Scholars@Duke
Aaron Timothy Vose

Aaron Timothy Vose

Medical Instructor in the Department of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine

Selected Publications

Hyaluronan Directs Alveolar Type II Cell Response to Acute Ozone Exposure in Mice.

Journal Article Am J Respir Cell Mol Biol · January 6, 2025 Becoming more frequent due to climate change, ozone (O3) exposures can cause lung injury. Alveolar type 2 (AT2) cells and hyaluronan (HA), a matrix component, are critical to repairing lung injury and restoring homeostasis. Here, we define the impact of HA ... Full text Link to item Cite

Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress.

Journal Article Antioxidants (Basel) · October 31, 2024 Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the presence (T2-high) or absence (T2-low) of high levels of eosinophils. Because most therapies for ... Full text Link to item Cite

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK-mediated Efferocytosis.

Journal Article Am J Respir Cell Mol Biol · June 2024 Lung inflammation, caused by acute exposure to ozone (O3), one of the six criteria air pollutants, is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung, and their ... Full text Link to item Cite

Tissue-resident alveolar macrophages reduce O3-induced inflammation via MerTK mediated efferocytosis.

Journal Article bioRxiv · November 6, 2023 Lung inflammation, caused by acute exposure to ozone (O3) - one of the six criteria air pollutants - is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung and thei ... Full text Link to item Cite

Wood smoke particle exposure in mice reduces the severity of influenza infection.

Journal Article Toxicol Appl Pharmacol · September 1, 2021 Elevated ambient temperatures and extreme weather events have increased the incidence of wildfires world-wide resulting in increased wood smoke particle (WSP). Epidemiologic data suggests that WSP exposure associates with exacerbations of respiratory disea ... Full text Open Access Link to item Cite

Role of Innate Immune System in Environmental Lung Diseases.

Journal Article Current allergy and asthma reports · May 2021 The lung mucosa functions as a principal barrier between the body and inhaled environmental irritants and pathogens. Precise and targeted surveillance mechanisms are required at this lung-environment interface to maintain homeostasis and preserve gas excha ... Full text Cite

Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains.

Journal Article Environ Health Perspect · November 2020 BACKGROUND: Epidemiological studies support the hypothesis that diabetes alters pulmonary responses to air pollutants like ozone (O3). The mechanism(s) underlying these associations and potential links among diabetes, O3, and lung inflammation and remodeli ... Full text Link to item Cite

Ozone Responses and Diet: Does Sex Determine the Relationship?

Journal Article Am J Respir Cell Mol Biol · April 2020 Full text Link to item Cite

A Prospective Analysis of Motor and Cognitive Skill Retention in Novice Learners of Point of Care Ultrasound

Journal Article Critical Care Medicine · December 2019 Objectives:To identify the time at which point of care ultrasound static image recognition and image acquisition skills decay in novice learners. ... Full text Cite