Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Internal Medicine Residency, Department Of Medicine, Beth Israel Deaconess Medical Center 1975 - 1977
  • M.D., Yeshiva University, Albert Einstein College of Medicine 1975
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Routh, Eric D., Steven D. Creacy, Peter E. Beerbower, Steven A. Akman, James P. Vaughn, and Philip J. Smaldino. “A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1.” J Vis Exp, no. 121 (March 18, 2017). https://doi.org/10.3791/55496.
       Full Text  Link to Item
    • Chifman, Julia, Seda Arat, Zhiyong Deng, Erica Lemler, James C. Pino, Leonard A. Harris, Michael A. Kochen, et al. “Activated Oncogenic Pathway Modifies Iron Network in Breast Epithelial Cells: A Dynamic Modeling Perspective.” Plos Comput Biol 13, no. 2 (February 2017): e1005352. https://doi.org/10.1371/journal.pcbi.1005352.
       Full Text  Link to Item
    • Cowherd, S., L. D. Miller, S. A. Melin, S. Akman, S. Isom, J. Cole, A. Pullikuth, and J. A. Lawrence. “A phase II clinical trial of weekly paclitaxel and carboplatin in combination with panitumumab in metastatic triple negative breast cancer.” Cancer Biol Ther 16, no. 5 (2015): 678–83. https://doi.org/10.1080/15384047.2015.1026481.
       Full Text  Link to Item
    • Smaldino, Philip J., Eric D. Routh, Jung H. Kim, Banabihari Giri, Steven D. Creacy, Roy R. Hantgan, Steven A. Akman, and James P. Vaughn. “Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding.” Plos One 10, no. 7 (2015): e0132668. https://doi.org/10.1371/journal.pone.0132668.
       Full Text  Link to Item
    • Swanner, Jessica, Jade Mims, David L. Carroll, Steven A. Akman, Cristina M. Furdui, Suzy V. Torti, and Ravi N. Singh. “Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.” Int J Nanomedicine 10 (2015): 3937–53. https://doi.org/10.2147/IJN.S80349.
       Full Text  Link to Item
    • Lawrence, Julia A., Steven A. Akman, Susan A. Melin, L Douglas Case, and Gary G. Schwartz. “Oral paricalcitol (19-nor-1,25-dihydroxyvitamin D2) in women receiving chemotherapy for metastatic breast cancer: a feasibility trial.” Cancer Biol Ther 14, no. 6 (June 2013): 476–80. https://doi.org/10.4161/cbt.24350.
       Full Text  Link to Item
    • O’Flaherty, Joseph T., Rhonda E. Wooten, Michael P. Samuel, Michael J. Thomas, Edward A. Levine, L Douglas Case, Steven A. Akman, and Iris J. Edwards. “Fatty acid metabolites in rapidly proliferating breast cancer.” Plos One 8, no. 5 (2013): e63076. https://doi.org/10.1371/journal.pone.0063076.
       Full Text  Link to Item
    • Chifman, J., A. Kniss, P. Neupane, I. Williams, B. Leung, Z. Deng, P. Mendes, et al. “The core control system of intracellular iron homeostasis: a mathematical model.” J Theor Biol 300 (May 7, 2012): 91–99. https://doi.org/10.1016/j.jtbi.2012.01.024.
       Full Text  Link to Item
    • Wan, Meimei, Weiwei Huang, Timothy E. Kute, Lance D. Miller, Qiang Zhang, Heather Hatcher, Jingxuan Wang, et al. “Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.” Am J Pathol 180, no. 5 (May 2012): 2120–33. https://doi.org/10.1016/j.ajpath.2012.01.037.
       Full Text  Link to Item
    • Akman, Steven A., Marissa Adams, Doug Case, Gyungse Park, and Richard A. Manderville. “Mutagenicity of ochratoxin A and its hydroquinone metabolite in the SupF gene of the mutation reporter plasmid Ps189.” Toxins (Basel) 4, no. 4 (April 2012): 267–80. https://doi.org/10.3390/toxins4040267.
       Full Text  Link to Item
    • Buchanan, Cara F., Christopher S. Szot, Tia D. Wilson, Steven Akman, Linda J. Metheny-Barlow, John L. Robertson, Joseph W. Freeman, and Marissa Nichole Rylander. “Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro.” J Cell Biochem 113, no. 4 (April 2012): 1142–51. https://doi.org/10.1002/jcb.23447.
       Full Text  Link to Item
    • Huang, Weiwei, Philip J. Smaldino, Qiang Zhang, Lance D. Miller, Paul Cao, Kristin Stadelman, Meimei Wan, et al. “Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1.” Nucleic Acids Res 40, no. 3 (February 2012): 1033–49. https://doi.org/10.1093/nar/gkr849.
       Full Text  Link to Item
    • Lattmann, Simon, Michael B. Stadler, James P. Vaughn, Steven A. Akman, and Yoshikuni Nagamine. “The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.” Nucleic Acids Res 39, no. 21 (November 2011): 9390–9404. https://doi.org/10.1093/nar/gkr630.
       Full Text  Link to Item
    • Ding, Xuanfeng, Ravi Singh, Andrew Burke, Heather Hatcher, John Olson, Robert A. Kraft, Michael Schmid, et al. “Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy.” Nanomedicine (Lond) 6, no. 8 (October 2011): 1341–52. https://doi.org/10.2217/nnm.11.37.
       Full Text  Link to Item
    • Blekherman, G., R. Laubenbacher, D. F. Cortes, P. Mendes, F. M. Torti, S. Akman, S. V. Torti, and V. Shulaev. “Bioinformatics tools for cancer metabolomics.” Metabolomics 7, no. 3 (September 1, 2011): 329–43. https://doi.org/10.1007/s11306-010-0270-3.
       Full Text
    • Giri, Banabihari, Philip J. Smaldino, Ryan G. Thys, Steven D. Creacy, Eric D. Routh, Roy R. Hantgan, Simon Lattmann, Yoshikuni Nagamine, Steven A. Akman, and James P. Vaughn. “G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA.” Nucleic Acids Res 39, no. 16 (September 1, 2011): 7161–78. https://doi.org/10.1093/nar/gkr234.
       Full Text  Link to Item
    • Cortes, Diego F., Wei Sha, Valerie Hower, Greg Blekherman, Reinhard Laubenbacher, Steven Akman, Suzy V. Torti, and Vladimir Shulaev. “Differential gene expression in normal and transformed human mammary epithelial cells in response to oxidative stress.” Free Radic Biol Med 50, no. 11 (June 1, 2011): 1565–74. https://doi.org/10.1016/j.freeradbiomed.2011.03.002.
       Full Text  Link to Item
    • Lattmann, Simon, Banabihari Giri, James P. Vaughn, Steven A. Akman, and Yoshikuni Nagamine. “Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU.” Nucleic Acids Res 38, no. 18 (October 2010): 6219–33. https://doi.org/10.1093/nar/gkq372.
       Full Text  Link to Item
    • Laubenbacher, Reinhard, Valerie Hower, Abdul Jarrah, Suzy V. Torti, Vladimir Shulaev, Pedro Mendes, Frank M. Torti, and Steven Akman. “A systems biology view of cancer.” Biochim Biophys Acta 1796, no. 2 (December 2009): 129–39. https://doi.org/10.1016/j.bbcan.2009.06.001.
       Full Text  Link to Item
    • Burke, Andrew, Xuanfeng Ding, Ravi Singh, Robert A. Kraft, Nicole Levi-Polyachenko, Marissa Nichole Rylander, Chris Szot, et al. “Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation.” Proc Natl Acad Sci U S A 106, no. 31 (August 4, 2009): 12897–902. https://doi.org/10.1073/pnas.0905195106.
       Full Text  Link to Item
    • Hower, Valerie, Pedro Mendes, Frank M. Torti, Reinhard Laubenbacher, Steven Akman, Vladmir Shulaev, and Suzy V. Torti. “A general map of iron metabolism and tissue-specific subnetworks.” Mol Biosyst 5, no. 5 (May 2009): 422–43. https://doi.org/10.1039/b816714c.
       Full Text  Link to Item
    • Creacy, Steven D., Eric D. Routh, Fumiko Iwamoto, Yoshikuni Nagamine, Steven A. Akman, and James P. Vaughn. “G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates.” J Biol Chem 283, no. 50 (December 12, 2008): 34626–34. https://doi.org/10.1074/jbc.M806277200.
       Full Text  Link to Item
    • Smith, Tasha R., Edward A. Levine, Rita I. Freimanis, Steven A. Akman, Glenn O. Allen, Kimberly N. Hoang, Wen Liu-Mares, and Jennifer J. Hu. “Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.” Carcinogenesis 29, no. 11 (November 2008): 2132–38. https://doi.org/10.1093/carcin/bgn193.
       Full Text  Link to Item
    • Gajewski, Ewa, Shikha Gaur, Steven A. Akman, Linda Matsumoto, Josephus N. A. van Balgooy, and James H. Doroshow. “Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin.” Biochem Pharmacol 73, no. 12 (June 15, 2007): 1947–56. https://doi.org/10.1016/j.bcp.2007.03.022.
       Full Text  Link to Item
    • Torti, Suzy V., Fiona Byrne, Orla Whelan, Nicole Levi, Burak Ucer, Michael Schmid, Frank M. Torti, et al. “Thermal ablation therapeutics based on CN(x) multi-walled nanotubes.” Int J Nanomedicine 2, no. 4 (2007): 707–14.
       Link to Item
    • Upton, D. C., X. Wang, P. Blans, F. W. Perrino, J. C. Fishbein, and S. A. Akman. “Erratum: Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 23 (Chemical Research in Toxicology (2006) 19,7, (960-967)).” Chemical Research in Toxicology 20, no. 1 (January 1, 2007): 164. https://doi.org/10.1021/tx6003419.
       Full Text
    • Upton, Dana C., Xueying Wang, Patrick Blans, Fred W. Perrino, James C. Fishbein, and Steven A. Akman. “Mutagenesis by exocyclic alkylamino purine adducts in Escherichia coli.” Mutat Res 599, no. 1–2 (July 25, 2006): 1–10. https://doi.org/10.1016/j.mrfmmm.2005.12.014.
       Full Text  Link to Item
    • Upton, Dana C., Xueying Wang, Patrick Blans, Fred W. Perrino, James C. Fishbein, and Steven A. Akman. “Replication of N2-ethyldeoxyguanosine DNA adducts in the human embryonic kidney cell line 293.” Chem Res Toxicol 19, no. 7 (July 2006): 960–67. https://doi.org/10.1021/tx060084a.
       Full Text  Link to Item
    • Vaughn, James P., Steven D. Creacy, Eric D. Routh, Christi Joyner-Butt, G Scott Jenkins, Sandra Pauli, Yoshikuni Nagamine, and Steven A. Akman. “The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.” J Biol Chem 280, no. 46 (November 18, 2005): 38117–20. https://doi.org/10.1074/jbc.C500348200.
       Full Text  Link to Item
    • Lim, Dean, Robert J. Morgan, Steven Akman, Kim Margolin, Brian I. Carr, Lucille Leong, Oluwole Odujinrin, and James H. Doroshow. “Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy.” Invest New Drugs 23, no. 3 (June 2005): 235–39. https://doi.org/10.1007/s10637-005-6731-2.
       Full Text  Link to Item
    • Hart, Lori S., Steven M. Yannone, Christine Naczki, Joseph S. Orlando, Stephen B. Waters, Steven A. Akman, David J. Chen, David Ornelles, and Constantinos Koumenis. “The adenovirus E4orf6 protein inhibits DNA double strand break repair and radiosensitizes human tumor cells in an E1B-55K-independent manner.” J Biol Chem 280, no. 2 (January 14, 2005): 1474–81. https://doi.org/10.1074/jbc.M409934200.
       Full Text  Link to Item
    • Perrino, Fred W., Patrick Blans, Scott Harvey, Stacy L. Gelhaus, Colleen McGrath, Steven A. Akman, G Scott Jenkins, William R. LaCourse, and James C. Fishbein. “The N2-ethylguanine and the O6-ethyl- and O6-methylguanine lesions in DNA: contrasting responses from the "bypass" DNA polymerase eta and the replicative DNA polymerase alpha.” Chem Res Toxicol 16, no. 12 (December 2003): 1616–23. https://doi.org/10.1021/tx034164f.
       Full Text  Link to Item
    • Manderville, R. A., M. W. Calcutt, J. Dai, G. Park, I. G. Gillman, R. E. Noftle, A. K. Mohammed, M. Dizdaroglu, H. Rodriguez, and S. A. Akman. “Erratum: Stoichiometric preference in copper-promoted oxidative DNA damage by ochratoxin A (Journal of Inorganic Biochemistry (2003) 95 (87-96).” Journal of Inorganic Biochemistry 97, no. 2 (October 1, 2003): 249. https://doi.org/10.1016/S0162-0134(03)00278-2.
       Full Text
    • Manderville, Richard A., M. Wade Calcutt, Jian Dai, Gyungse Park, Ivan G. Gillman, Ronald E. Noftle, Abdul K. Mohammed, et al. “Stoichiometric preference in copper-promoted oxidative DNA damage by ochratoxin A.” J Inorg Biochem 95, no. 2–3 (June 1, 2003): 87–96. https://doi.org/10.1016/s0162-0134(03)00104-1.
       Full Text  Link to Item
    • Morgan, Robert J., Edward M. Newman, Lawrence Sowers, Kevin Scanlon, Jonathan Harrison, Steven Akman, Lucille Leong, et al. “Phase I study of cisdiamminedichloroplatinum in combination with azidothymidine in the treatment of patients with advanced malignancies.” Cancer Chemother Pharmacol 51, no. 6 (June 2003): 459–64. https://doi.org/10.1007/s00280-003-0605-0.
       Full Text  Link to Item
    • Dai, Jian, Gyungse Park, Marcus W. Wright, Marissa Adams, Steven A. Akman, and Richard A. Manderville. “Detection and characterization of a glutathione conjugate of ochratoxin A.” Chem Res Toxicol 15, no. 12 (December 2002): 1581–88. https://doi.org/10.1021/tx0255929.
       Full Text  Link to Item
    • Waters, S. B., and S. A. Akman. “A new assay to quantify in vivo repair of G:T mispairs by base excision repair.” Mutat Res 487, no. 3–4 (December 19, 2001): 109–19. https://doi.org/10.1016/s0921-8777(01)00112-4.
       Full Text  Link to Item
    • Doroshow, J. H., T. W. Synold, G. Somlo, S. A. Akman, and E. Gajewski. “Oxidative DNA base modifications in peripheral blood mononuclear cells of patients treated with high-dose infusional doxorubicin.” Blood 97, no. 9 (May 1, 2001): 2839–45. https://doi.org/10.1182/blood.v97.9.2839.
       Full Text  Link to Item
    • Morgan, R. J., T. Synold, B. I. Carr, J. H. Doroshow, E. P. Womack, S. Shibata, G. Somlo, et al. “Continuous infusion prochlorperazine: pharmacokinetics, antiemetic efficacy, and feasibility of high-dose therapy.” Cancer Chemother Pharmacol 47, no. 4 (April 2001): 327–32. https://doi.org/10.1007/s002800000232.
       Full Text  Link to Item
    • Rodriguez, H., S. A. Akman, G. P. Holmquist, G. L. Wilson, W. J. Driggers, and S. P. LeDoux. “Mapping oxidative DNA damage using ligation-mediated polymerase chain reaction technology.” Methods 22, no. 2 (October 2000): 148–56. https://doi.org/10.1006/meth.2000.1055.
       Full Text  Link to Item
    • Tetef, M. L., K. A. Margolin, J. H. Doroshow, S. Akman, L. A. Leong, R. J. Morgan, J. W. Raschko, et al. “Pharmacokinetics and toxicity of high-dose intravenous methotrexate in the treatment of leptomeningeal carcinomatosis.” Cancer Chemother Pharmacol 46, no. 1 (2000): 19–26. https://doi.org/10.1007/s002800000118.
       Full Text  Link to Item
    • Rodriguez, H., M. R. Valentine, G. P. Holmquist, S. A. Akman, and J. Termini. “Mapping of peroxyl radical induced damage on genomic DNA.” Biochemistry 38, no. 50 (December 14, 1999): 16578–88. https://doi.org/10.1021/bi9918994.
       Full Text  Link to Item
    • Tetef, M., L. Leong, C. Ahn, S. Akman, W. Chow, K. Margolin, R. J. Morgan, et al. “Cisplatin and infusional cytosine arabinoside for the treatment of colorectal adenocarcinoma: a phase II trial.” Cancer Invest 17, no. 2 (1999): 114–17.
       Link to Item
    • Rodriguez, H., and S. A. Akman. “Mapping oxidative DNA damage at nucleotide level.” Free Radic Res 29, no. 6 (December 1998): 499–510. https://doi.org/10.1080/10715769800300551.
       Full Text  Link to Item
    • Rodriguez, H., and S. A. Akman. “Preparative-scale isolation of multiple genes by agarose-based continuous elution electrophoresis.” European Journal of Laboratory Medicine 6, no. 3 (December 1, 1998): 150–55.
    • Morgan, R. J., E. M. Newman, J. H. Doroshow, K. McGonigle, K. Margolin, J. Raschko, W. Chow, et al. “Phase I trial of intraperitoneal iododeoxyuridine with and without intravenous high-dose folinic acid in the treatment of advanced malignancies primarily confined to the peritoneal cavity: flow cytometric and pharmacokinetic analysis.” Cancer Res 58, no. 13 (July 1, 1998): 2793–2800.
       Link to Item
    • Rodriguez, H., and S. A. Akman. “Large scale isolation of genes as DNA fragment lengths by continuous elution electrophoresis through an agarose matrix.” Electrophoresis 19, no. 5 (May 1998): 646–52. https://doi.org/10.1002/elps.1150190506.
       Full Text  Link to Item
    • Morgan, R. J., J. H. Doroshow, K. Venkataraman, K. Chang, J. Raschko, G. Somlo, L. Leong, et al. “High-dose infusional doxorubicin and cyclophosphamide: a feasibility study of tandem high-dose chemotherapy cycles without stem cell support.” Clin Cancer Res 3, no. 12 Pt 1 (December 1997): 2337–45.
       Link to Item
    • Harrington, C., Y. Lan, and S. A. Akman. “The identification and characterization of a G4-DNA resolvase activity.” J Biol Chem 272, no. 39 (September 26, 1997): 24631–36. https://doi.org/10.1074/jbc.272.39.24631.
       Full Text  Link to Item
    • Rodriguez, H., G. P. Holmquist, R. D’Agostino, J. Keller, and S. A. Akman. “Metal ion-dependent hydrogen peroxide-induced DNA damage is more sequence specific than metal specific.” Cancer Res 57, no. 12 (June 15, 1997): 2394–2403.
       Link to Item
    • Rodriguez, H., R. Drouin, G. P. Holmquist, and S. A. Akman. “A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene.” Arch Biochem Biophys 338, no. 2 (February 15, 1997): 207–12. https://doi.org/10.1006/abbi.1996.9820.
       Full Text  Link to Item
    • Newman, E. M., M. Carroll, S. A. Akman, W. Chow, P. Coluzzi, V. Hamasaki, L. A. Leong, et al. “Pharmacokinetics and toxicity of 120-hour continuous-infusion hydroxyurea in patients with advanced solid tumors.” Cancer Chemother Pharmacol 39, no. 3 (1997): 254–58. https://doi.org/10.1007/s002800050569.
       Full Text  Link to Item
    • Akman, S. A., F. Sander, and K. Garbutt. “In vivo mutagenesis of the reporter plasmid pSP189 induced by exposure of host Ad293 cells to activated polymorphonuclear leukocytes.” Carcinogenesis 17, no. 10 (October 1996): 2137–41. https://doi.org/10.1093/carcin/17.10.2137.
       Full Text  Link to Item
    • Drouin, R., H. Rodriguez, S. W. Gao, Z. Gebreyes, T. R. O’Connor, G. P. Holmquist, and S. A. Akman. “Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications.” Free Radic Biol Med 21, no. 3 (1996): 261–73. https://doi.org/10.1016/0891-5849(96)00037-8.
       Full Text  Link to Item
    • Altman, S. A., T. H. Zastawny, L. Randers-Eichhorn, M. A. Cacciuttolo, S. A. Akman, M. Dizdaroglu, and G. Rao. “Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions.” Free Radic Biol Med 19, no. 6 (December 1995): 897–902. https://doi.org/10.1016/0891-5849(95)00095-f.
       Full Text  Link to Item
    • Gonzalez, B., S. Akman, J. Doroshow, H. Rivera, W. D. Kaplan, and G. L. Forrest. “Protection against daunorubicin cytotoxicity by expression of a cloned human carbonyl reductase cDNA in K562 leukemia cells.” Cancer Res 55, no. 20 (October 15, 1995): 4646–50.
       Link to Item
    • Morgan, R. J., K. Margolin, J. Raschko, S. Akman, L. Leong, G. Somlo, K. Scanlon, C. Ahn, M. Carroll, and J. H. Doroshow. “Phase I trial of carboplatin and infusional cyclosporin in advanced malignancy.” J Clin Oncol 13, no. 9 (September 1995): 2238–46. https://doi.org/10.1200/JCO.1995.13.9.2238.
       Full Text  Link to Item
    • Rodriguez, H., R. Drouin, G. P. Holmquist, T. R. O’Connor, S. Boiteux, J. Laval, J. H. Doroshow, and S. A. Akman. “Mapping of copper/hydrogen peroxide-induced DNA damage at nucleotide resolution in human genomic DNA by ligation-mediated polymerase chain reaction.” J Biol Chem 270, no. 29 (July 21, 1995): 17633–40. https://doi.org/10.1074/jbc.270.29.17633.
       Full Text  Link to Item
    • Morgan, R. J., J. Speyer, J. H. Doroshow, K. Margolin, J. Raschko, J. Sorich, S. Akman, L. Leong, G. Somlo, and S. Vasilev. “Modulation of 5-fluorouracil with high-dose leucovorin calcium: activity in ovarian cancer and correlation with CA-125 levels.” Gynecol Oncol 58, no. 1 (July 1995): 79–85. https://doi.org/10.1006/gyno.1995.1187.
       Full Text  Link to Item
    • Somlo, G., J. H. Doroshow, A. Lev-Ran, D. C. Ahn, L. Hwang, J. W. Raschko, S. J. Forman, K. A. Margolin, R. J. Morgan, and L. A. Leong. “Effect of low-dose prophylactic dopamine on high-dose cisplatin-induced electrolyte wasting, ototoxicity, and epidermal growth factor excretion: a randomized, placebo-controlled, double-blind trial.” J Clin Oncol 13, no. 5 (May 1995): 1231–37. https://doi.org/10.1200/JCO.1995.13.5.1231.
       Full Text  Link to Item
    • Pan, S. S., G. L. Forrest, S. A. Akman, and L. T. Hu. “NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HCT 116 cells.” Cancer Res 55, no. 2 (January 15, 1995): 330–35.
       Link to Item
    • Margolin, K. A., S. A. Akman, L. A. Leong, R. J. Morgan, G. Somlo, J. W. Raschko, C. Ahn, and J. H. Doroshow. “Phase I study of mitomycin C and menadione in advanced solid tumors.” Cancer Chemother Pharmacol 36, no. 4 (1995): 293–98. https://doi.org/10.1007/BF00689046.
       Full Text  Link to Item
    • Tetef, M., J. Doroshow, S. Akman, P. Coluzzi, L. Leong, K. Margolin, R. J. Morgan, J. Raschko, S. Shibata, and G. Somlo. “5-Fluorouracil and high-dose calcium leucovorin for hepatocellular carcinoma: a phase II trial.” Cancer Invest 13, no. 5 (1995): 460–63. https://doi.org/10.3109/07357909509024907.
       Full Text  Link to Item
    • Tetef, M., K. Margolin, C. Ahn, S. Akman, W. Chow, L. Leong, R. J. Morgan, J. Raschko, G. Somlo, and J. H. Doroshow. “Mitomycin C and menadione for the treatment of lung cancer: a phase II trial.” Invest New Drugs 13, no. 2 (1995): 157–62. https://doi.org/10.1007/BF00872865.
       Full Text  Link to Item
    • Tetef, M., K. Margolin, C. Ahn, S. Akman, W. Chow, P. Coluzzi, L. Leong, R. J. Morgan, J. Raschko, and S. Shibata. “Mitomycin C and menadione for the treatment of advanced gastrointestinal cancers: a phase II trial.” J Cancer Res Clin Oncol 121, no. 2 (1995): 103–6. https://doi.org/10.1007/BF01202221.
       Full Text  Link to Item
    • Margolin, K. A., S. Green, K. Osborne, J. H. Doroshow, S. A. Akman, L. A. Leong, R. J. Morgan, J. W. Raschko, G. Somlo, and L. Hutchins. “Phase II trial of 5-fluorouracil and high-dose folinic acid as first- or second-line therapy for advanced breast cancer.” Am J Clin Oncol 17, no. 2 (April 1994): 175–80. https://doi.org/10.1097/00000421-199404000-00018.
       Full Text  Link to Item
    • Somlo, G., J. H. Doroshow, S. J. Forman, L. A. Leong, K. A. Margolin, R. J. Morgan, J. W. Raschko, S. A. Akman, C. Ahn, and S. Nagasawa. “High-dose doxorubicin, etoposide, and cyclophosphamide with stem cell reinfusion in patients with metastatic or high-risk primary breast cancer. City of Hope Bone Marrow Oncology Team.” Cancer 73, no. 6 (March 15, 1994): 1678–85. https://doi.org/10.1002/1097-0142(19940315)73:6<1678::aid-cncr2820730621>3.0.co;2-u.
       Full Text  Link to Item
    • Raschko, J. W., S. A. Akman, L. A. Leong, K. A. Margolin, R. J. Morgan, E. Newman, G. Somlo, C. Ahn, and J. H. Doroshow. “Phase I study of 5-day continuous infusion fluorodeoxyuridine and high-dose folinic acid with oral hydroxyurea.” Cancer Chemother Pharmacol 35, no. 2 (1994): 161–64. https://doi.org/10.1007/BF00686640.
       Full Text  Link to Item
    • Somlo, G., J. H. Doroshow, S. J. Forman, L. A. Leong, K. A. Margolin, R. J. Morgan, J. W. Raschko, S. A. Akman, C. Ahn, and I. Sniecinski. “High-dose cisplatin, etoposide, and cyclophosphamide with autologous stem cell reinfusion in patients with responsive metastatic or high-risk primary breast cancer.” Cancer 73, no. 1 (January 1, 1994): 125–34. https://doi.org/10.1002/1097-0142(19940101)73:1<125::aid-cncr2820730122>3.0.co;2-w.
       Full Text  Link to Item
    • Akman, S. A., T. W. Kensler, J. H. Doroshow, and M. Dizdaroglu. “Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide.” Carcinogenesis 14, no. 9 (September 1993): 1971–74. https://doi.org/10.1093/carcin/14.9.1971.
       Full Text  Link to Item
    • Margolin, K. A., J. H. Doroshow, S. A. Akman, L. A. Leong, R. Morgan, J. Raschko, G. Somlo, J. Dutcher, K. Hawksworth, and L. Yonemoto. “Phase I trial of interleukin-2 plus doxorubicin.” J Immunother Emphasis Tumor Immunol 14, no. 1 (July 1993): 70–76. https://doi.org/10.1097/00002371-199307000-00010.
       Full Text  Link to Item
    • Dizdaroglu, M., R. Olinski, J. H. Doroshow, and S. A. Akman. “Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes.” Cancer Res 53, no. 6 (March 15, 1993): 1269–72.
       Link to Item
    • Akman, S. A., J. H. Doroshow, and T. W. Kensler. “Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189.” Carcinogenesis 13, no. 10 (October 1992): 1783–87. https://doi.org/10.1093/carcin/13.10.1783.
       Full Text  Link to Item
    • Margolin, K. A., J. H. Doroshow, S. A. Akman, L. A. Leong, R. J. Morgan, G. Somlo, J. Raschko, C. Pereira, L. Yonemoto, and C. Ahn. “Phase II trial of cisplatin and alpha-interferon in advanced malignant melanoma.” J Clin Oncol 10, no. 10 (October 1992): 1574–78. https://doi.org/10.1200/JCO.1992.10.10.1574.
       Full Text  Link to Item
    • Margolin, K. A., J. H. Doroshow, S. A. Akman, L. A. Leong, R. J. Morgan, J. W. Raschko, G. Somlo, and C. Blevins. “Effective initial therapy of advanced breast cancer with fluorouracil and high-dose, continuous infusion calcium leucovorin.” J Clin Oncol 10, no. 8 (August 1992): 1278–83. https://doi.org/10.1200/JCO.1992.10.8.1278.
       Full Text  Link to Item
    • Margolin, K. A., J. H. Doroshow, S. A. Akman, L. A. Leong, R. J. Morgan, J. Raschko, G. Somlo, B. Mills, D. Goldberg, and I. Sniecinski. “Phase I trial of interleukin-2 plus gamma-interferon.” J Immunother (1991) 11, no. 1 (January 1992): 50–55. https://doi.org/10.1097/00002371-199201000-00006.
       Full Text  Link to Item
    • Pan, S. S., S. A. Akman, G. L. Forrest, C. Hipsher, and R. Johnson. “The role of NAD(P)H:quinone oxidoreductase in mitomycin C- and porfiromycin-resistant HCT 116 human colon-cancer cells.” Cancer Chemother Pharmacol 31, no. 1 (1992): 23–31. https://doi.org/10.1007/BF00695990.
       Full Text  Link to Item
    • Singh, D., J. H. Doroshow, L. Leong, K. Margolin, S. Akman, J. Raschko, G. Somlo, R. Morgan, J. Harrison, and J. Cho. “Phase II trial of 5-fluorouracil, high-dose leucovorin calcium, and dipyridamole in advanced prostate cancer.” J Cancer Res Clin Oncol 119, no. 2 (1992): 117–20. https://doi.org/10.1007/BF01209667.
       Full Text  Link to Item
    • Akman, S. A., G. P. Forrest, J. H. Doroshow, and M. Dizdaroglu. “Mutation of potassium permanganate- and hydrogen peroxide-treated plasmid pZ189 replicating in CV-1 monkey kidney cells.” Mutat Res 261, no. 2 (October 1991): 123–30. https://doi.org/10.1016/0165-1218(91)90058-t.
       Full Text  Link to Item
    • Forrest, G. L., S. Akman, J. Doroshow, H. Rivera, and W. D. Kaplan. “Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.” Mol Pharmacol 40, no. 4 (October 1991): 502–7.
       Link to Item
    • Akman, S. A., R. G. Lingeman, J. H. Doroshow, and S. S. Smith. “Quadruplex DNA formation in a region of the tRNA gene supF associated with hydrogen peroxide mediated mutations.” Biochemistry 30, no. 35 (September 3, 1991): 8648–53. https://doi.org/10.1021/bi00099a022.
       Full Text  Link to Item
    • Esworthy, R. S., F. F. Chu, R. J. Paxton, S. Akman, and J. H. Doroshow. “Characterization and partial amino acid sequence of human plasma glutathione peroxidase.” Arch Biochem Biophys 286, no. 2 (May 1, 1991): 330–36. https://doi.org/10.1016/0003-9861(91)90048-n.
       Full Text  Link to Item
    • Somlo, G., J. Doroshow, S. Akman, L. Leong, K. Margolin, M. McNamara, P. Multhauf, D. Blayney, R. Morgan, and J. Raschko. “Phase II study of 4'-deoxydoxorubicin (esorubicin) in advanced or metastatic adenocarcinoma of the stomach.” Invest New Drugs 9, no. 1 (February 1991): 83–85. https://doi.org/10.1007/BF00194552.
       Full Text  Link to Item
    • Doroshow, J. H., S. Akman, S. Esworthy, F. F. Chu, and T. Burke. “Doxorubicin resistance conferred by selective enhancement of intracellular glutathione peroxidase or superoxide dismutase content in human MCF-7 breast cancer cells.” Free Radic Res Commun 12-13 Pt 2 (1991): 779–81. https://doi.org/10.3109/10715769109145859.
       Full Text  Link to Item
    • Margolin, K., J. Doroshow, L. Leong, S. Akman, B. Carr, O. Odujinrin, B. Flanagan, W. Grove, R. DeLap, and D. Goldberg. “3-Deazaguanine: report of a phase I trial and drug-related cardiac toxicity.” Invest New Drugs 8, no. 4 (November 1990): 369–76. https://doi.org/10.1007/BF00198593.
       Full Text  Link to Item
    • Akman, S. A., J. H. Doroshow, and M. Dizdaroglu. “Base modifications in plasmid DNA caused by potassium permanganate.” Arch Biochem Biophys 282, no. 1 (October 1990): 202–5. https://doi.org/10.1016/0003-9861(90)90105-8.
       Full Text  Link to Item
    • Forrest, G. L., J. Qian, J. X. Ma, W. D. Kaplan, S. Akman, J. Doroshow, and S. A. Chen. “Rat liver NAD(P)H:quinone oxidoreductase: cDNA expression and site-directed mutagenesis.” Biochem Biophys Res Commun 169, no. 3 (June 29, 1990): 1087–93. https://doi.org/10.1016/0006-291x(90)92006-l.
       Full Text  Link to Item
    • Forrest, G. L., S. Akman, S. Krutzik, R. J. Paxton, R. S. Sparkes, J. Doroshow, R. L. Felsted, C. J. Glover, T. Mohandas, and N. R. Bachur. “Induction of a human carbonyl reductase gene located on chromosome 21.” Biochim Biophys Acta 1048, no. 2–3 (April 6, 1990): 149–55. https://doi.org/10.1016/0167-4781(90)90050-c.
       Full Text  Link to Item
    • Chu, F. F., R. S. Esworthy, S. Akman, and J. H. Doroshow. “Modulation of glutathione peroxidase expression by selenium: effect on human MCF-7 breast cancer cell transfectants expressing a cellular glutathione peroxidase cDNA and doxorubicin-resistant MCF-7 cells.” Nucleic Acids Res 18, no. 6 (March 25, 1990): 1531–39. https://doi.org/10.1093/nar/18.6.1531.
       Full Text  Link to Item
    • Akman, S. A., G. Forrest, F. F. Chu, R. S. Esworthy, and J. H. Doroshow. “Antioxidant and xenobiotic-metabolizing enzyme gene expression in doxorubicin-resistant MCF-7 breast cancer cells.” Cancer Res 50, no. 5 (March 1, 1990): 1397–1402.
       Link to Item
    • Doroshow, J. H., P. Multhauf, L. Leong, K. Margolin, T. Litchfield, S. Akman, B. Carr, M. Bertrand, D. Goldberg, and D. Blayney. “Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.” J Clin Oncol 8, no. 3 (March 1990): 491–501. https://doi.org/10.1200/JCO.1990.8.3.491.
       Full Text  Link to Item
    • Doroshow, J. H., S. Akman, F. F. Chu, and S. Esworthy. “Role of the glutathione-glutathione peroxidase cycle in the cytotoxicity of the anticancer quinones.” Pharmacol Ther 47, no. 3 (1990): 359–70. https://doi.org/10.1016/0163-7258(90)90062-7.
       Full Text  Link to Item
    • Odujinrin, O., D. Goldberg, J. Doroshow, L. Leong, K. Margolin, W. Grove, B. Carr, and S. Akman. “Treatment of metastatic malignant melanoma with trimetrexate: a phase II study.” Med Pediatr Oncol 18, no. 1 (1990): 49–52. https://doi.org/10.1002/mpo.2950180110.
       Full Text  Link to Item
    • Margolin, K., J. Doroshow, L. Leong, S. Akman, B. I. Carr, O. Odujinrin, and B. Flanagan. “Combination chemotherapy with cytosine arabinoside (Ara-C) and cis-diamminedichloroplatinum (CDDP) for squamous cancers of the upper aerodigestive tract.” Am J Clin Oncol 12, no. 6 (December 1989): 494–97. https://doi.org/10.1097/00000421-198912000-00007.
       Full Text  Link to Item
    • Akman, S. A., G. Forrest, F. F. Chu, and J. H. Doroshow. “Resistance to hydrogen peroxide associated with altered catalase mRNA stability in MCF7 breast cancer cells.” Biochim Biophys Acta 1009, no. 1 (September 21, 1989): 70–74. https://doi.org/10.1016/0167-4781(89)90080-8.
       Full Text  Link to Item
    • Doroshow, J. H., L. Leong, K. Margolin, B. Flanagan, D. Goldberg, M. Bertrand, S. Akman, B. Carr, O. Odujinrin, and E. Newman. “Refractory metastatic breast cancer: salvage therapy with fluorouracil and high-dose continuous infusion leucovorin calcium.” J Clin Oncol 7, no. 4 (April 1989): 439–44. https://doi.org/10.1200/JCO.1989.7.4.439.
       Full Text  Link to Item
    • Margolin, K., S. Akman, B. Carr, L. Leong, and J. Doroshow. “Etoposide (VP-16) and cytosine arabinoside in the treatment of relapsed small-cell lung cancer.” Am J Clin Oncol 11, no. 4 (August 1988): 499–501. https://doi.org/10.1097/00000421-198808000-00017.
       Full Text  Link to Item
    • Doroshow, J. H., L. Leong, K. Margolin, B. Flanagan, D. Goldberg, M. Bertrand, S. Akman, B. Carr, O. Odujinrin, and T. Litchfield. “Effective salvage therapy for refractory disseminated breast cancer with 5-fluorouracil and high-dose continuous infusion folinic acid.” Adv Exp Med Biol 244 (1988): 245–53. https://doi.org/10.1007/978-1-4684-5607-3_26.
       Full Text  Link to Item
    • Ross, D. D., B. W. Thompson, C. C. Joneckis, S. A. Akman, and C. A. Schiffer. “Studies of ara-C metabolism in acute leukemia.” Semin Oncol 14, no. 2 Suppl 1 (June 1987): 182–91.
       Link to Item
    • Akman, S. A., J. H. Doroshow, M. F. Dietrich, R. T. Chlebowski, and J. S. Block. “Synergistic cytotoxicity between menadione and dicumarol vs. murine leukemia L1210.” J Pharmacol Exp Ther 240, no. 2 (February 1987): 486–91.
       Link to Item
    • Chlebowski, R. T., L. Bulcavage, M. Grosvenor, R. Tsunokai, J. B. Block, D. Heber, M. Scrooc, J. S. Chlebowski, J. Chi, and E. Oktay. “Hydrazine sulfate in cancer patients with weight loss. A placebo-controlled clinical experience.” Cancer 59, no. 3 (February 1, 1987): 406–10. https://doi.org/10.1002/1097-0142(19870201)59:3<406::aid-cncr2820590309>3.0.co;2-w.
       Full Text  Link to Item
    • Doroshow, J. H., M. Bertrand, E. Newman, P. Multhauf, L. Leong, D. Blayney, D. Goldberg, K. Margolin, B. Carr, and S. Akman. “Preliminary analysis of a randomized comparison of 5-fluorouracil versus 5-fluorouracil and high-dose continuous-infusion folinic acid in disseminated colorectal cancer.” Nci Monogr, no. 5 (1987): 171–74.
       Link to Item
    • Ross, D. D., B. W. Thompson, C. C. Joneckis, S. A. Akman, and C. A. Schiffer. “Metabolism of ara-C by blast cells from patients with ANLL.” Blood 68, no. 1 (July 1986): 76–82.
       Link to Item
    • Akman, S. A., M. Dietrich, R. Chlebowski, P. Limberg, and J. B. Block. “Modulation of cytotoxicity of menadione sodium bisulfite versus leukemia L1210 by the acid-soluble thiol pool.” Cancer Res 45, no. 11 Pt 1 (November 1985): 5257–62.
       Link to Item
    • Chlebowski, R. T., M. Dietrich, S. Akman, and J. B. Block. “Vitamin K3 inhibition of malignant murine cell growth and human tumor colony formation.” Cancer Treat Rep 69, no. 5 (May 1985): 527–32.
       Link to Item
    • Chlebowski, R. T., S. A. Akman, and J. B. Block. “Vitamin K in the treatment of cancer.” Cancer Treat Rev 12, no. 1 (March 1985): 49–63. https://doi.org/10.1016/0305-7372(85)90012-x.
       Full Text  Link to Item
    • Akman, S. A., D. D. Ross, C. C. Joneckis, B. M. Fox, and N. R. Bachur. “Deoxyguanosine enhancement of cytarabine nucleotide accumulation in human leukemia cells.” Cancer Treat Rep 69, no. 7–8 (1985): 851–57.
       Link to Item
    • Akman, S. A., and J. B. Block. “Neurologic complications of systemic cancer.” Prim Care 11, no. 4 (December 1984): 597–623.
       Link to Item
    • Akman, S. A., F. Kusu, K. Takamura, R. Chlebowski, and J. Block. “Differential pulse polarographic determination of plasma menadione.” Anal Biochem 141, no. 2 (September 1984): 488–93. https://doi.org/10.1016/0003-2697(84)90075-7.
       Full Text  Link to Item
    • Akman, S. A., D. D. Ross, C. C. Joneckis, B. M. Fox, and N. R. Bachur. “Synergistic inhibition of human leukemia cell growth by deoxyguanosine and 1-beta-D-arabinofuranosylcytosine.” Biochem Pharmacol 33, no. 7 (April 1, 1984): 1059–63. https://doi.org/10.1016/0006-2952(84)90513-6.
       Full Text  Link to Item
    • Ross, D. D., S. A. Akman, C. C. Joneckis, E. Yang, and N. R. Bachur. “Schedule-dependent enhancement of 1-beta-D-arabinofuranosylcytosine incorporation into HL-60 DNA by deoxyguanosine.” Cancer Res 44, no. 4 (April 1984): 1530–35.
       Link to Item
    • Biswal, N., U. Ko, S. Akman, D. D. Ross, A. Pollak, and E. Cimino. “Persistence of herpes simplex virus type-2 genome in a human leukemic cell line.” Biochim Biophys Acta 740, no. 3 (August 2, 1983): 271–81. https://doi.org/10.1016/0167-4781(83)90136-7.
       Full Text  Link to Item
    • Takahara, Y., F. Battaini, D. D. Ross, S. A. Akman, N. R. Bachur, K. R. Bailey, E. Lakatos, and A. Peterkofsky. “Detection in human serum by radioimmunoassay of histidyl-proline diketopiperazine, a metabolite of thyrotropin-releasing hormone.” J Clin Endocrinol Metab 56, no. 2 (February 1983): 312–19. https://doi.org/10.1210/jcem-56-2-312.
       Full Text  Link to Item
    • Akman, S. A., D. D. Ross, and C. C. Joneckis. “Mechanism of synergistic cytotoxicity between nucleosides and arabinofuranosyl cytosine (ara-C) against HL-60 cells.” Proceedings of the American Association for Cancer Research Vol. 23 (January 1, 1982).
    • Ross, D. D., S. A. Akman, A. W. Schrecker, and N. R. Bachur. “Effects of deoxynucleosides on cultured human leukemia cell growth and deoxynucleotide pools.” Cancer Res 41, no. 11 Pt 1 (November 1981): 4493–98.
       Link to Item
    • Akman, S. A., D. D. Ross, H. Rosen, C. Salinger, P. A. Andrews, F. E. Chou, and N. R. Bachur. “Growth inhibition by thymidine of leukemic HL-60 and normal human myeloid progenitor cells.” Cancer Res 41, no. 6 (June 1981): 2141–46.
       Link to Item
    • Ross, D. D., A. Pollak, S. A. Akman, and N. R. Bachur. “Diurnal variation of circulating human myeloid progenitor cells.” Exp Hematol 8, no. 7 (August 1980): 954–60.
       Link to Item
    • Ross, D. D., S. A. Akman, and H. Rosen. “Deoxynucleoside effects on growth and deoxynucleotide pools in cultured human leukemic cells.” Experimental Hematology 8, no. 7 SUPPL. (January 1, 1980).

  • Conference Papers

    • Akman, S. A., T. R. O’Connor, and H. Rodriguez. “Mapping oxidative DNA damage and mechanisms of repair.” In Ann N Y Acad Sci, 899:88–102, 2000. https://doi.org/10.1111/j.1749-6632.2000.tb06178.x.
       Full Text  Link to Item
    • Rodriguez, H., and S. A. Akman. “Measurement of oxidative DNA damage in the human p53 and PGK1 gene at nucleotide resolution.” In Ann N Y Acad Sci, 893:382–85, 1999. https://doi.org/10.1111/j.1749-6632.1999.tb07861.x.
       Full Text  Link to Item
    • Doroshow, J. H., K. Margolin, L. Leong, S. Akman, R. Morgan, J. Raschko, G. Somlo, V. Hamasaki, E. Womack, and E. Newman. “Fluorouracil and leucovorin in advanced breast cancer.” In Adv Exp Med Biol, 339:187–93, 1993. https://doi.org/10.1007/978-1-4615-2488-5_19.
       Full Text  Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.