Scholars@Duke
Amy Claudine Hobeika

Amy Claudine Hobeika

Assistant Professor in Surgery
Surgery, Surgical Sciences

Scholarly Works - Conferences

Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients

Conference Cancer Research · February 15, 2019 AbstractBackground: Immune-based therapy for metastatic breast cancer has had limited success. Strategies to augment adaptive immunity include vaccines targeting genomic amplifications like Human Epidermal G ... Full text Cite

Dendritic cell (DC) reconstitution after nonmyeloablative allogeneic stem cell transplants

Conference Blood · December 1, 2000 Non-myeloablative allogeneic peripheral blood stem cell transplants {mini-allo PBSCT) are being evaluated as a lower toxicity alternative to conventional allogeneic transplantation for harnessing graft versus tumor effects. Induction of anti-tumor immunity ... Cite

IFNγ induction of P21WAF1 in prostate cancer cells: Role in cell cycle and cell phenotype

Conference FASEB Journal · 1998 Type I and type II interferons (IFNs) are known to exert antitumor effects on a variety of tissues and cell types. We have previously shown that the type I IFN IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 ... Cite

IFNγ inhibition of cell growth in glioblastomas is accompanied by induction of the cyclin dependent kinase inhibitor p21

Conference FASEB Journal · 1998 Glioblastoma is a frequently occurring and highly aggressive form of brain cancer. It is characterized by uncontrolled cell growth caused by a loss of cell cycle regulation, frequently involving mutations in the tumor suppressor genes p53 and p16. In this ... Cite

Interferon induction of the tumor suppressor p21 inhibits cell cycle of tumor cells

Conference FASEB Journal · December 1, 1997 Type I and type II interferons (IFNs) are known to exert anticellular activity on a variety of cell types. We report here on the inhibitory effects of Interferon alpha (IFNa) and interferon gamma (IFN-y) on the cell cycle of the human prostate cancer cell ... Cite

Type I IFN induction of the CDK-inhibitor P21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis in the daudi bcell line

Conference FASEB Journal · December 1, 1997 We have previously shown that in the human Burkitt lymphoma B cell-line Oaudi, type I interférons (IFN) induce the expression of the cyclin-dependent kinase (cdk) inhibitor p21 that is linked to the G1 arrest induced by the IFN. Treatment of Daudi cells wi ... Cite

Biochemical effects of type i interferons on prostate cancer cell cycle.

Conference FASEB Journal · December 1, 1996 Prostate cancer is a serious health risk for men that has a marked agerelated increase in incidence. Tumors of the prostate, as with other types of cancer, have been found to be related to the loss of cell cycle control resulting in increased growth of cel ... Cite