Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Medical Oncology, Royal College of Physicians (United Kingdom) 1993 - 1995
  • Internal Medicine, Royal College of Physicians (United Kingdom) 1990 - 1993
  • M.D., McMaster University (Canada) 1990
• 

  Duke Appointment History

  • Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2018 - 2021
• Research
• 

  Selected Grants

  • A PHASEIB/III STUDY OF IPATASERTIB PLUS PALBOCICLIB AND FULVESTRANT VERSUS PLACEBO PLUS PALBOCICLIB AND FULVESTRANT IN HORMONE RECEPTOR POSITIVE AND HER2 NEGATIVE LOCALLY ADVANCED UNRESECTABLE OR METASTATIC BREAST CANCER awarded by F. Hoffmann-La Roche Ltd 2019 - 2024
  • Preventing Inflammatory Breast Cancer Metastases by Interrupting Cellular Stress Signaling in Lymphatic Emboli and Circulating Tumor Cell Clusters awarded by Department of Defense 2020 - 2023
  • CardiovAscular Risk profile and Treatment patterns in ER+HER2 - Advanced Breast Cancer: A retrospective cohort study (CAREB) awarded by Novartis Pharmaceuticals Corporation 2019 - 2022
• 

  External Relationships

  • Novartis pharmaceuticals
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Dent, Susan F., Amber Morse, Sarah Burnette, Avirup Guha, and Heather Moore. “Cardiovascular Toxicity of Novel HER2-Targeted Therapies in the Treatment of Breast Cancer.” Current Oncology Reports 23, no. 11 (August 27, 2021): 128. https://doi.org/10.1007/s11912-021-01114-x.
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    • Fradley, Michael G., Theresa M. Beckie, Sherry Ann Brown, Richard K. Cheng, Susan F. Dent, Anju Nohria, Kristen K. Patton, Jagmeet P. Singh, and Brian Olshansky. “Recognition, Prevention, and Management of Arrhythmias and Autonomic Disorders in Cardio-Oncology: A Scientific Statement From the American Heart Association.” Circulation 144, no. 3 (July 20, 2021): e41–55. https://doi.org/10.1161/CIR.0000000000000986.
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    • Dent, S. F., J. Botros, M. Rushton, O. Aseyev, M. N. Levine, W. R. Parulekar, P. O’Brien, et al. “Anthracycline-induced cardiotoxicity in patients with early-stage breast cancer: the Canadian Cancer Trials Group (CCTG) MA.21 experience.” Breast Cancer Res Treat 184, no. 3 (December 2020): 733–41. https://doi.org/10.1007/s10549-020-05887-w.
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    • Alvarez-Cardona, Jose A., Jordan Ray, Joseph Carver, Vlad Zaha, Richard Cheng, Eric Yang, Joshua D. Mitchell, et al. “Cardio-Oncology Education and Training: JACC Council Perspectives.” J Am Coll Cardiol 76, no. 19 (November 10, 2020): 2267–81. https://doi.org/10.1016/j.jacc.2020.08.079.
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    • Lenihan, Daniel, Joseph Carver, Charles Porter, Jennifer E. Liu, Susan Dent, Paaladinesh Thavendiranathan, Joshua D. Mitchell, et al. “Cardio-oncology care in the era of the coronavirus disease 2019 (COVID-19) pandemic: An International Cardio-Oncology Society (ICOS) statement.” Ca Cancer J Clin 70, no. 6 (November 2020): 480–504. https://doi.org/10.3322/caac.21635.
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    • Addison, Daniel, Courtney M. Campbell, Avirup Guha, Arjun K. Ghosh, Susan F. Dent, and Hani Jneid. “Cardio-Oncology in the Era of the COVID-19 Pandemic and Beyond.” J Am Heart Assoc 9, no. 19 (October 20, 2020): e017787. https://doi.org/10.1161/JAHA.120.017787.
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    • Kikuchi, Robin, Nishant P. Shah, and Susan F. Dent. “Strategies to Prevent Cardiovascular Toxicity in Breast Cancer: Is It Ready for Primetime?” J Clin Med 9, no. 4 (March 25, 2020). https://doi.org/10.3390/jcm9040896.
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    • Dent, Susan F., Robin Kikuchi, Lavanya Kondapalli, Roohi Ismail-Khan, Christine Brezden-Masley, Ana Barac, and Michael Fradley. “Optimizing Cardiovascular Health in Patients With Cancer: A Practical Review of Risk Assessment, Monitoring, and Prevention of Cancer Treatment-Related Cardiovascular Toxicity.” Am Soc Clin Oncol Educ Book 40 (March 2020): 1–15. https://doi.org/10.1200/EDBK_286019.
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    • Curigliano, G., D. Lenihan, M. Fradley, S. Ganatra, A. Barac, A. Blaes, J. Herrmann, et al. “Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations.” Ann Oncol 31, no. 2 (February 2020): 171–90. https://doi.org/10.1016/j.annonc.2019.10.023.
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    • Sammons, Sarah, Mythili Shastry, Susan Dent, Carey Anders, and Erika Hamilton. “Practical Treatment Strategies and Future Directions After Progression While Receiving CDK4/6 Inhibition and Endocrine Therapy in Advanced HR+/HER2- Breast Cancer.” Clin Breast Cancer 20, no. 1 (February 2020): 1–11. https://doi.org/10.1016/j.clbc.2019.06.017.
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    • Dent, Susan F., Thomas M. Suter, Teresa López-Fernández, Grzegorz Opolski, Pierantonio Menna, and Giorgio Minotti. “Cardio-oncology in clinical studies and real life.” Semin Oncol 46, no. 6 (December 2019): 421–25. https://doi.org/10.1053/j.seminoncol.2019.01.004.
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    • Dent, Susan, Chiara Melloni, Josee Ivars, Sarah Sammons, and Gretchen Kimmick. “Cardiotoxicities of Modern Treatments in Breast Cancer.” Curr Treat Options Cardiovasc Med 21, no. 7 (June 15, 2019): 34. https://doi.org/10.1007/s11936-019-0738-z.
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    • Kappel, C., M. Rushton, C. Johnson, O. Aseyev, G. Small, A. Law, J. Ivars, and S. Dent. “Clinical experience of patients referred to a multidisciplinary cardio-oncology clinic: an observational cohort study.” Curr Oncol 26, no. 3 (June 2019): e322–27. https://doi.org/10.3747/co.26.4509.
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    • Kosalka, P., C. Johnson, M. Turek, J. Sulpher, A. Law, J. Botros, S. Dent, and O. Aseyev. “Effect of obesity, dyslipidemia, and diabetes on trastuzumab-related cardiotoxicity in breast cancer.” Curr Oncol 26, no. 3 (June 2019): e314–21. https://doi.org/10.3747/co.26.4823.
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    • Kimmick, Gretchen, Susan Dent, and Igor Klem. “Risk of Cardiomyopathy in Breast Cancer: How Can We Attenuate the Risk of Heart Failure from Anthracyclines and Anti-HER2 Therapies?” Curr Treat Options Cardiovasc Med 21, no. 6 (May 31, 2019): 30. https://doi.org/10.1007/s11936-019-0736-1.
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    • Dent, S., C. Ammendolea, A. Christofides, S. Edwards, D. Incekol, B. Pourmirza, S. Kfoury, and B. Poirier. “A multidisciplinary perspective on the subcutaneous administration of trastuzumab in HER2-positive breast cancer.” Curr Oncol 26, no. 1 (February 2019): e70–80. https://doi.org/10.3747/co.26.4220.
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    • Devi, Gayathri R., Holly Hough, Nadine Barrett, Massimo Cristofanilli, Beth Overmoyer, Neil Spector, Naoto T. Ueno, et al. “Perspectives on Inflammatory Breast Cancer (IBC) Research, Clinical Management and Community Engagement from the Duke IBC Consortium.” J Cancer 10, no. 15 (2019): 3344–51. https://doi.org/10.7150/jca.31176.
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    • Armenian, Saro H., Christina Lacchetti, Ana Barac, Joseph Carver, Louis S. Constine, Neelima Denduluri, Susan Dent, et al. “Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.” J Clin Oncol 35, no. 8 (March 10, 2017): 893–911. https://doi.org/10.1200/JCO.2016.70.5400.
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    • Lenihan, Daniel J., Gregory Hartlage, Jeanne DeCara, Anne Blaes, J Emanuel Finet, Alexander R. Lyon, Robert F. Cornell, et al. “Cardio-Oncology Training: A Proposal From the International Cardioncology Society and Canadian Cardiac Oncology Network for a New Multidisciplinary Specialty.” J Card Fail 22, no. 6 (June 2016): 465–71. https://doi.org/10.1016/j.cardfail.2016.03.012.
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    • Brackstone, M., G. G. Fletcher, I. S. Dayes, Y. Madarnas, S. K. Sen Gupta, S. Verma, A. Eisen, et al. “Locoregional therapy of locally advanced breast cancer: A clinical practice guideline.” Current Oncology 22 (March 1, 2015): S54–66. https://doi.org/10.3747/co.22.2316.
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    • Eisen, A., G. G. Fletcher, S. Gandhi, M. Mates, O. C. Freedman, S. F. Dent, M. E. Trudeau, and M. E. members of the Early Breast Cancer Systemic Therapy Consensus Panel. “Optimal systemic therapy for early breast cancer in women: a clinical practice guideline.” Curr Oncol 22, no. Suppl 1 (March 2015): S67–81. https://doi.org/10.3747/co.22.2320.
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    • Freedman, O. C., G. G. Fletcher, S. Gandhi, M. Mates, S. F. Dent, M. E. Trudeau, and A. Eisen. “Adjuvant endocrine therapy for early breast cancer: a systematic review of the evidence for the 2014 Cancer Care Ontario systemic therapy guideline.” Curr Oncol 22, no. Suppl 1 (March 2015): S95–113. https://doi.org/10.3747/co.22.2326.
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    • Gandhi, S., G. G. Fletcher, A. Eisen, M. Mates, O. C. Freedman, S. F. Dent, and M. E. Trudeau. “Adjuvant chemotherapy for early female breast cancer: a systematic review of the evidence for the 2014 Cancer Care Ontario systemic therapy guideline.” Curr Oncol 22, no. Suppl 1 (March 2015): S82–94. https://doi.org/10.3747/co.22.2321.
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    • Mates, M., G. G. Fletcher, O. C. Freedman, A. Eisen, S. Gandhi, M. E. Trudeau, and S. F. Dent. “Systemic targeted therapy for her2-positive early female breast cancer: a systematic review of the evidence for the 2014 Cancer Care Ontario systemic therapy guideline.” Curr Oncol 22, no. Suppl 1 (March 2015): S114–22. https://doi.org/10.3747/co.22.2322.
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  • Book Sections

    • Khouri, M. G., I. Klem, C. Shenoy, J. Sulpher, and S. F. Dent. “Screening and monitoring for cardiotoxicity during cancer treatment.” In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 43–80, 2017. https://doi.org/10.1007/978-3-319-43096-6_3.
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  • Conference Papers

    • Dent, Susan Faye, Henning Steen, Moritz Montenbruck, Sebastian Esch, Pia Wulfing, Kyle Janson, and Daniel Lenihan. “Abstract P5-14-18: Cardioprotective therapy in breast cancer patients with subclinical and clinical cardiotoxicty.” In Poster Session Abstracts. American Association for Cancer Research, 2020. https://doi.org/10.1158/1538-7445.sabcs19-p5-14-18.
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    • Rushton-Marovac, Moira K., Isac Lima, Meltem Tuna, Chiara Melloni, Kathy Pritchard, Steven Hawken, and Susan F. Dent. “Abstract P5-14-11: Cardiac monitoring in advanced breast cancer patients treated with trastuzumab: Does it improve cardiac safety?” In Poster Session Abstracts. American Association for Cancer Research, 2020. https://doi.org/10.1158/1538-7445.sabcs19-p5-14-11.
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    • Melloni, Chiara, Gretchen G. Kimmick, Taofik Oyekunle, Leah L. Zullig, Michel G. Khouri, Lauren Howard, Michael J. Kelley, and Susan F. Dent. “Statin Use is Associated With Increased Overall Survival in Patients With Colorectal Cancer: Findings From a Cohort of 29,498 United States Veterans.” In Circulation, Vol. 140, 2019.
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