Scholars@Duke
Anastasia Georgiades
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Selected Publications

Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.

Journal Article Metabolomics · January 18, 2021 INTRODUCTION: Analyses of cerebrospinal fluid (CSF) metabolites in large, healthy samples have been limited and potential demographic moderators of brain metabolism are largely unknown. OBJECTIVE: Our objective in this study was to examine sex and race dif ... Full text Link to item Cite

The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.

Journal Article Psychosom Med · January 2019 OBJECTIVE: Central nervous system (CNS) serotonin (5-HT) exerts both excitatory and inhibitory effects on the sympathetic nervous system (SNS) in animals. In this study, we examine the effects of tryptophan enhancement and depletion on plasma catecholamine ... Full text Link to item Cite

Psychometric characteristics of the MATRICS Consensus Cognitive Battery in a large pooled cohort of stable schizophrenia patients.

Journal Article Schizophr Res · December 2017 The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre ... Full text Link to item Cite

Effects of exercise and stress management training on nighttime blood pressure dipping in patients with coronary heart disease: A randomized, controlled trial.

Journal Article Am Heart J · January 2017 INTRODUCTION: Blunted nighttime blood pressure (BP) dipping is prognostic of cardiovascular morbidity and mortality. Patients with coronary heart disease (CHD) are often characterized by a blunted nighttime BP dipping pattern. The present study compared th ... Full text Link to item Cite

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

Journal Article J Am Heart Assoc · October 26, 2015 BACKGROUND: While aspirin is a well-established and generally effective anti-platelet agent, considerable inter-individual variation in drug response exists, for which mechanisms are not completely understood. Metabolomics allows for extensive measurement ... Full text Link to item Cite

Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.

Journal Article Ann Behav Med · February 2015 BACKGROUND: Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits. PURPOSE: The purpos ... Full text Link to item Cite

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.

Journal Article CPT Pharmacometrics Syst Pharmacol · July 16, 2014 While aspirin is generally effective for prevention of cardiovascular disease, considerable variation in drug response exists, resulting in some individuals displaying high on-treatment platelet reactivity. We used pharmacometabolomics to define pathways i ... Full text Link to item Cite

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

Journal Article PLoS One · 2014 Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise caus ... Full text Open Access Link to item Cite

Integration of pharmacometabolomic and pharmacogenomic approaches reveals novel insights into antiplatelet therapy.

Journal Article Clin Pharmacol Ther · November 2013 Interindividual variability in response to antiplatelet therapy results in higher platelet reactivity as well as higher rates of cardiovascular events. Despite substantial effort, the genetic and nongenetic determinants of antiplatelet variability remain p ... Full text Link to item Cite

Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.

Journal Article Clin Pharmacol Ther · October 2013 Although aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples, enabling detailed mapping of pathways involv ... Full text Link to item Cite

Changes in body composition predict homocysteine changes and hyperhomocysteinemia in Korea.

Journal Article Journal of Korean medical science · July 2013 Cardiovascular disease (CVD) is the primary cause of death in Korea. Hyperhomocysteinemia confers an independent risk for CVD comparable to the risk of smoking and hyperlipidemia. The purpose of this study was to assess the effect of cardiovascular risk fa ... Full text Cite

Purine pathway implicated in mechanism of resistance to aspirin therapy: Pharmacometabolomics-informed pharmacogenomics

Journal Article Clinical Pharmacology and Therapeutics · 2013 Although aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples, enabling detailed mapping of pathways involv ... Full text Cite

Impaired plasmalogens in patients with schizophrenia.

Journal Article Psychiatry Res · August 15, 2012 Plasmalogens are a subclass of glycerophospholipids and ubiquitous constituents of cellular membranes and serum lipoproteins. Several neurological disorders show decreased level of plasmogens. An earlier study found differences in plasma phospholipids betw ... Full text Link to item Cite

Trait anxiety and glucose metabolism in people without diabetes: vulnerabilities among black women.

Journal Article Diabetic medicine : a journal of the British Diabetic Association · June 2012 AimsWe examined whether the relationship between anxiety and indicators of glucose metabolism in people without diabetes varies by race and gender.MethodsParticipants were 914 adults (777 white, 137 black) without diabetes in the MIDUS (M ... Full text Cite

Systolic blood pressure and adiposity: examination by race and gender in a nationally representative sample of young adults.

Journal Article Am J Hypertens · February 2012 BACKGROUND: Adiposity, or more specifically, underlying body fat distribution, has been associated with systolic blood pressure (SBP), and it has been suggested that these associations vary between whites and blacks, as well as by gender. METHODS: Here, we ... Full text Link to item Cite

Association of cortisol and the metabolic syndrome in Korean men and women.

Journal Article J Korean Med Sci · July 2011 Obesity and the metabolic syndrome are closely related and have become increasingly prevalent in Korea. The cardiovascular disease (CVD) risk factors comprising the metabolic syndrome have previously been associated with increased hypothalamic-pituitary-ad ... Full text Link to item Cite

Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.

Journal Article Psychosom Med · September 2010 OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in cluste ... Full text Link to item Cite

Plasma epinephrine predicts fasting glucose in centrally obese African-American women.

Journal Article Obesity (Silver Spring) · September 2010 The high prevalence of diabetes in African-American (AA) women has been widely assumed to be related to the greater prevalence of obesity in this group. Catecholamine release acting on central adipose tissue has been proposed to be a contributing factor. T ... Full text Link to item Cite

Hostility and minimal model of glucose kinetics in African American women.

Journal Article Psychosom Med · July 2009 OBJECTIVE: To explore the underlying physiology of hostility (HOST) and to test the hypothesis that HOST has a greater impact on fasting glucose in African American (AA) women than it does on AA men or white men or women, using an intravenous glucose toler ... Full text Link to item Cite

Sex and race differences of cerebrospinal fluid metabolites in healthy individuals.

Journal Article Metabolomics · January 18, 2021 INTRODUCTION: Analyses of cerebrospinal fluid (CSF) metabolites in large, healthy samples have been limited and potential demographic moderators of brain metabolism are largely unknown. OBJECTIVE: Our objective in this study was to examine sex and race dif ... Full text Link to item Cite

The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals.

Journal Article Psychosom Med · January 2019 OBJECTIVE: Central nervous system (CNS) serotonin (5-HT) exerts both excitatory and inhibitory effects on the sympathetic nervous system (SNS) in animals. In this study, we examine the effects of tryptophan enhancement and depletion on plasma catecholamine ... Full text Link to item Cite

Psychometric characteristics of the MATRICS Consensus Cognitive Battery in a large pooled cohort of stable schizophrenia patients.

Journal Article Schizophr Res · December 2017 The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre ... Full text Link to item Cite

Effects of exercise and stress management training on nighttime blood pressure dipping in patients with coronary heart disease: A randomized, controlled trial.

Journal Article Am Heart J · January 2017 INTRODUCTION: Blunted nighttime blood pressure (BP) dipping is prognostic of cardiovascular morbidity and mortality. Patients with coronary heart disease (CHD) are often characterized by a blunted nighttime BP dipping pattern. The present study compared th ... Full text Link to item Cite

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

Journal Article J Am Heart Assoc · October 26, 2015 BACKGROUND: While aspirin is a well-established and generally effective anti-platelet agent, considerable inter-individual variation in drug response exists, for which mechanisms are not completely understood. Metabolomics allows for extensive measurement ... Full text Link to item Cite

Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.

Journal Article Ann Behav Med · February 2015 BACKGROUND: Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits. PURPOSE: The purpos ... Full text Link to item Cite

Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability.

Journal Article CPT Pharmacometrics Syst Pharmacol · July 16, 2014 While aspirin is generally effective for prevention of cardiovascular disease, considerable variation in drug response exists, resulting in some individuals displaying high on-treatment platelet reactivity. We used pharmacometabolomics to define pathways i ... Full text Link to item Cite

A putatively functional polymorphism in the HTR2C gene is associated with depressive symptoms in white females reporting significant life stress.

Journal Article PLoS One · 2014 Psychosocial stress is well known to be positively associated with subsequent depressive symptoms. Cortisol response to stress may be one of a number of biological mechanisms that links psychological stress to depressive symptoms, although the precise caus ... Full text Open Access Link to item Cite

Integration of pharmacometabolomic and pharmacogenomic approaches reveals novel insights into antiplatelet therapy.

Journal Article Clin Pharmacol Ther · November 2013 Interindividual variability in response to antiplatelet therapy results in higher platelet reactivity as well as higher rates of cardiovascular events. Despite substantial effort, the genetic and nongenetic determinants of antiplatelet variability remain p ... Full text Link to item Cite

Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics.

Journal Article Clin Pharmacol Ther · October 2013 Although aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples, enabling detailed mapping of pathways involv ... Full text Link to item Cite

Changes in body composition predict homocysteine changes and hyperhomocysteinemia in Korea.

Journal Article Journal of Korean medical science · July 2013 Cardiovascular disease (CVD) is the primary cause of death in Korea. Hyperhomocysteinemia confers an independent risk for CVD comparable to the risk of smoking and hyperlipidemia. The purpose of this study was to assess the effect of cardiovascular risk fa ... Full text Cite

Purine pathway implicated in mechanism of resistance to aspirin therapy: Pharmacometabolomics-informed pharmacogenomics

Journal Article Clinical Pharmacology and Therapeutics · 2013 Although aspirin is a well-established antiplatelet agent, the mechanisms of aspirin resistance remain poorly understood. Metabolomics allows for measurement of hundreds of small molecules in biological samples, enabling detailed mapping of pathways involv ... Full text Cite

Impaired plasmalogens in patients with schizophrenia.

Journal Article Psychiatry Res · August 15, 2012 Plasmalogens are a subclass of glycerophospholipids and ubiquitous constituents of cellular membranes and serum lipoproteins. Several neurological disorders show decreased level of plasmogens. An earlier study found differences in plasma phospholipids betw ... Full text Link to item Cite

Trait anxiety and glucose metabolism in people without diabetes: vulnerabilities among black women.

Journal Article Diabetic medicine : a journal of the British Diabetic Association · June 2012 AimsWe examined whether the relationship between anxiety and indicators of glucose metabolism in people without diabetes varies by race and gender.MethodsParticipants were 914 adults (777 white, 137 black) without diabetes in the MIDUS (M ... Full text Cite

Systolic blood pressure and adiposity: examination by race and gender in a nationally representative sample of young adults.

Journal Article Am J Hypertens · February 2012 BACKGROUND: Adiposity, or more specifically, underlying body fat distribution, has been associated with systolic blood pressure (SBP), and it has been suggested that these associations vary between whites and blacks, as well as by gender. METHODS: Here, we ... Full text Link to item Cite

Association of cortisol and the metabolic syndrome in Korean men and women.

Journal Article J Korean Med Sci · July 2011 Obesity and the metabolic syndrome are closely related and have become increasingly prevalent in Korea. The cardiovascular disease (CVD) risk factors comprising the metabolic syndrome have previously been associated with increased hypothalamic-pituitary-ad ... Full text Link to item Cite

Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men.

Journal Article Psychosom Med · September 2010 OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in cluste ... Full text Link to item Cite

Plasma epinephrine predicts fasting glucose in centrally obese African-American women.

Journal Article Obesity (Silver Spring) · September 2010 The high prevalence of diabetes in African-American (AA) women has been widely assumed to be related to the greater prevalence of obesity in this group. Catecholamine release acting on central adipose tissue has been proposed to be a contributing factor. T ... Full text Link to item Cite

Hostility and minimal model of glucose kinetics in African American women.

Journal Article Psychosom Med · July 2009 OBJECTIVE: To explore the underlying physiology of hostility (HOST) and to test the hypothesis that HOST has a greater impact on fasting glucose in African American (AA) women than it does on AA men or white men or women, using an intravenous glucose toler ... Full text Link to item Cite

Hostility and fasting glucose in African American women.

Journal Article Psychosom Med · July 2009 OBJECTIVE: To examine whether the relationship of hostility (HOST) to fasting glucose indices is moderated by sex and race. HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevale ... Full text Link to item Cite

Financial strain predicts recurrent events among women with coronary artery disease.

Journal Article International journal of cardiology · June 2009 BackgroundAlthough a number of epidemiological studies have found an association between socioeconomic status (SES) indices such as income and education and coronary morbidity and mortality, few have looked at health consequences arising from actu ... Full text Cite

Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction.

Journal Article Am J Clin Nutr · May 2009 BACKGROUND: n-3 (omega-3) Fatty acids are associated with a reduced risk of cardiovascular disease; however, the relation between dietary intake of n-3 fatty acids and ventricular arrhythmias has not been investigated among acute post-myocardial infarction ... Full text Link to item Cite

A convenient LC-MS method for assessment of glucose kinetics in vivo with D-[13C6]glucose as a tracer.

Journal Article Clin Chem · March 2009 BACKGROUND: The isotope-labeled intravenous glucose tolerance test (IVGTT) combined with computer modeling is widely used to derive parameters related to glucose metabolism in vivo. Most of these methods involve use of either (2)H(2)-labeled or (13)C(1)-la ... Full text Link to item Cite

Daily stress and social support among women with CAD: results from a 1-year randomized controlled stress management intervention study.

Journal Article International journal of behavioral medicine · January 2009 BackgroundPsychosocial stress may play a causative role in development and progression of coronary artery disease (CAD).PurposeWe investigated the effects of a 1-year stress management program on daily stress behavior and social support a ... Full text Cite

Effects of a stress management program on vital exhaustion and depression in women with coronary heart disease: a randomized controlled intervention study.

Journal Article Journal of internal medicine · March 2008 ObjectivesPsychosocial factors, including depression and vital exhaustion (VE) are associated with adverse outcome in coronary heart disease (CHD). Women with CHD are poor responders to psychosocial treatment and knowledge regarding which treatmen ... Full text Cite

Effects of exercise and weight loss on depressive symptoms among men and women with hypertension.

Journal Article J Psychosom Res · November 2007 OBJECTIVE: This study aimed to investigate changes in depressive symptoms in hypertensive individuals participating in an exercise and weight loss intervention. METHODS: This study involved 133 sedentary men and women with high blood pressure (BP; 130-180 ... Full text Link to item Cite

Work and marital status in relation to depressive symptoms and social support among women with coronary artery disease.

Journal Article Journal of women's health (2002) · November 2007 BackgroundWork and marital status have been shown to be associated with health outcome in women. However, the effect of employment and marriage on psychosocial functioning has been studied predominantly in healthy subjects. We investigated whether ... Full text Cite

Depressive symptoms, race, and glucose concentrations: the role of cortisol as mediator.

Journal Article Diabetes Care · October 2007 OBJECTIVE: This study examined the associations of depressive symptoms with glucose concentrations and morning cortisol levels in 665 African-American and 4,216 Caucasian Vietnam-era veterans. RESEARCH DESIGN AND METHODS: Glucose level was measured as a th ... Full text Link to item Cite

Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea

Journal Article Nutrition and Metabolism · April 26, 2007 Objective. To determine the importance of IgM antibodies against phosphorylcholine (aPC), a novel protective factor for cardiovascular disease (CVD), in a population with a non-western life style as compared with a Swedish control group. Methods and result ... Full text Cite

Changes in depressive symptoms and glycemic control in diabetes mellitus.

Journal Article Psychosom Med · April 2007 OBJECTIVE: To investigate if changes in depressive symptoms would be associated with changes in glycemic control over a 12-month period in patients with Type 1 and Type 2 diabetes. METHODS: Ninety (Type 1 diabetes, n = 28; Type 2 diabetes, n = 62) patients ... Full text Link to item Cite

Ventricular ectopy: impact of self-reported stress after myocardial infarction.

Journal Article Am Heart J · January 2007 BACKGROUND: Although psychologic stress has been implicated in the pathogenesis of ventricular arrhythmias, the relationship between self-reported stress and ventricular ectopy has not been evaluated under naturalistic conditions in acute post-myocardial i ... Full text Link to item Cite

Hyperreactivity (Cardiovascular)

Journal Article · January 1, 2007 Cardiovascular reactivity is defined as an individual's propensity to display cardiovascular reactions of greater or lesser magnitude as compared to a baseline value when encountering stimuli or situations experienced as challenging or aversive. This chapt ... Full text Cite

Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension.

Journal Article Atherosclerosis · September 2006 ObjectiveTo determine the importance of antibodies against phosphorylcholine (PC) and oxidized low density lipoprotein (OxLDL) for development of atherosclerosis.Methods and resultsTwo hundred and twenty six individuals with established h ... Full text Cite

Self-rated health and vital exhaustion, but not depression, is related to inflammation in women with coronary heart disease.

Journal Article Brain, behavior, and immunity · November 2005 Poor subjective well-being has been associated with increased coronary heart disease (CHD) morbidity and mortality in population-based studies and with adverse outcomes in existing CHD. Little is known about the mechanisms responsible for this association, ... Full text Cite

Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial.

Journal Article JAMA · April 6, 2005 CONTEXT: Observational studies have shown that psychosocial factors are associated with increased risk for cardiovascular morbidity and mortality, but the effects of behavioral interventions on psychosocial and medical end points remain uncertain. OBJECTIV ... Full text Link to item Cite

Wine drinking is associated with increased heart rate variability in women with coronary heart disease.

Journal Article Heart (British Cardiac Society) · March 2005 ObjectiveTo test the hypothesis that alcohol consumption is positively related to heart rate variability (HRV) in women with coronary heart disease (CHD) and therefore that cardiac autonomic activity is potentially implicated in the mediation of t ... Full text Cite

Inflammatory markers and heart rate variability in women with coronary heart disease.

Journal Article Journal of internal medicine · November 2004 PurposeBoth heart rate variability (HRV) and inflammatory markers are carrying prognostic information in coronary heart disease (CHD), however, we know of no studies examining their relation in CHD. The aim of this study, therefore, was to assess ... Full text Cite

Clinical prediction of normotension in borderline hypertensive men--a 10 year study.

Journal Article Journal of hypertension · March 2004 ObjectiveTo investigate 24-h ambulatory blood pressure measurements (ABPM) as a tool for long-term prediction of future blood pressure (BP) status in high normal and low stage 1 hypertensives.Design, setting and participantsA total of 165 ... Full text Cite

Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension.

Journal Article Hypertension (Dallas, Tex. : 1979) · September 2003 Although heat shock proteins (Hsp's) are present in the sera of healthy individuals and at elevated levels in subjects with early cardiovascular disease, their physiologic role in and value for predicting the development and/or progression of atheroscleros ... Full text Cite

Reduction of left ventricular hypertrophy after exercise and weight loss in overweight patients with mild hypertension.

Journal Article Arch Intern Med · June 24, 2002 BACKGROUND: Hypertrophy and concentric remodeling of the left ventricle are important manifestations of hypertension that are associated with increased morbidity and mortality. Although lifestyle interventions are efficacious in lowering blood pressure, ev ... Full text Link to item Cite

Biobehavioral approaches to the treatment of essential hypertension.

Journal Article J Consult Clin Psychol · June 2002 Despite recent advances in the medical management of hypertension, chronically elevated blood pressure remains a major health problem in the United States, affecting almost 50 million Americans. It is widely recognized that lifestyle factors contribute to ... Link to item Cite

Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressure.

Journal Article Psychosom Med · 2002 OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP m ... Full text Link to item Cite

Effects of exercise and weight loss on blood pressure during daily life.

Journal Article Med Sci Sports Exerc · October 2001 PURPOSE: The objective of this study was to investigate the effects of exercise training and weight loss on blood pressure (BP) associated with physical activity and emotional stress during daily life. METHODS: One hundred twelve participants with unmedica ... Full text Link to item Cite

Psychosocial work characteristics and perceived control in relation to cardiovascular rewind at night.

Journal Article Journal of occupational health psychology · July 2001 This study examined the effects of psychosocial work characteristics on cardiovascular rewind at night. Ambulatory 24-hr recordings of blood pressure (BP) and heart rate (HR) of 75 borderline hypertensive and 74 normotensive men were related to diary ratin ... Full text Cite

Effects of exercise and weight loss on mental stress-induced cardiovascular responses in individuals with high blood pressure.

Journal Article Hypertension · August 2000 The purpose of this study was to determine the effects of exercise and weight loss on cardiovascular responses during mental stress in mildly to moderately overweight patients with elevated blood pressure. Ninety-nine men and women with high normal or unme ... Full text Link to item Cite

Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.

Journal Article Arch Intern Med · July 10, 2000 BACKGROUND: Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial. METHODS: O ... Full text Link to item Cite

Stress-induced laboratory blood pressure in relation to ambulatory blood pressure and left ventricular mass among borderline hypertensive and normotensive individuals.

Journal Article Hypertension (Dallas, Tex. : 1979) · October 1996 Our primary aim in the present study was to investigate the association between blood pressure measured in the laboratory and in the ambulatory state in a group of middle-aged borderline hypertensive men and age-matched normotensive control subjects. In ad ... Full text Cite

Structural cardiac changes in relation to 24-h ambulatory blood pressure levels in borderline hypertension.

Journal Article Journal of internal medicine · July 1995 ObjectivesTo investigate left ventricular hypertrophy (LVH) in relation to 24-h ambulatory blood pressure (24-ABPM) and insulin levels in borderline hypertension.DesignA case-control study.SubjectsBorderline hypertensive men (dia ... Full text Cite

Internal consistency and temporal stability of classically conditioned skin conductance responses.

Journal Article Biological psychology · April 1993 The reliability of classically conditioned skin conductance responses was investigated. Temporal stability was determined in 28 subjects studied three weeks apart (study 1), and internal consistency in 223 subjects studied once (study 2). A discriminative ... Full text Cite

Personality dimensions and classical conditioning of autonomic nervous system reactions

Journal Article Personality and Individual Differences · January 1, 1992 According to Eysenck's arousal theory, introverts and individuals high on neuroticism should show greater reactivity and better conditionability than extraverts and individuals low on neuroticism. Forty-six subjects recruited consecutively were subjected t ... Full text Cite