Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 2010
• Research
• 

  Selected Grants

  • In Vivo Knee Motion and ACL Biomechanics During Dynamic Activities awarded by National Institutes of Health 2019 - 2025
  • Weight loss, in vivo cartilage mechanics, and joint health awarded by National Institutes of Health 2019 - 2023
  • Development of Chondroregenerative Therapy for Human Osteoarthritis awarded by University of Rochester Medical Center 2017 - 2022
  • Biomechanical Markers of Knee Osteoarthritis and In Vivo Cartilage Loading awarded by National Institutes of Health 2015 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Tamayo, K. S., L. N. Heckelman, C. E. Spritzer, L. E. DeFrate, and A. T. Collins. “Obesity impacts the mechanical response and biochemical composition of patellofemoral cartilage: An in vivo, MRI-based investigation.” J Biomech 134 (March 2022): 110991. https://doi.org/10.1016/j.jbiomech.2022.110991.
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    • Crook, Bryan S., Amber T. Collins, Nimit K. Lad, Charles E. Spritzer, Jocelyn R. Wittstein, and Louis E. DeFrate. “Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees.” J Biomech 116 (February 12, 2021): 110210. https://doi.org/10.1016/j.jbiomech.2020.110210.
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    • Collins, Amber T., Guoli Hu, Hunter Newman, Michael H. Reinsvold, Monique R. Goldsmith, John N. Twomey-Kozak, Holly A. Leddy, et al. “Obesity alters the collagen organization and mechanical properties of murine cartilage.” Sci Rep 11, no. 1 (January 15, 2021): 1626. https://doi.org/10.1038/s41598-020-80599-1.
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    • Collins, Amber T., Micaela Kulvaranon, Charles E. Spritzer, Amy L. McNulty, and Louis E. DeFrate. “The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain.” Orthop J Sports Med 8, no. 12 (December 2020): 2325967120964468. https://doi.org/10.1177/2325967120964468.
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    • Heckelman, Lauren N., Alexie D. Riofrio, Emily N. Vinson, Amber T. Collins, Olivia R. Gwynn, Gangadhar M. Utturkar, Adam P. Goode, Charles E. Spritzer, and Louis E. DeFrate. “Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running.” Orthop J Sports Med 8, no. 12 (December 2020): 2325967120967512. https://doi.org/10.1177/2325967120967512.
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    • Heckelman, Lauren N., Wyatt A. R. Smith, Alexie D. Riofrio, Emily N. Vinson, Amber T. Collins, Olivia R. Gwynn, Gangadhar M. Utturkar, Adam P. Goode, Charles E. Spritzer, and Louis E. DeFrate. “Quantifying the biochemical state of knee cartilage in response to running using T1rho magnetic resonance imaging.” Sci Rep 10, no. 1 (February 5, 2020): 1870. https://doi.org/10.1038/s41598-020-58573-8.
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    • Paranjape, Chinmay S., Hattie C. Cutcliffe, Steven C. Grambow, Gangadhar M. Utturkar, Amber T. Collins, William E. Garrett, Charles E. Spritzer, and Louis E. DeFrate. “A New Stress Test for Knee Joint Cartilage.” Sci Rep 9, no. 1 (February 19, 2019): 2283. https://doi.org/10.1038/s41598-018-38104-2.
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    • Taylor, Kevin A., Amber T. Collins, Lauren N. Heckelman, Sophia Y. Kim, Gangadhar M. Utturkar, Charles E. Spritzer, William E. Garrett, and Louis E. DeFrate. “Activities of daily living influence tibial cartilage T1rho relaxation times.” J Biomech 82 (January 3, 2019): 228–33. https://doi.org/10.1016/j.jbiomech.2018.10.029.
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    • Collins, Amber T., Courtney C. Hatcher, Sophia Y. Kim, Sophia N. Ziemian, Charles E. Spritzer, Farshid Guilak, Louis E. DeFrate, and Amy L. McNulty. “Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times.” Ann Biomed Eng 47, no. 1 (January 2019): 190–201. https://doi.org/10.1007/s10439-018-02143-7.
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    • Collins, Amber T., Micaela L. Kulvaranon, Hattie C. Cutcliffe, Gangadhar M. Utturkar, Wyatt A. R. Smith, Charles E. Spritzer, Farshid Guilak, and Louis E. DeFrate. “Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.” Arthritis Res Ther 20, no. 1 (October 17, 2018): 232. https://doi.org/10.1186/s13075-018-1727-4.
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    • Owusu-Akyaw, Kwadwo A., Sophia Y. Kim, Charles E. Spritzer, Amber T. Collins, Zoë A. Englander, Gangadhar M. Utturkar, William E. Garrett, and Louis E. DeFrate. “Determination of the Position of the Knee at the Time of an Anterior Cruciate Ligament Rupture for Male Versus Female Patients by an Analysis of Bone Bruises: Response.” Am J Sports Med 46, no. 11 (September 2018): NP48–51. https://doi.org/10.1177/0363546518788316.
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    • Owusu-Akyaw, Kwadwo A., Sophia Y. Kim, Charles E. Spritzer, Amber T. Collins, Zoë A. Englander, Gangadhar M. Utturkar, William E. Garrett, and Louis E. DeFrate. “Determination of the Position of the Knee at the Time of an Anterior Cruciate Ligament Rupture for Male Versus Female Patients by an Analysis of Bone Bruises.” Am J Sports Med 46, no. 7 (June 2018): 1559–65. https://doi.org/10.1177/0363546518764681.
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    • Liu, Betty, Nimit K. Lad, Amber T. Collins, Pramodh K. Ganapathy, Gangadhar M. Utturkar, Amy L. McNulty, Charles E. Spritzer, et al. “In Vivo Tibial Cartilage Strains in Regions of Cartilage-to-Cartilage Contact and Cartilage-to-Meniscus Contact in Response to Walking.” Am J Sports Med 45, no. 12 (October 2017): 2817–23. https://doi.org/10.1177/0363546517712506.
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    • Hatcher, Courtney C., Amber T. Collins, Sophia Y. Kim, Lindsey C. Michel, William C. Mostertz, Sophia N. Ziemian, Charles E. Spritzer, Farshid Guilak, Louis E. DeFrate, and Amy L. McNulty. “Relationship between T1rho magnetic resonance imaging, synovial fluid biomarkers, and the biochemical and biomechanical properties of cartilage.” J Biomech 55 (April 11, 2017): 18–26. https://doi.org/10.1016/j.jbiomech.2017.02.001.
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    • Cher, Wei Liang, Gangadhar M. Utturkar, Charles E. Spritzer, James A. Nunley, Louis E. DeFrate, and Amber T. Collins. “An analysis of changes in in vivo cartilage thickness of the healthy ankle following dynamic activity.” J Biomech 49, no. 13 (September 6, 2016): 3026–30. https://doi.org/10.1016/j.jbiomech.2016.05.030.
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    • Collins, A. T., R. T. Richardson, and J. S. Higginson. “Interlimb symmetry of dynamic knee joint stiffness and co-contraction is maintained in early stage knee osteoarthritis.” J Electromyogr Kinesiol 24, no. 4 (August 2014): 497–501. https://doi.org/10.1016/j.jelekin.2014.03.010.
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    • Collins, Amber, Troy Blackburn, Chris Olcott, Joanne M. Jordan, Bing Yu, and Paul Weinhold. “A kinetic and kinematic analysis of the effect of stochastic resonance electrical stimulation and knee sleeve during gait in osteoarthritis of the knee.” J Appl Biomech 30, no. 1 (February 2014): 104–12. https://doi.org/10.1123/jab.2012-0257.
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    • Okafor, Eziamaka C., Gangadhar M. Utturkar, Margaret R. Widmyer, Ermias S. Abebe, Amber T. Collins, Dean C. Taylor, Charles E. Spritzer, C. T. Moorman, William E. Garrett, and Louis E. DeFrate. “The effects of femoral graft placement on cartilage thickness after anterior cruciate ligament reconstruction.” J Biomech 47, no. 1 (January 3, 2014): 96–101. https://doi.org/10.1016/j.jbiomech.2013.10.003.
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    • Collins, Amber T., J Troy Blackburn, Chris W. Olcott, Joanne M. Jordan, Bing Yu, and Paul S. Weinhold. “The assessment of postural control with stochastic resonance electrical stimulation and a neoprene knee sleeve in the osteoarthritic knee.” Arch Phys Med Rehabil 93, no. 7 (July 2012): 1123–28. https://doi.org/10.1016/j.apmr.2011.12.006.
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    • Collins, Amber T., J Troy Blackburn, Chris W. Olcott, Jodie Miles, Joanne Jordan, Douglas R. Dirschl, and Paul S. Weinhold. “Stochastic resonance electrical stimulation to improve proprioception in knee osteoarthritis.” Knee 18, no. 5 (October 2011): 317–22. https://doi.org/10.1016/j.knee.2010.07.001.
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    • Collins, Amber, J Troy Blackburn, Chris Olcott, Bing Yu, and Paul Weinhold. “The impact of stochastic resonance electrical stimulation and knee sleeve on impulsive loading and muscle co-contraction during gait in knee osteoarthritis.” Clin Biomech (Bristol, Avon) 26, no. 8 (October 2011): 853–58. https://doi.org/10.1016/j.clinbiomech.2011.04.011.
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    • Collins, A. T., J. T. Blackburn, C. W. Olcott, D. R. Dirschl, and P. S. Weinhold. “The effects of stochastic resonance electrical stimulation and neoprene sleeve on knee proprioception.” Journal of Orthopaedic Surgery and Research 4, no. 1 (March 13, 2009). https://doi.org/10.1186/1749-799X-4-3.
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  • Book Sections

    • Ganapathy, P. K., A. T. Collins, and W. E. Garrett. “Mechanisms of Noncontact Anterior Cruciate Ligament Injuries.” In The Anterior Cruciate Ligament: Reconstruction and Basic Science: Second Edition, 16-19.e2, 2018. https://doi.org/10.1016/B978-0-323-38962-4.00004-7.
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