Scholars@Duke
Alejandro Ochoa

Alejandro Ochoa

Assistant Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Integrative Genomics
Duke Box 103854, Durham, NC 27710
101 Science Dr, Room 2177C, FCIEMAS, Durham, NC 27705

Scholarly Works - Preprints

Polygenic Risk Scores and HLA Class II Variants are Biomarkers of Corticosteroid Response in Childhood Nephrotic Syndrome.

Preprint · August 7, 2025 INTRODUCTION: Nephrotic syndrome (NS), a common glomerular disease in children, is classified based on response to corticosteroid therapy as either steroid-sensitive nephrotic syndrome (SSNS), or steroid-resistant nephrotic syndrome (SRNS). However, there ... Full text Link to item Cite

Kinship estimation bias carries over to heritability estimation bias using variance components.

Preprint · May 15, 2025 Heritability is a fundamental parameter of diseases and other traits, quantifying the contribution of genetics to that trait. Kinship matrices, also known as Genetic Relatedness Matrices or "GRMs", are required for heritability estimation with variance com ... Full text Link to item Cite

Genetic association meta-analysis is susceptible to confounding by between-study cryptic relatedness.

Preprint · May 12, 2025 Meta-analysis of Genome-Wide Association Studies (GWAS) has important advantages, but it assumes that studies are independent, which does not hold when there is relatedness between studies. As a motivating example, recent work suggested applying sex-strati ... Full text Link to item Cite