Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Gastrointestinal Surgical Pathology, Brigham and Women's Hospital 2018 - 2019
  • Residency, Anatomic Pathology, Massachusetts General Hospital 2015 - 2018
  • MD./PhD., University of North Carolina, Chapel Hill, School of Medicine 2015
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Pathology, Pathology, Clinical Science Departments 2019 - 2020
• Research
• 

  Selected Grants

  • Defining the clinical characteristics for clinical trial endpoints of GSD VI and IX awarded by Kriya Therapeutics 2022 - 2025
  • CHARACTERIZATION OF GSD IX ¿2 and GSD VI MOUSE MODELS awarded by Kriya Therapeutics 2022 - 2025
  • Integrated Acoustofluidic Plasmonic Molecular Diagnostic System for Detecting MicroRNA Biomarkers awarded by National Institutes of Health 2020 - 2023
  • AAV-mPhkg2 Gene Therapy for the treatment of GSD IXy2 awarded by Kriya Therapeutics 2022 - 2023
  • PASC Autopsy (NYU) awarded by New York University School of Medicine 2021
• 

  External Relationships

  • Seagen
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Byrne, James D., Cameron C. Young, Jacqueline N. Chu, Jennifer Pursley, Mu Xian Chen, Adam J. Wentworth, Annie Feng, et al. “Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.” Adv Sci (Weinh) 8, no. 12 (June 2021): 2100510. https://doi.org/10.1002/advs.202100510.
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    • Jeck, William R., A John Iafrate, and Valentina Nardi. “Nanopore Flongle Sequencing as a Rapid, Single-Specimen Clinical Test for Fusion Detection.” J Mol Diagn 23, no. 5 (May 2021): 630–36. https://doi.org/10.1016/j.jmoldx.2021.02.001.
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    • Neyaz, Azfar, Robert D. Odze, Steffen Rickelt, Linda T. Nieman, Jacob R. Bledsoe, Krishnan K. Mahadevan, Kshitij Arora, et al. “LGR5 in Barrett's Esophagus and its Utility in Predicting Patients at Increased Risk of Advanced Neoplasia.” Clin Transl Gastroenterol 12, no. 1 (December 22, 2020): e00272. https://doi.org/10.14309/ctg.0000000000000272.
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    • Reiter, Johannes G., Wei-Ting Hung, I-Hsiu Lee, Shriya Nagpal, Peter Giunta, Sebastian Degner, Gang Liu, et al. “Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases.” Nat Genet 52, no. 7 (July 2020): 692–700. https://doi.org/10.1038/s41588-020-0633-2.
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    • Tabari, Azadeh, Aoife Kilcoyne, William R. Jeck, Mari Mino-Kenudson, and Michael S. Gee. “Texture Analysis of Magnetic Resonance Enterography Contrast Enhancement Can Detect Fibrosis in Crohn Disease Strictures.” J Pediatr Gastroenterol Nutr 69, no. 5 (November 2019): 533–38. https://doi.org/10.1097/MPG.0000000000002454.
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    • Tambouret, Rosemary, William R. Jeck, and Drucilla J. Roberts. “The Difference Between Unfixed and Postfixation Placental Weight.” Am J Clin Pathol 152, no. 2 (July 5, 2019): 217–20. https://doi.org/10.1093/ajcp/aqz033.
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    • Jeck, William R., Jesse Lee, Hayley Robinson, Long P. Le, A John Iafrate, and Valentina Nardi. “A Nanopore Sequencing-Based Assay for Rapid Detection of Gene Fusions.” J Mol Diagn 21, no. 1 (January 2019): 58–69. https://doi.org/10.1016/j.jmoldx.2018.08.003.
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    • Taylor, Martin S., Raghu R. Chivukula, Laura C. Myers, William R. Jeck, Avinash Waghray, Purushothama R. Tata, Martin K. Selig, et al. “A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury.” Am J Pathol 188, no. 5 (May 2018): 1149–60. https://doi.org/10.1016/j.ajpath.2018.01.021.
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    • Taylor, Martin S., Raghu R. Chivukula, Laura C. Myers, William R. Jeck, Purushothama R. Tata, Walter J. O’Donnell, Carol F. Farver, B Taylor Thompson, Jayaraj Rajagopal, and Richard L. Kradin. “Delayed Alveolar Epithelialization: A Distinct Pathology in Diffuse Acute Lung Injury.” Am J Respir Crit Care Med 197, no. 4 (February 15, 2018): 522–24. https://doi.org/10.1164/rccm.201706-1094LE.
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    • Liu, Wenjin, Jeff M. Snell, William R. Jeck, Katherine A. Hoadley, Matthew D. Wilkerson, Joel S. Parker, Nirali Patel, et al. “Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.” Jci Insight 2, no. 22 (November 16, 2017). https://doi.org/10.1172/jci.insight.98457.
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    • Fintelmann, Florian J., Jesaja K. Brinkmann, William R. Jeck, Fabian M. Troschel, Subba R. Digumarthy, Mari Mino-Kenudson, and Jo-Anne O. Shepard. “Lung Cancers Associated With Cystic Airspaces: Natural History, Pathologic Correlation, and Mutational Analysis.” J Thorac Imaging 32, no. 3 (May 2017): 176–88. https://doi.org/10.1097/RTI.0000000000000265.
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    • Liu, Wenjin, Jeff M. Snell, William R. Jeck, Katherine A. Hoadley, Matthew D. Wilkerson, Joel S. Parker, Nirali Patel, et al. “Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis.” Jci Insight 1, no. 16 (October 6, 2016): e88755. https://doi.org/10.1172/jci.insight.88755.
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    • Souroullas, George P., William R. Jeck, Joel S. Parker, Jeremy M. Simon, Jie-Yu Liu, Joshiawa Paulk, Jessie Xiong, et al. “An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.” Nat Med 22, no. 6 (June 2016): 632–40. https://doi.org/10.1038/nm.4092.
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    • Cancer Genome Atlas Network, Deborah M. “Genomic Classification of Cutaneous Melanoma.” Cell 161, no. 7 (June 18, 2015): 1681–96. https://doi.org/10.1016/j.cell.2015.05.044.
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    • Burd, Christin E., Wenjin Liu, Minh V. Huynh, Meriam A. Waqas, James E. Gillahan, Kelly S. Clark, Kailing Fu, et al. “Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.” Cancer Discov 4, no. 12 (December 2014): 1418–29. https://doi.org/10.1158/2159-8290.CD-14-0729.
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    • Jeck, William R., Joel Parker, Craig C. Carson, Janiel M. Shields, Maria J. Sambade, Eldon C. Peters, Christin E. Burd, et al. “Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.” Pigment Cell Melanoma Res 27, no. 4 (July 2014): 653–63. https://doi.org/10.1111/pcmr.12238.
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    • Jeck, William R., and Norman E. Sharpless. “Detecting and characterizing circular RNAs.” Nat Biotechnol 32, no. 5 (May 2014): 453–61. https://doi.org/10.1038/nbt.2890.
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    • Cleary, Sean P., William R. Jeck, Xiaobei Zhao, Kui Chen, Sara R. Selitsky, Gleb L. Savich, Ting-Xu Tan, et al. “Identification of driver genes in hepatocellular carcinoma by exome sequencing.” Hepatology 58, no. 5 (November 2013): 1693–1702. https://doi.org/10.1002/hep.26540.
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    • Wang, P., Q. Dong, C. Zhang, P. -. F. Kuan, Y. Liu, W. R. Jeck, J. B. Andersen, et al. “Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas.” Oncogene 32, no. 25 (June 20, 2013): 3091–3100. https://doi.org/10.1038/onc.2012.315.
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    • Jeck, W. R., J. A. Sorrentino, K. Wang, M. K. Slevin, C. E. Burd, J. Liu, W. F. Marzluff, and N. E. Sharpless. “Erratum: Circular RNAs are abundant, conserved, and associated with ALU repeats (RNA (156)).” Rna 19, no. 3 (March 1, 2013): 426.
    • Jeck, William R., Jessica A. Sorrentino, Kai Wang, Michael K. Slevin, Christin E. Burd, Jinze Liu, William F. Marzluff, and Norman E. Sharpless. “Circular RNAs are abundant, conserved, and associated with ALU repeats (vol 19, pg 141, 2013).” Rna a Publication of the Rna Society 19, no. 3 (March 1, 2013): 426–426.
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    • Jeck, William R., Jessica A. Sorrentino, Kai Wang, Michael K. Slevin, Christin E. Burd, Jinze Liu, William F. Marzluff, and Norman E. Sharpless. “Circular RNAs are abundant, conserved, and associated with ALU repeats.” Rna 19, no. 2 (February 2013): 141–57. https://doi.org/10.1261/rna.035667.112.
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    • Jeck, William R., Alex P. Siebold, and Norman E. Sharpless. “Review: a meta-analysis of GWAS and age-associated diseases.” Aging Cell 11, no. 5 (October 2012): 727–31. https://doi.org/10.1111/j.1474-9726.2012.00871.x.
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    • Burd, Christin E., William R. Jeck, Yan Liu, Hanna K. Sanoff, Zefeng Wang, and Norman E. Sharpless. “Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.” Plos Genet 6, no. 12 (December 2, 2010): e1001233. https://doi.org/10.1371/journal.pgen.1001233.
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    • Reinhardt, Josephine A., David A. Baltrus, Marc T. Nishimura, William R. Jeck, Corbin D. Jones, and Jeffery L. Dangl. “De novo assembly using low-coverage short read sequence data from the rice pathogen Pseudomonas syringae pv. oryzae.” Genome Res 19, no. 2 (February 2009): 294–305. https://doi.org/10.1101/gr.083311.108.
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    • Gabriel, Willow N., Robert McNuff, Sapna K. Patel, T Ryan Gregory, William R. Jeck, Corbin D. Jones, and Bob Goldstein. “The tardigrade Hypsibius dujardini, a new model for studying the evolution of development.” Dev Biol 312, no. 2 (December 15, 2007): 545–59. https://doi.org/10.1016/j.ydbio.2007.09.055.
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    • Drosophila 12 Genomes Consortium, Iain, Andrew G. Clark, Michael B. Eisen, Douglas R. Smith, Casey M. Bergman, Brian Oliver, Therese A. Markow, et al. “Evolution of genes and genomes on the Drosophila phylogeny.” Nature 450, no. 7167 (November 8, 2007): 203–18. https://doi.org/10.1038/nature06341.
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    • Jeck, William R., Josephine A. Reinhardt, David A. Baltrus, Matthew T. Hickenbotham, Vincent Magrini, Elaine R. Mardis, Jeffery L. Dangl, and Corbin D. Jones. “Extending assembly of short DNA sequences to handle error.” Bioinformatics 23, no. 21 (November 1, 2007): 2942–44. https://doi.org/10.1093/bioinformatics/btm451.
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  • Conference Papers

    • Jeck, William Richard, Kshitij S. Arora, Elena Brachtel, and Vikram Deshpande. “Harnessing TCGA RNAseq Data as a Springboard to Novel Tumor Markers.” In Modern Pathology, 30:178A-178A. NATURE PUBLISHING GROUP, 2017.
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    • Jeck, William Richard, Kshitij S. Arora, Elena Brachtel, and Vikram Deshpande. “Harnessing TCGA RNAseq Data as a Springboard to Novel Tumor Markers.” In Laboratory Investigation, 97:178A-178A. NATURE PUBLISHING GROUP, 2017.
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    • Roque, Dario R., Will R. Jeck, David N. Hayes, Arthur M. Dizon, Leslie Clark, Stuart Pierce, Weiya Z. Wysham, Tara Castellano, Paola A. Gehrig, and Victoria Bae-Jump. “Abstract 1852: Multiple PI3K pathway mutations predominate in low stage endometrial carcinomas.” In Cancer Research, 76:1852–1852. American Association for Cancer Research (AACR), 2016. https://doi.org/10.1158/1538-7445.am2016-1852.
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    • Cleary, Sean P., William R. Jeck, Xiaobei Zhao, Sara R. Selitsky, Gleb L. Savich, Ting-Xu Tan, Michael C. Wu, et al. “Abstract 4598: Identification of driver genes in hepatocellular carcinoma by exome sequencing.” In Cancer Research, 73:4598–4598. American Association for Cancer Research (AACR), 2013. https://doi.org/10.1158/1538-7445.am2013-4598.
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    • Wang, Pu, Qiong-Zhu Dong, Chong Zhang, Pei-Fen Kuan, Yufeng Liu, William R. Jeck, Jesper B. Andersen, et al. “Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas.” In Cancer Research, 72:1058–1058. American Association for Cancer Research (AACR), 2012. https://doi.org/10.1158/1538-7445.am2012-1058.
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