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Xianzhi Lin

Assistant Professor of Biology at Duke Kunshan University
DKU Faculty

Overview


The Lin group uses ovarian cancer as a model system to study the molecular mechanisms of cancer initiation and progression. We focus on the largest group of transcripts in the human genome known as long noncoding RNAs (lncRNAs), many of which have been demonstrated to have regulatory roles in multiple cellular processes in both physiology and diseases. Molecular and genetic analyses are being carried out to interrogate the functions of lncRNAs in the hallmarks and enabling characteristics of cancer. Using RNA-centric and protein-centric methods, our group identifies and validates lncRNA-binding partners that contribute to the functional role of lncRNAs in the hallmarks and enabling characteristics of cancer. The lncRNAs and their binding partners are potential targets for developing therapeutic drugs to prevent cancer progression.

Current Appointments & Affiliations


Assistant Professor of Biology at Duke Kunshan University · 2023 - Present DKU Faculty
Assistant Professor of the Practice of DKU Studies at Duke University · 2024 - Present DKU Studies

Recent Publications


Fallopian tube single cell analysis reveals myeloid cell alterations in high-grade serous ovarian cancer.

Journal Article iScience · March 2024 Most high-grade serous ovarian cancers (HGSCs) likely initiate from fallopian tube (FT) epithelia. While epithelial subtypes have been characterized using single-cell RNA-sequencing (scRNA-Seq), heterogeneity of other compartments and their involvement in ... Full text Cite

A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus.

Journal Article Nature communications · August 2023 To date, single-nucleotide polymorphisms (SNPs) have been the most intensively investigated class of polymorphisms in genome wide associations studies (GWAS), however, other classes such as insertion-deletion or multiple nucleotide length polymorphism (MNL ... Full text Cite
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Education, Training & Certifications


Chinese Academy of Sciences (China) · 2012 Ph.D.