Scholars@Duke
Alexis Jaramillo Cartagena

Alexis Jaramillo Cartagena

Assistant Professor of Pathology
Pathology
Duke Medical Center, Durham, NC 27710
ORCID iDhttps://orcid.org/0000-0001-7285-1419

Selected Publications

The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales.

Journal Article mBio · November 12, 2025 Carbapenem-resistant Enterobacterales (CRE) are important pathogens that can develop resistance via multiple molecular mechanisms, including hydrolysis or reduced antibiotic influx. Identifying these mechanisms can improve pathogen surveillance, infection ... Full text Link to item Cite

Cloacaenodin, an Antimicrobial Lasso Peptide with Activity against Enterobacter.

Journal Article ACS Infect Dis · January 13, 2023 Using genome mining and heterologous expression, we report the discovery and production of a new antimicrobial lasso peptide from species related to the Enterobacter cloacae complex. Using NMR and mass spectrometric analysis, we show that this lasso peptid ... Full text Link to item Cite

Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic Class.

Journal Article Antimicrob Agents Chemother · May 18, 2021 Current growth-based antibiotic susceptibility testing (AST) is too slow to guide early therapy. We previously developed a diagnostic approach that quantifies antibiotic-induced transcriptional signatures to distinguish susceptible from resistant isolates, ... Full text Link to item Cite

Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.

Journal Article Chembiochem · May 4, 2020 We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides, with 18 of its 28 amino acids foun ... Full text Link to item Cite

Structural basis for transcription activation by Crl through tethering of σS and RNA polymerase.

Journal Article Proc Natl Acad Sci U S A · September 17, 2019 In bacteria, a primary σ-factor associates with the core RNA polymerase (RNAP) to control most transcription initiation, while alternative σ-factors are used to coordinate expression of additional regulons in response to environmental conditions. Many alte ... Full text Link to item Cite

Discovery and structure of the antimicrobial lasso peptide citrocin.

Journal Article J Biol Chem · April 26, 2019 We report the identification of citrocin, a 19-amino acid-long antimicrobial lasso peptide from the bacteria Citrobacter pasteurii and Citrobacter braakii We refactored the citrocin gene cluster and heterologously expressed it in Escherichia coli We determ ... Full text Link to item Cite

Mapping Protein Conformational Landscapes under Strongly Native Conditions with Hydrogen Exchange Mass Spectrometry.

Journal Article J Phys Chem B · August 6, 2015 The thermodynamic stability and kinetic barriers separating protein conformations under native conditions are critical for proper protein function and for understanding dysfunction in diseases of protein conformation. Traditional methods to probe protein u ... Full text Link to item Cite

A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics.

Journal Article J Biol Chem · April 4, 2014 Cyclic nucleotide-modulated ion channels play crucial roles in signal transduction in eukaryotes. The molecular mechanism by which ligand binding leads to channel opening remains poorly understood, due in part to the lack of a robust method for preparing s ... Full text Link to item Cite