Scholars@Duke
Zachary Hing

Scholarly Works

Advances in T-cell lymphomas and risk factors for CNS involvement.

Journal article Leuk Lymphoma · September 2025 T-cell lymphomas (TCLs) are rare heterogenous hematologic neoplasms that exhibit poor response to traditional cytotoxic chemotherapy and have no universally accepted gold standard of treatment. Central nervous system (CNS) involvement is rare and generally ... Full text Link to item Cite

When You Drew the Graph.

Journal article JAMA · March 11, 2025 Full text Link to item Cite

CD37 in acute myeloid leukemia: a novel surface target for drug delivery.

Journal article Blood Adv · January 14, 2025 Acute myeloid leukemia (AML) is the most common and lethal leukemia in adults. AML consists of many genetic subtypes, which limits broad applicability of targeted therapy. We discovered that the hematopoiesis-restricted tetraspanin CD37 is expressed on the ... Full text Link to item Cite

Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation.

Journal article Nat Commun · January 6, 2023 Richter's Transformation (RT) is a poorly understood and fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma. Protein arginine methyltransferase 5 (PRMT5) is implicated in lymphomagenesis, but ... Full text Link to item Cite

Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia.

Journal article Nat Commun · November 3, 2021 Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but have ... Full text Link to item Cite

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.

Journal article J Hematol Oncol · January 15, 2021 BACKGROUND: Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we found to disrupt h ... Full text Link to item Cite

Eμ-TCL1xMyc: A Novel Mouse Model for Concurrent CLL and B-Cell Lymphoma.

Journal article Clin Cancer Res · October 15, 2019 PURPOSE: Aberrant Myc expression is a major factor in the pathogenesis of aggressive lymphoma, and these lymphomas, while clinically heterogeneous, often are resistant to currently available treatments and have poor survival. Myc expression can also be see ... Full text Link to item Cite

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.

Journal article Cancer Discov · April 2018 Bromodomain and extra-terminal (BET) family proteins are key regulators of gene expression in cancer. Herein, we utilize BRD4 profiling to identify critical pathways involved in pathogenesis of chronic lymphocytic leukemia (CLL). BRD4 is overexpressed in C ... Full text Link to item Cite

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.

Journal article Leukemia · December 2016 The nuclear export receptor, Exportin 1 (XPO1), mediates transport of growth-regulatory proteins, including tumor suppressors, and is overactive in many cancers, including chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML) and aggressive lymp ... Full text Link to item Cite

Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.

Journal article Blood · May 14, 2015 Despite the therapeutic efficacy of ibrutinib in chronic lymphocytic leukemia (CLL), complete responses are infrequent, and acquired resistance to Bruton agammaglobulinemia tyrosine kinase (BTK) inhibition is being observed in an increasing number of patie ... Full text Link to item Cite

Multiple in silico tools predict phenotypic manifestations in congenital thrombotic thrombocytopenic purpura.

Journal article Br J Haematol · March 2013 Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare, recessively inherited genetic disorder with varying clinical presentation that is caused by ADAMTS13 mutations. Several studies have found limited associations between ADAMTS13 mutations and ... Full text Link to item Cite

Characterization of coding synonymous and non-synonymous variants in ADAMTS13 using ex vivo and in silico approaches.

Journal article PLoS One · 2012 Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these "silent" varia ... Full text Link to item Cite