Overview
Michael Krangel Laboratory
Current Appointments & Affiliations
Research Associate, Senior
Integrative Immunobiology,
Basic Science Departments
Recent Publications
RORγt up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire.
Journal Article Sci Immunol · March 15, 2024 Recombination activating gene (RAG) expression increases as thymocytes transition from the CD4-CD8- double-negative (DN) to the CD4+CD8+ double-positive (DP) stage, but the physiological importance and mechanism of transcriptional up-regulation are unknown ... Full text Link to item CiteA role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.
Journal Article Nucleic Acids Res · September 25, 2020 The regulation of T cell receptor Tcra gene rearrangement has been extensively studied. The enhancer Eα plays an essential role in Tcra rearrangement by establishing a recombination centre in the Jα array and a chromatin hub for interactions between Vα and ... Full text Open Access Link to item CiteHierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes.
Journal Article J Exp Med · January 7, 2019 Expression of Rag1 and Rag2 is tightly regulated in developing T cells to mediate TCR gene assembly. Here we have investigated the molecular mechanisms governing the assembly and disassembly of a transcriptionally active RAG locus chromatin hub in CD4+CD8+ ... Full text Link to item CiteRecent Grants
Chromatin regulation of TCR locus V(D)J recombination
ResearchSenior Research Associate · Awarded by National Institute of General Medical Sciences · 2020 - 2025Control of TCR Delta and TCR Alpha Rearrangement
ResearchSenior Research Associate · Awarded by National Institutes of Health · 1989 - 2021View All Grants