Zhong Chen | Scholars@Duke

Zhong Chen
Assistant Professor in Pathology

Current Appointments & Affiliations

Assistant Professor in Pathology, Pathology, Clinical Science Departments 2021
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

GSRB I, Rm1027b, Box #103864, 905 South Lasalle Steet, Durham, NC 27710
GSRB I, Rm1027b, Box #103864, 905 South Lasalle Steet, Durham, NC 27710
zhong.chen128@duke.edu (919) 613-9981

Background
Education, Training, & Certifications
- Ph.D., Peking Union Medical College (China) 2008
Previous Appointments & Affiliations
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2017 - 2020
Research
Selected Grants
- Systems analysis of the prostate cancer epigenome awarded by National Institutes of Health 2020 - 2025
- Systems Analysis of Epigenomic Architecture in Cancer Progression (Project 2: Fine-scale nucleosome repositioning of enhancers for hormone-independent genomic function) awarded by University of Texas Health Science Center at San Antonio 2017 - 2022
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Li, Tianbao, Qi Liu, Zhong Chen, Kun Fang, Furong Huang, Xueqi Fu, Qianben Wang, and Victor X. Jin. “Dynamic nucleosome landscape elicits a noncanonical GATA2 pioneer model.” Nat Commun 13, no. 1 (June 7, 2022): 3145. https://doi.org/10.1038/s41467-022-30960-x.
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  - Chen, Zhong, Zhenqing Ye, Raymond E. Soccio, Tomoyoshi Nakadai, William Hankey, Yue Zhao, Furong Huang, et al. “Phosphorylated MED1 links transcription recycling and cancer growth.” Nucleic Acids Res 50, no. 8 (May 6, 2022): 4450–63. https://doi.org/10.1093/nar/gkac246.
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  - Chen, Zhong, William Hankey, Yue Zhao, Jeff Groth, Furong Huang, Hongyan Wang, Alexandre Rosa Campos, Jiaoti Huang, Robert G. Roeder, and Qianben Wang. “Transcription recycling assays identify PAF1 as a driver for RNA Pol II recycling.” Nat Commun 12, no. 1 (November 3, 2021): 6318. https://doi.org/10.1038/s41467-021-26604-1.
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  - Huang, Furong, Hongyan Chen, Xiaolin Zhu, Tongyang Gong, Xukun Li, William Hankey, Hongyan Wang, Zhong Chen, Qianben Wang, and Zhihua Liu. “The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3.” Cell Res 31, no. 3 (March 2021): 362–65. https://doi.org/10.1038/s41422-020-00428-y.
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  - Hankey, William, Benjamin Sunkel, Fuwen Yuan, Haiyan He, Jennifer M. Thomas-Ahner, Zhong Chen, Steven K. Clinton, Jiaoti Huang, and Qianben Wang. “Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range.” Transl Oncol 13, no. 9 (September 2020): 100797. https://doi.org/10.1016/j.tranon.2020.100797.
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  - Hankey, William, Zhong Chen, and Qianben Wang. “Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors.” Cancer Res 80, no. 12 (June 15, 2020): 2427–36. https://doi.org/10.1158/0008-5472.CAN-19-3447.
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  - Yuan, Fuwen, William Hankey, Dayong Wu, Hongyan Wang, Jason Somarelli, Andrew J. Armstrong, Jiaoti Huang, Zhong Chen, and Qianben Wang. “Molecular determinants for enzalutamide-induced transcription in prostate cancer.” Nucleic Acids Res 47, no. 19 (November 4, 2019): 10104–14. https://doi.org/10.1093/nar/gkz790.
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  - Atala, Anthony. “Re: Diverse AR-V7 Cistromes in Castration-Resistant Prostate Cancer are Governed by HoxB13.” J Urol 201, no. 3 (March 2019): 446–47. https://doi.org/10.1097/01.JU.0000553716.75971.4e.
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  - Hankey, William, Zhong Chen, Maxwell J. Bergman, Max O. Fernandez, Baris Hancioglu, Xun Lan, Anil G. Jegga, et al. “Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.” Oncotarget 9, no. 58 (July 27, 2018): 31214–30. https://doi.org/10.18632/oncotarget.25781.
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  - Chen, Zhong, Dayong Wu, Jennifer M. Thomas-Ahner, Changxue Lu, Pei Zhao, Qingfu Zhang, Connor Geraghty, et al. “Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13.” Proc Natl Acad Sci U S A 115, no. 26 (June 26, 2018): 6810–15. https://doi.org/10.1073/pnas.1718811115.
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  - Sunkel, Benjamin, Dayong Wu, Zhong Chen, Chiou-Miin Wang, Xiangtao Liu, Zhenqing Ye, Aaron M. Horning, et al. “Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.” Nucleic Acids Res 45, no. 11 (June 20, 2017): 6993. https://doi.org/10.1093/nar/gkx282.
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  - Ye, Zhenqing, Zhong Chen, Benjamin Sunkel, Seth Frietze, Tim H-M Huang, Qianben Wang, and Victor X. Jin. “Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1.” Nucleic Acids Res 44, no. 16 (September 19, 2016): 7540–54. https://doi.org/10.1093/nar/gkw659.
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  - Sunkel, Benjamin, Dayong Wu, Zhong Chen, Chiou-Miin Wang, Xiangtao Liu, Zhenqing Ye, Aaron M. Horning, et al. “Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.” Nucleic Acids Res 44, no. 9 (May 19, 2016): 4105–22. https://doi.org/10.1093/nar/gkv1528.
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  - Tang, Xing, Huayang Liu, Arunima Srivastava, Thierry Pécot, Zhong Chen, Qianben Wang, Kun Huang, et al. “Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice.” Sci Data 3 (February 16, 2016): 160008. https://doi.org/10.1038/sdata.2016.8.
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  - Chen, Kaifu, Zhong Chen, Dayong Wu, Lili Zhang, Xueqiu Lin, Jianzhong Su, Benjamin Rodriguez, et al. “Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes.” Nat Genet 47, no. 10 (October 2015): 1149–57. https://doi.org/10.1038/ng.3385.
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  - Chen, Zhong, Xun Lan, Dayong Wu, Benjamin Sunkel, Zhenqing Ye, Jiaoti Huang, Zhihua Liu, Steven K. Clinton, Victor X. Jin, and Qianben Wang. “Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer.” Nat Commun 6 (September 16, 2015): 8323. https://doi.org/10.1038/ncomms9323.
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  - Liu, Huayang, Xing Tang, Arunima Srivastava, Thierry Pécot, Piotr Daniel, Benjamin Hemmelgarn, Stephan Reyes, et al. “Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.” Nat Cell Biol 17, no. 8 (August 2015): 1036–48. https://doi.org/10.1038/ncb3210.
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  - Chen, Zhong, Xun Lan, Jennifer M. Thomas-Ahner, Dayong Wu, Xiangtao Liu, Zhenqing Ye, Liguo Wang, et al. “Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer.” Embo J 34, no. 4 (February 12, 2015): 502–16. https://doi.org/10.15252/embj.201490306.
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  - Wu, Dayong, Benjamin Sunkel, Zhong Chen, Xiangtao Liu, Zhenqing Ye, Qianjin Li, Cassandra Grenade, et al. “Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.” Nucleic Acids Res 42, no. 6 (April 2014): 3607–22. https://doi.org/10.1093/nar/gkt1382.
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  - Ye, Zhenqing, Zhong Chen, Xun Lan, Stephen Hara, Benjamin Sunkel, Tim H-M Huang, Laura Elnitski, Qianben Wang, and Victor X. Jin. “Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors.” Nucleic Acids Res 42, no. 5 (March 2014): 2856–69. https://doi.org/10.1093/nar/gkt1338.
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  - Taslim, Cenny, Zhong Chen, Kun Huang, Tim Hui-Ming Huang, Qianben Wang, and Shili Lin. “Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.” Nucleic Acids Res 40, no. 11 (June 2012): 4754–64. https://doi.org/10.1093/nar/gks139.
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  - Zhang, Chunpeng, Liguo Wang, Dayong Wu, Hongyan Chen, Zhong Chen, Jennifer M. Thomas-Ahner, Debra L. Zynger, et al. “Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.” Cancer Res 71, no. 21 (November 1, 2011): 6738–48. https://doi.org/10.1158/0008-5472.CAN-11-1882.
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  - Wang, Hongyan, Chunpeng Zhang, Anna Rorick, Dayong Wu, Ming Chiu, Jennifer Thomas-Ahner, Zhong Chen, et al. “CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability.” Cancer Res 71, no. 14 (July 15, 2011): 4866–76. https://doi.org/10.1158/0008-5472.CAN-10-4576.
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  - Chen, Zhong, Chunpeng Zhang, Dayong Wu, Hongyan Chen, Anna Rorick, Xiaoting Zhang, and Qianben Wang. “Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.” Embo J 30, no. 12 (May 10, 2011): 2405–19. https://doi.org/10.1038/emboj.2011.154.
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  - Chen, Zhong, Liguo Wang, Qianben Wang, and Wei Li. “Histone modifications and chromatin organization in prostate cancer.” Epigenomics 2, no. 4 (August 2010): 551–60. https://doi.org/10.2217/epi.10.31.
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  - Hsu, Pei-Yin, Hang-Kai Hsu, Gregory A. C. Singer, Pearlly S. Yan, Benjamin A. T. Rodriguez, Joseph C. Liu, Yu-I Weng, et al. “Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.” Genome Res 20, no. 6 (June 2010): 733–44. https://doi.org/10.1101/gr.101923.109.
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  - Fang, Zhi Hong, Chun Lan Dong, Zhong Chen, Bin Zhou, Na Liu, Hai Feng Lan, Lu Liang, Wen Bin Liao, Lei Zhang, and Zhong Chao Han. “Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.” J Cell Mol Med 13, no. 8B (August 2009): 2039–52. https://doi.org/10.1111/j.1582-4934.2008.00549.x.
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  - Wang, Qianben, Wei Li, Yong Zhang, Xin Yuan, Kexin Xu, Jindan Yu, Zhong Chen, et al. “Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.” Cell 138, no. 2 (July 23, 2009): 245–56. https://doi.org/10.1016/j.cell.2009.04.056.
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  - Liu, Fang, Zhong Chen, Jinhong Wang, Xiaofeng Shao, Ziyou Cui, Chunzheng Yang, Zhenping Zhu, and Dongsheng Xiong. “Overexpression of cell surface cytokeratin 8 in multidrug-resistant MCF-7/MX cells enhances cell adhesion to the extracellular matrix.” Neoplasia 10, no. 11 (November 2008): 1275–84. https://doi.org/10.1593/neo.08810.
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  - Chen, Zhong, and Zhong Chao Han. “ChemInform Abstract: STAT3: A Critical Transcription Activator in Angiogenesis.” Cheminform 39, no. 24 (June 10, 2008). https://doi.org/10.1002/chin.200824243.
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  - Ma, Feng Xia, Bin Zhou, Zhong Chen, Qian Ren, Shi Hong Lu, Tatsuya Sawamura, and Zhong Chao Han. “Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase.” J Lipid Res 47, no. 6 (June 2006): 1227–37. https://doi.org/10.1194/jlr.M500507-JLR200.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles