol Biol Transl Sci 106 (2012): 107–42. https://doi.org/10.1016/B978-0-12-396456-4.00007-9.
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    • Janes, Matthew R., Jose J. Limon, Lomon So, Jing Chen, Raymond J. Lim, Melissa A. Chavez, Collin Vu, et al. “Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.” Nat Med 16, no. 2 (February 2010): 205–13. https://doi.org/10.1038/nm.2091.
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    • Zhang, Min, Wuxia Fu, Sharmila Prabhu, James C. Moore, Je Ko, Jung Woo Kim, Brian J. Druker, et al. “Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance.” Mol Cell Biol 28, no. 20 (October 2008): 6496–6509. https://doi.org/10.1128/MCB.00477-08.
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    • Arechiga, Adrian F., Bryan D. Bell, Sabrina Leverrier, Brian M. Weist, Melissa Porter, Zhengqi Wu, Yuka Kanno, et al. “A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2.” J Immunol 179, no. 8 (October 15, 2007): 5291–5300. https://doi.org/10.4049/jimmunol.179.8.5291.
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    • Prabhu, S., D. Saadat, M. Zhang, L. Halbur, J. P. Fruehauf, and S. T. Ong. “A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation.” Oncogene 26, no. 8 (February 22, 2007): 1188–1200. https://doi.org/10.1038/sj.onc.1209901.
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    • Moore, James C., Carolyn F. Dennehey, Arash Anavim, Kevin M. Kong, and S. Tiong Ong. “Multiple joint effusions associated with high-dose imatinib therapy in a patient with chronic myelogenous leukaemia.” Eur J Haematol 76, no. 5 (May 2006): 444–46. https://doi.org/10.1111/j.1600-0609.2006.00649.x.
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    • Ly, Chi, Adrian F. Arechiga, Junia V. Melo, Craig M. Walsh, and S Tiong Ong. “Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin.” Cancer Res 63, no. 18 (September 15, 2003): 5716–22.
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    • Tiong Ong, S., Chi Ly, Mark Nguyen, B. Kay Brightman, and Hung Fan. “Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection.” Cell Immunol 221, no. 1 (January 2003): 64–79. https://doi.org/10.1016/s0008-8749(03)00065-0.
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    • Peters, U. R., U. Hasse, E. Oppliger, M. Tschan, S. T. Ong, F. V. Rassool, B. Borisch, A. Tobler, and M. F. Fey. “Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia.” Oncogene 18, no. 1 (January 7, 1999): 79–85. https://doi.org/10.1038/sj.onc.1202256.
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    • Ong, S. T., and M. M. Le Beau. “Chromosomal abnormalities and molecular genetics of non-Hodgkin's lymphoma.” Semin Oncol 25, no. 4 (August 1998): 447–60.
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    • Ong, S. T., M. L. Hackbarth, L. C. Degenstein, D. A. Baunoch, J. Anastasi, and T. W. McKeithan. “Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.” Oncogene 16, no. 18 (May 7, 1998): 2333–43. https://doi.org/10.1038/sj.onc.1201771.
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    • Ong, S. T., K. M. Fong, S. A. Bader, J. D. Minna, M. M. Le Beau, T. W. McKeithan, and F. V. Rassool. “Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines.” Genes Chromosomes Cancer 20, no. 1 (September 1997): 16–23. https://doi.org/10.1002/(sici)1098-2264(199709)20:1<16::aid-gcc3>3.0.co;2-c.
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    • Fong, K. M., E. J. Biesterveld, A. Virmani, I. Wistuba, Y. Sekido, S. A. Bader, M. Ahmadian, et al. “FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.” Cancer Res 57, no. 11 (June 1, 1997): 2256–67.
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    • Ong, S. T., R. Stupp, and J. E. Ultmann. “The sixth Lugano conference: Basic science papers.” Annals of Oncology 8, no. SUPPL. 2 (January 1, 1997). https://doi.org/10.1093/annonc/8.suppl_2.S1.
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    • Ultmann, J. E., S. T. Ong, and R. Stupp. “One and a half decades of the Lugano International Conference on Malignant Lymphoma: variations on a theme or true progress?” Ann Oncol 8 Suppl 1 (1997): 1–3.
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    • Ong, S. T., H. Koeppen, R. A. Larson, and O. I. Olopade. “Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia with fludarabine.” Blood 88, no. 6 (September 15, 1996): 2354–55.
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    • Rassool, F. V., M. M. Le Beau, M. L. Shen, M. E. Neilly, R. Espinosa, S. T. Ong, F. Boldog, H. Drabkin, R. McCarroll, and T. W. McKeithan. “Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.” Genomics 35, no. 1 (July 1, 1996): 109–17. https://doi.org/10.1006/geno.1996.0329.
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    • Ong, S. T., and N. J. Vogelzang. “Chemotherapy in malignant pleural mesothelioma. A review.” J Clin Oncol 14, no. 3 (March 1996): 1007–17. https://doi.org/10.1200/JCO.1996.14.3.1007.
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    • Ong, S. T., and R. A. Larson. “Current management of acute lymphoblastic leukemia in adults.” Oncology (Williston Park) 9, no. 5 (May 1995): 433–42.
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    • Ultmann, J. E., and S. T. Ong. “The cost-benefit ratio of the cure of Hodgkin's disease.” Cancer J Sci Am 1, no. 1 (May 1995): 23–25.
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    • Ong, S. T., and Y. K. Kueh. “Hepatic candidiasis: persistent pyrexia in a patient with acute myeloid leukaemia after recovery from consolidation therapy-induced neutropenia.” Ann Acad Med Singap 22, no. 2 (March 1993): 257–60.
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  • Book Sections

    • Than, H., C. Chuah, and S. T. Ong. “Molecular mechanism of TKI resistance and potential approaches to overcome resistance.” In Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia, 167–82, 2015. https://doi.org/10.1007/978-4-431-55714-2_11.
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  • Conference Papers

    • Nacro, Kassoum, Joseph Cherian, Haiyan Yang, Yoon Shen Yeap, Zhi Ying Poh, Lohitha Chennamaneni, Shi Hua Ang, et al. “Mnk1/2 and Abl inhibitions for the treatment of blast crisis chronic myelogenous leukemia.” In Abstracts of Papers of the American Chemical Society, Vol. 254. AMER CHEMICAL SOC, 2017.
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    • Ko, Tun Kiat, Xin Xuan Sheila Soh, Willie Yu, Peter S. Winter, Thushangi Pathiraja, Asif Javed, Simeen Malik, et al. “Functional Analysis of the CML Blast Crisis Transcriptome and Epigenome Using Crispr-CAS9 and Pharmacologic Approaches.” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Ong, S Tiong, Thushangi Pathiraja, Asif Javed, Xin Xuan Sheila Soh, Simeen Malik, Joanna H. J. Tan, Tun Kiat Ko, et al. “The Genomic and Epigenomic Landscapes of Blast Crisis Transformation in Chronic Myeloid Leukemia.” In Blood, 126:3737–3737. American Society of Hematology, 2015. https://doi.org/10.1182/blood.v126.23.3737.3737.
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    • Ng, King Pan, Aditi Manjeri, Kian Leong Lee, Weijie Huang, Soo Yong Tan, Charles T. H. Chuah, Lorenz Poellinger, and S Tiong Ong. “Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.” In Blood, 123:3316–26, 2014. https://doi.org/10.1182/blood-2013-07-511907.
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    • Hillmer, Axel M., King-Pan Ng, Charles Chuah, Wen Chun Juan, Tun-Kiat Ko, Audrey S. M. Teo, Pramila N. Ariyaratne, et al. “A Common Deletion Polymorphism in the BIM Gene Contributes to Intrinsic Imatinib Resistance in Chronic Myelogenous Leukemia.” In Blood, 118:724–724. AMER SOC HEMATOLOGY, 2011.
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    • Lim, Sharon, T Yih Saw, Charles Chuah, and S Tiong Ong. “Overexpression and Phosphorylation of eIF4E Is Required for Beta-Catenin Activation in Blast Crisis Chronic Myelogenous Leukemia.” In Blood, 114:22–22. AMER SOC HEMATOLOGY, 2009.
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    • Ng, King-Pan, Tuang Yeow Poh, Wen Tian Sun, Charles Chuah, and S Tiong Ong. “Physiologic Hypoxia Protects Chronic Myelogenous Leukemia Progenitors From Elimination by Imatinib Mesylate.” In Blood, 114:858–858. AMER SOC HEMATOLOGY, 2009.
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