Current Duke Appointments & Affiliations
Research Associate, Senior
Medicine, Gastroenterology,
Medicine
Recent Scholarly Works
Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice.
Journal article J Clin Invest · December 17, 2024 Vitamin D regulates mineral homeostasis. The most biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), is synthesized by CYP27B1 from 25-dihydroxyvitamin D (25D) and is inactivated by CYP24A1. Human monogenic diseases and genome-wide ass ... Full text Link to item CiteMutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin.
Journal article Nat Commun · July 19, 2023 Although the role of the Wnt pathway in colon carcinogenesis has been described previously, it has been recently demonstrated that Wnt signaling originates from highly dynamic nano-assemblies at the plasma membrane. However, little is known regarding the r ... Full text Link to item CiteRecent Grants
Tissue-Specific Regulation and Effects of CYP24A1
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2023 - 2027Contributions of X and Y to colorectal cancer pathogenesis in primary human organoids
ResearchPostdoctoral Associate · Awarded by Elsa U. Pardee Foundation · 2026 - 2027Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure
ResearchResearch Associate · Awarded by National Institutes of Health · 2024 - 2027View All Grants