Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • D.Phil., University of Oxford (United Kingdom) 2016
  • Fogarty International Clinical Research Fellowship, National Institutes of Health 2009 - 2011
  • Infectious Disease Fellowship, Yale University School of Medicine 2006 - 2009
  • Internal Medicine Residency, Tufts University School of Medicine 2002 - 2005
  • M.D., University of Arizona, College of Medicine 2002
• 

  Medical Licensure

  • 2018-00292. North Carolina. 2018
• 

  Duke Appointment History

  • Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2018 - 2019
• 

  Academic Positions Outside Duke

  • Assistant Professor of Medicine, University of Hawaii at Manoa, John A. Burns School of Medicine. 2011 - 2017
  • Senior Fellow - Deputy Group Head, University of Oxford, United Kingdom. 2011 - 2018
  • Visiting Senior Fellow, Oxford University Clinical Research Unit in Vietnam. 2009 - 2024
  • Clinical Instructor of Medicine, Tufts University School of Medicine. 2005 - 2006
• Recognition
• 

  In the News

  • APR 3, 2020

    Raltegravir-Based ART Shows Lower Rates of Hepatoxicity

  • JUN 27, 2017

    Amphotericin B superior to itraconazole for HIV-associated talaromycosis

  • JUN 14, 2017

    Amphotericin Is Still Essential for Talaromycosis in AIDS

  • AUG 11, 2016

    Risk factors, features and outcomes of invasive non-typhoidal Salmonella in Vietnam

  • NOV 2, 2015

    Wellcome Trust Researcher Spotlight: Dr Thuy Le

  • JUL 1, 2015

    PCR assay quicker but less sensitive at penicilliosis diagnosis

  • AUG 1, 2009

    Refugee returns to Vietnam in hope of saving lives
• 

  Awards & Honors

  • Best Medicine Grand Rounds. Duke Department of Medicine. 2019
  • Best Oral Presentation. 2nd Asia Pacific AIDS and Coinfection Conference. 2017
  • First Prize Poster Presentation at the Oxford Tropical Network Meeting in Kilifi, Kenya. Oxford University Tropical Medicine. 2013
  • Young Investigator Award. Conference of Retroviruses and Opportunistic Infections. 2009
  • Yale Johnson's and Johnson's International Scholar Award. Yale University. 2004
  • Eirene Lamb Scholarship. University of Arizona. 2002
  • Elizabeth Allison Scholarship. University of Arizona. 2002
  • National Science Foundation Biomedical Research Abroad Award. National Science Foundation. 2002
• Expertise
• 

  Subject Headings

  • China
  • Clinical trials
  • Epidemiology
  • Global health
  • HIV
  • Mycoses
  • Opportunistic Infections
  • Systemic Mycoses
  • Talaromyces Marneffei
  • Tropical Medicine
  • Tuberculosis
  • Vietnam
• 

  Global Scholarship

  • Research

    • China (Country) 
    • Myanmar (Country) 
    • Viet Nam (Country) 
• Research
• 

  Selected Grants

  • Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV infection in Southeast Asia awarded by National Institutes of Health 2019 - 2024
  • Molecular Mycology and Pathogenesis Training Program awarded by National Institutes of Health 2019 - 2021
• 

  Fellowships, Supported Research, & Other Grants

  • Short course liposomal amphotericin B for talaromycosis - a phase II randomized controlled trial awarded by Gilead Sciences 2021 - 2024
  • Development of a point of care diagnostic for the detection of Talaromyces marneffei infection awarded by NIH SBIR Phase I 2020 - 2021
  • Tackling a neglected HIV-associated infection - A validation study of the IgG and IgM serological responses to talaromycosis awarded by Duke Center for AIDS Research Pilot Award 2020 - 2021
  • Early detection of the invasive fungal infection talaromycosis by a novel portable point of care platform awarded by Duke Global Health Institute 2020 - 2021
  • Faculty Development Award from the Duke Center for AIDS Research awarded by NIH 2018 - 2020
  • Oxford University Clinical Research Unit Internal Grant. "Diagnostic untility of Talaromyces marneffei antigenemia in patients with advanced HIV disease" awarded by Wellcome Trust 2018 - 2020
  • Investigator Initiated Clinical Trials Award. "Randomized controlled trial of efficacy and hepatic safety of raltegravir-based and efavirenz-based antiretroviral therapy in antiretroviral-naive HIV-infected individuals coinfected with hepatitis C" awarded by Merck 2012 - 2018
  • International Pilot Award. "Exposure risk factors for HIV-associated Penicillium marneffei infection" awarded by University of Washington Center for AIDS Research 2011 - 2013
  • Seed Award in Health Economics of Emerging Infectious Diseases awarded by Li Ka Shing Foundation 2011 - 2013
  • Joint Global Health Trials Award. "A trial of itraconazole versus amphotericin B for initial therapy of HIV-associated penicilliosis" awarded by The Medical Research Council, the Wellcome Trust, and the Department of International Development in the UK 2011 - 2017
  • Fogarty International Clinical Research Fellowship. "Epidemiology of Penicillium marneffei infection in Vietnam" awarded by NIH 2009 - 2011
  • Virology Fellow Research Award. "Prevalence and pattern of HIV drug resistance mutations in HIV-01 CRF_AE in Vietnam" awarded by Bristol Myers Squibbs 2008 - 2010
  • T32 Training Grant. "Clinical significance of minority HIV drug resistance mutations using ultra deep sequencing" awarded by NIH 2007 - 2009
  • Emerging Infectious Disease Laboratory Fellowship. "Molecular epidemiology of Pneumocystis jirovecii infection in the US" awarded by Center for Disease Control and Prevention 1997 - 1999
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ly, Vo Trieu, Nguyen Tat Thanh, Nguyen Thi Mai Thu, Jasper Chan, Jeremy N. Day, John Perfect, Cao Ngoc Nga, Nguyen Van Vinh Chau, and Thuy Le. “Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay.” Open Forum Infectious Diseases 7, no. 11 (November 2020): ofaa502. https://doi.org/10.1093/ofid/ofaa502.
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    • Thu, Nguyen T. M., Jasper F. W. Chan, Vo Trieu Ly, Hoa T. Ngo, Ha T. A. Hien, Nguyen P. H. Lan, Nguyen V. V. Chau, et al. “Superiority of a novel Mp1p antigen detection enzyme immunoassay compared to standard BACTEC blood culture in the diagnosis of talaromycosis.” Clin Infect Dis, June 21, 2020. https://doi.org/10.1093/cid/ciaa826.
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    • Cuomo, C. A., T. Shea, T. Nguyen, P. Ashton, J. Perfect, and T. Leb. “Complete genome sequences for two talaromyces marneffei clinical isolates from Northern and Southern Vietnam.” Microbiology Resource Announcements 9, no. 2 (January 1, 2020). https://doi.org/10.1128/MRA.01367-19.
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    • Le, Thuy, Vo Trieu Ly, Nguyen Thi Mai Thu, Ashley Nguyen, Nguyen Tat Thanh, Nguyen Van Vinh Chau, Guy Thwaites, John Perfect, Ruwanthi Kolamunnage-Dona, and William Hope. “Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei.” Antimicrob Agents Chemother 63, no. 2 (February 2019). https://doi.org/10.1128/AAC.01739-18.
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    • Jiang, Junjun, Fengxiang Qin, Sirun Meng, Eric J. Nehl, Jinping Huang, Yanfen Liu, Jun Zou, et al. “Effects of cotrimoxazole prophylaxis on Talaromyces marneffei infection in HIV/AIDS patients receiving antiretroviral therapy: a retrospective cohort study.” Emerg Microbes Infect 8, no. 1 (2019): 367–76. https://doi.org/10.1080/22221751.2019.1588078.
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    • Le Ngoc, Chau, Thanh Tran Thi Thanh, Phuong Tran Thi Lan, Trinh Nguyen Mai, Trang Nguyen Hoa, Ngoc Nghiem My, Tan Le Van, et al. “Differential prevalence and geographic distribution of hepatitis C virus genotypes in acute and chronic hepatitis C patients in Vietnam.” Plos One 14, no. 3 (2019): e0212734. https://doi.org/10.1371/journal.pone.0212734.
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    • Thanh, N. T., L. D. Vinh, N. T. Liem, C. Shikuma, J. N. Day, G. Thwaites, and T. Le. “Clinical features of three patients with paradoxical immune reconstitution inflammatory syndrome associated with Talaromyces marneffei infection.” Medical Mycology Case Reports 19 (March 1, 2018): 33–37. https://doi.org/10.1016/j.mmcr.2016.12.005.
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    • Salzer, Helmut J. F., Gerd Burchard, Oliver A. Cornely, Christoph Lange, Thierry Rolling, Stefan Schmiedel, Michael Libman, et al. “Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.” Respiration 96, no. 3 (2018): 283–301. https://doi.org/10.1159/000489501.
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    • Le, Thuy, Antoine Adenis, Andrew Limper, and Thomas Harrison. “Itraconazole and antiretroviral therapy: strategies for empirical dosing - Author's reply.” Lancet Infect Dis 17, no. 11 (November 2017): 1123–24. https://doi.org/10.1016/S1473-3099(17)30582-0.
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    • Limper, Andrew H., Antoine Adenis, Thuy Le, and Thomas S. Harrison. “Fungal infections in HIV/AIDS.” Lancet Infect Dis 17, no. 11 (November 2017): e334–43. https://doi.org/10.1016/S1473-3099(17)30303-1.
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    • Le, Thuy, Guy Thwaites, and Marcel Wolbers. “Itraconazole or Amphotericin B for Talaromycosis.” N Engl J Med 377, no. 14 (October 5, 2017): 1403. https://doi.org/10.1056/NEJMc1709123.
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    • Le, Thuy, Nguyen Van Kinh, Ngo T. K. Cuc, Nguyen L. N. Tung, Nguyen T. Lam, Pham T. T. Thuy, Do D. Cuong, et al. “A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis.” N Engl J Med 376, no. 24 (June 15, 2017): 2329–40. https://doi.org/10.1056/NEJMoa1613306.
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    • Armstrong-James, Darius, Tihana Bicanic, Gordon D. Brown, Jennifer C. Hoving, Graeme Meintjes, and Kirsten Nielsen. “AIDS-Related Mycoses: Current Progress in the Field and Future Priorities.” Trends in Microbiology 25, no. 6 (June 2017): 428–30. https://doi.org/10.1016/j.tim.2017.02.013.
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    • Greene, Greg, Charlotte Sriruttan, Thuy Le, Tom Chiller, and Nelesh P. Govender. “Looking for fungi in all the right places: screening for cryptococcal disease and other AIDS-related mycoses among patients with advanced HIV disease.” Curr Opin Hiv Aids 12, no. 2 (March 2017): 139–47. https://doi.org/10.1097/COH.0000000000000347.
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    • Birger, Ruthie B., Thuy Le, Roger D. Kouyos, Bryan T. Grenfell, and Timothy B. Hallett. “The impact of HCV therapy in a high HIV-HCV prevalence population: A modeling study on people who inject drugs in Ho Chi Minh City, Vietnam.” Plos One 12, no. 5 (2017): e0177195. https://doi.org/10.1371/journal.pone.0177195.
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    • Hien, Ha Thuc Ai, Tran Tan Thanh, Nguyen Thi Mai Thu, Ashley Nguyen, Nguyen Tat Thanh, Nguyen Phu Huong Lan, Cameron Simmons, et al. “Development and evaluation of a real-time polymerase chain reaction assay for the rapid detection of Talaromyces marneffei MP1 gene in human plasma.” Mycoses 59, no. 12 (December 2016): 773–80. https://doi.org/10.1111/myc.12530.
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    • Thao, Vu Phuong, Vo Minh Quang, Jeremy N. Day, Nguyen Tran Chinh, Cecilia M. Shikuma, Jeremy Farrar, Nguyen Van Vinh Chau, Guy E. Thwaites, Sarah J. Dunstan, and Thuy Le. “High prevalence of PI resistance in patients failing second-line ART in Vietnam.” J Antimicrob Chemother 71, no. 3 (March 2016): 762–74. https://doi.org/10.1093/jac/dkv385.
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    • Beardsley, Justin, Marcel Wolbers, Freddie M. Kibengo, Abu-Baker M. Ggayi, Anatoli Kamali, Ngo Thi Kim Cuc, Tran Quang Binh, et al. “Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis.” New England Journal of Medicine 374, no. 6 (February 11, 2016): 542–54. https://doi.org/10.1056/nejmoa1509024.
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    • Le, T., T. T. Vi, P. T. Thuy, D. D. Cuong, N. T. Hue, D. Colby, and T. Pollack. “Prevalence and patterns of Transmitted Drug Resistance in HIV-Infected Adult Patients Initiating Antiretroviral Therapy in Hanoi, Vietnam.” Journal of Biotechnology 13, no. 1 (November 1, 2015): 13–22.
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    • Le, Thuy, Shama Cash-Goldwasser, Phan Vinh Tho, Nguyen Phu Huong Lan, James I. Campbell, H Rogier van Doorn, Nguyen Tien Lam, et al. “Diagnosing Rhodococcus equi infections in a setting where tuberculosis is highly endemic: a double challenge.” J Clin Microbiol 53, no. 4 (April 2015): 1431–33. https://doi.org/10.1128/JCM.02284-14.
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    • Beardsley, J., T. Le, E. C. Caniglia, and M. A. Hernan. “Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions.” Neurology 84, no. 6 (February 10, 2015): 632–33. https://doi.org/10.1212/01.wnl.0000461261.51494.39.
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    • Bulterys, Philip L., Thuy Le, Vo Minh Quang, Kenrad E. Nelson, and James O. Lloyd-Smith. “Environmental predictors and incubation period of AIDS-associated penicillium marneffei infection in Ho Chi Minh City, Vietnam.” Clin Infect Dis 56, no. 9 (May 2013): 1273–79. https://doi.org/10.1093/cid/cit058.
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    • Larsson, M., L. H. T. Nguyen, H. F. L. Wertheim, T. T. Dao, W. Taylor, P. Horby, T. V. Nguyen, M. H. T. Nguyen, T. Le, and K. V. Nguyen. “Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam.” Aids Research and Therapy 9 (August 16, 2012). https://doi.org/10.1186/1742-6405-9-24.
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    • Nga, Tran Vu Thieu, Christopher M. Parry, Thuy Le, Nguyen Phu Huong Lan, To Song Diep, James I. Campbell, Nguyen Van Minh Hoang, et al. “The decline of typhoid and the rise of non-typhoid salmonellae and fungal infections in a changing HIV landscape: bloodstream infection trends over 15 years in southern Vietnam.” Trans R Soc Trop Med Hyg 106, no. 1 (January 2012): 26–34. https://doi.org/10.1016/j.trstmh.2011.10.004.
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    • Thao, Vu P., Thuy Le, Estee M. Török, Nguyen T. B. Yen, Tran T. H. Chau, Suzanne Jurriaans, H Rogier van Doorn, Menno D. de Jong, Jeremy J. Farrar, and Sarah J. Dunstan. “HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculous meningitis initiating antiretroviral therapy in Vietnam.” Antivir Ther 17, no. 5 (2012): 905–13. https://doi.org/10.3851/IMP2092.
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    • Le, Thuy, Marcel Wolbers, Nguyen Huu Chi, Vo Minh Quang, Nguyen Tran Chinh, Nguyen Phu Huong Lan, Pham Si Lam, et al. “Epidemiology, seasonality, and predictors of outcome of AIDS-associated Penicillium marneffei infection in Ho Chi Minh City, Viet Nam.” Clin Infect Dis 52, no. 7 (April 1, 2011): 945–52. https://doi.org/10.1093/cid/cir028.
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    • Le, Thuy, Jeremy Farrar, and Cecilia Shikuma. “Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.” Aids 25, no. 6 (March 27, 2011): 871–72. https://doi.org/10.1097/QAD.0b013e32834490b1.
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    • Le, Thuy, Nguyen Huu Chi, Ngo T. Kim Cuc, Tran Phu Manh Sieu, Cecilia M. Shikuma, Jeremy Farrar, and Jeremy N. Day. “AIDS-associated Penicillium marneffei infection of the central nervous system.” Clin Infect Dis 51, no. 12 (December 15, 2010): 1458–62. https://doi.org/10.1086/657400.
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    • Le, Thuy, Tran Thi Hong Chau, Ngo Thi Kim Cuc, Pham Si Lam, Tran Phu Manh Sieu, Cecilia M. Shikuma, and Jeremy N. Day. “AIDS‐associated Cryptococcus neoformans and Penicillium marneffei coinfection: a therapeutic dilemma in resource‐limited settings.” Clin Infect Dis 51, no. 9 (November 1, 2010): e65–68. https://doi.org/10.1086/656685.
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    • Le, Thuy, Jennifer Chiarella, Birgitte B. Simen, Bozena Hanczaruk, Michael Egholm, Marie L. Landry, Kevin Dieckhaus, Marc I. Rosen, and Michael J. Kozal. “Low-abundance HIV drug-resistant viral variants in treatment-experienced persons correlate with historical antiretroviral use.” Plos One 4, no. 6 (June 29, 2009): e6079. https://doi.org/10.1371/journal.pone.0006079.
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    • Le, T., J. Salat, B. Sak, and J. Kopecky. “Susceptibility of INF-gamma or IL-12 Knock-out and SCID Mice to Infection with Two Microsporidian Species, Encephalitozoon cuniculi and E. intestinalis.” Folia Parasitologica 51, no. 4 (December 1, 2004): 275–82.
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    • Navin, Thomas R., Charles B. Beard, Laurence Huang, Carlos del Rio, Sherline Lee, Norman J. Pieniazek, Jane L. Carter, Thuy Le, Allen Hightower, and David Rimland. “Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study.” The Lancet 358, no. 9281 (August 2001): 545–49. https://doi.org/10.1016/s0140-6736(01)05705-1.
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    • Le, Thuy. “World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy,” n.d.
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    • Le, Thuy. “World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy,” n.d.
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    • Phu Huong Lan, Nguyen, Tu Le Thi Phuong, Hien Nguyen Huu, Le Thuy, Alison E. Mather, Se Eun Park, Florian Marks, et al. “Invasive Non-typhoidal Salmonella Infections in Asia: Clinical Observations, Disease Outcome and Dominant Serovars from an Infectious Disease Hospital in Vietnam.” Plos Neglected Tropical Diseases 10, no. 8 (n.d.): e0004857–e0004857. https://doi.org/10.1371/journal.pntd.0004857.
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  • Digital Publications

    • “Guidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children, March 2018. World Health Organization.,” n.d.
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    • “World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. WHO. Geneva. Published July 2017.,” n.d.
       Open Access Copy
    • “World Health Organization Guidelines for managing advanced HIV disease and rapid initiation of antiretroviral therapy. WHO. Geneva. Published July 2017.,” n.d.
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  • Conference Papers

    • Thao, Vu Phuong, Vo Minh Quang, Marcel Wolbers, Nguyen Duc Anh, Cecilia Shikuma, Jeremy Farrar, Sarah Dunstan, et al. “Second-Line HIV Therapy Outcomes and Determinants of Mortality at the Largest HIV Referral Center in Southern Vietnam.” In Medicine (Baltimore), 94:e1715, 2015. https://doi.org/10.1097/MD.0000000000001715.
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• Teaching & Mentoring
• 

  Advising & Mentoring

  • I have been a primary search supervisor for ID fellows, post-doc scholars, PhD students, MSc students, medical students, and undergraduate students
• Scholarly, Clinical, & Service Activities
• 

  Service to the Profession

  • Associate Editor of PLOS Neglected Tropical Diseases. 2020 - 2023  2020 - 2023
  • Associate Editor. Medical Mycology. August 2018  2018
  • World Health Organization Guidelines Development Group. Update guidelines for antiretroviral therapy for adults, adolescents, and children. May 2018  2018
  • World Health Organization Guidelines Development Group. Update guidelines on prevention, diagnosis and management of cryptococcal disease in HIV-infected adults, adolescents, and children. March 2018  2018
  • World Health Organization Technical Working Group on HIV treatment optimization for low and middle income countries. March 2018  2018
  • European Confederation of Medical Mycology Guidelines Coordinator for Endemic Mycoses 2019. ECMM. 2018  2018
  • NIH/IDSA/HIVMA Opportunistic Infections Guidelines Committee. 2018 - 2021  2018 - 2021
  • World Health Organization Guidelines Development Group. Management of advanced HIV disease. March 2017  2017
  • Associate Guest Editor . PLoS Neglected Tropical Diseases. 2017  2017
  • Organizing Committee. Asia Pacific AIDS and Coinfections Conference. 2017  2017
  • International AIDS-Related Mycoses Working Group. 2016  2016
  • Scientific Committee. Asia Pacific AIDS and Coinfections Conference. 2015  2015
• 

  Service to Duke

  • Duke COVID-19 Therapeutic Committee. March 2020  2020

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