Allen P. Killam

Development of a probe to be applied to the human fetus during labor, using near infrared spectroscopy. Dr. Jobsis has developed the technology for measuring both hemoglobin oxygen saturation and the redox potential of cytochrome C. This was first applied to the human neonate in conjunction with Dr. Jane Brazzy. Subsequently, other models have been applied here to the human fetus in Utah, England, and Japan. The probe being constructed at this time is an advanced model using newer technology and attached computer software and a configuration that will allow it to be applied non-invasively to the advancing head of a fetus while the mother is in active labor. This technology has the potential of being a much more specific indicator of fetal hypoxia and significant distress during labor.

Isolation and characterization of the cDNA for the receptor of Prostaglandin PGE in the human uterus.

Purification of human cytotrohoblast for studies on the regulation of thromboxane and prostacyclin production.

Collection and storing of stem cells from human blood. Umbilical blood is collected for Dr. Kurtzberg to perfect methods of storing and purifying stem cells from umbilical blood with the hope of storing in large number, stem cells for use in bone marrow transplantations.

Studying the mechanism by which human neonates born to mothers with preeclampsia have suppression of their white blood cells. The mitogenetic response of human white blood cells will be tested using additions to the media of human plasma from women with and without preeclampsia.

Polyunsaturated fatty acid precursors for prostaglandins in related substances in the blood of healthy and preeclamptic patients.