Current Appointments & Affiliations
Associate Professor of Pathology
·
2025 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2022 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Liver-directed AAV gene therapy in mice corrects glycogen storage disease type IX γ2.
Journal Article Sci Adv · November 14, 2025 Glycogen storage disease (GSD) type IX γ2 is a rare inborn error of metabolism where a defect in glycogenolysis leads to the inability to break down glycogen in the liver. Patients with GSD IX γ2 develop hypoglycemia and advanced liver disease, placing the ... Full text Link to item CiteT-cells are significantly reduced in the luminal gastrointestinal tract of patients with "complete" 22q11.2 deletion syndrome (DiGeorge syndrome): Utilization of chromogenic multiplex immunohistochemistry to define cellular populations.
Journal Article Ann Diagn Pathol · February 2025 Patients with 22q11.2 deletion syndrome or DiGeorge syndrome commonly report gastrointestinal symptoms in addition to more widely understood cardiac and immunodeficiency abnormalities. However, the morphologic features of gastrointestinal tract pathology i ... Full text Link to item CiteProgressive liver disease and dysregulated glycogen metabolism in murine GSD IX γ2 models human disease.
Journal Article Mol Genet Metab · December 2024 Hepatic glycogen storage disease type IX γ2 (GSD IX γ2) is a severe, liver-specific subtype of GSD IX. While all patients with hepatic GSD IX present with similar symptoms, over 95 % of patients with GSD IX γ2 progress to liver fibrosis and cirrhosis. Desp ... Full text Link to item CiteRecent Grants
Project 2: Inflammation and Submucosal Glands During Esophageal Injury and Repair
ResearchCo Investigator · Awarded by Case Western Reserve University · 2023 - 2028Therapeutic intervention to reverse gastric precancer
Clinical TrialCo Investigator · Awarded by Department of Defense · 2024 - 2028GYS2 knockdown on liver disease in hepatic GSD
ResearchCollaborator · Awarded by Alnylam Pharmaceuticals · 2025 - 2026View All Grants
Education, Training & Certifications
University of North Carolina, Chapel Hill, School of Medicine ·
2015
MD./PhD.