Scholars@Duke
Alexandra Badea

Alexandra Badea

Associate Professor in Radiology
Radiology
Box 3302 Duke University Medic, Durham, NC 27710
Center for in Vivo Microscopy, Room 139 Bryan Research Building, Durham, NC 27710

Scholarly Works - Conferences

Investigating brain-heart interactions using resting-state fMRI and photon-counting micro-CT in aged APOE mice

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · April 1, 2026 Understanding the interplay between brain and heart function is critical for mapping systemic aging and risk for neurodegenerative and cardiovascular diseases. We combined resting-state functional MRI (rs-fMRI) and photon-counting computed tomography (PCCT ... Full text Cite

Graph neural networks and cortical column modeling for AI-based brain age prediction in Alzheimer’s disease risk

Conference Proceedings of SPIE the International Society for Optical Engineering · September 17, 2025 Alzheimer’s disease (AD) affects over 10% of people above age 65. Current treatments remain largely ineffective, thus early biomarkers are essential for devising preventive interventions, and personalizing these based on risk profiles. Brain age gap (BAG)— ... Full text Cite

Multimodal graph attention networks for predicting brain age and stratifying Alzheimer’s disease risk in clinical populations

Conference Proceedings of SPIE the International Society for Optical Engineering · September 17, 2025 Alzheimer’s Disease (AD) remains a critical public health challenge due to its late clinical onset and lack of effective early interventions. Brain age prediction provides a powerful framework to detect deviations from normative aging and identify individu ... Full text Cite

Quantitative Comparison of Femurs in Apolipoprotein E Mouse Models using High Resolution Photon-Counting Micro-CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2025 Apolipoprotein E (APOE) genotype and nitric oxide synthase 2 (NOS2) expression are key genetic factors that influence bone health. While prior studies explored differences in bones by APOE genotype, the role of sex and NOS2 require further investigation. I ... Full text Cite

Predicting brain age and associated structural networks in mouse models with humanized APOE alleles using integrative and interpretable graph neural networks

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Alzheimer's disease (AD), a prevalent neurodegenerative disorder, is influenced by an intricate mix of risk factors including age, genetics, and environmental variables. In our study, we employed mouse models with human APOE alleles and nitric oxide syntha ... Full text Cite

Anatomical and functional cardiac PCCT imaging pipeline for characterization of Apolipoprotein E mouse models

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2022 Non-invasive imaging strategies are essential in understanding the factors associated with the ongoing rise in cardiovascular disease (CVD) and Alzheimer’s disease (AD), and the possible interactions between these diseases. Our scientific premise is based ... Full text Cite

MRI-based radiomics of sarcomas in the preclinical arm of a Co-clinical trial

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2020 Radiomics provide an exciting approach to developing imaging biomarkers in the context of precision medicine. We focus on the preclinical arm of a co-clinical trial investigating synergy of immunotherapy combined with radiation therapy (RT) and surgical re ... Full text Cite

Image-processing pipelines: Applications in magnetic resonance histology

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2016 Image processing has become ubiquitous in imaging research - so ubiquitous that it is easy to loose track of how diverse this processing has become. The Duke Center for In Vivo Microscopy has pioneered the development of Magnetic Resonance Histology (MRH), ... Full text Cite

Magnetic resonance histology—Applications in toxicology

Conference Toxicology Letters · September 2014 Full text Cite

Utilizing MRI information to estimate F18-FDG distributions in rat flank tumors

Conference IEEE Nuclear Science Symposium Conference Record · December 1, 2004 This paper investigates the potential of magnetic resonance imaging (MRI) to improve the estimation of within-tumor variations in F18-FDG concentration. An image model is described for incorporating MRI images into positron emission tomography (PET) and si ... Cite