Current Duke Appointments & Affiliations
Assistant Professor in Medicine
·
2021 - Present
Medicine, Cardiology,
Medicine
Recent Scholarly Works
Small-molecule modulation of β-arrestins.
Journal article Nature · August 2026 β-Arrestins are multifunctional regulators of G-protein-coupled receptor (GPCR) signalling and orchestrate diverse downstream signalling events and physiological responses across the GPCR superfamily1-3. Although GPCR pharmacology has advanced to target or ... Full text Link to item CiteStructure-guided discovery of non-catechol dopamine D1 receptor ligands with biased agonism and antagonism.
Journal article J Biol Chem · June 2026 The catechol L-DOPA, a cornerstone of Parkinson's disease (PD) treatment, has two major drawbacks: poor pharmacokinetics and, more significantly, debilitating dyskinesias from chronic dopamine D1 receptor (D1R) activation. Preclinical rodent studies sugges ... Full text Link to item CiteTargeting the host factor HGS-viral membrane protein interaction in coronavirus infection.
Journal article J Clin Invest · March 2, 2026 While current antivirals primarily target viral proteins, host-directed strategies remain underexplored. Here, we performed a genome-wide CRISPR inhibition (CRISPRi) screening to identify the host protein, hepatocyte growth factor-regulated tyrosine kinase ... Full text Link to item CiteRecent Grants
The GPCR Collaborative: Revealing the molecular determinants and fidelity of GPCR signaling in health and disease
ResearchAssistant Research Professor · Awarded by St. Jude Children's Research Hospital · 2023 - 2028Structural and Mechanistic Basis of ss-arrestin2 Signaling Through the MAPK JNK3
FellowshipCollaborating Investigator · Awarded by American Heart Association · 2026 - 2027Mechanisms of Maladaptation in Heart Failure
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 1996 - 2027View All Grants
Education
University of Connecticut ·
2008
Ph.D.