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Alice Yoosun Ho

Instructor in the Department of Radiation Oncology
Radiation Oncology

Selected Publications


Single-cell and spatial profiling identify three response trajectories to pembrolizumab and radiation therapy in triple negative breast cancer.

Journal Article Cancer Cell · January 8, 2024 Strategies are needed to better identify patients that will benefit from immunotherapy alone or who may require additional therapies like chemotherapy or radiotherapy to overcome resistance. Here we employ single-cell transcriptomics and spatial proteomics ... Full text Link to item Cite

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.

Journal Article Nature · January 2024 Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS-STING-mediated signalling and tumour suppression1-3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given th ... Full text Link to item Cite

INDIVIDUAL ARTICLE: USCOM Algorithm for the Prevention and Management of Cutaneous Immunotherapy-Related Adverse Events.

Journal Article J Drugs Dermatol · November 1, 2023 BACKGROUND: In 2023, nearly 2 million patients will be diagnosed with cancer in the United States and at least 40% will be eligible for treatment with an immune checkpoint inhibitor (ICI). Cutaneous immune related adverse events (cirAEs) from ICIs are comm ... Full text Link to item Cite

Pre-operative Radiation and Immunotherapy in the Treatment of Non-metastatic Breast Cancer

Journal Article Current Breast Cancer Reports · September 1, 2023 Purpose of Review: To discuss the rationale and latest strategies for combining pre-operative radiation therapy (pre-op RT) and immunotherapy (IO) in the treatment of non-metastatic breast cancer. Recent Findings: IO has recently been incorporated into the ... Full text Cite

Looking Back: International Practice Patterns in Breast Radiation Oncology From a Case-Based Survey Across 54 Countries During the First Surge of the COVID-19 Pandemic.

Journal Article JCO Glob Oncol · July 2023 PURPOSE: The COVID-19 pandemic has profoundly affected cancer care worldwide, including radiation therapy (RT) for breast cancer (BC), because of risk-based resource allocation. We report the evolution of international breast RT practices during the beginn ... Full text Link to item Cite

Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None?

Journal Article J Clin Oncol · December 20, 2022 The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summ ... Full text Link to item Cite

United States Cutaneous Oncodermatology Management (USCOM) II: A Multidisciplinary-Guided Algorithm for the Prevention and Management of Acute Radiation Dermatitis in Cancer Patients.

Journal Article J Drugs Dermatol · November 1, 2022 BACKGROUND: Among the 1,918,030 patients in the United States estimated to be diagnosed with cancer in 2022, approximately 50% will require radiation therapy (RT) as part of their treatment plan. Radiation dermatitis (RD) is the most common side effect of ... Link to item Cite

In brief

Journal Article Current Problems in Surgery · September 1, 2022 Full text Cite

Immunotherapy Combined with Radiation Therapy in Breast Cancer: A Rapidly Evolving Landscape.

Journal Article Semin Radiat Oncol · July 2022 Immune checkpoint inhibitors (ICI) can have significant anticancer activity, and are approved for many different cancer types, including breast cancer. In breast cancer, programmed cell death 1 (PD-1) inhibitors in combination with chemotherapy have demons ... Full text Link to item Cite

In Reply to Struikmans et al.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2022 Full text Link to item Cite

Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer.

Journal Article Breast Cancer Res Treat · January 2022 PURPOSE: Immune checkpoint inhibition (ICI) has demonstrated clinically significant efficacy when combined with chemotherapy in triple negative breast cancer (TNBC). Although many patients derived benefit, others do not respond to immunotherapy, therefore ... Full text Link to item Cite

Radiation Modality (Proton/Photon), Timing, and Complication Rates in Patients With Breast Cancer Receiving 2-Stages Expander/Implant Reconstruction.

Journal Article Pract Radiat Oncol · 2022 PURPOSE: Our purpose is to explore the effect of postmastectomy radiation therapy (PMRT) modality and timing on complication rates in breast cancer patients receiving immediate 2-stages expander/implant. METHODS AND MATERIALS: We reviewed the charts of 661 ... Full text Link to item Cite

Risk of Developing Breast Reconstruction Complications: A Machine-Learning Nomogram for Individualized Risk Estimation with and without Postmastectomy Radiation Therapy.

Journal Article Plast Reconstr Surg · January 1, 2022 BACKGROUND: The purpose of this study was to create a nomogram using machine learning models predicting risk of breast reconstruction complications with or without postmastectomy radiation therapy. METHODS: Between 1997 and 2017, 1617 breast cancer patient ... Full text Link to item Cite

Postmastectomy Irradiation in the Setting of Implant-Based Breast Reconstruction

Chapter · January 1, 2022 Postmastectomy irradiation is indicated for patients who are at high risk of local and regional recurrence. However, postmastectomy radiation therapy in the setting of reconstruction is associated with increased risk of complications. In the current sectio ... Full text Cite

A Delphi study and International Consensus Recommendations: The use of bolus in the setting of postmastectomy radiation therapy for early breast cancer.

Journal Article Radiother Oncol · November 2021 Bolus serves as a tissue equivalent material that shifts the 95-100% isodose line towards the skin and subcutaneous tissue. The need for bolus for all breast cancer patients planned for postmastectomy radiation therapy (PMRT) has been questioned. The work ... Full text Link to item Cite

Proton Therapy for Breast Cancer: A Consensus Statement From the Particle Therapy Cooperative Group Breast Cancer Subcommittee.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2021 Radiation therapy plays an important role in the multidisciplinary management of breast cancer. Recent years have seen improvements in breast cancer survival and a greater appreciation of potential long-term morbidity associated with the dose and volume of ... Full text Link to item Cite

US Cutaneous Oncodermatology Management (USCOM): A Practical Algorithm.

Journal Article J Drugs Dermatol · September 1, 2021 BACKGROUND: An increasing number of patients survive or are living with cancer. Anticancer treatments frequently have cutaneous adverse events (cAEs) that may severely impact patients' quality of life and interrupt anticancer treatment. The US Cutaneous On ... Full text Link to item Cite

ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2021 PURPOSE: Advances in germline genetic testing have led to a surge in identification of ataxia-telangiectasia mutated (ATM) variant carriers among breast cancer patients, raising numerous questions regarding use of breast radiation therapy (RT) in this popu ... Full text Link to item Cite

Single-cell and spatial profiling identify three response trajectories to pembrolizumab and radiation therapy in triple negative breast cancer.

Journal Article Cancer Cell · January 8, 2024 Strategies are needed to better identify patients that will benefit from immunotherapy alone or who may require additional therapies like chemotherapy or radiotherapy to overcome resistance. Here we employ single-cell transcriptomics and spatial proteomics ... Full text Link to item Cite

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis.

Journal Article Nature · January 2024 Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS-STING-mediated signalling and tumour suppression1-3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given th ... Full text Link to item Cite

INDIVIDUAL ARTICLE: USCOM Algorithm for the Prevention and Management of Cutaneous Immunotherapy-Related Adverse Events.

Journal Article J Drugs Dermatol · November 1, 2023 BACKGROUND: In 2023, nearly 2 million patients will be diagnosed with cancer in the United States and at least 40% will be eligible for treatment with an immune checkpoint inhibitor (ICI). Cutaneous immune related adverse events (cirAEs) from ICIs are comm ... Full text Link to item Cite

Pre-operative Radiation and Immunotherapy in the Treatment of Non-metastatic Breast Cancer

Journal Article Current Breast Cancer Reports · September 1, 2023 Purpose of Review: To discuss the rationale and latest strategies for combining pre-operative radiation therapy (pre-op RT) and immunotherapy (IO) in the treatment of non-metastatic breast cancer. Recent Findings: IO has recently been incorporated into the ... Full text Cite

Looking Back: International Practice Patterns in Breast Radiation Oncology From a Case-Based Survey Across 54 Countries During the First Surge of the COVID-19 Pandemic.

Journal Article JCO Glob Oncol · July 2023 PURPOSE: The COVID-19 pandemic has profoundly affected cancer care worldwide, including radiation therapy (RT) for breast cancer (BC), because of risk-based resource allocation. We report the evolution of international breast RT practices during the beginn ... Full text Link to item Cite

Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None?

Journal Article J Clin Oncol · December 20, 2022 The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summ ... Full text Link to item Cite

United States Cutaneous Oncodermatology Management (USCOM) II: A Multidisciplinary-Guided Algorithm for the Prevention and Management of Acute Radiation Dermatitis in Cancer Patients.

Journal Article J Drugs Dermatol · November 1, 2022 BACKGROUND: Among the 1,918,030 patients in the United States estimated to be diagnosed with cancer in 2022, approximately 50% will require radiation therapy (RT) as part of their treatment plan. Radiation dermatitis (RD) is the most common side effect of ... Link to item Cite

In brief

Journal Article Current Problems in Surgery · September 1, 2022 Full text Cite

Immunotherapy Combined with Radiation Therapy in Breast Cancer: A Rapidly Evolving Landscape.

Journal Article Semin Radiat Oncol · July 2022 Immune checkpoint inhibitors (ICI) can have significant anticancer activity, and are approved for many different cancer types, including breast cancer. In breast cancer, programmed cell death 1 (PD-1) inhibitors in combination with chemotherapy have demons ... Full text Link to item Cite

In Reply to Struikmans et al.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2022 Full text Link to item Cite

Current advances in immune checkpoint inhibitor combinations with radiation therapy or cryotherapy for breast cancer.

Journal Article Breast Cancer Res Treat · January 2022 PURPOSE: Immune checkpoint inhibition (ICI) has demonstrated clinically significant efficacy when combined with chemotherapy in triple negative breast cancer (TNBC). Although many patients derived benefit, others do not respond to immunotherapy, therefore ... Full text Link to item Cite

Radiation Modality (Proton/Photon), Timing, and Complication Rates in Patients With Breast Cancer Receiving 2-Stages Expander/Implant Reconstruction.

Journal Article Pract Radiat Oncol · 2022 PURPOSE: Our purpose is to explore the effect of postmastectomy radiation therapy (PMRT) modality and timing on complication rates in breast cancer patients receiving immediate 2-stages expander/implant. METHODS AND MATERIALS: We reviewed the charts of 661 ... Full text Link to item Cite

Risk of Developing Breast Reconstruction Complications: A Machine-Learning Nomogram for Individualized Risk Estimation with and without Postmastectomy Radiation Therapy.

Journal Article Plast Reconstr Surg · January 1, 2022 BACKGROUND: The purpose of this study was to create a nomogram using machine learning models predicting risk of breast reconstruction complications with or without postmastectomy radiation therapy. METHODS: Between 1997 and 2017, 1617 breast cancer patient ... Full text Link to item Cite

Postmastectomy Irradiation in the Setting of Implant-Based Breast Reconstruction

Chapter · January 1, 2022 Postmastectomy irradiation is indicated for patients who are at high risk of local and regional recurrence. However, postmastectomy radiation therapy in the setting of reconstruction is associated with increased risk of complications. In the current sectio ... Full text Cite

A Delphi study and International Consensus Recommendations: The use of bolus in the setting of postmastectomy radiation therapy for early breast cancer.

Journal Article Radiother Oncol · November 2021 Bolus serves as a tissue equivalent material that shifts the 95-100% isodose line towards the skin and subcutaneous tissue. The need for bolus for all breast cancer patients planned for postmastectomy radiation therapy (PMRT) has been questioned. The work ... Full text Link to item Cite

Proton Therapy for Breast Cancer: A Consensus Statement From the Particle Therapy Cooperative Group Breast Cancer Subcommittee.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2021 Radiation therapy plays an important role in the multidisciplinary management of breast cancer. Recent years have seen improvements in breast cancer survival and a greater appreciation of potential long-term morbidity associated with the dose and volume of ... Full text Link to item Cite

US Cutaneous Oncodermatology Management (USCOM): A Practical Algorithm.

Journal Article J Drugs Dermatol · September 1, 2021 BACKGROUND: An increasing number of patients survive or are living with cancer. Anticancer treatments frequently have cutaneous adverse events (cAEs) that may severely impact patients' quality of life and interrupt anticancer treatment. The US Cutaneous On ... Full text Link to item Cite

ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2021 PURPOSE: Advances in germline genetic testing have led to a surge in identification of ataxia-telangiectasia mutated (ATM) variant carriers among breast cancer patients, raising numerous questions regarding use of breast radiation therapy (RT) in this popu ... Full text Link to item Cite

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of breast cancer.

Journal Article J Immunother Cancer · August 2021 Breast cancer has historically been a disease for which immunotherapy was largely unavailable. Recently, the use of immune checkpoint inhibitors (ICIs) in combination with chemotherapy for the treatment of advanced/metastatic triple-negative breast cancer ... Full text Link to item Cite

The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review.

Journal Article Crit Rev Oncol Hematol · July 2021 PURPOSE: Post mastectomy radiation therapy (PMRT) reduces locoregional recurrence (LRR) and breast cancer mortality for selected patients. Bolus overcomes the skin-sparing effect of external-beam radiotherapy, ensuring adequate dose to superficial regions ... Full text Link to item Cite

Radiotherapy to Enhance Chimeric Antigen Receptor T-Cell Therapeutic Efficacy in Solid Tumors: A Narrative Review.

Journal Article JAMA Oncol · July 1, 2021 IMPORTANCE: Immunotherapy has emerged as a new pillar of cancer therapy over the past decade. Adoptive immunotherapy in particular has become a major area of research interest, with advances seen in the development of T-cell engineering. As a result, chime ... Full text Link to item Cite

The Financial Impact on Reimbursement of Moderately Hypofractionated Postoperative Radiation Therapy for Breast Cancer: An International Consortium Report.

Journal Article Clin Oncol (R Coll Radiol) · May 2021 AIMS: Moderately hypofractionated breast irradiation has been evaluated in several prospective studies, resulting in wide acceptance of shorter treatment protocols for postoperative breast irradiation. Reimbursement for radiation therapy varies between pri ... Full text Link to item Cite

New Frontiers in Hypofractionation for Regional Nodal Irradiation in Breast Cancer

Journal Article Current Breast Cancer Reports · December 1, 2020 Purpose of Review: In recent years, there have been a number of small, yet notable practice changes in the delivery of postmastectomy radiation therapy (PMRT) in breast cancer patients. Herein, we describe the role of PMRT and its evolving delivery with hy ... Full text Cite

The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice: A critical review.

Journal Article Crit Rev Oncol Hematol · December 2020 Post-operative radiation therapy (RT) reduces loco-regional recurrence rates and mortality in most patients with non-metastatic breast cancer. The aim of this critical review is to provide an overview of the applicability of moderately hypofractionated RT ... Full text Link to item Cite

A pilot study of 13N-ammonia cardiac PET imaging to assess subacute cardiotoxicity following adjuvant intensity-modulated radiotherapy for locally advanced breast cancer.

Journal Article Clin Imaging · December 2020 OBJECTIVE: (1) Assess the feasibility of 13 N-ammonia cardiac PET (13 N-ammonia-PET) imaging in radiotherapy (RT) treatment position in locally-advanced breast cancer (LABC) patients. (2) Correlate pre-/post-RT changes in myocardial flow reserve (MFR) with ... Full text Link to item Cite

Quantifying the Impact of Axillary Surgery and Nodal Irradiation on Breast Cancer-Related Lymphedema and Local Tumor Control: Long-Term Results From a Prospective Screening Trial.

Journal Article J Clin Oncol · October 10, 2020 PURPOSE: To independently evaluate the impact of axillary surgery type and regional lymph node radiation (RLNR) on breast cancer-related lymphedema (BCRL) rates in patients with breast cancer. PATIENTS AND METHODS: From 2005 to 2018, 1,815 patients with in ... Full text Link to item Cite

Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2020 Immunotherapy using immune checkpoint blockade has revolutionized the treatment of many types of cancer. Radiation therapy (RT)-particularly when delivered at high doses using newer techniques-may be capable of generating systemic antitumor effects when co ... Full text Link to item Cite

Optimal breast reconstruction type for patients treated with neoadjuvant chemotherapy, mastectomy followed by radiation therapy.

Journal Article Breast Cancer Res Treat · August 2020 PURPOSE: To explore the optimal type of breast reconstruction and the time interval to postmastectomy radiotherapy (PMRT) associated with lower complications in breast cancer patients receiving neoadjuvant chemotherapy. METHODS: We reviewed the medical rec ... Full text Link to item Cite

The Local Control of Systemic Therapy.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2020 Full text Link to item Cite

Single Stage Direct-to-Implant Breast Reconstruction Has Lower Complication Rates Than Tissue Expander and Implant and Comparable Rates to Autologous Reconstruction in Patients Receiving Postmastectomy Radiation.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2020 PURPOSE: To compare single-stage direct-to-implant (DTI) immediate reconstruction to the commonly used 2-stages expander and implant (TE/I) or autologous reconstruction with focus on postmastectomy radiation therapy (PMRT) setting. METHODS AND MATERIALS: W ... Full text Link to item Cite

A phase 2 clinical trial assessing the efficacy and safety of pembrolizumab and radiotherapy in patients with metastatic triple-negative breast cancer.

Journal Article Cancer · February 15, 2020 BACKGROUND: The current study was conducted to evaluate the efficacy and safety of pembrolizumab-mediated programmed cell death protein 1 inhibition plus radiotherapy (RT) in patients with metastatic triple-negative breast cancer who were unselected for pr ... Full text Link to item Cite

A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.

Journal Article Cell Rep · February 4, 2020 The Mre11-Rad50-Nbs1 complex is a DNA double-strand break sensor that mediates a tumor-suppressive DNA damage response (DDR) in cells undergoing oncogenic stress, yet the mechanisms underlying this effect are poorly understood. Using a genetically inducibl ... Full text Link to item Cite

Combining Radiation Therapy with Immune Checkpoint Blockadein Breast Cancer

Journal Article Current Breast Cancer Reports · December 1, 2019 Purpose of Review: Immune checkpoint blockade (ICB) is an emerging therapy in breast cancer. Its optimal integration with radiation therapy (RT) for breast cancer remains to be established. Herein, we review the current evidence on combining ICB and RT in ... Full text Cite

Phase II Study of Proton Beam Radiation Therapy for Patients With Breast Cancer Requiring Regional Nodal Irradiation.

Journal Article J Clin Oncol · October 20, 2019 PURPOSE: To evaluate the safety and efficacy of proton beam radiation therapy (RT) for patients with breast cancer who require regional nodal irradiation. METHODS: Patients with nonmetastatic breast cancer who required postoperative RT to the breast/chest ... Full text Link to item Cite

The Impact of Chest Wall Boost on Reconstruction Complications and Local Control in Patients Treated for Breast Cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2019 PURPOSE: Giving an additional radiation dose to the incision or chest wall has been a practice, but it has never been studied in a randomized setting, and it might lead to inferior cosmetic outcomes. This study aims to evaluate whether delivery of a chest ... Full text Link to item Cite

Daily Fractionation of External Beam Accelerated Partial Breast Irradiation to 40 Gy Is Well Tolerated and Locally Effective.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2019 PURPOSE: Most studies examining accelerated partial breast irradiation (APBI) have used twice-daily fractionation. Cosmesis with this approach has produced mixed results, and the optimal fractionation scheme remains unknown. We sought to evaluate the safet ... Full text Link to item Cite

Overall Survival of Breast Cancer Patients With Locoregional Failures Involving Internal Mammary Nodes

Journal Article Advances in Radiation Oncology · July 1, 2019 Purpose: Internal mammary node recurrence after definitive breast cancer treatment is poorly characterized, with limited data to guide clinical management. The aim of this study was to analyze the outcomes of patients with recurrent breast cancer involving ... Full text Cite

Assessment of Early Radiation-Induced Changes in Left Ventricular Function by Myocardial Strain Imaging After Breast Radiation Therapy.

Journal Article J Am Soc Echocardiogr · April 2019 BACKGROUND: Radiation therapy (RT)-induced cardiotoxicity is among the concerning sequelae of breast cancer (BCA) treatment, particularly in HER2-positive BCA patients who receive anthracyclines and trastuzumab-based therapy. The aim of this study was to a ... Full text Link to item Cite

Tattoo free setup for partial breast irradiation: A feasibility study.

Journal Article J Appl Clin Med Phys · April 2019 PURPOSE: Patients undergoing external beam accelerated partial breast irradiation (APBI) receive permanent tattoos to aid with daily setup alignment and verification. With the advent of three-dimensional (3D) body surface imaging and two-dimensional (2D) x ... Full text Link to item Cite

Long-Term Pulmonary Outcomes of a Feasibility Study of Inverse-Planned, Multibeam Intensity Modulated Radiation Therapy in Node-Positive Breast Cancer Patients Receiving Regional Nodal Irradiation.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2019 PURPOSE: Multibeam intensity modulated radiation therapy (IMRT) enhances the therapeutic index by increasing the dosimetric coverage of the targeted tumor tissues while minimizing volumes of adjacent organs receiving high doses of RT. The tradeoff is that ... Full text Link to item Cite

A 3-Dimensional Mapping Analysis of Regional Nodal Recurrences in Breast Cancer.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: The primary goal was to map the anatomic pattern of isolated nodal recurrences (NR) in the supraclavicular (SCV), axillary, and internal mammary nodes (IMNs) in patients with breast cancer treated with curative-intent surgery with or without radia ... Full text Link to item Cite

Postmastectomy Radiation

Chapter · January 1, 2019 Postmastectomy radiation is an integral part of breast cancer treatment. There are clear guidelines for administration in advanced disease. However, its use in early-stage breast cancer and in the setting of neoadjuvant systemic therapy remains an area of ... Full text Cite

Influence of Age on the Clinical Outcome of Breast Cancer for Men and the Development of Second Primary Cancers.

Journal Article Ann Surg Oncol · December 2018 BACKGROUND: Low incidence of breast cancer in men (BCM) (< 1% of all breast cancers) has led to a paucity of outcome data. This study evaluated the impact of age on BCM outcomes. METHODS: For this study, BCM patients treated between 2000 and 2011 were stra ... Full text Link to item Cite

Reduction in low-dose to normal tissue with the addition of deep inspiration breath hold (DIBH) to volumetric modulated arc therapy (VMAT) in breast cancer patients with implant reconstruction receiving regional nodal irradiation.

Journal Article Radiat Oncol · September 24, 2018 BACKGROUND: Despite dosimetric benefits of volumetric modulated arc therapy (VMAT) in breast cancer patients with implant reconstruction receiving regional nodal irradiation (RNI), low dose to the thoracic structures remains a concern. Our goal was to repo ... Full text Link to item Cite

A Randomized Trial of Mometasone Furoate 0.1% to Reduce High-Grade Acute Radiation Dermatitis in Breast Cancer Patients Receiving Postmastectomy Radiation.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2018 PURPOSE: A 2-arm, double-blinded randomized trial was conducted to evaluate the efficacy of 0.1% mometasone furoate (MF) versus Eucerin Original (E) cream in preventing the development of moderate to severe acute radiation dermatitis (ARD) in breast cancer ... Full text Link to item Cite

Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study.

Journal Article J Clin Oncol · May 1, 2018 Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP- ... Full text Link to item Cite

Trends and variations in postmastectomy radiation therapy for breast cancer in patients with 1 to 3 positive lymph nodes: A National Cancer Data Base analysis.

Journal Article Cancer · February 1, 2018 BACKGROUND: High-level evidence is lacking to guide treatment decisions about postmastectomy radiation therapy (PMRT) in patients who have breast cancer with 1 to 3 positive lymph nodes who receive contemporary systemic therapies, leading to potential vari ... Full text Link to item Cite

Breast Cancer Biology: Clinical Implications for Breast Radiation Therapy.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2018 Historically, prognosis and treatment decision making for breast cancer patients have been dictated by the anatomic extent of tumor spread. However, in recent years, "breast cancer" has proven to be a collection of unique phenotypes with distinct prognoses ... Full text Link to item Cite

Impact of an In Situ Component on Outcome After In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy.

Journal Article Ann Surg Oncol · January 2018 BACKGROUND: Among all in-breast tumor recurrences (IBTR) following breast-conserving therapy (BCT), some comprise metachronous new primaries (NPs) while others are true recurrences (TRs). Establishing this distinction remains a challenge. METHODS: We studi ... Full text Link to item Cite

Radiotherapy in the setting of breast reconstruction: types, techniques, and timing.

Journal Article Lancet Oncol · December 2017 As the use of breast reconstruction and postmastectomy radiotherapy (PMRT) has increased over the past decade, the typical approach to integrating radiotherapy with breast reconstruction has provoked intense controversy in the management of breast cancer. ... Full text Link to item Cite

Postmastectomy Radiation in Breast Cancer Patients With Pathologically Positive Lymph Nodes After Neoadjuvant Chemotherapy: Usage Rates and Survival Trends.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2017 PURPOSE: To analyze postmastectomy radiation therapy (PMRT) usage and its association with overall survival (OS) in breast cancer patients with pathologically positive lymph nodes after neoadjuvant chemotherapy (NAC). METHODS AND MATERIALS: Using the Natio ... Full text Link to item Cite

Axillary Dissection and Nodal Irradiation Can Be Avoided for Most Node-positive Z0011-eligible Breast Cancers: A Prospective Validation Study of 793 Patients.

Journal Article Ann Surg · September 2017 OBJECTIVE: To determine rates of axillary dissection (ALND) and nodal recurrence in patients eligible for ACOSOG Z0011. BACKGROUND: Z0011 demonstrated that patients with cT1-2N0 breast cancers and 1 to 2 involved sentinel lymph nodes (SLNs) having breast-c ... Full text Link to item Cite

Combined Radiation Therapy and Immune Checkpoint Blockade Therapy for Breast Cancer.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2017 PURPOSE: Treatment with checkpoint inhibitors has shown durable responses in a number of solid tumors, including melanoma, lung, and renal cell carcinoma. However, most breast cancers are resistant to monotherapy with checkpoint inhibitors. Radiation thera ... Full text Link to item Cite

National Breast Reconstruction Utilization in the Setting of Postmastectomy Radiotherapy.

Journal Article J Reconstr Microsurg · June 2017 Background Immediate breast reconstruction (IBR) is often deferred, when postmastectomy radiotherapy (PMRT) is anticipated, due to high complication rates. Nonetheless, because of robust data supporting improved health-related quality of life associated wi ... Full text Link to item Cite

The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?

Journal Article Current Breast Cancer Reports · March 1, 2017 The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects. Over the past 50 years, reports on the abscopal effect arising from conventional radiation have been relatively rare. However, with the continued develo ... Full text Cite

Morphologic Features of Magnetic Resonance Imaging as a Surrogate of Capsular Contracture in Breast Cancer Patients With Implant-based Reconstructions.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2017 PURPOSE: Capsular contracture (CC) is a serious complication in patients receiving implant-based reconstruction for breast cancer. Currently, no objective methods are available for assessing CC. The goal of the present study was to identify image-based sur ... Full text Link to item Cite

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

Journal Article Ann Surg Oncol · January 2017 PURPOSE: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastec ... Full text Link to item Cite

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

Journal Article J Clin Oncol · December 20, 2016 Purpose A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmastect ... Full text Link to item Cite

Postmastectomy Radiotherapy: An American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Focused Guideline Update.

Journal Article Pract Radiat Oncol · 2016 UNLABELLED: A joint American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology panel convened to develop a focused update of the American Society of Clinical Oncology guideline concerning use of postmas ... Full text Link to item Cite

Radiotherapy following neoadjuvant chemotherapy in locally advanced breast cancer

Chapter · January 1, 2016 Neoadjuvant chemotherapy (NAC) is commonly used in patients with locally advanced breast cancer. Several challenges faced by radiation oncologists in treating these patients include the lack of an accurate pathologic stage to guide management and determini ... Full text Cite

The Effect of Molecular Subtype and Residual Disease on Locoregional Recurrence in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy and Postmastectomy Radiation.

Journal Article Ann Surg Oncol · December 2015 BACKGROUND: The relative contribution of biologic subtype to locoregional recurrence (LRR) in patients treated with neoadjuvant chemotherapy (NAC), mastectomy, and postmastectomy radiotherapy (PMRT) is not clearly defined. METHODS: 233 patients with stages ... Full text Link to item Cite

Breast-Conserving Surgery in Bilateral Breast Cancer.

Journal Article Ann Surg Oncol · October 2015 BACKGROUND: Bilateral breast cancer (BBC) may present as synchronous (SBC) or metachronous breast cancer (MBC). Optimal surgical management of BBC patients is not well-defined. In this study, we report on histopathology, treatment, and outcomes in BBC pati ... Full text Link to item Cite

The Effect of Adjuvant Trastuzumab on Locoregional Recurrence of Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Treated with Mastectomy.

Journal Article Ann Surg Oncol · August 2015 BACKGROUND: Human epidermal growth factor receptor 2 (HER2) overexpression was associated with locoregional recurrence (LRR) in the preadjuvant trastuzumab era. This study aimed to examine the effect of trastuzumab on LRR in mastectomy patients and whether ... Full text Link to item Cite

Early toxicity in patients treated with postoperative proton therapy for locally advanced breast cancer.

Journal Article Int J Radiat Oncol Biol Phys · June 1, 2015 PURPOSE: To report dosimetry and early toxicity data in breast cancer patients treated with postoperative proton radiation therapy. METHODS AND MATERIALS: From March 2013 to April 2014, 30 patients with nonmetastatic breast cancer and no history of prior r ... Full text Link to item Cite

Personalization of loco-regional care for primary breast cancer patients (part 1).

Conference Future Oncol · 2015 ABSTRACT  Kyoto Breast Cancer Consensus Conference, Kyoto, Japan, 18-20 February 2014 The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breas ... Full text Link to item Cite

Personalization of loco-regional care for primary breast cancer patients (part 2).

Conference Future Oncol · 2015 Kyoto Breast Cancer Consensus Conference, Kyoto, Japan, 18-20 February 2014 The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breast cancer s ... Full text Link to item Cite

Breast reconstruction

Chapter · May 14, 2014 Cite

Impact of molecular subtype on locoregional recurrence in mastectomy patients with T1-T2 breast cancer and 1-3 positive lymph nodes.

Journal Article Ann Surg Oncol · May 2014 BACKGROUND: Postmastectomy radiation (PMRT) in T1-T2 tumors with 1-3 positive axillary lymph nodes (ALNs) is controversial. Impact of molecular subtype (MST) on locoregional recurrence (LRR) and PMRT benefit is uncertain. We examined the association betwee ... Full text Link to item Cite

Effect of margin width on local recurrence in triple-negative breast cancer patients treated with breast-conserving therapy.

Journal Article Ann Surg Oncol · April 2014 BACKGROUND: The effect of increasing negative margin width after breast-conserving therapy (BCT) on local recurrence (LR) is controversial. LR rates vary by subtype, with the highest rates seen in triple-negative breast cancer (TNBC). This study examined L ... Full text Link to item Cite

Locally advanced breast cancer

Journal Article Medical Radiology · January 1, 2014 Full text Cite

Mesothelin expression in triple negative breast carcinomas correlates significantly with basal-like phenotype, distant metastases and decreased survival.

Journal Article PLoS One · 2014 Mesothelin is a cell surface associated antigen expressed on mesothelial cells and in some malignant neoplasms. Mesothelin-targeted therapies are in phase I/II clinical trials. The clinicopathologic and prognostic significance of mesothelin expression in t ... Full text Link to item Cite

Bilateral implant reconstruction does not affect the quality of postmastectomy radiation therapy.

Journal Article Med Dosim · 2014 To determine if the presence of bilateral implants, in addition to other anatomic and treatment-related variables, affects coverage of the target volume and dose to the heart and lung in patients receiving postmastectomy radiation therapy (PMRT). A total o ... Full text Link to item Cite

Breast-conserving therapy achieves locoregional outcomes comparable to mastectomy in women with T1-2N0 triple-negative breast cancer.

Journal Article Ann Surg Oncol · October 2013 BACKGROUND: Conflicting data exist regarding optimum local therapy for early-stage triple-negative breast cancer (TNBC). We examined outcomes according to local treatment type in a large cohort of node-negative TNBC patients. METHODS: A total of 1,242 cons ... Full text Link to item Cite

Selection criteria for postmastectomy radiotherapy in t1-t2 tumors with 1 to 3 positive lymph nodes.

Journal Article Ann Surg Oncol · October 2013 BACKGROUND: Postmastectomy radiotherapy (PMRT) is well established in patients with ≥4 positive axillary lymph nodes (ALN); indications in 1 to 3 positive ALN remains controversial. We examined clinicopathologic criteria used for PMRT selection and compare ... Full text Link to item Cite

The evolving role of partial breast irradiation in early-stage breast cancer.

Journal Article Ann Surg Oncol · August 2013 Whole breast irradiation (WBI) over 5-7 weeks has long been considered standard adjuvant treatment after breast-conserving surgery. Recently the concept of irradiating the whole breast has been challenged by accelerated partial breast irradiation (APBI), w ... Full text Link to item Cite

Black race as a prognostic factor in triple-negative breast cancer patients treated with breast-conserving therapy: a large, single-institution retrospective analysis.

Journal Article Breast Cancer Res Treat · June 2013 Triple-negative breast cancer (TNBC) disproportionately affects black women. However, black race as a prognostic factor in TNBC has not been well studied. We evaluated the effect of race, among other variables, on outcomes in women with TNBC. A total of 70 ... Full text Link to item Cite

Toxicity and outcomes of thoracic re-irradiation using stereotactic body radiation therapy (SBRT).

Journal Article Radiat Oncol · April 25, 2013 BACKGROUND: Patients treated for a thoracic malignancy carry a significant risk of developing other lung lesions. Locoregional control of intrathoracic recurrences is challenging due to the impact of prior therapies on normal tissues. We examined the safet ... Full text Link to item Cite

Radiation therapy in the management of breast cancer.

Journal Article Surg Clin North Am · April 2013 Radiation therapy (RT) plays an essential role in the management of breast cancer by eradicating subclinical disease after surgical removal of grossly evident tumor. Radiation reduces local recurrence rates and increases breast cancer-specific survival in ... Full text Link to item Cite

Which patients with sentinel node-positive breast cancer can avoid axillary dissection?

Journal Article Am Soc Clin Oncol Educ Book · 2013 Sentinel lymph node (SLN) biopsy is standard care for patients with cN0 breast cancer. An extensive literature, including seven randomized trials, has established that patients with negative SLN do not require axillary dissection (ALND), that axillary loca ... Full text Link to item Cite

Characteristics and outcomes of sentinel node-positive breast cancer patients after total mastectomy without axillary-specific treatment.

Journal Article Ann Surg Oncol · November 2012 PURPOSE: Regional failure rates are low in patients with a positive sentinel lymph node biopsy (SLNB) who undergo breast-conserving therapy without axillary lymph node dissection (ALND). The applicability of these findings to total mastectomy (TM) patients ... Full text Link to item Cite

Favorable prognosis in patients with T1a/T1bN0 triple-negative breast cancers treated with multimodality therapy.

Journal Article Cancer · October 15, 2012 BACKGROUND: The authors evaluated the clinical characteristics, natural history, and outcomes of patients who had ≤1 cm, lymph node-negative, triple-negative breast cancer (TNBC). METHODS: After excluding patients who had received neoadjuvant therapy, 1022 ... Full text Link to item Cite

Quantifying the impact of immediate reconstruction in postmastectomy radiation: a large, dose-volume histogram-based analysis.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2012 PURPOSE: To assess the impact of immediate breast reconstruction on postmastectomy radiation (PMRT) using dose-volume histogram (DVH) data. METHODS AND MATERIALS: Two hundred forty-seven women underwent PMRT at our center, 196 with implant reconstruction a ... Full text Link to item Cite

Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation.

Journal Article Breast Cancer Res Treat · August 2012 BRCA1 germline mutation carriers usually develop ER, PR and HER2 negative breast carcinoma. Somatic BRCA1 mutations are rare in sporadic breast cancers, but other mechanisms could impair BRCA1 functions in these tumors, particularly in triple-negative brea ... Full text Link to item Cite

Long-term outcomes in breast cancer patients undergoing immediate 2-stage expander/implant reconstruction and postmastectomy radiation.

Journal Article Cancer · May 1, 2012 BACKGROUND: Breast reconstruction with tissue expander (TE)/permanent implant (PI) followed by postmastectomy radiation (PMRT) is an increasingly popular treatment for breast cancer patients. The long-term rates of permanent implant removal or replacement ... Full text Link to item Cite

Adjuvant trastuzumab reduces locoregional recurrence in women who receive breast-conservation therapy for lymph node-negative, human epidermal growth factor receptor 2-positive breast cancer.

Journal Article Cancer · April 15, 2012 BACKGROUND: Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer have a higher risk of locoregional recurrence (LRR), even in the setting of early stage, lymph node-negative disease. In this sequential, retrospective study, ... Full text Link to item Cite

Radiation field design and regional control in sentinel lymph node-positive breast cancer patients with omission of axillary dissection.

Journal Article Cancer · April 15, 2012 BACKGROUND: Randomized data suggest that axillary clearance is not necessary in select, clinically lymph node-negative women with positive sentinel lymph node (SLN) biopsies (SLNBs) who undergo breast-conserving surgery or receive whole-breast radiotherapy ... Full text Link to item Cite

Patterns of utilization of adjuvant radiotherapy and outcomes in black women after breast conservation at a large multidisciplinary cancer center.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2011 PURPOSE: Population-based studies have reported that as many of 35% of black women do not undergo radiotherapy (RT) after breast conservation surgery (BCS). The objective of the present study was to determine whether this trend persisted at a large multidi ... Full text Link to item Cite

Determinants of outcome in elderly patients with positive sentinel lymph nodes.

Journal Article Am J Surg · June 2011 BACKGROUND: Older women are less likely to receive standard of care treatment for breast cancer. METHODS: We examined variables that affected the outcome of elderly patients ≥70 years old among 1,470 patients with invasive cancer with positive sentinel lym ... Full text Link to item Cite

The effect of age in the outcome and treatment of older women with ductal carcinoma in situ.

Journal Article Breast · February 2011 The effect of increasing age on outcomes and type of treatment given to older women with ductal carcinoma in situ (DCIS) was assessed. 646 women ≥60 years old (654 cases) receiving surgery for DCIS at Memorial Sloan-Kettering Cancer Center between 2000 and ... Full text Link to item Cite

The evolution of the locoregional therapy of breast cancer.

Journal Article Oncologist · 2011 Breast-conserving therapy (BCT) and mastectomy have equal survival outcomes. Rates of local recurrence after BCT have declined steadily, largely as a result of the widespread use of systemic therapy. Sentinel node biopsy has replaced axillary dissection fo ... Full text Link to item Cite

A novel respiratory tracking system for smart-gated PET acquisition

Journal Article Medical Physics · January 1, 2011 Purpose: In this study, the authors validated a novel respiratory tracking device, the multidimensional respiratory tracking (MDRT) system, that was designed to assist in correcting for respiratory motion in PET/CT images. The authors also investigated a n ... Full text Cite

The clinical impact and outcomes of immunohistochemistry-only metastasis in breast cancer.

Journal Article Am J Surg · September 2010 BACKGROUND: Modern surgical and pathological techniques can detect small-volume axillary metastases in breast cancer with unknown clinical significance. METHODS: A retrospective database review from 1996 through 2004 identified all patients with immunohist ... Full text Link to item Cite

Young men have equivalent biochemical outcomes compared with older men after treatment with brachytherapy for prostate cancer.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2010 PURPOSE: To evaluate retrospectively the biochemical outcomes of young men treated with low-dose-rate brachytherapy for prostate cancer. METHODS AND MATERIALS: From 1990 to 2005, 1,665 men with clinically localized prostate cancer were treated with low-dos ... Full text Link to item Cite

Locoregional outcomes of inflammatory breast cancer patients treated with standard fractionation radiation and daily skin bolus in the taxane era.

Journal Article Int J Radiat Oncol Biol Phys · July 15, 2010 PURPOSE: To assess locoregional outcomes of inflammatory breast cancer (IBC) patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy (CMT). METHODS AND MATERIALS: We retrospectively revi ... Full text Link to item Cite

EUS-guided fiducial placement for image-guided radiation therapy in GI malignancies by using a 22-gauge needle (with videos).

Journal Article Gastrointest Endosc · June 2010 BACKGROUND: Image-guided radiation therapy (IGRT) is dependent on the presence of fiducial markers for target localization and tracking. EUS-guided placement of fiducial markers with a 19-gauge needle has been reported. However, the size and stiffness of t ... Full text Link to item Cite

Predictors of completion axillary lymph node dissection in patients with immunohistochemical metastases to the sentinel lymph node in breast cancer.

Journal Article Ann Surg Oncol · April 2010 BACKGROUND: Axillary lymph node dissection (ALND) in patients with immunohistochemistry (IHC)-determined metastases to the sentinel lymph node (SLN) is controversial. The goal of this study was to examine factors associated with ALND in IHC-only patients. ... Full text Link to item Cite

Radiation dose predicts for biochemical control in intermediate-risk prostate cancer patients treated with low-dose-rate brachytherapy.

Journal Article Int J Radiat Oncol Biol Phys · September 1, 2009 PURPOSE: To evaluate the influence of patient- and treatment-related factors on freedom from biochemical failure (FFbF) in patients with intermediate-risk prostate cancer. METHODS AND MATERIALS: From a prospectively collected database of 2250 men treated a ... Full text Link to item Cite

Predictors of completion axillary lymph node dissection in patients with positive sentinel lymph nodes.

Journal Article Ann Surg Oncol · July 2009 BACKGROUND: Completion axillary lymph node dissection (CALND) is routinely performed in breast cancer patients with positive sentinel lymph nodes (SLN). We sought to determine the sociodemographic, pathologic, and therapeutic variables that were associated ... Full text Link to item Cite

Concurrent use of chemotherapy or novel agents in combination with radiation in breast cancer

Journal Article Current Breast Cancer Reports · March 1, 2009 Treating breast cancer patients concurrently with chemotherapy and radiation is a potentially attractive approach. The goal is to develop strategies that enhance the effects of each modality while minimizing toxicity. Most data evaluating the role of simul ... Full text Cite

Incidence of major corrective surgery after post-mastectomy breast reconstruction and radiation therapy.

Journal Article Breast J · 2008 To evaluate the likelihood of requiring major corrective surgery (MCS) after modified radical mastectomy (MRM), immediate reconstruction and radiation therapy (RT) to the reconstructed breast. The study population consisted of 62 patients who underwent MRM ... Full text Link to item Cite

Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2007 PURPOSE: The ATM gene product is a central component of cell cycle regulation and genomic surveillance. We hypothesized that DNA sequence alterations in ATM predict for adverse effects after external beam radiotherapy for early breast cancer. METHODS AND M ... Full text Link to item Cite

Is seminal vesicle implantation with permanent sources possible? A dose-volume histogram analysis in patients undergoing combined 103Pd implantation and external beam radiation for T3c prostate cancer.

Journal Article Brachytherapy · 2007 PURPOSE: Combined brachytherapy and external beam radiation therapy (EBRT) of the prostate and seminal vesicles (SVs) is evolving as a successful treatment option for high-risk prostate cancer. Dose-volume histogram (DVH) analysis of the SV was performed i ... Full text Link to item Cite

Changing the patterns of failure for high-risk prostate cancer patients by optimizing local control.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2006 PURPOSE: Standard therapies for high-risk prostate cancer have resulted in suboptimal outcomes with both local and distant failures. Prostate-specific antigen (PSA) and distant metastases rates as well as biopsy outcomes are reported after a regimen of tri ... Full text Link to item Cite

Genetic predictors of adverse radiotherapy effects: the Gene-PARE project.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2006 PURPOSE: The development of adverse effects resulting from the radiotherapy of cancer limits the use of this treatment modality. The validation of a test capable of predicting which patients would be most likely to develop adverse responses to radiation tr ... Full text Link to item Cite

A VMAT planning technique for locally advanced breast cancer patients with expander or implant reconstructions requiring comprehensive postmastectomy radiation therapy.

Journal Article Med Dosim Locally advanced breast cancer patients with expander or implant reconstructions who require comprehensive postmastectomy radiotherapy (PMRT) can pose unique treatment planning challenges. Traditional 3D conformal radiation techniques often result in large ... Full text Link to item Cite