Scholars@Duke
Abani Naik

Abani Naik

Research Associate, Senior
Integrative Immunobiology
abani.naik@duke.edu
207 Research Drive, Jones Bldg, Room 316, Po 3010, Durham, NC 27710

Selected Publications

Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes.

Journal Article J Exp Med · January 7, 2019 Expression of Rag1 and Rag2 is tightly regulated in developing T cells to mediate TCR gene assembly. Here we have investigated the molecular mechanisms governing the assembly and disassembly of a transcriptionally active RAG locus chromatin hub in CD4+CD8+ ... Full text Link to item Cite

An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.

Journal Article J Exp Med · May 4, 2015 Rag1 and Rag2 gene expression in CD4(+)CD8(+) double-positive (DP) thymocytes depends on the activity of a distant anti-silencer element (ASE) that counteracts the activity of an intergenic silencer. However, the mechanistic basis for ASE activity is unkno ... Full text Link to item Cite

Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.

Journal Article J Immunol · January 15, 2015 The Tcra/Tcrd locus undergoes V-Dδ-Jδ rearrangement in CD4(-)CD8(-) thymocytes to form the TCRδ chain of the γδ TCR and V-Jα rearrangement in CD4(+)CD8(+) thymocytes to form the TCRα-chain of the αβ TCR. Most V segments in the locus participate in V-Jα rea ... Full text Link to item Cite