Scholars@Duke
Alev Brigande

Scholarly Works

Integrated metabolomics and proteomics from voxelated cortical hemispheres of adult rhesus monkeys.

Preprint · April 16, 2026 The spatial organization of molecular networks across cortex likely contributes to differences in local circuit vulnerability in aging and Alzheimer's disease; yet many existing molecular datasets sacrifice spatial structure, sampling only a handful of reg ... Full text Link to item Cite

Calcium-binding protein expression alone is insufficient to identify and classify GABAergic neurons in macaque cortex.

Preprint · January 28, 2026 Understanding neuron subclasses and their functional consequences can contribute to understanding brain circuits. A scheme long used to classify GABAergic neurons in the neocortex is based on expression of three calcium-binding proteins (CBPs): parvalbumin ... Full text Link to item Cite

Mesolimbic exendin-4 attenuates reward salience evoked by neuropeptide Y and ghrelin.

Journal article Behavioural brain research · February 2023 In the present study, we investigated the effects of the glucagon-like peptide-1 (GLP-1) agonist exendin-4 (Ex-4) on the stimulatory action of neuropeptide Y (NPY) and ghrelin. These effects were examined in relation to operant responding for palatable foo ... Full text Cite

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats.

Journal article Developmental psychobiology · March 2022 A growing body of evidence links prenatal and early postnatal acetaminophen (APAP) exposure to atypical development of brain and behavior. In adult rodents, APAP is known to produce oxidative stress and lower anxiety-related behavior following acute exposu ... Full text Cite

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction.

Journal article Nucleic acids research · May 2020 Disabling hearing loss impacts ∼466 million individuals worldwide with 34 million children affected. Gene and pharmacotherapeutic strategies to rescue auditory function in mouse models of human deafness are most effective when administered before hearing o ... Full text Cite