Scholars@Duke
Xin Li

Xin Li

Postdoctoral Associate
Pharmacology & Cancer Biology

Scholarly Works

Hemizygous loss of helicases promotes genomic instability and cancer development.

Journal article Science advances · February 2026 Cancer mutations perturb key processes, driving uncontrolled cell proliferation. With critical roles of enzymes in cell function and growth, we hypothesized that cancer driver mutations alter specific and recurrent enzymatic functions. Leveraging large pan ... Full text Cite

G6PC3 promotes genome maintenance and is a candidate mammary tumor suppressor.

Journal article JCI insight · June 2025 Mutations in genome maintenance factors drive sporadic and hereditary breast cancers. Here, we searched for potential drivers based on germline DNA analysis from a cohort consisting of patients with early-onset breast cancer negative for BRCA1/BRCA2 mutati ... Full text Cite

The class II myosin MYH4 safeguards genome integrity and suppresses tumor progression.

Journal article The Journal of clinical investigation · June 2025 Loss-of-function mutations in genome maintenance genes fuel tumorigenesis through increased genomic instability. A subset of these tumor suppressors are challenging to identify due to context dependency, including functional interactions with other genes a ... Full text Cite

BRCAness, DNA gaps, and gain and loss of PARP inhibitor-induced synthetic lethality.

Journal article J Clin Invest · July 15, 2024 Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2 deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other cancers. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-d ... Full text Link to item Cite

Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR-Select.

Journal article Nature genetics · December 2022 Determining the functional role of thousands of genetic sequence variants (mutations) associated with genetic diseases is a major challenge. Here we present clustered regularly interspaced short palindromic repeat (CRISPR)-SelectTIME, CRISPR-Sel ... Full text Cite