William Richard Jeck

Conference Cancer Immunology Research · February 23, 2025 AbstractINTRODUCTION: Immunotherapy outcomes have been underwhelming in most gastrointestinal malignancies. Microsatellite instable (MSI-H) colorectal cancers (CRC) are an exception. Immune checkpoint blocka ... Full text Cite

Utilization of an In-House Solid Tumor Next-Generation Sequencing Fusion Panel: A 1-Year institutional Experience with a Focus on the Diagnosis of Soft Tissue Tumors

Conference JOURNAL OF MOLECULAR DIAGNOSTICS · June 2024 Link to item Cite

Analytical Validation (Accuracy, Reproducibility, Limit of Detection) of FoundationOne RNA Assay for Fusion Detection in 189 Clinical Tumor Specimens

Conference JOURNAL OF MOLECULAR DIAGNOSTICS · November 2023 Link to item Cite

Enhancing Fusion Oncogene Detection in Driver Negative Pancreaticobiliary Carcinomas, a Single Institution Experience

Conference JOURNAL OF MOLECULAR DIAGNOSTICS · November 2023 Link to item Cite

Patient-derived skin MicroOrganoSpheres and clinical response to immunotherapy

Conference JOURNAL OF CLINICAL ONCOLOGY · June 1, 2023 Link to item Cite

Patient-derived skin MicroOrganoSpheres and clinical response to immunotherapy.

Conference Journal of Clinical Oncology · June 1, 2023 2588 Background: Immunotherapies, including immune checkpoint inhibitors (ICI), have revolutionized the treatment of many cancers, producing significant improvements in survival in patients with many different cancers. However, t ... Full text Cite

HEPATIC INVOLVEMENT IN GLYCOGEN STORAGE DISEASE TYPE IV: NEW INSIGHTS AND THERAPEUTIC IMPLICATIONS

Conference Molecular Genetics and Metabolism · March 2023 Full text Cite

Case Report: Primary Alveolar Soft Part Sarcoma of the Breast

Conference AMERICAN JOURNAL OF CLINICAL PATHOLOGY · November 9, 2022 Link to item Cite

Liver Directed AAV Gene Therapy Reverses Progression of Glycogen Storage Disease Type IX γ2 in Mice

Conference MOLECULAR THERAPY · April 2022 Link to item Cite

Harnessing TCGA RNAseq Data as a Springboard to Novel Tumor Markers

Conference MODERN PATHOLOGY · February 1, 2017 Link to item Cite

Harnessing TCGA RNAseq Data as a Springboard to Novel Tumor Markers

Conference LABORATORY INVESTIGATION · February 1, 2017 Link to item Cite

Abstract 1852: Multiple PI3K pathway mutations predominate in low stage endometrial carcinomas

Conference Cancer Research · July 15, 2016 AbstractObjectives: Endometrial cancers (ECs) frequently harbor mutations in PI3K pathway genes. Our objective was to determine the mutation frequency of the PIK3 pathway in the tumors of EC patients prospec ... Full text Cite

Abstract 4598: Identification of driver genes in hepatocellular carcinoma by exome sequencing.

Conference Cancer Research · April 15, 2013 AbstractGenetic alterations in specific driver genes lead to disruption of cellular pathways and are critical events in the instigation and progression of hepatocellular carcinoma. As a prerequisite for indi ... Full text Cite

Abstract 1087: Differential oncogenicity of N-RAS mutations in melanoma.

Conference Cancer Research · April 15, 2013 AbstractIn human cancer, N-RAS mutations resulting in constitutive, oncogenic signaling are predominately localized to codons 12, 13 or 61. Traditionally, activating RAS mutations have been considered oncoge ... Full text Cite

Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas

Conference Cancer Research · April 15, 2012 AbstractCholangiocarcinomas are rare but aggressive cancers, with an increasing incidence and a dismal 5-year survival rate of less than 5%. Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and ... Full text Cite