Scholarly Works - Book sections
Book section
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January 1, 2016
Age is a major risk factor for phenotypes characterizing human health, well-being, and survival in late life. The risks of these phenotypes expressed in forms of pathological dysregulation of physiological functions, incidence or prevalence of diseases, ca ...
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January 1, 2016
Life expectancy in humans worldwide has been experiencing dramatic increases for the past two centuries (Oeppen and Vaupel 2002). In most countries, the extension of lifespan is associated with a transition from a long historical period of high fertility a ...
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January 1, 2016
It is well known from epidemiological research that values of indices describing physiological states at a given age may influence human morbidity and mortality risks. Studies of the connections between aging and life span suggest that the dynamic properti ...
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January 1, 2016
Decades of studies of candidate genes show that they are not linked to aging-related traits in a straightforward manner. Recent genome-wide association studies (GWAS) have reached fundamentally the same conclusion by showing that traits in late life are li ...
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January 1, 2016
A better understanding of relationships among human aging, health, and longevity requires integrative statistical methods capable of taking into account relevant knowledge accumulated in the field when extracting useful information from the data. In this c ...
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January 1, 2016
Demographic calculations evaluating the role of chronic diseases in life expectancy use the assumption that diseases are independent. Disease independence was a plausible hypothesis in the era of infectious diseases. However, the health problems of modern ...
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January 1, 2016
Longitudinal data on aging, health, and longevity provide researchers with a unique opportunity to observe aging-related changes in biomarkers that describe the functioning of individual organisms during people’s life courses. In this chapter, empirical es ...
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January 1, 2016
In a number of longitudinal studies, individual health and physiological/biological variables are repeatedly measured for a relatively large number of study subjects. Such data have good potential for evaluating properties of dynamic mechanisms involved in ...
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January 1, 2016
Mortality rates are important characteristics of life span distributions that integrate the influences of many external and internal factors affecting individuals in the population during their life course. These include the ontogenetic program, individual ...
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January 1, 2016
The tremendous research potential of U.S. Medicare data for evaluation of current, and forecasting of future, patterns of aging-related diseases among older U.S. adults remains largely unexplored. In this chapter, we present and discuss the results of a se ...
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January 1, 2016
Aging-related deterioration in health impacts an important economic component: the medical costs associated with disease diagnosis and treatment. Because almost all U.S. residents aged 65+ years old are covered by the Medicare system, prediction of future ...
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January 1, 2016
Cancer incidence rates for all disease sites combined and life expectancy have increased over time in many countries around the world. These increases were concurrent with economic progress and the spread of the Western lifestyle. Overall cancer risk and l ...
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January 1, 2013
Age trajectories of mortality rates in human populations characterize individuals’ inequality in the duration of life. Various models of mortality rates are used in the analyses of survival data in demographic and epidemiological applications aiming to ide ...
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