Svetlana Ukraintseva

Journal article BMC medicine · April 2026 BackgroundFamilies with exceptional longevity often experience delayed onset of age-related diseases and reduced mortality across generations-a pattern influenced by shared genetic and behavioral factors. While several studies have focused on the ... Full text Cite

Towards personalized vaccine repurposing for Alzheimer's prevention: genotype-specific protective association of the shingles vaccine with odds of Alzheimer's disease in participants of two large cohort studies.

Journal article BMC neurology · February 2026 BACKGROUND: Our earlier study found that adult vaccination against shingles (herpes zoster infection caused by the reactivation of the varicella-zoster virus) was associated with significantly reduced risk of Alzheimer's disease (AD) later in life. Here, w ... Full text Cite

Lower hippocampal volume partly mediates the association between rs6859 in the <i>NECTIN2</i> gene and Alzheimer's disease: new findings from causal mediation analysis of ADNI data.

Journal article Frontiers in aging neuroscience · January 2026 IntroductionAlzheimer's disease (AD) is a complex disorder influenced by many factors. The rs6859 polymorphism in the NECTIN2 gene has been consistently linked to AD risk. The NECTIN2 is involved in vulnerability to infections, which ... Full text Cite

Disease-specific drivers of sex- and locality-related disparities in life expectancy at age 65: two decades of progress before COVID-19.

Journal article Innovation in aging · January 2026 Background and objectivesThe distribution of life expectancy at age 65 (LE65 ) in the United States is characterized by profound sex- and locality-related disparities. Quantifying the disease-specific drivers of these disparities ... Full text Cite

Basic Science and Pathogenesis.

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAPOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), with a higher effect in females than in males. Identifying factors that may reduce the detrimental impact of APOE4 on AD is an important research objecti ... Full text Cite

Developing Topics.

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAccumulating evidence points to a major role of compromised immunity in Alzheimer's Disease (AD). The MIR146a and COMT genes are both known for their involvement in immune responses, as well as in AD-related traits. COMT also regulates t ... Full text Cite

Developing Topics.

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundInfections and neuroinflammation are increasingly recognized as key contributors to the pathogenesis of Alzheimer's disease (AD). Emerging evidence suggests that the immune-regulating genes GDF15 and MIR146A are promising targets for dev ... Full text Cite

Public Health.

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAlzheimer's disease (AD) likely results from a combination of genetic, environmental, and other factors. Accumulating evidence points to a role of infections in AD. Traffic-related air pollution (TRAP) and APOE4 are major risk factors fo ... Full text Cite

Public Health.

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundOur earlier study using Medicare-linked data found that vaccination against shingles was associated with ∼20% reduced risk of Alzheimer's disease (AD) later in life. Here, we investigated genotype-specific associations of the shingles va ... Full text Cite

Developing Topics.

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAPOE4 and its proxy, rs2075650 (G) allele, are strongly associated with Alzheimer's disease (AD), though the mechanisms remain debated. APOE4 has also been linked to infection severity. Infections, including pneumonia, have, in turn, bee ... Full text Cite

Changing Story of the Dementia Epidemic.

Journal article JAMA · May 13, 2025 Full text Link to item Cite

Methods for joint modeling of longitudinal omics data and time-to-event outcomes: applications to lysophosphatidylcholines in connection to aging and mortality in the Long Life Family Study.

Journal article Aging · May 2025 Studying the relationships between longitudinal changes in omics variables and event risks requires specific methodologies for joint analyses of longitudinal and time-to-event outcomes. We applied two such approaches (joint models [JM], stochastic process ... Full text Cite

Genome-Related Mechanisms Contributing to Differences in Alzheimer's Disease Incidence Between White and Black Older US Adults.

Journal article Journal of racial and ethnic health disparities · April 2025 In this manuscript, we leverage a modified GWAS algorithm adapted for use with multidimensional Cox models and data from the Health and Retirement Study to explore how genetic variation influences the size of the disparity in Alzheimer's disease (AD) incid ... Full text Cite

APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer's pathology: New findings from the ADNI.

Journal article PloS one · January 2025 BackgroundImpaired brain glucose metabolism is a preclinical feature of neurodegenerative diseases such as Alzheimer's disease (AD). Infections may promote AD-related pathology. Therefore, we investigated the interplay between infections and APOE4 ... Full text Cite

Traffic-related air pollution significantly aggravates the detrimental effect of infections on the risk of Alzheimer's disease and other dementias, especially in non-carriers of APOE4.

Journal article Front Dement · 2025 Alzheimer's disease (AD) is a complex neurodegenerative disorder influenced by various factors, including genetic and exposure-related. Certain combinations of these factors may promote AD more substantially than others. APOE4 is the strongest genetic risk ... Full text Link to item Cite

Basic Science and Pathogenesis

Journal article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous system. Polymor ... Full text Cite

Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD.

Journal article Experimental gerontology · June 2024 IntroductionDiverse pathogens (viral, bacterial, fungal) have been associated with Alzheimer's disease (AD) and related traits in various studies. This suggests that compromised immunity, rather than specific microbes, may play a role in AD by inc ... Full text Cite

Systemic inflammation in relation to exceptional memory in the Long Life Family Study (LLFS).

Journal article Brain, behavior, & immunity - health · May 2024 Background and objectivesWe previously found a substantial familial aggregation of healthy aging phenotypes, including exceptional memory (EM) in long-lived persons. In the current study, we aim to assess whether long-lived families with EM and wi ... Full text Cite

Genome-Wide Epistatic Network Analyses of Semantic Fluency in Older Adults.

Journal article International journal of molecular sciences · May 2024 Semantic fluency impairment has been attributed to a wide range of neurocognitive and psychiatric conditions, especially in the older population. Moderate heritability estimates on semantic fluency were obtained from both twin and family-based studies sugg ... Full text Cite

The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults.

Journal article BMC neurology · February 2024 BackgroundFunctional decline associated with dementia, including in Alzheimer's disease (AD), is not uniform across individuals, and respective heterogeneity is not yet fully explained. Such heterogeneity may in part be related to genetic variabil ... Full text Cite

The Protective Effect of Familial Longevity Persists After Age 100: Findings From the Danish National Registers.

Journal article The journals of gerontology. Series A, Biological sciences and medical sciences · January 2024 BackgroundA recent study suggested that the protective effect of familial longevity becomes negligible for centenarians. However, the authors assessed the dependence on familial longevity in centenarians by comparing centenarians with 1 parent sur ... Full text Cite

Patterns of Aging Changes in Bodyweight May Predict Alzheimer's Disease.

Journal article J Alzheimers Dis · 2024 Relationships between patterns of aging-changes in bodyweight and AD are not fully understood. We compared mean age-trajectories of weight between those who did and did not develop late-onset-AD, and evaluated impact of age at maximum weight (AgeMax), and ... Full text Link to item Cite

How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.

Journal article Frontiers in aging · January 2024 The ε4 allele of the APOE gene (APOE4) is known for its negative association with human longevity; however, the mechanism is unclear. APOE4 is also linked to changes in body weight, and the latter changes were associated with survival in some ... Full text Cite

Prior infections are associated with smaller hippocampal volume in older women.

Journal article Frontiers in dementia · January 2024 Accumulating evidence suggests that infections may play a major role in Alzheimer's disease (AD), however, mechanism is unclear, as multiple pathways may be involved. One possibility is that infections could contribute to neurodegeneration directly by prom ... Full text Cite

End of Life Events and Causes of Death in Danish Long-Lived Siblings: Reduced Dementia Risk Compared to Sporadic Long-Livers.

Journal article Journal of Alzheimer's disease : JAD · January 2024 BackgroundBetter physical robustness and resilience of long-lived siblings compared to sporadic long-livers has been demonstrated in several studies. However, it is unknown whether long-lived siblings also end their lives better.Objective ... Full text Cite

Traffic-related air pollution and APOE4 can synergistically affect hippocampal volume in older women: new findings from UK Biobank.

Journal article Frontiers in dementia · January 2024 A growing research body supports the connection between neurodegenerative disorders, including Alzheimer's disease (AD), and traffic-related air pollution (TRAP). However, the underlying mechanisms are not well understood. A deeper investigation of TRAP ef ... Full text Cite

The association between rs6859 in NECTIN2 gene and Alzheimer's disease is partly mediated by pTau.

Journal article Frontiers in aging neuroscience · January 2024 IntroductionEmerging evidence suggests a connection between vulnerability to infections and Alzheimer's disease (AD). The nectin cell adhesion molecule 2 (NECTIN2) gene coding for a membrane component of adherens junctions is involved in re ... Full text Cite

Is being overweight a causal factor in better survival among the oldest old? a Mendelian randomization study.

Journal article Frontiers in aging · January 2024 Overweight, defined by a body mass index (BMI) between 25 and 30, has been associated with enhanced survival among older adults in some studies. However, whether being overweight is causally linked to longevity remains unclear. To investigate this, we cond ... Full text Cite

Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota.

Journal article Nature metabolism · September 2023 Restriction of methionine (MR), a sulfur-containing essential amino acid, has been reported to repress cancer growth and improve therapeutic responses in several preclinical settings. However, how MR impacts cancer progression in the context of the intact ... Full text Cite

Rare genetic variants correlate with better processing speed.

Journal article Neurobiology of aging · May 2023 We conducted a genome-wide association study of Digit Symbol Substitution Test scores administered in 4207 family members of the Long Life Family Study (LLFS). Genotype data were imputed to the HRC panel of 64,940 haplotypes resulting in ∼15M genetic varia ... Full text Cite

Understanding Alzheimer's disease in the context of aging: Findings from applications of stochastic process models to the Health and Retirement Study.

Journal article Mechanisms of ageing and development · April 2023 There is growing literature on applications of biodemographic models, including stochastic process models (SPM), to studying regularities of age dynamics of biological variables in relation to aging and disease development. Alzheimer's disease (AD) is espe ... Full text Cite

A metabolomic signature of the APOE2 allele.

Journal article GeroScience · February 2023 With the goal of identifying metabolites that significantly correlate with the protective e2 allele of the apolipoprotein E (APOE) gene, we established a consortium of five studies of healthy aging and extreme human longevity with 3545 participants. This c ... Full text Cite

Interactions between genes involved in physiological dysregulation and axon guidance: role in Alzheimer's disease.

Journal article Front Genet · 2023 Dysregulation of physiological processes may contribute to Alzheimer's disease (AD) development. We previously found that an increase in the level of physiological dysregulation (PD) in the aging body is associated with declining resilience and robustness ... Full text Link to item Cite

The Construction of a Multidomain Risk Model of Alzheimer's Disease and Related Dementias.

Journal article Journal of Alzheimer's disease : JAD · January 2023 BackgroundAlzheimer's disease (AD) and related dementia (ADRD) risk is affected by multiple dependent risk factors; however, there is no consensus about their relative impact in the development of these disorders.ObjectiveTo rank the effe ... Full text Cite

Vaccination Against Pneumonia May Provide Genotype-Specific Protection Against Alzheimer's Disease.

Journal article J Alzheimers Dis · 2023 Vaccine repurposing that considers individual genotype may aid personalized prevention of Alzheimer's disease (AD). In this retrospective cohort study, we used Cardiovascular Health Study data to estimate associations of pneumococcal polysaccharide vaccine ... Full text Link to item Cite

APOE ɛ4 allele and TOMM40-APOC1 variants jointly contribute to survival to older ages.

Journal article Aging cell · December 2022 Age-related diseases characteristic of post-reproductive life, aging, and life span are the examples of polygenic non-Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks ... Full text Cite

Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.

Journal article Mechanisms of ageing and development · June 2021 Emerging evidence from experimental and clinical research suggests that stress-related genes may play key roles in AD development. The fact that genome-wide association studies were not able to detect a contribution of such genes to AD indicates the possib ... Full text Cite

Relationship Between Serum IGF-1 and BMI Differs by Age.

Journal article The journals of gerontology. Series A, Biological sciences and medical sciences · June 2021 BackgroundSerum levels of insulin-like growth factor 1 (IGF-1) and body mass index (BMI) are both associated with susceptibility to age-related diseases. Reports on the correlation between them have been conflicting, with both positive to negative ... Full text Cite

Decline in biological resilience as key manifestation of aging: Potential mechanisms and role in health and longevity.

Journal article Mechanisms of ageing and development · March 2021 Decline in biological resilience (ability to recover) is a key manifestation of aging that contributes to increase in vulnerability to death with age eventually limiting longevity even in people without major chronic diseases. Understanding the mechanisms ... Full text Cite

Interactions Between Genes From Aging Pathways May Influence Human Lifespan and Improve Animal to Human Translation.

Journal article Frontiers in cell and developmental biology · January 2021 A major goal of aging research is identifying genetic targets that could be used to slow or reverse aging - changes in the body and extend limits of human lifespan. However, majority of genes that showed the anti-aging and pro-survival effects in animal mo ... Full text Cite

Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.

Journal article Journal of translational genetics and genomics · January 2021 AimExperimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress signals and those regulating ... Full text Cite

The conundrum of human immune system "senescence".

Journal article Mechanisms of ageing and development · December 2020 There is a great deal of debate on the question of whether or not we know what ageing is (Ref. Cohen et al., 2020). Here, we consider what we believe to be the especially confused and confusing case of the ageing of the human immune system, commonly referr ... Full text Cite

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.

Journal article Mechanisms of ageing and development · October 2020 At a recent symposium on aging biology, a debate was held as to whether or not we know what biological aging is. Most of the participants were struck not only by the lack of consensus on this core question, but also on many basic tenets of the field. Accor ... Full text Cite

Physical robustness and resilience among long-lived female siblings: a comparison with sporadic long-livers.

Journal article Aging · July 2020 Long-lived individuals are central in studies of healthy longevity. However, few pro-longevity factors have been identified, presumably because of "phenocopies", i.e. individuals that live long by chance. Familial longevity cases may include less phenocopi ... Full text Cite

Genetics of physiological dysregulation: findings from the long life family study using joint models.

Journal article Aging · April 2020 Recently, Mahalanobis distance (DM) was suggested as a statistical measure of physiological dysregulation in aging individuals. We constructed DM variants using sets of biomarkers collected at the two visits of the Long Life Family St ... Full text Cite

APOE region molecular signatures of Alzheimer's disease across races/ethnicities.

Journal article Neurobiology of aging · March 2020 The role of even the strongest genetic risk factor for Alzheimer's disease (AD), the apolipoprotein E (APOE) ε4 allele, in its etiology remains poorly understood. We examined molecular signatures of AD defined as differences in linkage disequilibrium patte ... Full text Cite

Genetic and regulatory architecture of Alzheimer's disease in the <i>APOE</i> region.

Journal article Alzheimer's & dementia (Amsterdam, Netherlands) · January 2020 IntroductionApolipoprotein E (APOE) ε2 and ε4 alleles encoded by rs7412 and rs429358 polymorphisms, respectively, are landmark contra and pro "risk" factors for Alzheimer's disease (AD).MethodsWe examined differences in linkage dis ... Full text Cite

Composite Measure of Physiological Dysregulation as a Predictor of Mortality: The Long Life Family Study.

Journal article Frontiers in public health · January 2020 Biological aging results in changes in an organism that accumulate over age in a complex fashion across different regulatory systems, and their cumulative effect manifests in increased physiological dysregulation (PD) and declining robustness and resilienc ... Full text Cite

Heterogeneity of healthy aging: comparing long-lived families across five healthy aging phenotypes of blood pressure, memory, pulmonary function, grip strength, and metabolism.

Journal article GeroScience · August 2019 Five healthy aging phenotypes were developed in the Long Life Family Study to uncover longevity pathways and determine if healthy aging across multiple systems clustered in a subset of long-lived families. Using blood pressure, memory, pulmonary function, ... Full text Cite

"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.

Journal article The journals of gerontology. Series A, Biological sciences and medical sciences · March 2019 Recently suggested novel implementation of the statistical distance measure (DM) for evaluating "physiological dysregulation" (PD) in aging individuals (based on measuring deviations of multiple biomarkers from baseline or normal physiological states) allo ... Full text Cite

Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms.

Journal article Frontiers in genetics · January 2019 Age-related phenotypes are characterized by genetic heterogeneity attributed to an uncertain role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic meta-analyses of 24 age-related phenotypes dealing with ... Full text Cite

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Journal article The journals of gerontology. Series A, Biological sciences and medical sciences · October 2018 The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studie ... Full text Cite

Impact of demography and population dynamics on the genetic architecture of human longevity.

Journal article Aging · August 2018 The study of the genetics of longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. The "price to pay" is that population-specific evolutionary histories and trade-offs were negle ... Full text Cite

Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.

Journal article Experimental gerontology · July 2018 Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet available. The reasons are likely to be the fact that AD is a multifactorial and heterogeneous healt ... Full text Cite

A novel healthy blood pressure phenotype in the Long Life Family Study.

Journal article Journal of hypertension · January 2018 BackgroundHypertension tends to run in families and has both genetic and environmental determinants. We assessed the hypothesis that a novel healthy blood pressure (BP) phenotype is also familial and sought to identify its associated factors.M ... Full text Cite

Time Trends in the Prevalence of Neurocognitive Disorders and Cognitive Impairment in the United States: The Effects of Disease Severity and Improved Ascertainment.

Journal article J Alzheimers Dis · 2018 BACKGROUND: Trends in the prevalence of cognitive impairment (CI) based on cognitive assessment instruments are often inconsistent with those of neurocognitive disorders (ND) based on Medicare claims records. OBJECTIVE: We hypothesized that improved ascert ... Full text Link to item Cite

How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database.

Journal article Frontiers in public health · January 2018 The Family Longevity Selection Score (FLoSS) was used to select families for the Long Life Family Study (LLFS) but has never been validated in other populations. The goal of this paper is to validate how well the FLoSS-based selection procedure works in an ... Full text Cite

Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.

Journal article Aging cell · February 2017 Traditionally, genomewide association studies (GWAS) have emphasized the benefits of large samples in the analyses of age-related traits rather than their specific properties. We adopted a realistic concept of genetic susceptibility to inherently heterogen ... Full text Open Access Cite

haploR: an R package for querying web-based annotation tools.

Journal article F1000Research · January 2017 We developed haploR, an R package for querying web based genome annotation tools HaploReg and RegulomeDB. haploR gathers information in a data frame which is suitable for downstream bioinformatic analyses. This will facilitate post-genome wid ... Full text Cite

Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

Journal article Frontiers in genetics · January 2017 [This corrects the article on p. 179 in vol. 7, PMID: 27790247.]. ... Full text Cite

Resilience Versus Robustness in Aging.

Journal article The journals of gerontology. Series A, Biological sciences and medical sciences · November 2016 Full text Open Access Cite

Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.

Journal article Biogerontology · November 2016 The apolipoprotein E (apoE) is a classic example of a gene exhibiting pleiotropism. We examine potential pleiotropic associations of the apoE2 allele in three biodemographic cohorts of long-living individuals, offspring, and spouses from the Long Life Fami ... Full text Open Access Cite

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.

Journal article PLoS genetics · November 2016 Gaining insights into genetic predisposition to age-related diseases and lifespan is a challenging task complicated by the elusive role of evolution in these phenotypes. To gain more insights, we combined methods of genome-wide and candidate-gene studies. ... Full text Cite

Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.

Journal article Scientific reports · October 2016 Common strategy of genome-wide association studies (GWAS) relying on large samples faces difficulties, which raise concerns that GWAS have exhausted their potential, particularly for complex traits. Here, we examine the efficiency of the traditional sample ... Full text Open Access Cite

Dynamics of biomarkers in relation to aging and mortality.

Journal article Mechanisms of ageing and development · June 2016 Contemporary longitudinal studies collect repeated measurements of biomarkers allowing one to analyze their dynamics in relation to mortality, morbidity, or other health-related outcomes. Rich and diverse data collected in such studies provide opportunitie ... Full text Open Access Cite

Puzzling role of genetic risk factors in human longevity: "risk alleles" as pro-longevity variants.

Journal article Biogerontology · February 2016 Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. ... Full text Open Access Cite

How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Journal article Biogerontology · February 2016 Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process of aging by individuals is a ma ... Full text Open Access Cite

Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.

Journal article Frontiers in public health · January 2016 While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk. We implemented the recently devel ... Full text Open Access Cite

How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.

Journal article North American actuarial journal : NAAJ · January 2016 Background and objectiveTo clarify mechanisms of genetic regulation of human aging and longevity traits, a number of genome-wide association studies (GWAS) of these traits have been performed. However, the results of these analyses did not meet ex ... Full text Open Access Cite

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.

Journal article Frontiers in genetics · January 2016 Age-related diseases may result from shared biological mechanisms in intrinsic processes of aging. Genetic effects on age-related diseases are often modulated by environmental factors due to their little contribution to fitness or are mediated through cert ... Full text Open Access Cite

Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.

Journal article Frontiers in genetics · January 2016 This paper shows that the effects of causal SNPs on lifespan, estimated through GWAS, may be confounded and the genetic structure of the study population may be responsible for this effect. Simulation experiments show that levels of linkage disequilibrium ... Full text Open Access Cite

Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.

Journal article Rejuvenation research · April 2015 The lack of evolutionary established mechanisms linking genes to age-related traits makes the problem of genetic susceptibility to health span inherently complex. One complicating factor is genetic trade-off. Here we focused on long-living participants of ... Full text Open Access Cite

Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.

Journal article Frontiers in genetics · January 2015 BackgroundThe roles of genetic factors in human longevity would be better understood if one can use more efficient methods in genetic analyses and investigate pleiotropic effects of genetic variants on aging and health related traits.Data and ... Full text Open Access Cite

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.

Journal article PloS one · January 2015 Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries of unconditional risk alleles of complex ... Full text Open Access Cite

Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.

Journal article PLoS genetics · January 2014 Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framingham H ... Full text Open Access Cite

Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan

Journal article Plos Genetics · January 1, 2014 Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed populations from the Framingham H ... Full text Cite

Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.

Journal article Frontiers in public health · January 2014 Longitudinal data on aging, health, and longevity provide a wealth of information to investigate different aspects of the processes of aging and development of diseases leading to death. Statistical methods aimed at analyses of time-to-event data jointly w ... Full text Open Access Cite

Biodemographic Analyses of Longitudinal Data on Aging, Health, and Longevity: Recent Advances and Future Perspectives.

Journal article Advances in geriatrics · January 2014 Biodemography became one of the most innovative and fastest growing areas in demography. This progress is fueled by the growing variability and amount of relevant data available for analyses as well as by methodological developments allowing for addressing ... Full text Open Access Cite

Genetic Structures of Population Cohorts Change with Increasing Age: Implications for Genetic Analyses of Human aging and Life Span.

Journal article Annals of gerontology and geriatric research · January 2014 BackgroundCorrecting for the potential effects of population stratification is an important issue in genome wide association studies (GWAS) of complex traits. Principal component analysis (PCA) of the genetic structure of the population under stud ... Open Access Cite

Morbidity risks among older adults with pre-existing age-related diseases.

Journal article Exp Gerontol · December 2013 Multi-morbidity is common among older adults; however, for many aging-related diseases there is no information for U.S. elderly population on how earlier-manifested disease affects the risk of another disease manifested later during patient's lifetime. Qua ... Full text Open Access Link to item Cite

THE ROLE OF THE APOLIPOPROTEIN E4 ALLELE, CANCER, CVD AND NEURODEGENERATIVE DISORDERS IN HUMAN LIFESPAN

Journal article GERONTOLOGIST · November 1, 2013 Open Access Link to item Cite

Recovery and survival from aging-associated diseases.

Journal article Exp Gerontol · August 2013 OBJECTIVES: Considering disease incidence to be a main contributor to healthy lifespan of the US elderly population may lead to erroneous conclusions when recovery/long-term remission factors are underestimated. Using two Medicare-based population datasets ... Full text Open Access Link to item Cite

Time trends of incidence of age-associated diseases in the US elderly population: Medicare-based analysis.

Journal article Age Ageing · July 2013 OBJECTIVES: time trends of age-adjusted incidence rates of 19 ageing-related diseases were evaluated for 1992-2005 period with the National Long Term Care Survey and the Surveillance, Epidemiology and End RESULTS Registry data both linked to Medicare data ... Full text Open Access Link to item Cite

Circulatory Diseases in the U.S. Elderly in the Linked National Long-Term Care Survey-Medicare Database: Population-Based Analysis of Incidence, Comorbidity, and Disability.

Journal article Res Aging · July 2013 Incidence rates of acute coronary heart disease (ACHD; including myocardial infarction and angina pectoris), stroke, and heart failure (HF) were studied for their age, disability, and comorbidity patterns in the U.S. elderly population using the National L ... Full text Open Access Link to item Cite

The role of lipid-related genes, aging-related processes, and environment in healthspan.

Journal article Aging cell · April 2013 The inherent complexity of aging-related traits can temper progress in unraveling the genetic origins of healthspan. We focus on two generations in the Framingham Heart Study, the original (FHS) and offspring (FHSO) cohorts, to determine whether aging-rela ... Full text Open Access Cite

Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.

Journal article Rejuvenation research · February 2013 Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingha ... Full text Open Access Cite

How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.

Journal article Frontiers in genetics · January 2013 Background and objectiveThe influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms linking aging, health ... Full text Open Access Cite

Why does melanoma metastasize into the brain? Genes with pleiotropic effects might be the key.

Journal article Frontiers in genetics · January 2013 Full text Open Access Cite

How the quality of GWAS of human lifespan and health span can be improved.

Journal article Frontiers in genetics · January 2013 Full text Open Access Cite

Patterns of Aging-Related changes on the way to 100: An Approach to studying aging, mortality, and longevity from longitudinal data

Journal article North American Actuarial Journal · December 1, 2012 The objective of this paper is to investigate dynamic properties of age trajectories of physiological indices and their effects on mortality risk and longevity using longitudinal data on more than 5,000 individuals collected in biennial examinations of the ... Full text Open Access Cite

MEDICARE-BASED MULTIMORBIDITY INDEX FOR PROJECTING MORBIDITY AND MORTALITY AMONG OLDER ADULTS IN THE U.S

Journal article GERONTOLOGIST · November 1, 2012 Open Access Link to item Cite