Current Appointments & Affiliations
Assistant Professor in Medicine
·
2021 - Present
Medicine, Cardiology,
Medicine
Recent Publications
Biased Allosteric Modulation in GPCR Drug Discovery.
Journal Article Handb Exp Pharmacol · 2026 Allosteric modulation of G protein-coupled receptors (GPCRs) is emerging as a powerful approach in drug discovery, offering enhanced subtype selectivity and the ability to bias signaling toward therapeutically preferred pathways, thereby reducing off-targe ... Full text Link to item CiteA positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia.
Journal Article J Clin Invest · December 15, 2025 Orthosteric beta blockers represent the leading pharmacological intervention for managing heart diseases owing to their ability to competitively antagonize β-adrenergic receptors (βARs). However, their use is often limited by adverse effects such as fatigu ... Full text Link to item CiteRecent Grants
The GPCR Collaborative: Revealing the molecular determinants and fidelity of GPCR signaling in health and disease
ResearchAssistant Research Professor · Awarded by St. Jude Children's Research Hospital · 2023 - 2028Structural and Mechanistic Basis of ss-arrestin2 Signaling Through the MAPK JNK3
FellowshipCollaborating Investigator · Awarded by American Heart Association · 2026 - 2027Mechanisms of Maladaptation in Heart Failure
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 1996 - 2027View All Grants
Education, Training & Certifications
University of Connecticut ·
2008
Ph.D.