Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Second Moscow State Institute of Medicine (Russia) 1973
• 

  Previous Appointments & Affiliations

  • Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2013 - 2020
  • Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2008 - 2013
  • Instructor, Temporary of Medical Psychology in the Department of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2007
• Research
• 

  Selected Grants

  • E-cigarettes: deposition, absorption and brain accumulation of nicotine awarded by National Institutes of Health 2017 - 2023
  • The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence awarded by National Institutes of Health 2015 - 2021
  • Neural Circuitry Involved in Pulmonary Nicotine Sensation during Smoking awarded by Altria Client Services LLC 2019 - 2020
  • Alpha 5 Nicotinic Receptor Subunit Gene Polymorphisms and Smoking Addiction awarded by National Institutes of Health 2013 - 2019
  • Novel Approach to Quantify Nicotinic Receptor Upregulation in Smokers awarded by National Institutes of Health 2014 - 2017
  • P50 Supplement awarded by National Institutes of Health 2010 - 2015
  • Effects of Cigarette Mentholation on Brain Nicotine Accumulation During Smoking awarded by National Institutes of Health 2011 - 2013
  • Improving the efficacy of anti-nicotine immunotherapy awarded by National Institutes of Health 2009 - 2012
• 

  External Relationships

  • Rose Research Center LLC
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Solingapuram Sai, Kiran Kumar, Yantao Zuo, Jed E. Rose, Pradeep K. Garg, Sudha Garg, Rachid Nazih, Akiva Mintz, and Alexey G. Mukhin. “Rapid Brain Nicotine Uptake from Electronic Cigarettes.” J Nucl Med 61, no. 6 (June 2020): 928–30. https://doi.org/10.2967/jnumed.119.230748.
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    • Zuo, Yantao, Pradeep K. Garg, Rachid Nazih, Sudha Garg, Jed E. Rose, Thangaraju Murugesan, and Alexey G. Mukhin. “A programmable smoke delivery device for PET imaging with cigarettes containing 11C-nicotine.” J Neurosci Methods 283 (May 1, 2017): 55–61. https://doi.org/10.1016/j.jneumeth.2017.03.016.
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    • Le Foll, Bernard, Svetlana I. Chefer, Alane S. Kimes, Elliot A. Stein, Steven R. Goldberg, and Alexey G. Mukhin. “Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates.” Psychopharmacology (Berl) 233, no. 10 (May 2016): 1829–35. https://doi.org/10.1007/s00213-016-4250-9.
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    • Zuo, Yantao, Alexey G. Mukhin, Sudha Garg, Rachid Nazih, Frederique M. Behm, Pradeep K. Garg, and Jed E. Rose. “Sex-specific effects of cigarette mentholation on brain nicotine accumulation and smoking behavior.” Neuropsychopharmacology 40, no. 4 (March 2015): 884–92. https://doi.org/10.1038/npp.2014.263.
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    • Brody, Arthur L., Alexey G. Mukhin, Michael S. Mamoun, Trinh Luu, Meaghan Neary, Lidia Liang, Jennifer Shieh, Catherine A. Sugar, Jed E. Rose, and Mark A. Mandelkern. “Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial.” Jama Psychiatry 71, no. 7 (July 1, 2014): 797–805. https://doi.org/10.1001/jamapsychiatry.2014.138.
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    • Brody, Arthur L., Alexey G. Mukhin, Alexey G. Stephanie Shulenberger, Michael S. Mamoun, Maggie Kozman, Jonathan Phuong, Meaghan Neary, Trinh Luu, and Mark A. Mandelkern. “Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density.” Neuropsychopharmacology 38, no. 8 (July 2013): 1548–56. https://doi.org/10.1038/npp.2013.53.
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    • Brody, Arthur L., Alexey G. Mukhin, Jaime La Charite, Karen Ta, Judah Farahi, Catherine A. Sugar, Michael S. Mamoun, et al. “Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers.” Int J Neuropsychopharmacol 16, no. 5 (June 2013): 957–66. https://doi.org/10.1017/S1461145712001022.
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    • Brody, Arthur L., Mark A. Mandelkern, Edythe D. London, Aliyah Khan, Daniel Kozman, Matthew R. Costello, Evan E. Vellios, Meena M. Archie, Rebecca Bascom, and Alexey G. Mukhin. “Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain.” Arch Gen Psychiatry 68, no. 9 (September 2011): 953–60. https://doi.org/10.1001/archgenpsychiatry.2011.51.
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    • Rose, Jed E., Alexey G. Mukhin, Stephen J. Lokitz, Timothy G. Turkington, Joseph Herskovic, Frederique M. Behm, Sudha Garg, and Pradeep K. Garg. “Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine.” Proc Natl Acad Sci U S A 107, no. 11 (March 16, 2010): 5190–95. https://doi.org/10.1073/pnas.0909184107.
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    • Le Foll, Bernard, Svetlana I. Chefer, Alane S. Kimes, Dean Shumway, Elliot A. Stein, Alexey G. Mukhin, and Steven R. Goldberg. “Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine.” Biol Psychiatry 65, no. 8 (April 15, 2009): 714–16. https://doi.org/10.1016/j.biopsych.2008.09.036.
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    • Brody, Arthur L., Mark A. Mandelkern, Matthew R. Costello, Anna L. Abrams, David Scheibal, Judah Farahi, Edythe D. London, Richard E. Olmstead, Jed E. Rose, and Alexey G. Mukhin. “Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette.” Int J Neuropsychopharmacol 12, no. 3 (April 2009): 305–16. https://doi.org/10.1017/S146114570800922X.
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    • Justinova, Zuzana, Regina A. Mangieri, Marco Bortolato, Svetlana I. Chefer, Alexey G. Mukhin, Jason R. Clapper, Alvin R. King, et al. “Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.” Biol Psychiatry 64, no. 11 (December 1, 2008): 930–37. https://doi.org/10.1016/j.biopsych.2008.08.008.
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    • Mukhin, Alexey G., Alane S. Kimes, Svetlana I. Chefer, John A. Matochik, Carlo S. Contoreggi, Andrew G. Horti, D Bruce Vaupel, Olga Pavlova, and Elliot A. Stein. “Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380.” J Nucl Med 49, no. 10 (October 2008): 1628–35. https://doi.org/10.2967/jnumed.108.050716.
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    • Kimes, Alane S., Svetlana I. Chefer, John A. Matochik, Carlo S. Contoreggi, D Bruce Vaupel, Elliot A. Stein, and Alexey G. Mukhin. “Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380.” Neuroimage 39, no. 2 (January 15, 2008): 717–27. https://doi.org/10.1016/j.neuroimage.2007.09.015.
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    • Chefer, Svetlana I., Alane S. Kimes, John A. Matochik, Andrew G. Horti, Varughese Kurian, Dean Shumway, Edward F. Domino, Edythe D. London, and Alexey G. Mukhin. “Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys.” Neuropsychopharmacology 33, no. 2 (January 2008): 270–78. https://doi.org/10.1038/sj.npp.1301404.
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    • Chefer, Svetlana I., Olga A. Pavlova, Yi Zhang, D Bruce Vaupel, Alane S. Kimes, Andrew G. Horti, Elliot Stein, and Alexey G. Mukhin. “NIDA522131, a new radioligand for imaging extrathalamic nicotinic acetylcholine receptors: in vitro and in vivo evaluation.” J Neurochem 104, no. 2 (January 2008): 306–15. https://doi.org/10.1111/j.1471-4159.2007.05009.x.
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    • Le Foll, Bernard, Svetlana I. Chefer, Alane S. Kimes, Dean Shumway, Steven R. Goldberg, Elliot A. Stein, and Alexey G. Mukhin. “Validation of an extracerebral reference region approach for the quantification of brain nicotinic acetylcholine receptors in squirrel monkeys with PET and 2-18F-fluoro-A-85380.” J Nucl Med 48, no. 9 (September 2007): 1492–1500. https://doi.org/10.2967/jnumed.107.039776.
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    • Sorger, Dietlind, Georg A. Becker, Marianne Patt, Andreas Schildan, Udo Grossmann, Reinhard Schliebs, Anita Seese, et al. “Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study.” Nucl Med Biol 34, no. 3 (April 2007): 331–42. https://doi.org/10.1016/j.nucmedbio.2006.12.008.
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    • Vaupel, D Bruce, Elliot A. Stein, and Alexey G. Mukhin. “Quantification of alpha4beta2* nicotinic receptors in the rat brain with microPET and 2-[18F]F-A-85380.” Neuroimage 34, no. 4 (February 15, 2007): 1352–62. https://doi.org/10.1016/j.neuroimage.2006.10.036.
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    • Shumway, Dean A., Olga A. Pavlova, and Alexey G. Mukhin. “A simplified method for the measurement of nonmetabolized 2-[18F]F-A-85380 in blood plasma using solid-phase extraction.” Nucl Med Biol 34, no. 2 (February 2007): 221–28. https://doi.org/10.1016/j.nucmedbio.2006.12.001.
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    • Brody, Arthur L., Mark A. Mandelkern, Edythe D. London, Richard E. Olmstead, Judah Farahi, David Scheibal, Jennifer Jou, et al. “Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors.” Arch Gen Psychiatry 63, no. 8 (August 2006): 907–15. https://doi.org/10.1001/archpsyc.63.8.907.
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    • Willis, Peter G., Olga A. Pavlova, Svetlana I. Chefer, D Bruce Vaupel, Alexey G. Mukhin, and Andrew G. Horti. “Synthesis and structure-activity relationship of a novel series of aminoalkylindoles with potential for imaging the neuronal cannabinoid receptor by positron emission tomography.” J Med Chem 48, no. 18 (September 8, 2005): 5813–22. https://doi.org/10.1021/jm0502743.
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    • Dennis, Phillip A., Carter Van Waes, J Silvio Gutkind, Kenneth J. Kellar, Charles Vinson, Alexey G. Mukhin, Margaret R. Spitz, et al. “The biology of tobacco and nicotine: bench to bedside.” Cancer Epidemiol Biomarkers Prev 14, no. 4 (April 2005): 764–67. https://doi.org/10.1158/1055-9965.EPI-04-0652.
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    • Gündisch, Daniela, Andrei O. Koren, Andrew G. Horti, Olga A. Pavlova, Alane S. Kimes, Alexey G. Mukhin, and Edythe D. London. “In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors.” Synapse 55, no. 2 (February 2005): 89–97. https://doi.org/10.1002/syn.20096.
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    • Vaupel, D Bruce, Srihari R. Tella, David L. Huso, Valentine O. Wagner, Alexey G. Mukhin, Svetlana I. Chefer, Andrew G. Horti, Edythe D. London, Andrei O. Koren, and Alane S. Kimes. “Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography.” J Pharmacol Exp Ther 312, no. 1 (January 2005): 355–65. https://doi.org/10.1124/jpet.104.073999.
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    • Brown, LaVerne, Svetlana Chefer, Olga Pavlova, D Bruce Vaupel, Andrei O. Koren, Alane S. Kimes, Andrew G. Horti, and Alexey G. Mukhin. “Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors.” J Neurochem 91, no. 3 (November 2004): 600–612. https://doi.org/10.1111/j.1471-4159.2004.02762.x.
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    • Zhang, Yi, Olga A. Pavlova, Svetlana I. Chefer, Andrew W. Hall, Varughese Kurian, LaVerne L. Brown, Alane S. Kimes, Alexey G. Mukhin, and Andrew G. Horti. “5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.” J Med Chem 47, no. 10 (May 6, 2004): 2453–65. https://doi.org/10.1021/jm030432v.
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    • Fujita, Masahiro, Masanori Ichise, Christopher H. van Dyck, Sami S. Zoghbi, Gilles Tamagnan, Alexey G. Mukhin, Ali Bozkurt, et al. “Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET.” Eur J Nucl Med Mol Imaging 30, no. 12 (December 2003): 1620–29. https://doi.org/10.1007/s00259-003-1320-0.
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    • Kimes, Alane S., Andrew G. Horti, Edythe D. London, Svetlana I. Chefer, Carlo Contoreggi, Monique Ernst, Phyllis Friello, et al. “2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans.” Faseb J 17, no. 10 (July 2003): 1331–33. https://doi.org/10.1096/fj.02-0492fje.
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    • King, Sarah L., Michael J. Marks, Sharon R. Grady, Barbara J. Caldarone, Andrei O. Koren, Alexey G. Mukhin, Allan C. Collins, and Marina R. Picciotto. “Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior.” J Neurosci 23, no. 9 (May 1, 2003): 3837–43. https://doi.org/10.1523/JNEUROSCI.23-09-03837.2003.
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    • Chefer, Svetlana I., Edythe D. London, Andrei O. Koren, Olga A. Pavlova, Varughese Kurian, Alane S. Kimes, Andrew G. Horti, and Alexey G. Mukhin. “Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain.” Synapse 48, no. 1 (April 2003): 25–34. https://doi.org/10.1002/syn.10180.
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    • Katoch-Rouse, Reeti, Olga A. Pavlova, Tara Caulder, Alexander F. Hoffman, Alexey G. Mukhin, and Andrew G. Horti. “Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.” J Med Chem 46, no. 4 (February 13, 2003): 642–45. https://doi.org/10.1021/jm020157x.
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    • Vaupel, D. B., S. R. Tella, D. L. Huso, A. G. Mukhin, I. Baum, V. O. Wagner, A. G. Horti, E. D. London, A. O. Koren, and A. S. Kimes. “Pharmacology, toxicology, and radiation dosimetry evaluation of [¹²³I] 5-I-A-85380, a radioligand for in vivo imaging of cerebral neuronal nicotinic acetylcholine receptors in humans.” Drug Development Research 58, no. 2 (February 1, 2003): 149–68. https://doi.org/10.1002/ddr.10152.
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    • Brown, LaVerne L., Santosh Kulkarni, Olga A. Pavlova, Andrei O. Koren, Alexey G. Mukhin, Amy H. Newman, and Andrew G. Horti. “Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors.” J Med Chem 45, no. 13 (June 20, 2002): 2841–49. https://doi.org/10.1021/jm010550n.
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    • Fujita, Masahiro, John P. Seibyl, D Bruce Vaupel, Gilles Tamagnan, Michele Early, Sami S. Zoghbi, Ronald M. Baldwin, et al. “Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects.” Eur J Nucl Med Mol Imaging 29, no. 2 (February 2002): 183–90. https://doi.org/10.1007/s00259-001-0695-z.
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    • Brown, L. L., O. Pavlova, A. Mukhin, A. S. Kimes, and A. G. Horti. “Radiosynthesis of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-[(11)C]methyl-2-(S)-pyrrolidinylmethoxy)pyridine, a high affinity ligand for studying nicotinic acetylcholine receptors by positron emission tomography.” Bioorg Med Chem 9, no. 11 (November 2001): 3055–58. https://doi.org/10.1016/s0968-0896(01)00224-3.
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    • Mukhin, A. G., S. I. Chefer, A. G. Horti, A. O. Koren, D. B. Vaupel, D. Gündisch, O. I. Pavlova, V. Kurian, A. S. Kimes, and E. D. London. “Radiohalogenated analogs of A-85380: Potential ligands for mapping α4β2 nicotinic receptors in human brain.” Neuroimage 11, no. 6 PART II (December 1, 2000).
    • Sihver, W., A. Nordberg, B. Långström, A. G. Mukhin, A. O. Koren, A. S. Kimes, and E. D. London. “Development of ligands for in vivo imaging of cerebral nicotinic receptors.” Behav Brain Res 113, no. 1–2 (August 2000): 143–57. https://doi.org/10.1016/s0166-4328(00)00209-6.
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    • Horti, A. G., S. I. Chefer, A. G. Mukhin, A. O. Koren, D. Gündisch, J. M. Links, V. Kurian, R. F. Dannals, and E. D. London. “6-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors.” Life Sci 67, no. 4 (June 16, 2000): 463–69. https://doi.org/10.1016/s0024-3205(00)00635-4.
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    • Mukhin, A. G., D. Gündisch, A. G. Horti, A. O. Koren, G. Tamagnan, A. S. Kimes, J. Chambers, et al. “5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors.” Mol Pharmacol 57, no. 3 (March 2000): 642–49. https://doi.org/10.1124/mol.57.3.642.
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    • Koren, A. O., A. G. Horti, A. G. Mukhin, D. Gündisch, R. F. Dannals, and E. D. London. “Synthesis and initial in vitro characterization of 6-[¹⁸F]fluoro-3-(2(S)-azetidinylmethoxy)puridine, a high-affinity radioligand for central nicotinic acetylcholine receptors.” Journal of Labelled Compounds and Radiopharmaceuticals 43, no. 5 (January 1, 2000): 413–23. https://doi.org/10.1002/(SICI)1099-1344(200004)43:5<413::AID-JLCR326>3.0.CO;2-1.
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    • Chefer, S. I., A. G. Horti, A. O. Koren, D. Gündisch, J. M. Links, V. Kurian, R. F. Dannals, A. G. Mukhin, and E. D. London. “2-[18F]F-A-85380: a PET radioligand for alpha4beta2 nicotinic acetylcholine receptors.” Neuroreport 10, no. 13 (September 9, 1999): 2715–21. https://doi.org/10.1097/00001756-199909090-00005.
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    • Gnädisch, D., E. D. London, P. Terry, G. R. Hill, and A. G. Mukhin. “High affinity binding of [3H]epibatidine to rat brain membranes.” Neuroreport 10, no. 8 (June 3, 1999): 1631–36. https://doi.org/10.1097/00001756-199906030-00002.
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    • Horti, A. G., A. O. Koren, K. S. Lee, A. G. Mukhin, D. B. Vaupel, A. S. Kimes, M. Stratton, and E. D. London. “Radiosynthesis and preliminary evaluation of 5-[123/125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine: a radioligand for nicotinic acetylcholine receptors.” Nucl Med Biol 26, no. 2 (February 1999): 175–82. https://doi.org/10.1016/s0969-8051(98)00086-9.
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    • Chefer, S. I., A. G. Horti, A. O. Koren, D. Gündisch, J. M. Links, V. Kurian, R. F. Dannals, A. G. Mukhin, and E. D. London. “2-[¹⁸F]F-A-85380: A PET radioligand for α₄β₂ nicotinic acetylcholine receptors.” Neuroreport 10, no. 13 (1999): 2715–21.
    • Koren, A. O., A. G. Horti, A. G. Mukhin, D. Gundisch, R. F. Dannals, and E. D. London. “Synthesis and in vitro charactertzation of 6-[¹⁸F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine, a high-affinity radioligand for central nicotinic acetylcholine receptors.” Journal of Labelled Compounds and Radiopharmaceuticals 42, no. SUPPL. 1 (January 1, 1999).
    • Koren, A. O., A. G. Horti, A. G. Mukhin, D. Gündisch, A. S. Kimes, R. F. Dannals, and E. D. London. “2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.” J Med Chem 41, no. 19 (September 10, 1998): 3690–98. https://doi.org/10.1021/jm980170a.
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    • Vaupel, D. B., A. G. Mukhin, A. S. Kimes, A. G. Horti, A. O. Koren, and E. D. London. “In vivo studies with [125I]5-I-A-85380, a nicotinic acetylcholine receptor radioligand.” Neuroreport 9, no. 10 (July 13, 1998): 2311–17. https://doi.org/10.1097/00001756-199807130-00030.
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    • Mukhin, A. G., S. A. Ivanova, J. W. Allen, and A. I. Faden. “Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death.” J Neurosci Res 51, no. 6 (March 15, 1998): 748–58. https://doi.org/10.1002/(SICI)1097-4547(19980315)51:6<748::AID-JNR8>3.0.CO;2-B.
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    • Chefer, S. I., A. G. Horti, K. S. Lee, A. O. Koren, D. W. Jones, J. G. Gorey, J. M. Links, A. G. Mukhin, D. R. Weinberger, and E. D. London. “In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography.” Life Sci 63, no. 25 (1998): PL355–60. https://doi.org/10.1016/s0024-3205(98)00514-1.
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    • Faden, A. I., S. A. Ivanova, A. G. Yakovlev, and A. G. Mukhin. “Neuroprotective effects of group III mGluR in traumatic neuronal injury.” J Neurotrauma 14, no. 12 (December 1997): 885–95. https://doi.org/10.1089/neu.1997.14.885.
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    • Mukhin, A. G., S. A. Ivanova, S. M. Knoblach, and A. I. Faden. “New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity.” J Neurotrauma 14, no. 9 (September 1997): 651–63. https://doi.org/10.1089/neu.1997.14.651.
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    • Mukhin, A., E. S. Kovaleva, and E. D. London. “Two affinity states of N-methyl-D-aspartate recognition sites: modulation by cations.” J Pharmacol Exp Ther 282, no. 2 (August 1997): 945–54.
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    • Mukhin, A. G., S. A. Ivanova, and A. I. Faden. “mGluR modulation of post-traumatic neuronal death: role of NMDA receptors.” Neuroreport 8, no. 11 (July 28, 1997): 2561–66. https://doi.org/10.1097/00001756-199707280-00028.
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    • Shimada, A., A. Mukhin, D. K. Ingram, and E. D. London. “N-methyl-D-aspartate receptor binding in brains of rats at different ages.” Neurobiol Aging 18, no. 3 (1997): 329–33. https://doi.org/10.1016/s0197-4580(97)80315-6.
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    • Mukhin, A., L. Fan, and A. I. Faden. “Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.” J Neurosci 16, no. 19 (October 1, 1996): 6012–20. https://doi.org/10.1523/JNEUROSCI.16-19-06012.1996.
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    • Matsunaga, T., A. G. Mukhin, and E. D. London. “Regionally distinct stoichiometry for N-methyl-D-aspartate receptor domains in brain.” Neuroreport 7, no. 3 (February 29, 1996): 833–37. https://doi.org/10.1097/00001756-199602290-00036.
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    • London, E. D., and A. Mukhin. “Polyamines as endogenous modulators of the N-methyl-D-aspartate receptor.” Ann N Y Acad Sci 757 (May 10, 1995): 430–36. https://doi.org/10.1111/j.1749-6632.1995.tb17502.x.
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    • Mukhin, A. G., P. Y. Zhong, and K. E. Krueger. “Cofractionation of the 17-kD PK 14105 binding site protein with solubilized peripheral-type benzodiazepine binding sites.” Biochem Pharmacol 40, no. 5 (September 1, 1990): 983–89. https://doi.org/10.1016/0006-2952(90)90483-2.
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    • Papadopoulos, V., A. G. Mukhin, E. Costa, and K. E. Krueger. “The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis.” J Biol Chem 265, no. 7 (March 5, 1990): 3772–79.
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    • Krueger, K. E., A. G. Mukhin, L. Antkiewicz-Michaluk, M. R. Santi, D. R. Grayson, A. Guidotti, R. Sprengel, P. Werner, and P. H. Seeburg. “Purification, cloning, and expression of a peripheral-type benzodiazepine receptor.” Adv Biochem Psychopharmacol 46 (1990): 1–13.
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    • Sprengel, R., P. Werner, P. H. Seeburg, A. G. Mukhin, M. R. Santi, D. R. Grayson, A. Guidotti, and K. E. Krueger. “Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor.” J Biol Chem 264, no. 34 (December 5, 1989): 20415–21.
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    • Mukhin, A. G., V. Papadopoulos, E. Costa, and K. E. Krueger. “Mitochondrial benzodiazepine receptors regulate steroid biosynthesis.” Proc Natl Acad Sci U S A 86, no. 24 (December 1989): 9813–16. https://doi.org/10.1073/pnas.86.24.9813.
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    • Antkiewicz-Michaluk, L., A. G. Mukhin, A. Guidotti, and K. E. Krueger. “Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites.” J Biol Chem 263, no. 33 (November 25, 1988): 17317–21.
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    • Kladnitskiĭ, A. V., and A. G. Mukhin. “[Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex].” Zh Nevropatol Psikhiatr Im S S Korsakova 88, no. 12 (1988): 98–103.
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    • Mukhin, A. G., M. L. Belyaeva, and A. V. Kladnitsky. “Pharmacokinetic peculiarities of a new form of diazepam: sibazon.” Zhurnal Nevropatologii I Psikhiatrii Imeni S.S.Korsakova 88, no. 10 (January 1, 1988): 95–97.
    • Mukhin, A. G., A. V. Kladnitskii, E. S. Kovaleva, and T. B. Kudryakova. “Isolation from bovine brain of substances inhibiting specific binding of imipramine and serotonin uptake.” Bulletin of Experimental Biology and Medicine 100, no. 2 (August 1, 1985): 1074–76. https://doi.org/10.1007/BF00837392.
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    • Mukhin, A. G., A. V. Kladnitsky, E. S. Kovaleva, and T. B. Kudryakova. “Isolation of inhibitors of imipramine specific binding and serotonin uptake from bovine brain.” Byulleten Eksperimentalnoi Biologii I Meditsiny 99, no. 8 (January 1, 1985): 197–99.
    • Kladnitskii, A. V., and A. G. Mukhin. “Endogenous inhibitors of specific benzodiazepine binding in the bovine cerebral cortex.” Bulletin of Experimental Biology and Medicine 98, no. 4 (October 1, 1984): 1366–68. https://doi.org/10.1007/BF00808192.
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    • Kladnitskiĭ, A. V., and A. G. Mukhin. “[Endogenous inhibitors of specific benzodiazepine binding in the cerebral cortex of the bull].” Biull Eksp Biol Med 98, no. 10 (October 1984): 439–41.
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    • Zlobina, G. P., L. I. Kondakova, and A. G. Mukhin. “New type of specific binding sites for gamma-aminobutyric acid (GABA) found in a mouse glioblastoma.” Doklady Akademii Nauk Sssr 272, no. 5 (December 1, 1983): 1262–64.
    • Mukhin, A. G. “Effect of parachlorophenylalanine and 5-hydroxytryptophan on the serum tryptophan level and its ability to stimulate tryptophan uptake by cells.” Bulletin of Experimental Biology and Medicine 95, no. 2 (February 1, 1983): 235–37. https://doi.org/10.1007/BF01179141.
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    • Korneev, A. Y., L. G. Dubova, and A. G. Mukhin. “Stimulation of specific binding of diazepam with muscimol in intensively washed rat brain membranes.” Bulletin of Experimental Biology and Medicine 95, no. 6 (January 1, 1983): 825–27. https://doi.org/10.1007/BF00834918.
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    • Korneev, A. Y., L. G. Dubova, and A. G. Mukhin. “Muscimol-induced stimulation of diazepam binding in intensely washed membranes of the rat brain.” Byulleten Eksperimentalnoi Biologii I Meditsiny 95, no. 6 (January 1, 1983): 86–87.
    • Mukhin, A. G. “Effect of parachlorphenylalanine and 5-hydroxytryptophan on blood serum tryptophan content and its ability to stimulate tryptophan cell uptake.” Byulleten Eksperimentalnoi Biologii I Meditsiny 95, no. 2 (January 1, 1983): 59–61.
    • Zlobina, G. P., L. I. Kondakova, and A. G. Mukhin. “[New type of specific binding sites for gamma-aminobutyric acid (GABA) found in a mouse glioblastoma].” Dokl Akad Nauk Sssr 272, no. 5 (1983): 1262–64.
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    • Zlobina, G. P., L. I. Kondakova, and A. G. Mukhin. “A new type of site of specific binding of γ-aminobutyric acid (GABA), detected in murine glioblastoma.” Doklady Biochemistry 272, no. 1–6 (January 1, 1983): 337–39.
    • Zlobina, G. P., L. I. Kondakova, and A. G. Mukhin. “Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding.” Doklady Akademii Nauk Sssr 267, no. 6 (December 1, 1982): 1501–3.
    • Zlobina, G. P., N. D. Chekalina, A. I. Oifa, and A. G. Mukhin. “Detection and properties of benzodiazepine receptors of glial and neuronal fractions of the human cerebral cortex.” Bulletin of Experimental Biology and Medicine 94, no. 4 (October 1, 1982): 1370–72. https://doi.org/10.1007/BF00827202.
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    • Zlobina, G. P., N. D. Chekalina, A. I. Oifa, and A. G. Mukhin. “[Identification and evaluation of properties of benzodiazepine receptors of glial and neuronal fractions of human cerebral cortex].” Biull Eksp Biol Med 94, no. 10 (October 1982): 51–54.
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    • Korneev, A Ia, A. G. Mukhin, and M. I. Faktor. “[Molecular mechanisms of the pharmacologic action of benzodiazepines].” Vestn Akad Med Nauk Sssr, no. 1 (1982): 20–28.
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    • Korneev, A. I., A. G. Mukhin, and M. I. Faktor. “Molecular mechanisms of the pharmacologic action of benzodiazepines.” Vestnik Akademii Meditsinskikh Nauk Sssr, no. 1 (January 1, 1982): 20–28.
    • Zlobina, G. P., L. I. Kondakova, and A. G. Mukhin. “Benzodiazepine receptors of a cell line of murine glioblastoma: Anomalous influence of γ-aminobutyric acid (GABA) on the binding of diazepam.” Doklady Biochemistry 267, no. 1–6 (January 1, 1982): 359–61.
    • Zlobina, G. P., L. I. Kondakova, and A. G. Mukhin. “[Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding].” Dokl Akad Nauk Sssr 267, no. 6 (1982): 1501–3.
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    • Korneev, A Ia, and A. G. Mukhin. “[Receptor-ligand reaction in the central nervous system (principal problems and prospects for development)].” Vestn Akad Med Nauk Sssr, no. 5 (1981): 56–59.
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    • Korneev, A. I., and A. G. Mukhin. “Receptor-ligand reaction in the central nervous system (principal problems and prospects for development).” Vestnik Akademii Meditsinskikh Nauk Sssr, no. 5 (January 1, 1981): 56–59.
    • Lideman, R. R., G. P. Zlobina, and A. G. Mukhin. “[Problem of neuronal reception and the dopamine hypothesis of schizophrenia].” Zh Nevropatol Psikhiatr Im S S Korsakova 80, no. 5 (1980): 762–69.
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    • Liedeman, R. R., G. P. Zlobina, and A. G. Mukhin. “The problem of neuronal receptors and the dopamine hypothesis of schizophrenia.” Zhurnal Nevropatologii I Psikhiatrii Imeni S.S.Korsakova 80, no. 5 (January 1, 1980): 762–69.
    • Mukhin, A. G., and M. I. Faktor. “[Stimulating effect of schizophrenic patients' plasma on the cellular incorportation of tryptophan in vitro].” Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952) 79, no. 7 (January 1979): 941–47.

  • Conference Papers

    • Zuo, Yantao, Alexey G. Mukhin, Hannah Berg, Janiece D. Morgan, Akiva Mintz, Jed E. Rose, and Kiran Kumar Solingapuram Sai. “Comparison of brain nicotine uptake from electronic cigarettes and combustible cigarettes.” In Neuropsychopharmacology, 47:1939–44, 2022. https://doi.org/10.1038/s41386-022-01410-5.
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