Alireza Nazarian

Journal Article GeroScience · June 2025 Genetics is the second strongest risk factor for Alzheimer's disease (AD) after age. More than 70 loci have been implicated in AD susceptibility so far, and the genetic architecture of AD entails both additive and nonadditive contributions from these loci. ... Full text Cite

Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.

Journal Article GeroScience · February 2023 The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer's disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium (LD) patte ... Full text Cite

Genome-wide analysis of genetic predisposition to common polygenic cancers.

Journal Article Journal of applied genetics · May 2022 Lung, breast, prostate, and colorectal cancers are among the most common and fatal malignancies worldwide. They are mainly caused by multifactorial mechanisms and are genetically heterogeneous. We investigated the genetic architecture of these cancers thro ... Full text Cite

The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees.

Journal Article Journal of applied genetics · February 2020 The generalized linear mixed models (GLMMs) methodology is the standard framework for genome-wide association studies (GWAS) of complex diseases in family-based cohorts. Fitting GLMMs in very large cohorts, however, can be computationally demanding. Also, ... Full text Cite

Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.

Journal Article GeroScience · April 2019 Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused by the interplay of multiple genetic and non-genetic factors. Hypertension is one of the AD risk factors that has been linked to underlying pathological changes like senile plaques ... Full text Cite

Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.

Journal Article Alzheimer's research & therapy · January 2019 BackgroundAlzheimer's disease (AD) is the most common cause of dementia in the elderly and the sixth leading cause of death in the United States. AD is mainly considered a complex disorder with polygenic inheritance. Despite discovering many susce ... Full text Cite