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William Richard Jeck

Associate Professor of Pathology
Pathology
40 Duke Medicine Circle, 3017 Yellow Zone, Durham, NC 27710

Current Duke Appointments & Affiliations


Associate Professor of Pathology · 2025 - Present Pathology, Clinical Science Departments
Member of the Duke Cancer Institute · 2022 - Present Duke Cancer Institute, Institutes and Centers

Recent Scholarly Works


Systemic Disease Progression and Neurodegeneration in the Gbe1ys/ys Mouse Model of Glycogen Storage Disease Type IV.

Journal article Am J Pathol · March 2026 Glycogen storage disease type IV (GSD IV) is a rare autosomal recessive disorder caused by glycogen branching enzyme (GBE1) deficiency, resulting in the accumulation of insoluble polyglucosan. The Gbe1ys/ys mouse model, carrying the p.Y329S variant, recapi ... Full text Link to item Cite

Machine Learning-Based Detection of Intestinal Metaplasia Identifies Clinically Missed Cases.

Journal article Arch Pathol Lab Med · January 22, 2026 CONTEXT.—: Gastric intestinal metaplasia is a recognized precursor and risk factor to gastric cancer, and correct diagnosis is required for clinical decision-making. OBJECTIVE.—: To evaluate potential missed intestinal metaplasia diagnoses and develop auto ... Full text Link to item Cite
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Recent Grants


Project 2: Inflammation and Submucosal Glands During Esophageal Injury and Repair

ResearchCo Investigator · Awarded by Case Western Reserve University · 2023 - 2028

Therapeutic intervention to reverse gastric precancer

Clinical TrialCo Investigator · Awarded by Department of Defense · 2024 - 2028

GYS2 knockdown on liver disease in hepatic GSD

ResearchCollaborator · Awarded by Alnylam Pharmaceuticals · 2025 - 2026

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Education


University of North Carolina, Chapel Hill, School of Medicine · 2015 MD./PhD.