Overview
Research in statistical genetics and computational biology. Focused on estimation of population structure / relatedness and applications, including GWAS, heritability estimation, and admixture.
Current Appointments & Affiliations
Assistant Professor of Biostatistics & Bioinformatics
·
2018 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Faculty Network Member of the Duke Institute for Brain Sciences
·
2020 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Recent Publications
Genetic association models are robust to common population kinship estimation biases.
Journal Article Genetics · May 4, 2023 Common genetic association models for structured populations, including principal component analysis (PCA) and linear mixed-effects models (LMMs), model the correlation structure between individuals using population kinship matrices, also known as genetic ... Full text Link to item CiteLimitations of principal components in quantitative genetic association models for human studies.
Journal Article Elife · May 4, 2023 Principal Component Analysis (PCA) and the Linear Mixed-effects Model (LMM), sometimes in combination, are the most common genetic association models. Previous PCA-LMM comparisons give mixed results, unclear guidance, and have several limitations, includin ... Full text Link to item CiteGenetic risk variants for childhood nephrotic syndrome and corticosteroid response.
Journal Article Front Pediatr · 2023 INTRODUCTION: The etiology of most cases of nephrotic syndrome (NS) remains unknown, therefore patients are phenotypically categorized based on response to corticosteroid therapy as steroid sensitive NS (SSNS), or steroid resistant NS (SRNS). Genetic risk ... Full text Link to item CiteRecent Grants
REGULATORS OF CALCINEURIN PATHWAYS AS DIAGNOSTIC AND THERAPEUTIC TARGETS FOR NEPHROTIC SYNDROME
ResearchInvestigator · Awarded by National Institutes of Health · 2023 - 2026The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of disease
ResearchCo Investigator · Awarded by National Human Genome Research Institute · 2020 - 2025Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025View All Grants
Education, Training & Certifications
Princeton University ·
2013
Ph.D.