Current Appointments & Affiliations
Assistant Professor of Medicine
·
2021 - Present
Medicine, Hematology,
Medicine
Recent Publications
Emicizumab promotes factor Xa generation on endothelial cells.
Journal Article J Thromb Haemost · June 2024 BACKGROUND: Until recently, the treatment of hemophilia A relied on factor (F)VIII replacement. However, up to one-third of patients with severe hemophilia A develop neutralizing alloantibodies that render replacement therapies ineffective. The development ... Full text Link to item CiteStopping the bleed when platelets don’t stick
Journal Article Nature Cardiovascular Research · February 1, 2024 Defects in platelet adhesion at sites of injury can lead to excessive bleeding. A study by Gandhi et al. investigates a new bispecific antibody as a possible therapy to prevent bleeding in patients with inherited defects in platelet adhesion. ... Full text CiteInhalation of an RNA aptamer that selectively binds extracellular histones protects from acute lung injury.
Journal Article Mol Ther Nucleic Acids · March 14, 2023 Acute lung injury (ALI) is a syndrome of acute inflammation, barrier disruption, and hypoxemic respiratory failure associated with high morbidity and mortality. Diverse conditions lead to ALI, including inhalation of toxic substances, aspiration of gastric ... Full text Open Access Link to item CiteRecent Grants
Understanding and Enhancing the Therapeutic Efficacy of Factor VIIa for Emergency Hemostasis
ResearchPrincipal Investigator · Awarded by Hemostasis & Thrombosis Research Society · 2020 - 2021PC-ChFVIIa Proof of Concept Studies
ResearchPrincipal Investigator · Awarded by Otello Medical, Inc. · 2019 - 2020View All Grants
Education, Training & Certifications
University of Vermont, College of Medicine ·
2010
M.D.
University of Vermont ·
2009
Ph.D.