Scholars@Duke
Ann LeFurgey

Ann LeFurgey

Associate Research Professor of Cell Biology
Cell Biology
ann.lefurgey@duke.edu
Duke Box 3709, Durham, NC 27710
VAMC Rm F3194, 508 Fulton St, Durham, NC 27705

Featured Works

Leishmania donovani amastigotes mobilize organic and inorganic osmolytes during regulatory volume decrease.

Journal article J Eukaryot Microbiol · 2005 Featured Publication The protozoan parasite Leishmania donovani encounters large fluctuations in osmolality as it cycles between its insect vector and human host. The flagellated promastigote exhibits regulatory volume responses involving organic and inorganic osmolytes, but l ... Full text Link to item Cite

Compartmental responses to acute osmotic stress in Leishmania major result in rapid loss of Na+ and Cl-.

Journal article Comp Biochem Physiol A Mol Integr Physiol · February 2001 Featured Publication The elemental composition of the cytoplasm, electron dense vacuoles, and heterochromatin and euchromatin regions of the nucleus of Leishmania major promastigotes was measured by electron probe X-ray microanalysis under iso-osmotic conditions (305 mOsM) and ... Full text Link to item Cite

Intermittent perfusion protects the brain during deep hypothermic circulatory arrest.

Journal article Ann Thorac Surg · July 1999 Featured Publication BACKGROUND: Deep hypothermic circulatory arrest (DHCA) has been shown to cause impairment in recovery of cerebral blood flow (CBF) and cerebral metabolism (CMRO2) proportional to the duration of the DHCA period. This effect on CMRO2 may be a marker for bra ... Full text Link to item Cite

In vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber.

Journal article J Toxicol Environ Health · February 7, 1997 Featured Publication In vivo exposures to fibrous silicates are characterized by the formation of asbestos bodies. These structures consist of the original fiber with a coating of inexact composition, but it will include iron and protein. We tested the hypothesis that this iro ... Full text Link to item Cite

Elemental composition of Na pump inhibited rabbit aorta VSM cells by electron probe X-ray microanalysis.

Journal article Am J Physiol · August 1996 Featured Publication The Na pump in vascular smooth muscle (VSM) is likely to influence not only intracellular Na content but also the content and distribution of other cations and anions measured by electron probe X-ray microanalysis (EPXMA). The hypothesis we tested was that ... Full text Link to item Cite