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William Richard Jeck

Assistant Professor of Pathology
Pathology
40 Duke Medicine Circle, 3017 Yellow Zone, Durham, NC 27710

Current Appointments & Affiliations


Assistant Professor of Pathology · 2021 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

Recent Publications


T-cells are significantly reduced in the luminal gastrointestinal tract of patients with "complete" 22q11.2 deletion syndrome (DiGeorge syndrome): Utilization of chromogenic multiplex immunohistochemistry to define cellular populations.

Journal Article Ann Diagn Pathol · February 2025 Patients with 22q11.2 deletion syndrome or DiGeorge syndrome commonly report gastrointestinal symptoms in addition to more widely understood cardiac and immunodeficiency abnormalities. However, the morphologic features of gastrointestinal tract pathology i ... Full text Link to item Cite

Progressive liver disease and dysregulated glycogen metabolism in murine GSD IX γ2 models human disease.

Journal Article Mol Genet Metab · December 2024 Hepatic glycogen storage disease type IX γ2 (GSD IX γ2) is a severe, liver-specific subtype of GSD IX. While all patients with hepatic GSD IX present with similar symptoms, over 95 % of patients with GSD IX γ2 progress to liver fibrosis and cirrhosis. Desp ... Full text Link to item Cite

Case of a CIC::DUX4 fusion gene in a vascular neoplasm extends the spectrum of CIC-rearranged sarcomas.

Journal Article J Cutan Pathol · November 2024 CIC-rearranged sarcomas comprise a group of exceptionally aggressive round-cell sarcomas. These tumors most commonly demonstrate CIC::DUX4 fusion and show similar histopathology to Ewing sarcomas, though lesions mimicking vascular neoplasms have recently b ... Full text Link to item Cite
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Recent Grants


Project 2: Inflammation and Submucosal Glands During Esophageal Injury and Repair

ResearchCo Investigator · Awarded by Case Western Reserve University · 2023 - 2028

Therapeutic intervention to reverse gastric precancer

Clinical TrialCo Investigator · Awarded by Department of Defense · 2024 - 2028

SRA with Alnylam Pharmaceuticals

ResearchCollaborator · Awarded by Alnylam Pharmaceuticals · 2025 - 2026

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Education, Training & Certifications


University of North Carolina, Chapel Hill, School of Medicine · 2015 MD./PhD.