Abanish Singh

Journal article Innovation in Aging · December 20, 2022 Featured Publication AbstractMore than 6 million people in the US live with Alzheimer's disease (AD) and related-dementia. There is a racial disparity in the prevalence of disease. However, its full genetic architecture and comp ... Full text Cite

Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants.

Journal article Transl Psychiatry · October 20, 2020 Featured Publication In prior work, we identified a novel gene-by-stress association of EBF1's common variation (SNP rs4704963) with obesity (i.e., hip, waist) in Whites, which was further strengthened through multiple replications using our synthetic stress measure. We now ex ... Full text Open Access Link to item Cite

Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.

Journal article BMC Res Notes · July 24, 2018 Featured Publication OBJECTIVES: Among many challenges in cardiovascular disease (CVD) risk prediction are interactions of genes with stress, race, and/or sex and developing robust estimates of these interactions. Improved power with larger sample size contributed by the accum ... Full text Link to item Cite

Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene.

Journal article Genet Epidemiol · September 2015 Featured Publication Chronic psychosocial stress adversely affects health and is associated with the development of disease [Williams, 2008]. Systematic epidemiological and genetic studies are needed to uncover genetic variants that interact with stress to modify metabolic res ... Full text Link to item Cite

Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.

Journal article Eur J Hum Genet · June 2015 Featured Publication We performed gene-environment interaction genome-wide association analysis (G × E GWAS) to identify SNPs whose effects on metabolic traits are modified by chronic psychosocial stress in the Multi-Ethnic Study of Atherosclerosis (MESA). In Whites, the G × E ... Full text Open Access Link to item Cite

Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.

Journal article J Hepatol · February 2012 Featured Publication BACKGROUND & AIMS: Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting. We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-α (pegIFN)-related ... Full text Link to item Cite

The characterization of twenty sequenced human genomes.

Journal article PLoS Genet · September 9, 2010 Featured Publication We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and te ... Full text Open Access Link to item Cite

An algorithm for the reconstruction of consensus sequences of ancient segmental duplications and transposon copies in eukaryotic genomes.

Journal article Int J Bioinform Res Appl · 2010 Featured Publication Interspersed repeats, mostly resulting from the activity and accumulation of transposable elements, occupy a significant fraction of many eukaryotic genomes. More than half of human genomic sequence consists of known repeats, however a very large part has ... Full text Link to item Cite

Screening the human exome: a comparison of whole genome and whole transcriptome sequencing.

Journal article Genome Biol · 2010 Featured Publication BACKGROUND: There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans. There are three approaches possible: whole-genome sequencing, whole-exome sequencing using exon cap ... Full text Open Access Link to item Cite