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Adrianna Katrina San Roman

Adrianna Katrina San Roman

Assistant Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
adrianna.sanroman@duke.edu
101 Science Drive, CIEMAS 2175, Box 3382, Durham, NC 27708
101 Science Drive, CIEMAS 2175, Durham, NC 27708

Selected Publications

Stable and robust Xi and Y transcriptomes drive cell-type-specific autosomal and Xa responses in vivo and in vitro in four human cell types.

Journal Article bioRxiv · March 19, 2024 Recent in vitro studies of human sex chromosome aneuploidy showed that the Xi ("inactive" X) and Y chromosomes broadly modulate autosomal and Xa ("active" X) gene expression in two cell types. We tested these findings in vivo in two additional cell types. ... Full text Link to item Cite

A strategic research alliance: Turner syndrome and sex differences.

Journal Article Am J Med Genet C Semin Med Genet · March 2019 Sex chromosome constitution varies in the human population, both between the sexes (46,XX females and 46,XY males), and within the sexes (e.g., 45,X and 46,XX females, and 47,XXY and 46,XY males). Coincident with this genetic variation are numerous phenoty ... Full text Open Access Link to item Cite

Transcription factor-dependent ‘anti-repressive’ mammalian enhancers exclude H3K27me3 from extended genomic domains

Journal Article Genes & Development · December 1, 2017 Compacted chromatin and nucleosomes are known barriers to gene expression; the nature and relative importance of other transcriptional constraints remain unclear, especially at distant enhancers. Polycomb repressor complex 2 (PRC2) places the histo ... Full text Cite

Abstract LB-286: ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

Conference Cancer Research · July 1, 2017 AbstractGenes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are collectively mutated in ~20% of all human cancers, but the mechanism by which these mutations promote tumorigenesis is uncl ... Full text Cite

Boundaries, junctions and transitions in the gastrointestinal tract

Journal Article Experimental Cell Research · November 2011 Full text Cite

Control of Arabidopsis meristem development by thioredoxin-dependent regulation of intercellular transport

Journal Article Proceedings of the National Academy of Sciences · March 3, 2009 Cell-to-cell transport in plants occurs through cytoplasmic channels called “plasmodesmata” and is regulated by developmental and environmental factors. Callose deposition modulates plasmodesmal transport in vivo, but little is known a ... Full text Cite

Role of Phosphopantetheinyl Transferase Genes in Antibiotic Production by Streptomyces coelicolor

Journal Article Journal of Bacteriology · October 15, 2008 ABSTRACT The phosphopantetheinyl transferase genes SCO5883 ( redU ) and SCO6673 were disrupted in Streptomyces coelicolor Full text Cite