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Alem W Kahsai

Assistant Professor in Medicine
Medicine, Cardiology

Scholarly Works - Preprints


Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.

Preprint · September 27, 2025 Beta-arrestins (βarrs) are key regulators and transducers of G-protein coupled receptor signaling; however, little is known of how βarrs communicate with their downstream effectors. Here, we report the first structural insights into the fundamental mechani ... Full text Link to item Cite

Small-molecule modulation of β-arrestins.

Preprint · April 8, 2025 β-arrestins are multifunctional regulators of G protein-coupled receptor (GPCR) signaling, orchestrating diverse downstream signaling events and physiological responses across the vast GPCR superfamily. While GPCR pharmacology has advanced to target orthos ... Full text Link to item Cite