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Tatiana Segura

Robert Plonsey Distinguished Professor of Biomedical Engineering
Biomedical Engineering

Overview


Tatiana Segura is a Professor of Biomedical Engineering, Neurology, and Dermatology at Duke University. She received her B.S. degree in Bioengineering from the University of California, Berkeley (UC Berkeley) and her doctorate in Chemical Engineering from Northwestern University.  She began her career in Biomaterials research during her doctoral work working with Prof. Lonnie Shea. She designed hydrogels for local non-viral gene delivery, a topic that she still works on today. She continued her Biomaterials training during her postdoctoral work with Jeffrey Hubbell. There she worked on the design of hydrogels and self-assembled polysulfides for gene delivery. She began her independent career at the University of California, Los Angeles (UCLA) in the Department of Chemical and Biomolecular Engineering reaching the title of Professor. At UCLA she participated actively in service culminating with her election as department Vice Chair and running the Graduate Program. At Duke she has continued to be heavily involved in service at the department, school, and university level. In only 5 years, she has Chaired 6 committees, and participated in at least 6 more, is the direct mentor to two young assistant professors, is the Co-director of the Center for Biotechnology and Tissue Engineering and serves as MPI of the T32 Biotechnology Training grant. Notably she is currently the Chair of the BME department Diversity Equity and Inclusion Committee.

Prof. Segura’s research is centered on biomaterials and in engineering biomaterial-soft tissue interactions to promote repair and regeneration. Together with her lab members, she designs new biomaterial interventions that can promote brain plasticity after stroke, promote scarless healing in skin wounds, induce tolerance of transplanted skin, and promote constructive immune responses after biomaterial implantation. Currently, her lab has 12 graduate students, 4 postdoctoral scholars, 2 master students, 1 plastic surgery resident, 16 undergraduate students, one high school student, and one research associate.

Professor Segura has received numerous awards and distinctions during her career, including being named a Senior Member of the National Academy of Inventors, receiving the Acta Biomaterialia Silver Medal, a CAREER Award from the National Science Foundation, a Outstanding Young Investigator Award from the American Society of Gene and Cell Therapy, and a National Scientist Development Grant from the American Heart Association. She was also named a Fellow of the American Institute for Medical and Biological Engineers (AIMBE). Professor Segura has published over 100 peer-reviewed papers and reviews and has over 10,000 citations. Her laboratory has been continuously funded since 2008 with several grants from the National Institutes of Health (NIH). 

Current Duke Appointments & Affiliations


Robert Plonsey Distinguished Professor of Biomedical Engineering · 2026 - Present Biomedical Engineering, Pratt School of Engineering
Professor of Biomedical Engineering · 2018 - Present Biomedical Engineering, Pratt School of Engineering
Professor in Neurology · 2019 - Present Neurology, Clinical Science Departments
Professor in Dermatology · 2021 - Present Dermatology, Clinical Science Departments
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

Recent News Items


Published September 22, 2026
New National Effort to Better Understand the Human Genome
Published August 2, 2026
A Shot at Healing the Brain
Published March 25, 2026
Duke Honors 38 Distinguished Professors in 2026

View All News Items

Recent Scholarly Works


Physical continuity at biomaterial-ECM interfaces is associated with reduced fibroblast activation and NF-κB signaling.

Journal article Biomaterials · December 2026 Fibrotic responses at biomaterial-tissue interfaces limit implant integration and regenerative healing, yet how the interaction between biomaterials and the extracellular matrix (ECM) regulates fibroblast activation remains poorly understood. Granular hydr ... Full text Cite

Systemic humoral activation facilitates tissue regeneration by D-chiral biomaterial scaffolds.

Journal article Cell Biomater · August 13, 2026 Biomaterial design increasingly considers how adaptive immunity influences tissue regeneration, yet most efforts have focused on T lymphocyte responses. Here, we show that D-chiral Microporous Annealed Particle (DMAP) scaffolds promote dermal appendage reg ... Full text Link to item Cite

MAP Crosslinker Chirality Regulates Macrophage Polarization Through MD-2 Engagement and Enables Tunable Immunomodulation Through Novel Peptide Design.

Journal article Advanced healthcare materials · August 2026 Microporous annealed particle (MAP) scaffolds are injectable hydrogel biomaterials that promote tissue regeneration by enabling rapid cell infiltration and presenting reparative cues. Previous work showed that substituting L- with D-chiral residues in matr ... Full text Cite
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Recent Grants


Pharmacological Sciences Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030

Biomaterials strategies to promote functional recovery after ischemic stroke

ResearchPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2020 - 2030

Stimulating Access to Research in Residency (StARR) - NIAID

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2029

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Education


Northwestern University · 2004 Ph.D.
University of California, Berkeley · 1999 B.S.