Journal articleAnn Allergy Asthma Immunol · May 2026
BACKGROUND: Atopic comorbidities are common in patients with atopic dermatitis (AD) and increase disease burden. Lebrikizumab monotherapy demonstrated efficacy and safety through 52 weeks in patients with moderate-to-severe AD in phase 3 trials (ADvocate1 ...
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Journal articleDermatitis · March 10, 2026
Background: Prevalence of positive patch test (ppt) reactions to propolis in Europe has varied with different allergen source origins. Compared with previous cycles, the North American Contact Dermatitis Group (NACDG) noted a marked increase in propolis po ...
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Journal articleDermatology and Therapy · February 1, 2026
Historically, dermatology research and clinical practice in the United States (USA) have overlooked important considerations in the dermatological care of individuals with skin of color (SOC). With growing awareness of the disparities in health outcomes am ...
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Journal articleDermatol Ther (Heidelb) · February 2026
INTRODUCTION: Patients with moderate-to-severe atopic dermatitis (AD) who discontinue dupilumab need additional therapeutic options. Lebrikizumab's distinct mechanism of action may provide that alternative treatment. We evaluated efficacy and safety of leb ...
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Journal articleCutis · February 2026
Patch testing (PT) is the gold standard diagnostic test for allergic contact dermatitis (ACD) and is essential for guiding allergen avoidance. Comprehensive PT refers to the completion of PT for all potentially relevant and testable allergens for a given p ...
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Journal articleAdvances in Therapy · January 1, 2026
Introduction: Understanding how race and ethnicity affect health outcomes in patients with atopic dermatitis (AD) is crucial to optimizing patient-centered care and narrowing health disparities. Here, we aim to explore social drivers of health, treatment e ...
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Journal articleJ Dermatolog Treat · December 2025
BACKGROUND: Lebrikizumab monotherapy significantly improved signs and symptoms in patients with moderate-to-severe atopic dermatitis (AD) in phase 3 Advocate1 and ADvocate2 studies. OBJECTIVE: To evaluate improvements in patient-reported symptoms and quali ...
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Journal articleJ Dermatolog Treat · December 2025
PURPOSE OF THE STUDY: Head, neck (HN), and face involvement in atopic dermatitis (AD) poses a major psychological burden and can be challenging to effectively treat. New appearance of HN dermatitis has been reported with biologics used to treat AD. Lebriki ...
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Journal articleJ Eur Acad Dermatol Venereol · September 2025
BACKGROUND: Hand eczema (HE) is a common and complex skin disease. A uniform set of core outcomes and related measures for use in clinical trials is lacking, making it difficult to compare results across HE studies. OBJECTIVE: To reach consensus on a set o ...
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Journal articleAm J Clin Dermatol · September 2025
BACKGROUND: Data are lacking to guide diagnosis and treatment in patients with skin of color and atopic dermatitis (AD), a population traditionally underrepresented in clinical trials. OBJECTIVE: The aim of this study was to evaluate the efficacy and safet ...
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Journal articleJ Am Acad Dermatol · May 2025
BACKGROUND: Lebrikizumab demonstrated statistically significant improvements in patients with moderate-to-severe atopic dermatitis at week 16 with a durable response up to week 52. OBJECTIVE: To investigate the efficacy of lebrikizumab-treated patients at ...
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Journal articleCutis · April 2025
For patients, managing allergic contact dermatitis (ACD) can be like a strategic game of poker-many begin with a few chips, but only those who can skillfully read the cards and avoid common pitfalls can maximize their winnings. Physicians should be aware o ...
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Journal articleArch Dermatol Res · January 10, 2025
BACKGROUND: Psoriasiform dermatitis can be defined both clinically and histologically, but is not a traditionally recognized clinical or histologic diagnosis. OBJECTIVE: Analyze the final clinical diagnosis, demographics and clinical characteristics in pat ...
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Journal articleDermatitis · 2025
Background: Mentha piperita (MP; peppermint) oil has many commercial uses. Objective: To characterize the epidemiology of contact allergy to MP oil 2% petrolatum. Methods: Retrospective analysis of North American Contact Dermatitis Group data (2009-2020). ...
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Journal articleDermatitis · 2025
Toluene-2,5-diamine sulfate (PTDS), also known as toluene diamine sulfate or 2,5-diaminotoluene sulfate, is an aromatic amine that can be used as a paraphenylenediamine (PPD) hair dye alternative. Patients may develop contact allergy to PTDS, and it is oft ...
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Journal articleSkin Journal of Cutaneous Medicine · January 1, 2025
ntroduction: Lebrikizumab is a novel monoclonal antibody that binds with high affinity and a slow off-rate to interleukin (IL)-13, thereby blocking the downstream effects of IL13 with high potency. ADmirable (NCT05372419) is an ongoing, open-label, Phase 3 ...
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Journal articleSkin Journal of Cutaneous Medicine · January 1, 2025
Introduction: Atopic dermatitis (AD) is a chronic, relapsing, heterogeneous inflammatory disorder. After a flare-up, the affected skin may have areas of post-inflammatory hyper- or hypo-pigmentation (PIH). A new scale, the PDCA-Derm™, assesses PIH by compa ...
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Journal articleSkin Journal of Cutaneous Medicine · January 1, 2025
ADapt (NCT05369403), an open-label, Phase 3b, 24-week study, evaluated the efficacy and safety of lebrikizumab (LEB) in patients with moderate-to-severe atopic dermatitis (AD) previously treated with dupilumab (DUPI). Patients must have discontinued DUPI d ...
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Journal articleDermatitis · 2025
Background: Patch testing is an important diagnostic tool for the assessment of allergic contact dermatitis (ACD). Objective: This study documents the North American Contact Dermatitis Group (NACDG) patch testing results from 2021 to 2022. Methods: At 12 c ...
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Journal articlePediatr Dermatol · 2025
Atopic dermatitis (AD) is a common and burdensome disease. Treatment options for pediatric and adolescent patients (< 18 years old) with moderate-to-severe AD are limited, and real-world data on disease burden are lacking. This study examined patient-repor ...
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Journal articleContact Dermatitis · December 2024
BACKGROUND: Photoallergic contact dermatitis (PACD) is a delayed hypersensitivity reaction to allergens only in the presence of ultraviolet radiation in sunlight. Photopatch testing (PhotoPT) is necessary to confirm the diagnosis of PACD. There are few pub ...
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Journal articleJEADV Clinical Practice · September 1, 2024
Background: Atopic dermatitis (AD) is associated with patient burden, but few studies describe the anatomic distribution of the disease or the impact of number of lesion locations. Objectives: To describe lesion locations and assess the relationship betwee ...
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Journal articleDermatology and Therapy · May 1, 2024
Introduction: Atopic dermatitis (AD) affects multiple areas of the body, some of which may be more refractory to treatment. We evaluated improvements in the Eczema Area and Severity Index (EASI) by body region and clinical signs for each body region in leb ...
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Journal articleJ Am Acad Dermatol · February 2024
BACKGROUND: Isothiazolinones are a common cause of allergic contact dermatitis. OBJECTIVE: To examine the prevalence of positive patch test reactions to isothiazolinones from 2017-2020 and characterize isothiazolinone-allergic (Is+) patients compared with ...
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Journal articleDermatitis · 2024
Background: Allergic contact Dermatitis® (ACD) in older adults (OA) represents a significant health burden, but few studies examine the prevalence and characteristics of contact allergy and ACD in this population. Objective: To compare positive and clinica ...
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Journal articleDermatitis · 2024
Background: Allergic contact dermatitis is frequently caused by metals, including multiple metals simultaneously. Objectives: To assess characteristics and associations of positive and clinically relevant patch test (PT) reactions with solitary and concurr ...
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Journal articleDermatitis · 2024
Background: Supplemental patch testing is an adjunct to standard patch test screening series. Objective: To determine the demographics, characteristics, frequency, relevance, and interpretation of patch test reactions for supplemental patch testing. Method ...
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Journal articleDermatitis · 2024
Background: Doubtful patch test reactions generally do not meet criterion for positivity in patch testing. However, the North American Contact Dermatitis Group (NACDG) allows for doubtful reactions to be coded with a final determination of "allergic/positi ...
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Journal articleDermatitis · 2024
Background: Construction workers (CWs) are at risk for occupational contact dermatitis (CD) owing to workplace exposures. Objective: Determine the prevalence of occupational allergic CD and characterize common occupational allergens in CWs referred for pat ...
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Journal articleJ Dermatolog Treat · December 2023
OBJECTIVE: Patients with atopic dermatitis (AD) have low treatment satisfaction. In this study, we evaluated the humanistic burden, treatment satisfaction, and treatment expectations in patients with AD in the United States. METHODS: Adults with AD recruit ...
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Journal articleJ Dermatolog Treat · December 2023
BACKGROUND: Real-world data on the effectiveness of systemic therapy in atopic dermatitis (AD) are limited. METHODS: Adult patients with AD in the CorEvitas AD registry (2020-2021) who received systemic therapies for 4-12 months prior to enrollment were in ...
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Journal articleSkin Journal of Cutaneous Medicine · November 1, 2023
BACKGROUND AD is a chronic skin disease that can be a serious burden, affecting sleep, daily activities, and social relationships1 Lebrikizumab is a monoclonal antibody that binds with high affinity and slow off-rate to IL-13, thereby blocking the downstre ...
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Journal articleDermatology and Therapy · September 1, 2023
Introduction: This real-world, cross-sectional study compared sociodemographic, clinical and treatment characteristics, and patient-reported outcomes (PROs) among racial/ethnic groups in patients with atopic dermatitis (AD) who are candidates for systemic ...
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Journal articleContact Dermatitis · April 2023
BACKGROUND: An updated understanding of allergic contact cheilitis is needed. OBJECTIVES: To characterize clinical characteristics and allergen relevance in patients with cheilitis referred for patch testing. METHODS: Retrospective analysis of 43 772 patie ...
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Journal articleJAMA Dermatol · March 1, 2023
IMPORTANCE: The common use of isothiazolinones as preservatives is a global cause of allergic contact dermatitis. Differences in allowable concentrations of methylisothiazolinone (MI) exist in Europe, Canada, and the US. OBJECTIVE: To compare the prevalenc ...
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Journal articleDermatitis · 2023
Background: Benzophenone (BZP)-3 and BZP-4 are ultraviolet (UV) absorbers used in sunscreens and personal care products (PCPs) and may cause allergic contact dermatitis. Objective: To characterize positive patch test reactions to BZP-3 (10% in petrolatum [ ...
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Journal articleDermatitis · 2023
Background: Patch testing is an important diagnostic tool for assessment of allergic contact dermatitis (ACD). Objective: This study documents the North American Contact Dermatitis Group (NACDG) patch testing results from January 1, 2019, to December 31, 2 ...
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Journal articleDermatitis · 2023
Background: Cobalt is a recognized cause of allergic contact dermatitis (ACD); however, detailed information on patient characteristics, sites, and sources is lacking. Objective: The aim of the study is to assess trends in patch test reactions to cobalt an ...
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Journal articleDermatitis · 2023
Background: Chlorhexidine is an antiseptic that may cause allergic contact dermatitis. Objectives: To describe the epidemiology of chlorhexidine allergy and characterize positive patch test reactions. Methods: This retrospective study analyzed patients pat ...
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Journal articleDermatitis · 2023
Background/Objectives: Paraphenylenediamine (PPD) is an aromatic amine dye that may cause allergic contact dermatitis. This study examines the epidemiology of allergic patch test reactions to PPD. Methods: This retrospective analysis characterizes individu ...
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Journal articleJ Am Acad Dermatol · November 2022
BACKGROUND: Ammonium persulfate (APS), an oxidizing agent used in hair products, manufacturing, and pool/spa water, can cause skin reactions, including allergic contact dermatitis. OBJECTIVE: To characterize positive patch test reactions to APS (2.5% petro ...
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Journal articleArch Dermatol Res · November 2022
BACKGROUND: Few studies explored the relationship between stasis dermatitis (SD) and allergic contact dermatitis (ACD). OBJECTIVE: To examine trends, associations, and clinical relevance of ACD in patients referred for patch testing who had a final SD diag ...
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Journal articleJ Am Acad Dermatol · November 2022
BACKGROUND: Identification of allergens causing medical adhesive contact allergy is difficult. OBJECTIVE: To characterize the demographics, clinical characteristics, patch test results, and occupational data for North American Contact Dermatitis Group pati ...
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Journal articleJ Am Acad Dermatol · November 2022
BACKGROUND: Alkyl glucosides are nonionic surfactants that are increasingly used in personal care products. OBJECTIVE: To characterize positive patch test reactions to decyl glucoside (5% petrolatum, tested 2009-2018) and lauryl glucoside (3% petrolatum, t ...
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Journal articleContact Dermatitis · November 2022
BACKGROUND: Allergic contact dermatitis (ACD) to cobalt is more common in children and adolescents than adults. However, detailed information on sites and sources of cobalt ACD is limited. OBJECTIVES: To assess trends in positive and clinically relevant pa ...
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Journal articleJ Am Acad Dermatol · November 2022
BACKGROUND: Dermatitis localized to hands (HD), feet (FD), or both hands and feet (HFD) has multiple etiologies, including atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis. Unfortunately, little is known about clinical differ ...
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Journal articleDermatitis · May 2022
BACKGROUND: Lanolin is an important cause of allergic contact dermatitis. OBJECTIVES: The aims of this study were to describe the epidemiology of lanolin allergy and to assess trends in patch test reactions to lanolin over time. METHODS: This study used a ...
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Journal articleJ Am Acad Dermatol · April 2022
BACKGROUND: Patch testing is an important diagnostic tool for suspected allergic contact dermatitis (ACD) in occupational settings. OBJECTIVE: Provide an overview of occupational skin disease (OSD) and an analysis of occupational ACD in North American pati ...
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Journal articleJ Am Acad Dermatol · April 2022
BACKGROUND: An updated understanding of allergic contact dermatitis is needed, particularly in children. OBJECTIVES: To compare positive and clinically relevant reactions in children versus adults referred for patch testing. METHODS: Retrospective analysis ...
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Journal articleDermatitis · March 2022
BACKGROUND/OBJECTIVES: Topical medications may lead to allergic contact dermatitis. This study characterized positive patch test reactions associated with medications in patients evaluated by the North American Contact Dermatitis Group (NACDG). METHODS: Th ...
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Journal articleCurrent Dermatology Reports · March 1, 2022
Purpose of Review: To describe contact allergy to diabetes devices and recommend steps for evaluation and management of these complex cutaneous complications. Recent Findings: Allergens reported in glucose monitors include isobornyl acrylate (IBOA), coloph ...
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Journal articleDermatitis · January 2022
BACKGROUND/OBJECTIVES: Carvone, a flavoring agent, may cause allergic contact dermatitis. This study summarizes patch test reactions to carvone in patients tested by the North American Contact Dermatitis Group, 2009 to 2018. METHODS: This was a retrospecti ...
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Journal articleDermatitis · January 2022
BACKGROUND: Hair care products (HCPs) may cause both allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). OBJECTIVES: The aims of the study were to determine the prevalence of HCP-associated ICD/ACD and to characterize relevant allergen ...
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Journal articleDermatitis · January 2022
BACKGROUND: Ethylhexylglycerin (EHG) is a recently recognized contact allergen. OBJECTIVE: The aims of the study were to characterize individuals with positive patch test reactions to EHG and to analyze reaction strength, clinical relevance, and allergen s ...
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Journal articleDermatitis · January 2022
BACKGROUND: Shoe contact allergy can be difficult to diagnose and manage. OBJECTIVE: The aim of the study was to characterize demographics, clinical characteristics, patch test results, and occupational data for the North American Contact Dermatitis Group ...
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Journal articleDermatitis · January 2022
BACKGROUND: Dental personnel are at risk of developing occupational contact dermatitis. OBJECTIVES: The aims of the study were to determine prevalence of occupational contact dermatitis in dental personnel referred for patch testing and to characterize rel ...
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Journal articleCutis · January 2022
Topical drugs are used to treat a variety of cutaneous and noncutaneous conditions. Direct application to the skin can result in adverse cutaneous effects, including allergic contact dermatitis (ACD). In part 2 of this series on topical medicament ACD, we ...
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Journal articleJ Am Acad Dermatol · December 2021
BACKGROUND: Personal care products (PCPs) are commonly responsible for allergic contact dermatitis and irritant contact dermatitis. PCP use was historically associated with females, but male-targeted PCPs are increasingly being marketed. OBJECTIVE: To char ...
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Journal articleJAMA Dermatol · December 1, 2021
IMPORTANCE: Patch test screening series for patients with dermatitis are limited and may miss clinically relevant contact allergens. OBJECTIVE: To characterize individuals with dermatitis who showed clinically relevant patch test findings to supplemental ( ...
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Journal articleDermatitis · November 2021
OBJECTIVE: The aim of the study was to describe the differences in contact allergy between the United States (US) and Canada. METHODS: This is a retrospective cross-sectional analysis of the North American Contact Dermatitis Group data from 2005 to 2016. F ...
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Journal articleCutis · November 2021
Topical drugs are used to treat a variety of cutaneous and noncutaneous conditions. Direct application to the skin can result in adverse cutaneous effects, including allergic contact dermatitis (ACD). In this article, we review medicament ACD with a focus ...
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Journal articleContact Dermatitis · October 2021
BACKGROUND: Little is known about the relationship between psoriasis and allergic contact dermatitis (ACD). OBJECTIVE: To examine the associations with ACD, related clinical characteristics, and common positive and clinically relevant allergens of patients ...
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Journal articleContact Dermatitis · September 2021
BACKGROUND: Sodium disulfite (SD), also known as sodium metabisulfite, is an increasingly recognized cause of allergic contact dermatitis. OBJECTIVES: The objective of this work was to characterize individuals with positive patch test reactions to SD as we ...
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Journal articleDermatitis · September 2021
BACKGROUND: Vitamin E (tocopherol) a naturally occurring mixture of antioxidants commonly used in topical skin care products, may cause allergic contact dermatitis. OBJECTIVE: The aim of this study was to characterize positive patch test reactions to tocop ...
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Journal articleCutis · September 2021
Plants can cause allergic contact dermatitis (ACD), mechanical irritant contact dermatitis, chemical irritant contact dermatitis, light-mediated dermatitis, and pseudophytodermatitis. Allergic contact dermatitis to chemicals in the Toxicodendron genus, whi ...
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Journal articleDermatitis · July 2021
OBJECTIVES: Mercapto compounds are a category of rubber accelerators that may cause allergic contact dermatitis. This study characterizes patch test reactions to mercaptobenzothiazole (MBT) and mercapto mix (MM) in a large North American population. METHOD ...
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Journal articleBr J Dermatol · July 2021
BACKGROUND: Little is known about the aetiologies and relevant allergens in paediatric patients with hand eczema (HE). OBJECTIVES: To characterize the aetiologies and determine the proportion of positive and currently relevant allergens in children/adolesc ...
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Journal articleDermatitis · July 2021
BACKGROUND: Methyldibromoglutaronitrile/phenoxyethanol (MDBGN/PE) is a broad-spectrum preservative mixture used in consumer and industrial products. OBJECTIVES: The aims of the study were (1) to characterize the prevalence and clinical relevance of patch t ...
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Journal articleContact Dermatitis · July 2021
BACKGROUND: Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD). OBJECTIVE: To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch t ...
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Journal articleJ Allergy Clin Immunol Pract · July 2021
BACKGROUND: The association between atopic dermatitis (AD) and allergic contact dermatitis (ACD) is controversial. OBJECTIVE: To analyze the prevalence, reaction strength, and trends of the most commonly positive and relevant allergens in patients with AD ...
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Journal articleCutis · July 2021
Allergic contact dermatitis (ACD) is a common dermatologic condition that presents with unique features in patients with skin of color (SOC). Additionally, the types of allergens that most frequently cause ACD vary in Black and White patients and are attri ...
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Journal articleDermatitis · May 2021
BACKGROUND/OBJECTIVE: This study characterizes concomitant reactions to carba mix (CM) and thiuram mix (TM) in a large North American population. Because thiurams and dithiocarbamates have structural similarity, concomitant reactions are expected. METHODS: ...
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Journal articleCutis · May 2021
The American Contact Dermatitis Society chose acetophenone azine (AA) as the 2021 Allergen of the Year. Acetophenone azine is an emerging contact allergen that often is associated with the use of sports equipment and footwear. The pattern of dermatitis ini ...
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Journal articleJ Am Acad Dermatol · April 2021
BACKGROUND: Eyelid dermatitis is a common dermatologic complaint. OBJECTIVE: To characterize patients with eyelid dermatitis. METHODS: Retrospective analysis (1994-2016) of North American Contact Dermatitis Group data. RESULTS: Of 50,795 patients, 2332 (4. ...
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Journal articleJ Am Acad Dermatol · April 2021
BACKGROUND: Scalp conditions are often multifactorial. OBJECTIVE: To characterize patients with scalp involvement and patch-testing outcomes. METHODS: Retrospective cross-sectional analysis of North American Contact Dermatitis Group data (1996-2016). Study ...
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Journal articleJ Am Acad Dermatol · April 2021
BACKGROUND: Hand eczema (HE) is a heterogeneous and burdensome disorder. OBJECTIVE: To characterize the clinical characteristics, etiologies and allergen relevance in adults with HE referred for patch testing. METHODS: Retrospective analysis (2000-2016) of ...
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Journal articleJ Am Acad Dermatol · April 2021
BACKGROUND: Preservatives are often necessary components of commercial products. Large-scale North American studies on preservative allergy are limited. OBJECTIVE: To evaluate demographics, positive patch test reactions (PPTRs), clinical relevance, and tre ...
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Journal articleDermatol Online J · March 15, 2021
One of the many consequences of the COVID-19 pandemic was the cancelation of the 2020 American Academy of Dermatology Annual Meeting. This conference historically features lectures from world-renowned experts in all areas of dermatology, thus providing an ...
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Journal articleDermatitis · March 2021
BACKGROUND: The coronavirus infectious disease 2019 pandemic has resulted in health care workers donning personal protective equipment (PPE) for extended periods. OBJECTIVES: The aims of the study were to review facial PPE (surgical masks and N95 respirato ...
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Journal articleDermatitis · March 2021
BACKGROUND: Hair products are a potential cause of allergic contact dermatitis. There are limited data on the allergen content of ethnic hair products. OBJECTIVE: To identify allergens unique to ethnic hair products (shampoos, conditioners, styling product ...
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Journal articleDermatitis · March 2021
BACKGROUND: Carmine is a natural red dye that may cause allergic contact dermatitis. OBJECTIVE: The aim of this study was to analyze patch test reactions to carmine (2.5% in petrolatum) and characterize carmine-positive patients. METHODS: This study conduc ...
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Journal articleCutis · March 2021
Hand contact dermatitis is common, and irritant contact dermatitis (ICD) is more likely than allergic contact dermatitis (ACD) in both occupational and nonoccupational settings. Irritant contact dermatitis can have acute and chronic presentations, and hand ...
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Journal articleDermatitis · March 2021
BACKGROUND: Patch testing is an important diagnostic tool for assessment of allergic contact dermatitis (ACD). OBJECTIVE: This study documented the North American Contact Dermatitis Group (NACDG) patch testing results from March 1, 2017, to December 31, 20 ...
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Journal articleJ Am Acad Dermatol · February 2021
BACKGROUND: Prolonged wear of facial protective equipment can lead to occupational dermatoses. OBJECTIVE: To identify important causes of occupational dermatoses from facial protective equipment. METHODS: A systematic review following Preferred Reporting I ...
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Journal articleDermatitis · January 2021
IMPORTANCE: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations. OBJECTIVE: This study aimed to determine the CR rates for F/BR allergens. DESIGN: A retrospecti ...
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Journal articleCutis · January 2021
Nickel is ubiquitous in our daily environment and remains the most common cause of contact allergy worldwide. Regulation of nickel release exists in Europe but unfortunately continues to be absent in the United States. Nickel contact allergy most often is ...
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Journal articleFront Immunol · 2021
Crosstalk between T cells, dendritic cells, and macrophages in temporal leukocyte clusters within barrier tissues provides a new concept for T cell activation in the skin. Activated T cells from these leukocyte clusters play critical roles in the efferent ...
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Journal articleJ Am Acad Dermatol · December 2020
The recent COVID-19 pandemic has resulted in increased hand hygiene and hand cleansing awareness. To prevent virus transmission, the Centers for Disease Control and Prevention recommends frequent hand washing with soap and water. Hand hygiene products are ...
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Journal articleCutis · December 2020
After the patch test, the physician must interpret positive reactions in the clinical context of the patient's dermatitis. Relevance can be graded as current, past, or unknown. Counseling the patient on allergen avoidance is the most important step, and re ...
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Journal articleCutis · October 2020
Understanding the basics of patch testing is essential to caring for patients with contact dermatitis. Several screening or standard series are available, and additional allergens or series may be necessary based on the patient's history. A delayed reading ...
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Journal articleCutis · August 2020
Hypersensitivity reactions can occur in both temporary and permanent tattoos. Traditional temporary tattoos consist of red henna or black henna; paraphenylenediamine is the most common allergen and usually is present in black henna. Contact allergy to geni ...
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Journal articleDermatol Clin · July 2020
Orthopedic implant hypersensitivity reactions (IHRs) are known to occur but are uncommon. Clinical presentations include local and generalized cutaneous reactions and noncutaneous complications. Pathogenesis traditionally was believed a type IV delayed hyp ...
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Journal articleCutis · June 2020
Diabetic devices including glucose monitoring systems and insulin pumps are used worldwide and are increasingly recognized as a source of irritant contact dermatitis and allergic contact dermatitis (ACD). Isobornyl acrylate is a chemical used in the glue o ...
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Journal articleCutis · April 2020
Essential oils (EOs) are present in products we use at home, at work, and in our environment. In recent years, there has been an increasing trend to use EOs rather than products containing chemicals perceived as harmful by consumers. In this review, we sep ...
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Journal articleCutis · February 2020
Hypersensitivity reactions to orthopedic implanted materials exist but are rare. Potential allergens include metals and bone cement components. Clinical presentation can include localized or generalized cutaneous reactions and noncutaneous reactions. Preim ...
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Journal articleJ Invest Dermatol · January 2020
The role of the innate immune system in allergic contact dermatitis (ACD) has traditionally been confined to the initial antigen sensitization phase. However, more recent findings have shown the role of innate immunity in additional aspects of ACD, includi ...
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Journal articleDermatitis · 2020
BACKGROUND: Patch testing is the criterion standard for diagnosis and management of allergic contact dermatitis. Limitations on the number of allergens tested can negatively impact patient care. OBJECTIVE: This study reports clinical practice patterns of A ...
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Journal articleJAMA dermatology · January 2020
ImportanceContact dermatitis in the anogenital area is associated with sleep disturbance and dyspareunia and can profoundly affect quality of life. The literature on anogenital contact dermatitis and culprit allergens is limited. The last large-sc ...
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Journal articleJAMA dermatology · January 2020
ImportanceFacial dermatitis in women is well characterized. However, recent shifts in the men's grooming industry may have important implications for male facial dermatitis.ObjectiveTo characterize male patients with facial dermatitis.
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Journal articleCutis · January 2020
Flipped and traditional classroom models were compared in the Duke University Medical Center (Durham, North Carolina) dermatology residency program for the 2014-2015 academic year. The residents participated in 12 lectures-6 traditional and 6 flipped-that ...
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Journal articleDermatitis · 2020
BACKGROUND: Contact dermatitis is a common disease that is associated with impaired quality of life. OBJECTIVE: We examined the effect of travel distance and other socioeconomic factors on duration of dermatitis before presentation at the Duke Contact Derm ...
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Journal articleDermatitis · 2020
BACKGROUND: Ingredients in nail care products may lead to allergic and/or irritant contact dermatitis. OBJECTIVE: The aims of this study were to determine frequency of contact dermatitis associated with nail care products, characterize associated body site ...
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Journal articleDermatitis · 2020
: Cutaneous exposure to aluminum may occur via contact with metal items, medications, and personal care products. Despite the widespread use of aluminum, allergic contact dermatitis is relatively rare. Sensitization is often incidentally identified during ...
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Journal articleDermatitis · 2020
BACKGROUND/OBJECTIVES: Carba mix (CM, 3% petrolatum) contains 1,3-diphenylguanidine (DPG, 1%), zinc diethyldithiocarbamate (1%), and zinc dibutyldithiocarbamate (1%). Because DPG is a component of CM, DPG is often not tested separately. The purpose of this ...
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Journal articleFront Immunol · 2020
The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin's early immune responses to viral invaders often determine the cours ...
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Journal articleCutis · December 2019
Systemic contact dermatitis (SCD) represents a unique pattern of allergic contact dermatitis that may cause a symmetric eruption involving intertriginous skin, genitals, eyelids, and/or hands. Common culprits known to elicit SCD for some patients include p ...
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Journal articleCutis · August 2019
Methylisothiazolinone (MI) is a preservative commonly used in water-based personal care products. Increases in the allowable concentration of MI alone in these products has led to an epidemic of allergic contact dermatitis (ACD). Although personal care pro ...
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Journal articleJAMA Dermatol · June 1, 2019
This retrospective study evaluated 11 patients who underwent cardiac implant patch testing to assess the frequency of allergic reaction. ...
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Journal articleCutis · June 2019
The advent of acrylate-based nail treatments-known as gels, dips, or shellac-has resulted in an uptick in nail-related acrylate allergy. Acrylate dermatitis related to nail services can affect both clients and technicians and can present on the hands, fing ...
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Journal articleDermatitis · 2019
BACKGROUND: The epidemiology of nickel allergy in occupational settings is not well understood. OBJECTIVE: The aim of the study was to characterize occupationally related nickel allergy (ORNA). METHODS: This is a retrospective cross-sectional analysis of 4 ...
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Journal articleDermatitis · 2019
Health care workers may be at risk of occupational allergic contact dermatitis because of their frequent exposure to medical hand skin cleansers. We identified American Contact Dermatitis Society Core 80 Allergens found in medical hand skin cleansers (wate ...
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Journal articleDermatitis · 2019
The year 2019 marks the 30th anniversary of the American Contact Dermatitis Society (ACDS). The work of inaugural ACDS members and the 3 decades of camaraderie, collaboration, education, and investigation of contact dermatitis that followed the inception o ...
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Journal articleDermatitis · December 18, 2018
Parabens have been widely used as preservatives in the cosmetics, food, and pharmaceutical industries for more than 70 years. Monitoring for paraben allergy closely followed with studies reporting paraben testing in standard screening fashion as early as 1 ...
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Journal articleSci Signal · November 6, 2018
The chemokine receptor CXCR3 plays a central role in inflammation by mediating effector/memory T cell migration in various diseases; however, drugs targeting CXCR3 and other chemokine receptors are largely ineffective in treating inflammation. Chemokines, ...
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Journal articleSouth Med J · August 2018
OBJECTIVES: Health systems are adopting electronic health records (EHRs). There are few studies on the effects of EHR implementation on graduate medical education. The authors sought to longitudinally assess perceptions of the impact of EHRs on graduate me ...
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Journal articleDermatitis · 2018
BACKGROUND: Allergic contact dermatitis (ACD) remains a significant burden of disease in the United States. Patch testing is the criterion standard for diagnosing ACD, but its use may be limited by reimbursement challenges. OBJECTIVE: This study aimed to a ...
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Journal articleDermatitis · 2018
Allergic contact dermatitis is associated with significant disease and economic burden in the United States. To properly manage allergic contact dermatitis, it is important to accurately identify the substance(s) implicated in the dermatitis to prevent dis ...
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Journal articleDermatitis · 2018
Allergic contact dermatitis (ACD) is a common skin disease that results in significant cost and morbidity. Despite its high prevalence, therapeutic options are limited. Allergic contact dermatitis is regulated primarily by T cells within the adaptive immun ...
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Journal articleDermatitis · 2018
BACKGROUND: Allergic contact dermatitis is a challenging diagnostic problem in children. Although epicutaneous patch testing is the diagnostic standard for confirmation of contact sensitization, it is less used in children by dermatologists treating childr ...
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Journal articleDermatitis · 2017
Allergic contact dermatitis related to cosmetic use can result from allergens not routinely evaluated by standard patch test protocols. Propyl, octyl, and dodecyl gallates are commonly used antioxidant preservatives with reports of associated allergic cont ...
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Journal articleDermatitis · 2017
BACKGROUND: Linalool and D-limonene are common fragrance ingredients that readily oxidize on exposure to air. The resulting hydroperoxides of linalool and D-limonene have been shown to have high frequencies of positive patch test reactions in several Europ ...
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Journal articleJ Grad Med Educ · October 2016
BACKGROUND: There is limited information on the impact of widespread adoption of the electronic health record (EHR) on graduate medical education (GME). OBJECTIVE: To identify areas of consensus by education experts, where the use of EHR impacts GME, with ...
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Journal articleJournal of the Dermatology Nurses Association · May 1, 2016
Epicutaneous patch testing is the gold standard for obtaining a diagnosis of allergic contact dermatitis. Patients with allergic contact dermatitis who are undergoing patch testing may be taking or using topical, oral, or injectable immunosuppressant medic ...
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Journal articleDermatitis · 2016
The American Contact Dermatitis Society recognizes the interest in the evaluation and management of metal hypersensitivity reactions. Given the paucity of robust evidence with which to guide our practices, we provide reasonable evidence and expert opinion- ...
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Journal articleDermatitis · 2013
Patch testing is widely used in evaluating suspected contact dermatitis. One major component of a quality patch test result is a dependable, predictable allergen supply. The allergen needs to be present at a sufficient concentration to elicit a reaction in ...
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Journal articleArch Dermatol · November 2011
BACKGROUND: Dermatitis herpetiformis is an autoimmune disease typically characterized by pruritic vesicles located on the extensor surfaces. Classic disease consists of neutrophils in the dermal papillae. Additional histopathologic findings include fibrin ...
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Journal articleJ Am Acad Dermatol · July 2008
Kikuchi's disease, also known as histiocytic necrotizing lymphadenitis, is a systemic illness with classic clinical findings of cervical lymphadenopathy and fever. Diagnosis is confirmed by lymph node histology, which reveals paracortical foci of necrosis ...
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