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Amanda S MacLeod

Adjunct Associate Professor in the Department of Dermatology
Dermatology

Selected Publications


Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.

Journal Article J Invest Dermatol · August 2022 The skin serves as the interface between the body and the environment and plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins (AVPs) are part of the innate host defense system and provide protection against viral pathogens. H ... Full text Link to item Cite

ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.

Journal Article J Invest Dermatol · October 2021 UVR and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells promote cSCC carcinogenesis, and in other solid tumors, infiltrating regulatory T cells and CD8+ T cells express ectonucleoside triphosphate d ... Full text Link to item Cite

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Journal Article JAAD Int · September 2021 BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ... Full text Link to item Cite

Age and circadian regulation of cutaneous innate antiviral immunity at homeostasis

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2021 Cite

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.

Journal Article Front Med (Lausanne) · 2021 Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ... Full text Open Access Link to item Cite

IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.

Journal Article Front Immunol · 2021 Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells from these leukocyte clusters play critical roles in the efferent ... Full text Link to item Cite

What causes hidradenitis suppurativa ?-15 years after.

Journal Article Exp Dermatol · December 2020 Featured Publication The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Ger ... Full text Link to item Cite

The Cutaneous Wound Innate Immunological Microenvironment.

Journal Article Int J Mol Sci · November 19, 2020 The skin represents the first line of defense and innate immune protection against pathogens. Skin normally provides a physical barrier to prevent infection by pathogens; however, wounds, microinjuries, and minor barrier impediments can present open avenue ... Full text Link to item Cite

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

Journal Article JCI Insight · October 2, 2020 Featured Publication Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approache ... Full text Link to item Cite

Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure.

Journal Article J Allergy Clin Immunol · May 2020 Featured Publication BACKGROUND: Control of the inflammatory response is critical to maintaining homeostasis, and failure to do so contributes to the burden of chronic inflammation associated with several disease states. The mechanisms that underlie immunosuppression, however, ... Full text Link to item Cite

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.

Journal Article Science advances · April 2020 Featured Publication In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense. Here, we identify and characterize the induction of cutaneous innate antiviral proteins in response to IL-27 and its functional role during cuta ... Full text Cite

Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.

Journal Article J Invest Dermatol · January 2020 Featured Publication The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, includi ... Full text Link to item Cite

Age and circadian regulation of cutaneous innate antimicrobial immunity

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2020 Cite

Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis.

Journal Article Front Immunol · 2020 Featured Publication Current treatments for chronic immune-mediated diseases such as psoriasis, rheumatoid arthritis, or Crohn's disease commonly rely on cytokine neutralization using monoclonal antibodies; however, such approaches have drawbacks. Frequent repeated dosing can ... Full text Link to item Cite

Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.

Journal Article Front Immunol · 2020 The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the cours ... Full text Link to item Cite

Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.

Journal Article J Invest Dermatol · August 2022 The skin serves as the interface between the body and the environment and plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins (AVPs) are part of the innate host defense system and provide protection against viral pathogens. H ... Full text Link to item Cite

ENTPD1 (CD39) Expression Inhibits UVR-Induced DNA Damage Repair through Purinergic Signaling and Is Associated with Metastasis in Human Cutaneous Squamous Cell Carcinoma.

Journal Article J Invest Dermatol · October 2021 UVR and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells promote cSCC carcinogenesis, and in other solid tumors, infiltrating regulatory T cells and CD8+ T cells express ectonucleoside triphosphate d ... Full text Link to item Cite

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Journal Article JAAD Int · September 2021 BACKGROUND: Hidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatmen ... Full text Link to item Cite

Age and circadian regulation of cutaneous innate antiviral immunity at homeostasis

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2021 Cite

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa.

Journal Article Front Med (Lausanne) · 2021 Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by recurrent abscesses, nodules, and sinus tracts in areas of high hair follicle and sweat gland density. These sinus tracts can present with purulent drainage and scar form ... Full text Open Access Link to item Cite

IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses.

Journal Article Front Immunol · 2021 Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells from these leukocyte clusters play critical roles in the efferent ... Full text Link to item Cite

What causes hidradenitis suppurativa ?-15 years after.

Journal Article Exp Dermatol · December 2020 Featured Publication The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Ger ... Full text Link to item Cite

The Cutaneous Wound Innate Immunological Microenvironment.

Journal Article Int J Mol Sci · November 19, 2020 The skin represents the first line of defense and innate immune protection against pathogens. Skin normally provides a physical barrier to prevent infection by pathogens; however, wounds, microinjuries, and minor barrier impediments can present open avenue ... Full text Link to item Cite

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis.

Journal Article JCI Insight · October 2, 2020 Featured Publication Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Using proteomic and transcriptomic approache ... Full text Link to item Cite

Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure.

Journal Article J Allergy Clin Immunol · May 2020 Featured Publication BACKGROUND: Control of the inflammatory response is critical to maintaining homeostasis, and failure to do so contributes to the burden of chronic inflammation associated with several disease states. The mechanisms that underlie immunosuppression, however, ... Full text Link to item Cite

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.

Journal Article Science advances · April 2020 Featured Publication In the skin, antiviral proteins and other immune molecules serve as the first line of innate antiviral defense. Here, we identify and characterize the induction of cutaneous innate antiviral proteins in response to IL-27 and its functional role during cuta ... Full text Cite

Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.

Journal Article J Invest Dermatol · January 2020 Featured Publication The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, includi ... Full text Link to item Cite

Age and circadian regulation of cutaneous innate antimicrobial immunity

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2020 Cite

Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis.

Journal Article Front Immunol · 2020 Featured Publication Current treatments for chronic immune-mediated diseases such as psoriasis, rheumatoid arthritis, or Crohn's disease commonly rely on cytokine neutralization using monoclonal antibodies; however, such approaches have drawbacks. Frequent repeated dosing can ... Full text Link to item Cite

Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.

Journal Article Front Immunol · 2020 The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the cours ... Full text Link to item Cite

Activation of nociceptive fibers following skin injury triggers antiviral host defense immunity

Conference JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY · October 1, 2019 Featured Publication Link to item Cite

494 UV-induced CD39 expression promotes epidermal DNA damage and development of cutaneous squamous cell carcinoma

Conference Journal of Investigative Dermatology · September 2019 Featured Publication Full text Cite

Bad "Staph" in the Wound Environment of Diabetic Foot Ulcers.

Journal Article Cell Host Microbe · May 8, 2019 Featured Publication Diabetic foot ulcers (DFUs) are a leading cause of high morbidity among diabetic patients. In this issue of Cell Host & Microbe, Kalan et al. (2019) examine the microbial bio-burden of DFUs and reveal biofilm and virulence pathways in the microbial metagen ... Full text Link to item Cite

Inverted U-shaped relationship between vitamin D and ever-reported eczema in US adults.

Journal Article Allergy · May 2019 Featured Publication BACKGROUND: Eczema is a skin condition which affects up to 10% to 20% of people worldwide. Previous literature finds that low vitamin D levels may be a risk factor for eczema, but the association is not clear. METHODS: We used the cross-sectional data from ... Full text Link to item Cite

Cutaneous antiviral protein expression is regulated by the circadian clock

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2019 Featured Publication Link to item Cite

UV-induced CD39 expression on immunosuppressive memory T cells in human cutaneous squamous cell carcinoma

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2019 Featured Publication Link to item Cite

Activation of Trpv1(+) nociceptive fibers stimulates an innate antiviral immune response following skin injury

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2019 Featured Publication Link to item Cite

Staphylococcus aureus components increase Th2 response in cutaneous lymphoma

Conference JOURNAL OF INVESTIGATIVE DERMATOLOGY · May 1, 2019 Link to item Cite

Autoimmune Theories of Chronic Spontaneous Urticaria.

Journal Article Front Immunol · 2019 Featured Publication Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable pro ... Full text Link to item Cite

The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.

Journal Article PLoS One · 2019 Featured Publication Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle and sweat gland density. The pathogenesis of HS is not well understood but appears to involve dysbi ... Full text Link to item Cite

The Skin and Intestinal Microbiota and Their Specific Innate Immune Systems.

Journal Article Front Immunol · 2019 Featured Publication The skin and intestine are active organs of the immune system that are constantly exposed to the outside environment. They support diverse microbiota, both commensal and pathogenic, which encompass bacteria, viruses, fungi, and parasites. The skin and inte ... Full text Link to item Cite

Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.

Journal Article Science · November 9, 2018 Featured Publication Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive ... Full text Link to item Cite

Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.

Journal Article Sci Signal · November 6, 2018 The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting CXCR3 and other chemokine receptors are largely ineffective in treating inflammation. Chemokines, ... Full text Link to item Cite

A trichogenic tumor with aggressive features initially diagnosed as basal cell carcinoma.

Journal Article Dermatol Online J · September 15, 2018 Trichoblastic carcinoma is a rare carcinoma often arising in a pre-existing trichoblastoma. It may resemble basal cell carcinoma, posing a diagnostic challenge. Trichoblastic carcinoma is divided into low-grade and high-grade tumors. Low-grade tumors resem ... Link to item Cite

Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

Journal Article Sci Transl Med · July 25, 2018 Featured Publication Meibomian glands (MGs) are sebaceous glands of the eyelid margin that secrete lipids needed to avert tear evaporation and to help maintain ocular surface homeostasis. Obstruction of MGs or other forms of MG dysfunction can promote chronic diseases of the o ... Full text Link to item Cite

Innate Antiviral Immunity in the Skin.

Journal Article Trends Immunol · April 2018 Featured Publication Barrier sites such as the skin play a critical role in immune defense. They must maintain homeostasis with commensals and rapidly detect and limit pathogen invasion. This is accomplished in part through the production of endogenous antimicrobial peptides a ... Full text Link to item Cite

Inflammation in Wound Repair: Role and Function of Inflammation in Wound Repair

Chapter · January 23, 2018 Coordination of the innate immune and adaptive system during the inflammation stage is essential to successful wound healing. The process of acute wound healing can be divided into three phases: inflammation, proliferation, and remodeling. It is during the ... Full text Cite

Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.

Journal Article Elife · December 4, 2017 The cutaneous wound-healing program is a product of a complex interplay among diverse cell types within the skin. One fundamental process that is mediated by these reciprocal interactions is the mobilization of local stem cell pools to promote tissue regen ... Full text Link to item Cite

Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.

Journal Article J Immunol · September 1, 2017 The innate immune components that modulate allergic contact hypersensitivity (CHS) responses are poorly defined. Using human skin from contact dermatitis patients and a mouse model of CHS, we find that hapten allergens disrupt the Arginase1 (Arg1) and indu ... Full text Link to item Cite

IL-27 PROMOTES INNATE IMMUNITY AND ANTIVIRAL COMPETENCE IN WOUNDS

Conference WOUND REPAIR AND REGENERATION · July 1, 2017 Link to item Cite

IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense.

Conference J Invest Dermatol · May 2017 Skin wound repair requires a coordinated program of epithelial cell proliferation and differentiation as well as resistance to invading microbes. However, the factors that trigger epithelial cell proliferation in this inflammatory process are incompletely ... Full text Open Access Link to item Cite

594 IL-27 promotes innate antiviral competence in wounds

Conference Journal of Investigative Dermatology · May 2017 Full text Cite

TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis.

Journal Article J Invest Dermatol · April 2017 Mascarenhas et al. report that TRPV4 expression is upregulated in mast cells in response to the proteolytic cathelicidin fragment LL37 in a murine rosacea model and that TRPV4 loss of function attenuates mast cell degranulation. These findings render TRPV4 ... Full text Link to item Cite

Emerging Skin T-Cell Functions in Response to Environmental Insults.

Journal Article J Invest Dermatol · February 2017 Featured Publication Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutan ... Full text Link to item Cite

IL-27 Facilitates Skin Wound Healing through Induction of Epidermal Proliferation and Host Defense

Journal Article JOURNAL OF INVESTIGATIVE DERMATOLOGY · 2017 Featured Publication Full text Cite

OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

Journal Article Clin Cancer Res · August 15, 2016 Featured Publication PURPOSE: Cutaneous squamous cell carcinoma (cSCC) is the most common human cancer with metastatic potential. Despite T cells accumulating around cSCCs, these tumors continue to grow and persist. To investigate reasons for failure of T cells to mount a prot ... Full text Link to item Cite

Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch.

Journal Article J Biol Chem · May 6, 2016 TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to neurosensory function remains to be elucidated. We recently reported TRPV4 as a critical component of the ... Full text Open Access Link to item Cite

The Innate Immune System in Acute and Chronic Wounds.

Journal Article Adv Wound Care (New Rochelle) · February 1, 2016 Featured Publication Significance: This review article provides an overview of the critical roles of the innate immune system to wound healing. It explores aspects of dysregulation of individual innate immune elements known to compromise wound repair and promote nonhealing wou ... Full text Open Access Link to item Cite

Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.

Journal Article J Immunol · June 15, 2014 Featured Publication Skin-resident T cells have been shown to play important roles in tissue homeostasis and wound repair, but their role in UV radiation (UVR)-mediated skin injury and subsequent tissue regeneration is less clear. In this study, we demonstrate that acute UVR r ... Full text Link to item Cite

IL-1β-dependent activation of dendritic epidermal T cells in contact hypersensitivity.

Journal Article J Immunol · April 1, 2014 Featured Publication Substances that penetrate the skin surface can act as allergens and induce a T cell-mediated inflammatory skin disease called contact hypersensitivity (CHS). IL-17 is a key cytokine in CHS and was originally thought to be produced solely by CD4(+) T cells. ... Full text Link to item Cite

A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union

Journal Article Science · January 1, 2014 Featured Publication We report the discovery of a broadly reactive antibody-binding protein (Protein M) from human mycoplasma. The crystal structure of the ectodomain of transmembrane Protein M differs from other known protein structures, as does its mechanism of antibody bind ... Full text Cite

Dendritic epidermal T cells regulate skin antimicrobial barrier function.

Journal Article J Clin Invest · October 2013 Featured Publication The epidermis, the outer layer of the skin, forms a physical and antimicrobial shield to protect the body from environmental threats. Skin injury severely compromises the epidermal barrier and requires immediate repair. Dendritic epidermal T cells (DETC) r ... Full text Link to item Cite

Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response.

Journal Article Nat Commun · December 6, 2011 Featured Publication Activin is an important orchestrator of wound repair, but its potential role in skin carcinogenesis has not been addressed. Here we show using different types of genetically modified mice that enhanced levels of activin in the skin promote skin tumour form ... Full text Link to item Cite

Functions of skin-resident γδ T cells.

Journal Article Cell Mol Life Sci · July 2011 Featured Publication The murine epidermis contains resident T cells that express a canonical γδ TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low ... Full text Link to item Cite

Cutaneous infection by Mycobacterium haemophilum and kansasii in an IgA-deficient man.

Journal Article BMC Dermatol · January 26, 2011 Featured Publication BACKGROUND: The prevalence of infections by nontuberculous mycobacteria (NTM) has steadily increased over the past decades, especially in immunocompromised patients. CASE PRESENTATION: We present a patient with IgA-deficiency and mixed cutaneous infection ... Full text Link to item Cite

EGFR (trans)activation mediates IL-8 and distinct human antimicrobial peptide and protein production following skin injury.

Journal Article J Invest Dermatol · April 2010 Featured Publication Antimicrobial peptides and proteins (AMPs) are tools of the innate immune system employed at injury sites to protect the host from invading microbes and to promote wound repair. In this issue, Roupé et al. characterize epidermal innate immune responses ind ... Full text Link to item Cite

The host defense peptide cathelicidin is required for NK cell-mediated suppression of tumor growth.

Journal Article J Immunol · January 1, 2010 Featured Publication Tumor surveillance requires the interaction of multiple molecules and cells that participate in innate and the adaptive immunity. Cathelicidin was initially identified as an antimicrobial peptide, although it is now clear that it fulfills a variety of immu ... Full text Link to item Cite

Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.

Journal Article J Invest Dermatol · September 2009 Featured Publication Innate immune responses involve the production of antimicrobial peptides (AMPs), chemokines, and cytokines. We report here the identification of B-cell leukemia (Bcl)-3 as a modulator of innate immune signaling in keratinocytes. In this study, it is shown ... Full text Link to item Cite

Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis.

Journal Article PLoS One · July 22, 2009 Featured Publication Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease. Vitamin D analogs like calcipotriol have antipsoriatic effects and might mediate this ... Full text Link to item Cite

Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes.

Journal Article J Invest Dermatol · November 2008 Featured Publication Calcineurin inhibitors are potent inhibitors of T-cell-receptor mediated activation of the adaptive immune system. The effects of this class of drug on the innate immune response system are not known. Keratinocytes are essential to innate immunity in skin ... Full text Link to item Cite

Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.

Journal Article J Invest Dermatol · April 2008 Featured Publication Hormonally active vitamin D(3)-1,25-dihydroxyvitamin D(3) (1,25D3)-acts as a signaling molecule in cutaneous immunity by increasing pattern recognition through Toll-like receptor-2 (TLR2), and increasing the expression and function of antimicrobial peptide ... Full text Link to item Cite

S100A15, an antimicrobial protein of the skin: regulation by E. coli through Toll-like receptor 4.

Journal Article J Invest Dermatol · November 2007 Featured Publication E. coli is a gram-negative bacterium rarely found on human skin. We investigated whether direct interaction of E. coli with keratinocytes might induce an innate immune response through recognition by pattern recognition receptors. The capacity of E. coli t ... Full text Link to item Cite

Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium.

Journal Article Exp Dermatol · August 2007 Featured Publication The human calcium-binding protein (hS100A15) was first identified in inflamed hyperplastic psoriatic skin, where the S100A15 gene is transcribed into two mRNA splice variants, hS100A15-S and hS100A15-L. To compare the contribution of the human S100A15 (hS1 ... Full text Link to item Cite

Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.

Journal Article J Clin Invest · March 2007 Featured Publication An essential element of the innate immune response to injury is the capacity to recognize microbial invasion and stimulate production of antimicrobial peptides. We investigated how this process is controlled in the epidermis. Keratinocytes surrounding a wo ... Full text Link to item Cite

Innate immunity and antimicrobial defense systems in psoriasis.

Journal Article Clin Dermatol · 2007 Featured Publication Psoriasis is a chronic inflammatory disorder that is mediated by elements of the innate and adaptive immune systems. Its characteristic features in the skin consist of inflammatory changes in both dermis and epidermis, with abnormal keratinocyte differenti ... Full text Link to item Cite

Fever, episcleritis, epistaxis, and rash after safari holiday in Swaziland.

Journal Article Arch Dermatol · October 2006 Featured Publication Full text Link to item Cite

[Rickettsiosis subsequent to vacation in Swaziland].

Journal Article Hautarzt · April 2006 Featured Publication Full text Link to item Cite

[A severe course of bullous pemphigoid in a young man].

Journal Article Hautarzt · April 2006 Featured Publication Full text Link to item Cite

[Reactive perforating collagenosis disease].

Journal Article Hautarzt · October 2005 Featured Publication Full text Link to item Cite

[Livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome].

Journal Article Hautarzt · April 2004 Featured Publication A 64-year-old male patient presented with painful ulcerations and livedo racemosa of both lower limbs. He had a history of cerebral and myocardial infarctions. Dermatohistologic findings and laboratory tests of the patient's coagulation system revealed the ... Full text Link to item Cite

[IgA pemphigus. Successful treatment with mycophenolate mofetil].

Journal Article Hautarzt · April 2004 Featured Publication IgA pemphigus is a rare intraepidermal autoimmune disease characterized by the presence of intercellular IgA deposits, intraepidermal acantholysis with infiltration of neutrophils, and circulating IgA autoantibodies against keratinocyte cell surface compon ... Full text Link to item Cite

Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin.

Journal Article Diabetologia · April 2004 Featured Publication AIMS/HYPOTHESIS: We studied the impact of the reactive oxygen species hydrogen peroxide (H2O2) and antioxidative enzymes on the pathogenesis of diabetes induced by multiple low doses of streptozotocin (MLD-STZ). METHODS: We isolated the islets of C57BL/6 m ... Full text Link to item Cite