Allison Elizabeth Ashley-Koch

Conference Blood · November 3, 2025 AbstractBackground: Individuals with sickle cell disease (SCD) face an elevated risk of myeloid leukemias. Recently, myelodysplastic syndro ... Full text Cite

Nontargeted Plasma Proteomic Analysis in Sickle Cell Disease Implicates Pathways Involving Cell Structure, Immunity and Heme and Oxygen Transport in the Occurrence of Leg Ulcers

Conference Blood · November 5, 2024 Background: Leg ulcers are a recurrent and debilitating complication of sickle cell disease (SCD), significantly impacting quality of life (QOL) and decreasing survival. The pathogenesis ... Full text Cite

Electronic Heath Record Phenotypes to Classify Sickle Cell Anemia Versus Other Subtypes of Sickle Cell Disease

Conference Blood · November 5, 2024 Introduction: Sickle cell disease (SCD) comprises a group of severe hemoglobinopathies caused by mutations in the β-globin gene (HBB) and includes sickle cell anemia (homozygous SCD, HbSS ... Full text Cite

Evaluation of the Role of PIEZO1 Genetic Variants in Red Blood Cell Health in Sickle Cell Disease

Conference Blood · November 5, 2024 BackgroundSickle cell disease (SCD) is a disorder arising from genetic variation in β-globin. Homozygosity for the sickle variant (HbSS) most commonly ... Full text Cite

Novel Loci Associated with Acute Chest Syndrome in Sickle Cell Disease Patients

Conference Blood · November 5, 2024 Sickle cell disease (SCD) results from a genetic mutation in the beta hemoglobin gene. Despite the same underlying causal mutation, patients exhibit highly heterogeneous clinical outcomes ... Full text Cite

A Phase 2 Prospective Randomized Trial of Topical Sodium Nitrite in Patients with Sickle Cell Disease and Leg Ulcers

Conference Blood · November 5, 2024 Background: Leg ulcers are a recurrent, painful and severe complication of sickle cell disease (SCD). Their occurrence significantly affects quality of life and is associated with decreas ... Full text Cite

W15. A MULTIVARIATE GENOMIC INVESTIGATION OF THE EXTERNALIZING SPECTRUM AND SUICIDE RISK

Conference European Neuropsychopharmacology · October 2024 Full text Cite

Potentiated JAK-STAT Signaling Differentiates Stem Cell-Derived Podocytes of Patients with APOL1-Associated FSGS from Those of Healthy Carriers with a High-Risk APOL1 Genotype

Conference Journal of the American Society of Nephrology · October 2024 Full text Cite

POSTTRAUMATIC STRESS DISORDER, TRAUMA, AND ACCELERATED BIOLOGICAL AGING IN A DIVERSE COHORT OF POST-9/11 VETERANS

Conference PSYCHOSOMATIC MEDICINE · June 2024 Link to item Cite

TOXIC EXPOSURE DURING DEPLOYMENT IS ASSOCIATED WITH DECLINING MENTAL AND PHYSICAL HEALTH AMONG VETERANS DEPLOYED AFTER 9/11

Conference PSYCHOSOMATIC MEDICINE · June 2024 Link to item Cite

Associations between Epigenetic Age Acceleration and Psychoneurological Symptoms in Sickle Cell Disease

Conference Blood · November 2, 2023 Introduction:Sickle cell disease (SCD) affects approximately 100,000 predominantly Black or African American individuals in the United States. The disease has several acute and chronic c ... Full text Cite

PROGRESS AND PROMISE OF NEUROGENETICS METHODS TO STUDY PTSD

Conference European Neuropsychopharmacology · October 2023 Full text Cite

PTSD Moderates the Association Between Brain Aging and Epigenetic Aging

Conference BIOLOGICAL PSYCHIATRY · May 1, 2023 Link to item Cite

IDENTIFICATION OF NOVEL, REPLICABLE GENETIC RISK LOCI FOR SUICIDAL THOUGHTS AND BEHAVIORS WITHIN THE MILLION VETERAN PROGRAM (MVP) COHORT

Conference European Neuropsychopharmacology · October 2022 Full text Cite

Genome Wide Association Analysis of Iron Overload in the Trans-Omics for Precision Medicine (TOPMed) Sickle Cell Disease Cohorts

Conference Blood · November 5, 2020 Introduction: Transfusional iron (Fe) overload is a significant problem among patients with chronic, transfusion-dependent anemias. Iron overload is an important problem in pediatric sickle cell disease (SCD) patients on chronic transfusion regimen ... Full text Cite

IDENTIFICATION OF NOVEL CANDIDATE RISK GENES FOR MYELOMENINGOCELE WITHIN THE GLUCOSE HOMEOSTASIS AND FOLATE AND ONE CARBON METABOLISM NETWORKS

Conference JOURNAL OF INVESTIGATIVE MEDICINE · January 1, 2020 Full text Link to item Cite

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.

Conference Chest · December 2019 BACKGROUND: Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function ... Full text Link to item Cite

RNA sequencing of isolated cell populations expressing human APOL1 G2 risk variant reveals molecular correlates of sickle cell nephropathy in zebrafish podocytes.

Conference PLoS One · 2019 Kidney failure occurs in 5-13% of individuals with sickle cell disease and is associated with early mortality. Two APOL1 alleles (G1 and G2) have been identified as risk factors for sickle cell disease nephropathy. Both risk alleles are prevalent in indivi ... Full text Link to item Cite

Fumonisin B1 (FB1) and Fingolimod (FTY720): Tortilla Toxin and Oral Therapeutic Target Sphingolipid Pathways during Neural Tube Closure

Conference BIRTH DEFECTS RESEARCH · May 15, 2018 Link to item Cite

Meta-Analysis of DNA Methylation and PTSD in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup

Conference NEUROPSYCHOPHARMACOLOGY · November 1, 2017 Link to item Cite

27: Single nucleotide polymorphisms in the oxytocin receptor and GRK6 are associated with oxytocin dosing requirements and labor outcomes

Conference American Journal of Obstetrics and Gynecology · January 2017 Full text Cite

Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia

Conference Blood · December 2, 2016 AbstractBackground: Sickle cell anemia (SCA) is characterized by the "sickling" of red blood cells (RBCs) and red cell rigidity, as well as increased cellular adhesiveness of blood cells and endothelium, lea ... Full text Cite

Factors Related to the Progression of Sickle Cell Disease Nephropathy

Conference Blood · December 2, 2016 AbstractBACKGROUND: As life expectancy in sickle cell disease (SCD) has continued to increase, chronic diseases are playing a bigger role in morbidity and mortality in this population. SCD nephropathy is a k ... Full text Cite

GWAS Meta-Analysis of Glomerular Filtration Rate in Three Cohorts of Sickle Cell Disease Patients and In Vivo Functional Analysis Reveals Potential Nephropathy Candidate Genes

Conference Blood · December 2, 2016 AbstractBACKGROUND: Sickle cell disease nephropathy (SCDN) is a common complication of sickle cell disease (SCD) associated with risk for early mortality (Platt et al., 1994; Elmari ... Full text Cite

Epigenome-Wide Association of PTSD from Heterogeneous Cohorts with a Common Multi-Site Analysis Pipeline

Conference BIOLOGICAL PSYCHIATRY · May 1, 2016 Link to item Cite

Genome-Wide Association of Neuroimaging Phenotypes in PTSD at Multiple Sites

Conference BIOLOGICAL PSYCHIATRY · May 1, 2016 Link to item Cite

Fumonisin exposure in women linked to inhibition of an enzyme that is a key event in farm and laboratory animal diseases

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 13, 2016 Link to item Cite

Genome-Wide Evaluation of Epistasis with APOL1 Risk Variants in Sickle Cell Disease Nephropathy

Conference BLOOD · December 3, 2015 Link to item Cite

Posttraumatic Stress Disorder and Common Genetic Variants Affect Subcortical Brain Volumes in Recent Military Veterans

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2015 Link to item Cite

Mouse Genomic Loci Modulating Corneal Thickness

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Interval mapping reveals a quantitative trait locus controlling retinal ganglion cell number in mice

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

GENOMIC LOCI MODULATING GANGLION CELL DEATH FOLLOWING ELEVATED IOP IN THE MOUSE

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

A GENE REGULATORY NETWORK SHARED BETWEEN NEURULATION AND OROFACIAL DEVELOPMENT

Conference JOURNAL OF INVESTIGATIVE MEDICINE · April 1, 2015 Link to item Cite

Genes Associated with Survival in Adult Sickle Cell Disease

Conference BLOOD · December 6, 2014 Link to item Cite

Evidence for a Dominant Negative Effect Conferred By the APOL1 G2 Sickle Cell Nephropathy Risk Allele in an in Vivo Model

Conference BLOOD · December 6, 2014 Link to item Cite

Genome-Wide Association Study of Glomerular Filtration Rate in a Cohort of Sickle Cell Disease Patients

Conference BLOOD · December 6, 2014 Link to item Cite

Genes Associated with Alloimmunization to Blood Group Antigens in Sickle Cell Disease

Conference BLOOD · December 6, 2014 Link to item Cite

The Influence of APOE Genotype on Aging's Effect on Brain Structure and Cognition in Younger Adults with and without Depression

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2014 Link to item Cite

Effect of the APOE epsilon 4 allele and combat exposure on PTSD and psychiatric comorbidity

Conference BEHAVIOR GENETICS · November 1, 2014 Link to item Cite

The retinal nerve fiber layer is reduced in POAG cases homozygous for the common Six6 risk-allele of rs33912345 (Asn141His)

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Copy Number Variants associated with Glaucoma in the NEIGHBOR Study

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Rare Genetic Variants are Associated with POAG in Populations of African Ancestry

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Variants associated with exfoliation glaucoma affect promoter activity of the LOXL1 antisense gene

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

In Vivo Modeling Of Genetic Mechanisms Associated With Sickle Cell Disease Nephropathy

Conference Blood · November 15, 2013 AbstractEnd-organ damage in patients with sickle cell disease (SCD) has become an emergent clinical priority over recent decades due to the increased lifespan of affected individuals. Renal failure (ESRD), w ... Full text Cite

Rare Genetic Variants in African Americans with Primary Open Angle Glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

The Role of Protein-Coding Variants in South Africans with Exfoliation Glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

The role of SIX6 in primary open-angle glaucoma

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

ADRENERGIC GENE VARIANTS ARE ASSOCIATED WITH PLATELET AGGREGATION TO EPINEPHRINE

Conference PSYCHOSOMATIC MEDICINE · April 1, 2013 Link to item Cite

Heavy Metals, Organic Solvents and Multiple Sclerosis: An Exploratory Analysis of Gene-environment Interactions

Conference GENETIC EPIDEMIOLOGY · November 1, 2012 Link to item Cite

Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease

Conference HEPATOLOGY · October 1, 2012 Link to item Cite

Epigenetic Regulation of Gene Expression in NAFLD

Conference GASTROENTEROLOGY · May 1, 2012 Link to item Cite

An Elevated Tricuspid Regurgitant Jet Velocity in Sickle Cell Disease Is Associated with Polymorphisms in Genes Impacting Innate Immunity

Conference BLOOD · November 18, 2011 Link to item Cite

Inflammatory Polymorphisms Link the Risk of Acute Chest Syndrome with Asthma in Adults with Sickle Cell Disease

Conference BLOOD · November 18, 2011 Link to item Cite

Genotype and ADHD symptoms interact to predict adolescents' early smoking experiences in an epidemiological sample

Conference BEHAVIOR GENETICS · November 1, 2011 Link to item Cite

Evaluating human exposure to fumonisins in Guatemala and its possible role as a contributing factor to neural tube defects

Conference PHYTOPATHOLOGY · June 1, 2011 Link to item Cite

Genotypic Differences in Angiotensin Receptor Genes in Late-Life Depression

Conference BIOLOGICAL PSYCHIATRY · May 1, 2011 Link to item Cite

Variation in the AGTR1 Gene and Altered Frontotemporal Structural Connectivity in Late-Life Depression

Conference AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2011 Link to item Cite

Anti-Inflammatory Markers Are Associated with Glomerular Filtration Rate In Adults with Sickle Cell Disease

Conference BLOOD · November 19, 2010 Link to item Cite

Hydroxyurea Induces Genome-Wide Epigenetic Changes In Sickle Cell Disease

Conference Blood · November 19, 2010 AbstractAbstract 2670Introduction:Hydroxyurea (HU) is currently the only pharmacologic agent widely u ... Full text Cite

Genetic Variation In MYH9 Is Associated with Sickle Cell Disease Nephropathy

Conference BLOOD · November 19, 2010 Link to item Cite

743: Genetic variation in G-protein coupled receptor kinase-5 and preeclampsia

Conference American Journal of Obstetrics and Gynecology · December 2009 Full text Cite

Genome-Wide Studies in Sickle Cell Anemia Show Associations Between SNPs in the Olfactory Receptor Gene Cluster and Fetal Hemoglobin Concentration

Conference BLOOD · November 20, 2009 Link to item Cite

Polymorphisms in TNFα Are Associated with Cerebrovascular Events in Sickle Cell Disease.

Conference Blood · November 20, 2009 AbstractAbstract 1540Poster Board I-563Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that stimulates phagocytosis, neutro ... Full text Cite

The Effects of Chronic Opiates Pain Therapy in Sickle Cell Anemia.

Conference Blood · November 16, 2007 AbstractSickle cell disease (SCD) patients experience high rates of morbidity and early mortality. Hydroxyurea (HU) therapy is associated with decreased morbidity and mortality as well as improved patient he ... Full text Cite

Further investigation of the role of factor XIII in priapism associated with SCD

Conference BLOOD · November 16, 2007 Link to item Cite

Genetic associations with reaction time variability in AD/HD

Conference AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS · October 5, 2006 Link to item Cite

Polymorphisms in DRD2 are associated with AD/HD

Conference AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS · October 5, 2006 Link to item Cite

Trichotillomania is associated with mutations in SLITRK1

Conference AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS · October 5, 2006 Link to item Cite

Allolimmunization and clinical disease severity in sickle cell disease

Conference TRANSFUSION · September 1, 2006 Link to item Cite

Duffy genotype is associated with sickle cell nephropathy

Conference TRANSFUSION · September 1, 2006 Link to item Cite

Hereditary spastic paraplegia is caused by mutations in the novel mitochondrial protein REEP1

Conference ANNALS OF NEUROLOGY · January 1, 2006 Link to item Cite

5HTTLPR genotypes and environmental stress interact to affect sleep quality

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2005 Link to item Cite

Candidate gene polymorphisms and birth weight (BW) in the national longitudinal study of adolescent health (add health)

Conference NEUROPSYCHOPHARMACOLOGY · December 1, 2005 Link to item Cite

Priapism in SCD: Clinical and genetic correlations.

Conference BLOOD · November 16, 2005 Link to item Cite

Clinical and genetic profiles of the aging sickle cell patient.

Conference BLOOD · November 16, 2005 Link to item Cite

Results from 10k SNP genomic screen provide further evidence for genetic heterogeneity in essential tremor

Conference MOVEMENT DISORDERS · January 1, 2005 Link to item Cite

Genetic Polymorphisms Associated with Risk for Pulmonary Hypertension and Proteinuria in Sickle Cell Disease.

Conference Blood · November 16, 2004 AbstractIn order to identify genetic variants that modify the clinical severity of sickle cell disease (SCD), 118 patients with Hb SS or Hb Sβ0-thalassemia at our centers have undergone echocardiography (ech ... Full text Cite

Pulmonary Hypertension in SS, SC and Sβ Thalassemia: Prevalence, Associated Clinical Syndromes, and Mortality.

Conference Blood · November 16, 2004 AbstractThe natural history and mechanisms associated with pulmonary hypertension (pHTN) in sickle cell disease (SCD) are incompletely characterized. We investigated the prevalence of pHTN, diagnosed by echo ... Full text Cite

Effects of Single Nucleotide Polymorphisms of the β2 Adrenergic Receptor and of Adenylate Cyclase on Sickle Red Cell Adhesion to Laminin.

Conference Blood · November 16, 2004 AbstractSingle nucleotide polymorphisms (SNPs) of the β2 adrenergic receptor (β2AR) gene (ADRB2) on chromosome 5 have been implicated in clinical variability of several cardiopulmonary disorders. Also, Hoppe ... Full text Cite

An intragenic modifier of hereditary spastic paraplegia due to spastin gene mutation suggests a role for cyclin-dependent kinase 5 in HSP pathogenesis.

Conference AMERICAN JOURNAL OF HUMAN GENETICS · November 1, 2003 Link to item Cite

Examination of epigenetic factors and gene-gene interactions influencing genetic susceptibility at chromosomes 7 and 15 for autistic disorder.

Conference AMERICAN JOURNAL OF HUMAN GENETICS · October 1, 2000 Link to item Cite

Characterization of an inversion breakpoint in a multiplex autistic disorder family: Defining the candidate region on chromosome 7q.

Conference MOLECULAR PSYCHIATRY · September 1, 1999 Link to item Cite