Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • D.Phil., University of Oxford (UK) 2016
  • Fogarty International Clinical Research Fellowship, National Institutes of Health 2009 - 2011
  • Infectious Disease Fellowship, Yale University School of Medicine 2006 - 2009
  • Internal Medicine Residency, Tufts University School of Medicine 2002 - 2005
  • M.D., University of Arizona College of Medicine 2002
• 

  Medical Licensure

  • 2018-00292. North Carolina. 2018
• 

  Academic Positions Outside Duke

  • Assistant Professor of Medicine, University of Hawaii at Manoa, John A. Burns School of Medicine. 2011 - 2017
  • Senior Fellow - Deputy Group Head, University of Oxford, United Kingdom. 2011 - 2018
  • Clinical Instructor of Medicine, Tufts University School of Medicine. 2005 - 2006
• Recognition
• 

  In the News

  • JUN 27, 2017

    Amphotericin B superior to itraconazole for HIV-associated talaromycosis

  • JUN 14, 2017

    Amphotericin Is Still Essential for Talaromycosis in AIDS

  • AUG 11, 2016

    Risk factors, features and outcomes of invasive non-typhoidal Salmonella in Vietnam

  • NOV 2, 2015

    Wellcome Trust Researcher Spotlight: Dr Thuy Le

  • JUL 1, 2015

    PCR assay quicker but less sensitive at penicilliosis diagnosis

  • AUG 1, 2009

    Refugee returns to Vietnam in hope of saving lives
• 

  Awards & Honors

  • Best Oral Presentation. 2nd Asia Pacific AIDS and Coinfection Conference. 2017
  • First Prize Poster Presentation at the Oxford Tropical Network Meeting in Kilifi, Kenya. Oxford University Tropical Medicine. 2013
  • Young Investigator Award. Conference of Retroviruses and Opportunistic Infections. 2009
  • Yale Johnson's and Johnson's International Scholar Award. Yale University. 2004
  • Eirene Lamb Scholarship. University of Arizona. 2002
  • Elizabeth Allison Scholarship. University of Arizona. 2002
  • National Science Foundation Biomedical Research Abroad Award. National Science Foundation. 2002
• Expertise
• 

  Subject Headings

  • China
  • Clinical trials
  • Epidemiology
  • Global health
  • HIV
  • Mycoses
  • Opportunistic Infections
  • Systemic Mycoses
  • Talaromyces Marneffei
  • Tropical Medicine
  • Tuberculosis
  • Vietnam
• 

  Global Scholarship

  • Research

    • China (Country) 
    • Viet Nam (Country) 
• Research
• 

  Fellowships, Supported Research, & Other Grants

  • Faculty Development Award from the Duke Center for AIDS Research awarded by NIH 2018 - 2020
  • Oxford University Clinical Research Unit Internal Grant. "Diagnostic untility of Talaromyces marneffei antigenemia in patients with advanced HIV disease" awarded by Wellcome Trust 2018 - 2020
  • Investigator Initiated Clinical Trials Award. "Randomized controlled trial of efficacy and hepatic safety of raltegravir-based and efavirenz-based antiretroviral therapy in antiretroviral-naive HIV-infected individuals coinfected with hepatitis C" awarded by Merck 2012 - 2018
  • International Pilot Award. "Exposure risk factors for HIV-associated Penicillium marneffei infection" awarded by University of Washington Center for AIDS Research 2011 - 2013
  • Seed Award in Health Economics of Emerging Infectious Diseases awarded by Li Ka Shing Foundation 2011 - 2013
  • Joint Global Health Trials Award. "A trial of itraconazole versus amphotericin B for initial therapy of HIV-associated penicilliosis" awarded by The Medical Research Council, the Wellcome Trust, and the Department of International Development in the UK 2011 - 2017
  • Fogarty International Clinical Research Fellowship. "Epidemiology of Penicillium marneffei infection in Vietnam" awarded by NIH 2009 - 2011
  • Virology Fellow Research Award. "Prevalence and pattern of HIV drug resistance mutations in HIV-01 CRF_AE in Vietnam" awarded by Bristol Myers Squibbs 2008 - 2010
  • T32 Training Grant. "Clinical significance of minority HIV drug resistance mutations using ultra deep sequencing" awarded by NIH 2007 - 2009
  • Emerging Infectious Disease Laboratory Fellowship. "Molecular epidemiology of Pneumocystis jirovecii infection in the US" awarded by Center for Disease Control and Prevention 1997 - 1999
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Thao, VP, Quang, VM, Wolbers, M, Anh, ND, Shikuma, C, Farrar, J, Dunstan, S, Chau, NVV, Day, J, Thwaites, G, and Le, T. "Second-Line HIV Therapy Outcomes and Determinants of Mortality at the Largest HIV Referral Center in Southern Vietnam." October 2015.  Full Text  Open Access Copy

  • Digital Publications

    • "Guidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children, March 2018. World Health Organization." .  Open Access Copy  Link to Item
    • "World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. WHO. Geneva. Published July 2017." .  Open Access Copy
    • "World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. WHO. Geneva. Published July 2017." .  Open Access Copy

  • Journal Articles

    • Thanh, NT, Vinh, LD, Liem, NT, Shikuma, C, Day, JN, Thwaites, G, and Le, T. "Clinical features of three patients with paradoxical immune reconstitution inflammatory syndrome associated with Talaromyces marneffei infection." Medical Mycology Case Reports 19 (March 2018): 33-37.  Full Text  Open Access Copy
    • Le, T, Adenis, A, Limper, A, and Harrison, T. "Itraconazole and antiretroviral therapy: strategies for empirical dosing – Author's reply." The Lancet Infectious Diseases 17, no. 11 (November 2017): 1123-1124.  Full Text  Open Access Copy
    • Limper, AH, Adenis, A, Le, T, and Harrison, TS. "Fungal infections in HIV/AIDS." The Lancet. Infectious Diseases 17, no. 11 (November 2017): e334-e343. (Review)  Full Text  Open Access Copy
    • Le, T, Thwaites, G, and Wolbers, M. "Itraconazole or Amphotericin B for Talaromycosis." The New England Journal of Medicine 377, no. 14 (October 2017): 1403-null. (Letter)  Full Text  Open Access Copy
    • Armstrong-James, D, Bicanic, T, Brown, GD, Hoving, JC, Meintjes, G, and Nielsen, K. "AIDS-Related Mycoses: Current Progress in the Field and Future Priorities." Trends in Microbiology 25, no. 6 (June 2017): 428-430.  Full Text  Open Access Copy
    • Le, T, Kinh, NV, Cuc, NTK, Tung, NLN, Lam, NT, Thuy, PTT, Cuong, DD, Phuc, PTH, Vinh, VH, Hanh, DTH, Tam, VV, Thanh, NT, Thuy, TP, Hang, NT, Long, HB, Nhan, HT, Wertheim, HFL, Merson, L, Shikuma, C, Day, JN, Chau, NVV, Farrar, J, Thwaites, G, Wolbers, M, and IVAP Investigators, . "A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis." The New England Journal of Medicine 376, no. 24 (June 2017): 2329-2340.  Full Text  Open Access Copy
    • Birger, RB, Le, T, Kouyos, RD, Grenfell, BT, and Hallett, TB. "The impact of HCV therapy in a high HIV-HCV prevalence population: A modeling study on people who inject drugs in Ho Chi Minh City, Vietnam." Edited by Khudyakov, YE. Plos One 12, no. 5 (May 11, 2017): e0177195-e0177195.  Full Text  Open Access Copy
    • Greene, G, Sriruttan, C, Le, T, Chiller, T, and Govender, NP. "Looking for fungi in all the right places: screening for cryptococcal disease and other AIDS-related mycoses among patients with advanced HIV disease." Current Opinion in Hiv and Aids 12, no. 2 (March 2017): 139-147. (Review)  Full Text  Open Access Copy
    • Hien, HTA, Thanh, TT, Thu, NTM, Nguyen, A, Thanh, NT, Lan, NPH, Simmons, C, Shikuma, C, Chau, NVV, Thwaites, G, and Le, T. "Development and evaluation of a real-time polymerase chain reaction assay for the rapid detection of Talaromyces marneffei MP1 gene in human plasma." Mycoses 59, no. 12 (December 2016): 773-780.  Full Text  Open Access Copy
    • Phu Huong Lan, N, Le Thi Phuong, T, Nguyen Huu, H, Thuy, L, Mather, AE, Park, SE, Marks, F, Thwaites, GE, Van Vinh Chau, N, Thompson, CN, and Baker, S. "Invasive Non-typhoidal Salmonella Infections in Asia: Clinical Observations, Disease Outcome and Dominant Serovars from an Infectious Disease Hospital in Vietnam." Edited by Small, PLC. Plos Neglected Tropical Diseases 10, no. 8 (August 11, 2016): e0004857-e0004857.  Full Text  Open Access Copy
    • Thao, VP, Quang, VM, Day, JN, Chinh, NT, Shikuma, CM, Farrar, J, Van Vinh Chau, N, Thwaites, GE, Dunstan, SJ, and Le, T. "High prevalence of PI resistance in patients failing second-line ART in Vietnam." The Journal of Antimicrobial Chemotherapy 71, no. 3 (March 2016): 762-774.  Full Text  Open Access Copy
    • Beardsley, J, Wolbers, M, Kibengo, FM, Ggayi, A-BM, Kamali, A, Cuc, NTK, Binh, TQ, Chau, NVV, Farrar, J, Merson, L, Phuong, L, Thwaites, G, Van Kinh, N, Thuy, PT, Chierakul, W, Siriboon, S, Thiansukhon, E, Onsanit, S, Supphamongkholchaikul, W, Chan, AK, Heyderman, R, Mwinjiwa, E, van Oosterhout, JJ, Imran, D, Basri, H, Mayxay, M, Dance, D, Phimmasone, P, Rattanavong, S, Lalloo, DG, and Day, JN. "Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis." New England Journal of Medicine 374, no. 6 (February 11, 2016): 542-554.  Full Text  Open Access Copy
    • Le, T, Vi, TT, Thuy, PT, Cuong, DD, Hue, NT, Colby, D, and Pollack, T. "Prevalence and patterns of Transmitted Drug Resistance in HIV-Infected Adult Patients Initiating Antiretroviral Therapy in Hanoi, Vietnam." Journal of Biotechnology 13, no. 1 (November 1, 2015): 13-22.  Open Access Copy
    • Le, T, Cash-Goldwasser, S, Tho, PV, Lan, NPH, Campbell, JI, van Doorn, HR, Lam, NT, Trung, NV, Trinh, DT, Van Kinh, N, and Wertheim, HFL. "Diagnosing Rhodococcus equi infections in a setting where tuberculosis is highly endemic: a double challenge." Journal of Clinical Microbiology 53, no. 4 (April 2015): 1431-1433.  Full Text  Open Access Copy
    • Beardsley, J, Le, T, Caniglia, EC, and Hernan, MA. "Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions." Neurology 84, no. 6 (February 10, 2015): 632-633.  Full Text  Open Access Copy
    • Thompson, CN, Phan, VTM, Le, TPT, Pham, TNT, Hoang, LP, Ha, V, Nguyen, VMH, Pham, VM, Nguyen, TV, Cao, TT, Tran, TTN, Nguyen, TTH, Dao, MT, Campbell, JI, Nguyen, TC, Tang, CT, Ha, MT, Farrar, J, and Baker, S. "Epidemiological features and risk factors of Salmonella gastroenteritis in children resident in Ho Chi Minh City, Vietnam." Epidemiology and Infection 141, no. 8 (August 2013): 1604-1613.  Full Text
    • Bulterys, PL, Le, T, Quang, VM, Nelson, KE, and Lloyd-Smith, JO. "Environmental predictors and incubation period of AIDS-associated penicillium marneffei infection in Ho Chi Minh City, Vietnam." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 56, no. 9 (May 2013): 1273-1279.  Full Text  Open Access Copy
    • Larsson, M, Nguyen, LH, Wertheim, HF, Dao, T, Taylor, W, Horby, P, Nguyen, T, Nguyen, MH, Le, T, and Nguyen, K. "Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam." Aids Research and Therapy 9, no. 1 (2012): 24-24.  Full Text  Open Access Copy
    • Nga, TVT, Parry, CM, Le, T, Lan, NPH, Diep, TS, Campbell, JI, Hoang, NVM, Dung, LT, Wain, J, Dolecek, C, Farrar, JJ, Chau, NVV, Hien, TT, Day, JN, and Baker, S. "The decline of typhoid and the rise of non-typhoid salmonellae and fungal infections in a changing HIV landscape: bloodstream infection trends over 15 years in southern Vietnam." Transactions of the Royal Society of Tropical Medicine and Hygiene 106, no. 1 (January 2012): 26-34.  Full Text  Open Access Copy
    • Thao, VP, Le, T, Török, EM, Yen, NTB, Chau, TTH, Jurriaans, S, van Doorn, HR, de Jong, MD, Farrar, JJ, and Dunstan, SJ. "HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculous meningitis initiating antiretroviral therapy in Vietnam." Antiviral Therapy 17, no. 5 (January 2012): 905-913.  Full Text  Open Access Copy
    • Le, T, Wolbers, M, Chi, NH, Quang, VM, Chinh, NT, Lan, NPH, Lam, PS, Kozal, MJ, Shikuma, CM, Day, JN, and Farrar, J. "Epidemiology, seasonality, and predictors of outcome of AIDS-associated Penicillium marneffei infection in Ho Chi Minh City, Viet Nam." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 52, no. 7 (April 2011): 945-952.  Full Text  Open Access Copy
    • Le, T, Farrar, J, and Shikuma, C. "Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication." Aids (London, England) 25, no. 6 (March 2011): 871-872. (Letter)  Full Text  Open Access Copy
    • Le, T, Huu Chi, N, Kim Cuc, NT, Manh Sieu, TP, Shikuma, CM, Farrar, J, and Day, JN. "AIDS-associated Penicillium marneffei infection of the central nervous system." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America 51, no. 12 (December 2010): 1458-1462.  Full Text  Open Access Copy
    • Le, T, Hong Chau, TT, Kim Cuc, NT, Si Lam, P, Manh Sieu, TP, Shikuma, CM, and Day, JN. "AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings." Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America 51, no. 9 (November 2010): e65-e68.  Full Text  Open Access Copy
    • Le, T, Chiarella, J, Simen, BB, Hanczaruk, B, Egholm, M, Landry, ML, Dieckhaus, K, Rosen, MI, and Kozal, MJ. "Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use." Edited by Kaul, R. Plos One 4, no. 6 (June 29, 2009): e6079-e6079.  Full Text  Open Access Copy
    • Le, T, Salat, J, Sak, B, and Kopecky, J. "Susceptibility of INF-gamma or IL-12 Knock-out and SCID Mice to Infection with Two Microsporidian Species, Encephalitozoon cuniculi and E. intestinalis." Folia Parasitologica 51, no. 4 (December 1, 2004): 275-282.  Open Access Copy
    • Navin, TR, Beard, CB, Huang, L, del Rio, C, Lee, S, Pieniazek, NJ, Carter, JL, Le, T, Hightower, A, and Rimland, D. "Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study." The Lancet 358, no. 9281 (August 2001): 545-549.  Full Text  Open Access Copy
    • Le, T. "World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy." .  Open Access Copy
    • Le, T. "World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy." .  Open Access Copy
    • Salzer, H, Burchard, G, Cornely, O, Lange, C, Rolling, T, Schmiedel, S, Libman, M, Capone, D, Le, T, Dalcolmo, M, and Heyckendorf, J. "Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease(Published online)." Respiration : 1-19.  Full Text  Open Access Copy
• Scholarly, Clinical, & Service Activities
• 

  Service to the Profession

  • Associate Editor. Medical Mycology. August 2018  2018
  • World Health Organization Guidelines Development Group. Update guidelines for antiretroviral therapy for adults, adolescents, and children. May 2018  2018
  • World Health Organization Guidelines Development Group. Update guidelines on prevention, diagnosis and management of cryptococcal disease in HIV-infected adults, adolescents, and children. March 2018  2018
  • World Health Organization Technical Working Group on HIV treatment optimization for low and middle income countries. March 2018  2018
  • European Confederation of Medical Mycology Guidelines Coordinator for Endemic Mycoses 2019. ECMM. 2018  2018
  • NIH/IDSA/HIVMA Opportunistic Infections Guidelines Committee. 2018 - 2021  2018 - 2021
  • World Health Organization Guidelines Development Group. Management of advanced HIV disease. March 2017  2017
  • Associate Guest Editor . PLoS Neglected Tropical Diseases. 2017  2017
  • Organizing Committee. Asia Pacific AIDS and Coinfections Conference. 2017  2017
  • International AIDS-Related Mycoses Working Group. 2016  2016
  • Scientific Committee. Asia Pacific AIDS and Coinfections Conference. 2015  2015

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