Overview
I am a surgeon with interest in immune management of transplant recipients. I am particularly interested in therapies that influence T cell costimulation pathways and adjuvant therapies that facilitate costimulation blockade to prevent the rejection of transplanted organs without undue suppression of protective immunity. I am also interested in understanding how injury, such as that occurring during trauma or in elective surgery, influences immune responses and subsequent healing following injury.
Current Appointments & Affiliations
David C. Sabiston, Jr. Distinguished Professor of Surgery
·
2015 - Present
Surgery, Abdominal Transplant Surgery,
Surgery
Professor of Surgery
·
2014 - Present
Surgery, Abdominal Transplant Surgery,
Surgery
Professor in Pediatrics
·
2014 - Present
Pediatrics,
Clinical Science Departments
Professor in Integrative Immunobiology
·
2014 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2015 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Costimulatory blockade and infectious risk in solid organ transplantation.
Journal Article Am J Transplant · April 2026 Costimulatory blockade has emerged as a promising alternative to conventional immunosuppression with the potential to reduce chronic allograft injury and minimize drug-related toxicities, including nephrotoxicity, cardiometabolic complications, and maligna ... Full text Link to item CiteDual costimulation blockade with the CD154-specific fusion protein dazodalibep and belatacept for prophylaxis of kidney allograft rejection.
Journal Article Am J Transplant · April 2026 Organ transplant immunosuppression includes daily calcineurin inhibitors and corticosteroids, which target broad, toxic metabolic pathways. This phase 2a, open-label, single-arm trial evaluated the efficacy and safety of combining dazodalibep (cluster of d ... Full text Link to item CiteSurgical Case Sequencing and Patient Flow: A Simulation Study With Downstream Resources.
Journal Article J Surg Res · March 27, 2026 INTRODUCTION: Surgical sequencing impacts patient flow and hospital operations. Discrete event simulation has been used to study these effects, specifically examining heuristics such as shortest cases first (SCF) and longest cases first (LCF). We propose a ... Full text Link to item CiteRecent Grants
Stimulating Access to Research in Residency (StARR) - NIAID
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2029Advanced Immunobiology Traning Program for Surgeons
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2019 - 2029Tolerance to Allogeneic Hearts via Implantation of Cultured Donor Thymus
ResearchAdvisor · Awarded by National Heart, Lung, and Blood Institute · 2025 - 2028View All Grants
Education
Duke University ·
1992
Ph.D.
Duke University, School of Medicine ·
1987
M.D.
Old Dominion University ·
1983
B.S.