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Alejandro Ochoa

Assistant Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Integrative Genomics
Duke Box 103854, Durham, NC 27710
101 Science Dr, Room 2177C, FCIEMAS, Durham, NC 27705

Overview


Research in statistical genetics and computational biology.  Focused on estimation of population structure / relatedness and applications, including GWAS, heritability estimation, and admixture.

Current Duke Appointments & Affiliations


Assistant Professor of Biostatistics & Bioinformatics · 2018 - Present Biostatistics & Bioinformatics, Division of Integrative Genomics, Biostatistics & Bioinformatics
Faculty Network Member of the Duke Institute for Brain Sciences · 2020 - Present Duke Institute for Brain Sciences, University Institutes and Centers

Recent Scholarly Works


Polygenic risk scores and HLA class II variants are biomarkers of corticosteroid response in childhood nephrotic syndrome.

Journal article Kidney Int · June 2026 INTRODUCTION: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there ... Full text Link to item Cite

Kinship estimation bias carries over to heritability estimation bias using variance components.

Journal article Genetics · February 4, 2026 Heritability is a fundamental parameter of diseases and other traits, quantifying the contribution of genetics to that trait. Kinship matrices are required for heritability estimation with variance components models. However, the most common "standard" kin ... Full text Link to item Cite

Polygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic Syndrome.

Preprint · August 7, 2025 INTRODUCTION: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there ... Full text Link to item Cite
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Recent Grants


Genetics and Genomics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031

Computational Biology and Bioinformatics Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031

Evolutionary Dynamics of Zoonotic Malaria

ResearchCo Investigator · Awarded by University of California - Los Angeles · 2025 - 2026

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Education


Princeton University · 2013 Ph.D.

External Links


Ochoa Lab website