Amy Martha Pastva

Journal article J Immunol · May 15, 2012 Featured Publication Graft-versus-host disease (GVHD) is a severe and frequent complication of allogeneic bone marrow transplantation (BMT) that involves the gastrointestinal (GI) tract and lungs. The pathobiology of GVHD is complex and involves immune cell recognition of host ... Full text Link to item Cite

Surfactant protein A modulates induction of regulatory T cells via TGF-β.

Journal article J Immunol · May 1, 2012 Featured Publication TCR signaling plays a critical role in regulatory T cell (Treg) development. However, the mechanism for tissue-specific induction of Tregs in the periphery remains unclear. We observed that surfactant protein A (SP-A)-deficient mice have impaired expressio ... Full text Link to item Cite

Surfactant protein A integrates activation signal strength to differentially modulate T cell proliferation.

Journal article J Immunol · February 1, 2012 Featured Publication Pulmonary surfactant lipoproteins lower the surface tension at the alveolar-airway interface of the lung and participate in host defense. Previous studies reported that surfactant protein A (SP-A) inhibits lymphocyte proliferation. We hypothesized that SP- ... Full text Link to item Cite

Lung effector memory and activated CD4+ T cells display enhanced proliferation in surfactant protein A-deficient mice during allergen-mediated inflammation.

Journal article J Immunol · March 1, 2011 Featured Publication Although many studies have shown that pulmonary surfactant protein (SP)-A functions in innate immunity, fewer studies have addressed its role in adaptive immunity and allergic hypersensitivity. We hypothesized that SP-A modulates the phenotype and prevalen ... Full text Link to item Cite

Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice.

Journal article Am J Respir Cell Mol Biol · February 2011 Featured Publication Surfactant protein A (SP-A) mediates innate immune cell responses to LPS, a cell wall component of gram-negative bacteria that is found ubiquitously in the environment and is associated with adverse health effects. Inhaled LPS induces lung inflammation and ... Full text Link to item Cite

Review: Collectins link innate and adaptive immunity in allergic airway disease.

Journal article Innate Immun · June 2010 Featured Publication Although the lipoprotein complex of pulmonary surfactant has long been recognized as essential for reducing lung surface tension, its role in lung immune host defense has only relatively recently been elucidated. Surfactant-associated proteins A (SP-A) and ... Full text Link to item Cite

Immunomodulatory roles of surfactant proteins A and D: implications in lung disease.

Journal article Proc Am Thorac Soc · July 2007 Featured Publication Surfactant, a lipoprotein complex, was originally described for its essential role in reducing surface tension at the air-liquid interface of the lung; however, it is now recognized as being a critical component in lung immune host defense. Surfactant prot ... Full text Link to item Cite

RU486 blocks the anti-inflammatory effects of exercise in a murine model of allergen-induced pulmonary inflammation.

Journal article Brain Behav Immun · September 2005 Featured Publication In an ovalbumin (OVA)-driven murine model of allergic pulmonary inflammation, we have shown previously that moderate-intensity aerobic exercise training attenuates inflammatory responses, disease progression, and NF-kappaB activation within the sensitized ... Full text Link to item Cite

Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma.

Journal article J Immunol · April 1, 2004 Featured Publication Recent reports indicate that aerobic exercise improves the overall physical fitness and health of asthmatic patients. The specific exercise-induced improvements in the pathology of asthma and the mechanisms by which these improvements occur, however, are i ... Full text Link to item Cite