Tomokazu Souma

Journal article Curr Opin Nephrol Hypertens · July 2018 Featured Publication PURPOSE OF REVIEW: Recent epidemiological and preclinical mechanistic studies provide strong evidence that acute kidney injury (AKI) and chronic kidney disease (CKD) form an interconnected syndrome. Injured kidneys undergo a coordinated reparative process ... Full text Open Access Link to item Cite

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

Journal article Proc Natl Acad Sci U S A · February 6, 2018 Featured Publication The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of ... Full text Open Access Link to item Cite

Angiopoietin-1 is required for Schlemm's canal development in mice and humans.

Journal article J Clin Invest · December 1, 2017 Featured Publication Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-functio ... Full text Open Access Link to item Cite

Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.

Journal article Sci Signal · May 16, 2017 Featured Publication Placental activation of the renin-angiotensin system (RAS) plays a key role in the pathogenesis of preeclampsia. Reactive oxygen species (ROS) are thought to affect placental angiogenesis, which is critical for preventing preeclampsia pathology. We examine ... Full text Open Access Link to item Cite

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.

Journal article Kidney Int · February 2017 Featured Publication Acute kidney injury is a devastating disease with high morbidity in hospitalized patients and contributes to the pathogenesis of chronic kidney disease. An underlying mechanism of acute kidney injury involves ischemia-reperfusion injury which, in turn, ind ... Full text Open Access Link to item Cite

Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity.

Journal article J Clin Invest · July 1, 2016 Featured Publication Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated intraocular pressure (IOP); howev ... Full text Open Access Link to item Cite

Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.

Journal article J Am Soc Nephrol · February 2016 Featured Publication Erythropoietin (Epo) is produced by renal Epo-producing cells (REPs) in a hypoxia-inducible manner. The conversion of REPs into myofibroblasts and coincident loss of Epo-producing ability are the major cause of renal fibrosis and anemia. However, the hypox ... Full text Link to item Cite

Renal erythropoietin-producing cells in health and disease.

Journal article Front Physiol · 2015 Featured Publication Erythropoietin (Epo) is an indispensable erythropoietic hormone primarily produced from renal Epo-producing cells (REPs). Epo production in REPs is tightly regulated in a hypoxia-inducible manner to maintain tissue oxygen homeostasis. Insufficient Epo prod ... Full text Link to item Cite

Plasticity of renal erythropoietin-producing cells governs fibrosis.

Journal article J Am Soc Nephrol · October 2013 Featured Publication CKD progresses with fibrosis and erythropoietin (Epo)-dependent anemia, leading to increased cardiovascular complications, but the mechanisms linking Epo-dependent anemia and fibrosis remain unclear. Here, we show that the cellular phenotype of renal Epo-p ... Full text Link to item Cite