Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Endocrinology Fellowship, University of Washington, School of Medicine 2000 - 2003
  • M.S., University of Washington 2003
  • Internal Medicine Residency, Medicine, Duke University School of Medicine 1995 - 1998
  • M.D., Duke University School of Medicine 1995
• Research
• 

  Selected Grants

  • REGN1500-CL-1643 awarded by Regeneron Pharmaceuticals, Inc. 2018 - 2022
• 

  External Relationships

  • GI Dynamics
  • Orthus Health
  • The Endocrine Society
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Huang, Grace, Andrea Coviello, Michael P. LaValley, Kristine E. Ensrud, Jane A. Cauley, Peggy M. Cawthon, and Lisa Fredman. “Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures.” J Am Geriatr Soc 66, no. 11 (November 2018): 2172–77. https://doi.org/10.1111/jgs.15505.
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    • Eriksson, Anna L., John R. B. Perry, Andrea D. Coviello, Graciela E. Delgado, Luigi Ferrucci, Andrew R. Hoffman, Ilpo T. Huhtaniemi, et al. “Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men.” J Clin Endocrinol Metab 103, no. 3 (March 1, 2018): 991–1004. https://doi.org/10.1210/jc.2017-02060.
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    • Stuver, Sherri O., Jennifer Lyons, Andrea Coviello, and Lisa Fredman. “Feasibility of 24-Hr Urine Collection for Measurement of Biomarkers in Community-Dwelling Older Adults.” J Appl Gerontol 36, no. 11 (November 2017): 1393–1408. https://doi.org/10.1177/0733464815624153.
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    • Jasuja, Guneet Kaur, Thomas G. Travison, Joanne M. Murabito, Maithili N. Davda, Adam J. Rose, Shehzad Basaria, Andrea Coviello, Ramachandran S. Vasan, Ralph D’Agostino, and Shalender Bhasin. “Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study.” J Gerontol a Biol Sci Med Sci 72, no. 8 (August 1, 2017): 1137–42. https://doi.org/10.1093/gerona/glw197.
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    • Hinney, A., M. Kesselmeier, S. Jall, A. -. L. Volckmar, M. Föcker, J. Antel, J. GCAN, et al. “Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.” Mol Psychiatry 22, no. 2 (February 2017): 192–201. https://doi.org/10.1038/mp.2016.71.
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    • Lunetta, K. L., F. R. Day, P. Sulem, K. S. Ruth, J. Y. Tung, D. A. Hinds, T. Esko, et al. “Corrigendum: Rare coding variants and X-linked loci associated with age at menarche.” Nature Communications 6 (December 17, 2015). https://doi.org/10.1038/ncomms10257.
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    • Day, F. R., K. S. Ruth, D. J. Thompson, K. L. Lunetta, N. Pervjakova, D. I. Chasman, L. Stolk, et al. “Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair.” Obstetrical and Gynecological Survey 70, no. 12 (December 1, 2015): 758–62. https://doi.org/10.1097/01.ogx.0000473766.71624.99.
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    • Day, Felix R., Katherine S. Ruth, Deborah J. Thompson, Kathryn L. Lunetta, Natalia Pervjakova, Daniel I. Chasman, Lisette Stolk, et al. “Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.” Nat Genet 47, no. 11 (November 2015): 1294–1303. https://doi.org/10.1038/ng.3412.
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    • Basaria, Shehzad, S Mitchell Harman, Thomas G. Travison, Howard Hodis, Panayiotis Tsitouras, Matthew Budoff, Karol M. Pencina, et al. “Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial.” Jama 314, no. 6 (August 11, 2015): 570–81. https://doi.org/10.1001/jama.2015.8881.
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    • Lunetta, Kathryn L., Felix R. Day, Patrick Sulem, Katherine S. Ruth, Joyce Y. Tung, David A. Hinds, Tõnu Esko, et al. “Rare coding variants and X-linked loci associated with age at menarche.” Nat Commun 6 (August 4, 2015): 7756. https://doi.org/10.1038/ncomms8756.
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    • Perry, John Rb, Felix Day, Cathy E. Elks, Patrick Sulem, Deborah J. Thompson, Teresa Ferreira, Chunyan He, et al. “Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.” Nature 514, no. 7520 (October 2, 2014): 92–97. https://doi.org/10.1038/nature13545.
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    • Magnani, Jared W., Carlee B. Moser, Joanne M. Murabito, Lisa M. Sullivan, Na Wang, Patrick T. Ellinor, Ramachandran S. Vasan, Emelia J. Benjamin, and Andrea D. Coviello. “Association of sex hormones, aging, and atrial fibrillation in men: the Framingham Heart Study.” Circ Arrhythm Electrophysiol 7, no. 2 (April 2014): 307–12. https://doi.org/10.1161/CIRCEP.113.001322.
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    • Juang, Patricia S., Susan Peng, Kambiz Allehmazedeh, Ansal Shah, Andrea D. Coviello, and Karen L. Herbst. “Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: a randomized controlled trial.” J Sex Med 11, no. 2 (February 2014): 563–73. https://doi.org/10.1111/jsm.12368.
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    • Travison, T. G., W. V. Zhuang, K. L. Lunetta, D. Karasik, S. Bhasin, D. P. Kiel, A. D. Coviello, and J. M. Murabito. “The heritability of circulating testosterone, oestradiol, oestrone and sex hormone binding globulin concentrations in men: the Framingham Heart Study.” Clin Endocrinol (Oxf) 80, no. 2 (February 2014): 277–82. https://doi.org/10.1111/cen.12260.
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    • Mott, M. M., N. R. Kitos, and A. D. Coviello. “Practice patterns in screening for metabolic disease in women with pcos of diverse race-ethnic backgrounds.” Endocrine Practice 20, no. 9 (January 1, 2014): 855–63. https://doi.org/10.4158/EP13414.OR.
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    • Jasuja, Guneet Kaur, Thomas G. Travison, Maithili Davda, Adam J. Rose, Anqi Zhang, Mark M. Kushnir, Alan L. Rockwood, et al. “Circulating estrone levels are associated prospectively with diabetes risk in men of the Framingham Heart Study.” Diabetes Care 36, no. 9 (September 2013): 2591–96. https://doi.org/10.2337/dc12-2477.
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    • Jasuja, Guneet Kaur, Thomas G. Travison, Maithili Davda, Joanne M. Murabito, Shehzad Basaria, Anqi Zhang, Mark M. Kushnir, et al. “Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.” J Gerontol a Biol Sci Med Sci 68, no. 6 (June 2013): 733–40. https://doi.org/10.1093/gerona/gls216.
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    • Haring, Robin, Zhaoyang Teng, Vanessa Xanthakis, Andrea Coviello, Lisa Sullivan, Shalender Bhasin, Joanne M. Murabito, Henri Wallaschofski, and Ramachandran S. Vasan. “Association of sex steroids, gonadotrophins, and their trajectories with clinical cardiovascular disease and all-cause mortality in elderly men from the Framingham Heart Study.” Clin Endocrinol (Oxf) 78, no. 4 (April 2013): 629–34. https://doi.org/10.1111/cen.12013.
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    • Haring, R., V. Xanthakis, A. Coviello, L. Sullivan, S. Bhasin, H. Wallaschofski, J. M. Murabito, and R. S. Vasan. “Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study.” Int J Androl 35, no. 6 (December 2012): 775–82. https://doi.org/10.1111/j.1365-2605.2012.01285.x.
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    • Huang, Grace, and Andrea Coviello. “Clinical update on screening, diagnosis and management of metabolic disorders and cardiovascular risk factors associated with polycystic ovary syndrome.” Curr Opin Endocrinol Diabetes Obes 19, no. 6 (December 2012): 512–19. https://doi.org/10.1097/MED.0b013e32835a000e.
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    • Stolk, Lisette, John R. B. Perry, Daniel I. Chasman, Chunyan He, Massimo Mangino, Patrick Sulem, Maja Barbalic, et al. “Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.” Nat Genet 44, no. 3 (January 22, 2012): 260–68. https://doi.org/10.1038/ng.1051.
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    • Coviello, Andrea D., Robin Haring, Melissa Wellons, Dhananjay Vaidya, Terho Lehtimäki, Sarah Keildson, Kathryn L. Lunetta, et al. “A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.” Plos Genet 8, no. 7 (2012): e1002805. https://doi.org/10.1371/journal.pgen.1002805.
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    • Haring, Robin, Thomas G. Travison, Shalender Bhasin, Ramachandran S. Vasan, Henri Wallaschofski, Maithili N. Davda, Andrea Coviello, and Joanne M. Murabito. “Relation between sex hormone concentrations, peripheral arterial disease, and change in ankle-brachial index: findings from the Framingham Heart Study.” J Clin Endocrinol Metab 96, no. 12 (December 2011): 3724–32. https://doi.org/10.1210/jc.2011-1068.
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    • Bhasin, Shalender, Guneet K. Jasjua, Michael Pencina, Ralph D’Agostino, Andrea D. Coviello, Ramachandran S. Vasan, and Thomas G. Travison. “Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study.” Diabetes Care 34, no. 11 (November 2011): 2464–70. https://doi.org/10.2337/dc11-0888.
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    • Cheng, Susan, Caroline S. Fox, Martin G. Larson, Joseph M. Massaro, Elizabeth L. McCabe, Abigail May Khan, Daniel Levy, et al. “Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals.” Am J Cardiol 108, no. 7 (October 1, 2011): 979–84. https://doi.org/10.1016/j.amjcard.2011.05.033.
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    • Khan, Abigail May, Susan Cheng, Martin Magnusson, Martin G. Larson, Christopher Newton-Cheh, Elizabeth L. McCabe, Andrea D. Coviello, et al. “Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies.” J Clin Endocrinol Metab 96, no. 10 (October 2011): 3242–49. https://doi.org/10.1210/jc.2011-1182.
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    • Travison, Thomas G., Shehzad Basaria, Thomas W. Storer, Alan M. Jette, Renee Miciek, Wildon R. Farwell, Karen Choong, et al. “Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation.” J Gerontol a Biol Sci Med Sci 66, no. 10 (October 2011): 1090–99. https://doi.org/10.1093/gerona/glr100.
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    • Coviello, A. D., W. V. Zhuang, K. L. Lunetta, S. Bhasin, J. Ulloor, A. Zhang, D. Karasik, D. P. Kiel, R. S. Vasan, and J. M. Murabito. “Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study.” J Clin Endocrinol Metab 96, no. 9 (September 2011): E1491–95. https://doi.org/10.1210/jc.2011-0050.
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    • Lam, Carolyn S. P., Susan Cheng, Karen Choong, Martin G. Larson, Joanne M. Murabito, Christopher Newton-Cheh, Shalender Bhasin, et al. “Influence of sex and hormone status on circulating natriuretic peptides.” J Am Coll Cardiol 58, no. 6 (August 2, 2011): 618–26. https://doi.org/10.1016/j.jacc.2011.03.042.
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    • Bhasin, Shalender, Michael Pencina, Guneet Kaur Jasuja, Thomas G. Travison, Andrea Coviello, Eric Orwoll, Patty Y. Wang, et al. “Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts.” J Clin Endocrinol Metab 96, no. 8 (August 2011): 2430–39. https://doi.org/10.1210/jc.2010-3012.
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    • Elks, C. E., J. R. B. Perry, P. Sulem, D. I. Chasman, N. Franceschini, C. He, K. L. Lunetta, et al. “Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.” Nature Genetics 42, no. 12 (December 1, 2010): 1077–85. https://doi.org/10.1038/ng.714.
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    • Basaria, S., A. D. Coviello, T. G. Travison, T. W. Storer, W. R. Farwell, A. M. Jette, R. Eder, et al. “Adverse events associated with testosterone administration.” New England Journal of Medicine 363, no. 2 (July 8, 2010): 109–22. https://doi.org/10.1056/NEJMoa1000485.
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    • Krasnoff, Joanne B., Shehzad Basaria, Michael J. Pencina, Guneet K. Jasuja, Ramachandran S. Vasan, Jagadish Ulloor, Anqi Zhang, et al. “Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study.” J Clin Endocrinol Metab 95, no. 6 (June 2010): 2790–99. https://doi.org/10.1210/jc.2009-2680.
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    • Coviello, Andrea D., Susan Sam, Richard S. Legro, and Andrea Dunaif. “High prevalence of metabolic syndrome in first-degree male relatives of women with polycystic ovary syndrome is related to high rates of obesity.” J Clin Endocrinol Metab 94, no. 11 (November 2009): 4361–66. https://doi.org/10.1210/jc.2009-1333.
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    • Herbst, K. L., A. D. Coviello, A. Chang, and D. L. Boyle. “Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa.” Int J Obes (Lond) 33, no. 9 (September 2009): 1031–38. https://doi.org/10.1038/ijo.2009.119.
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    • Coviello, Andrea D. “Polycystic ovary syndrome: multiple pathways to a common phenotype?” Endocr Pract 15, no. 4 (May 2009): 387–89. https://doi.org/10.4158/EP09120.ED.
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    • Bhasin, Shalender, Anqi Zhang, Andrea Coviello, Ravi Jasuja, Jagadish Ulloor, Ravinder Singh, Hubert Vesper, and Ramachandran S. Vasan. “The impact of assay quality and reference ranges on clinical decision making in the diagnosis of androgen disorders.” Steroids 73, no. 13 (December 12, 2008): 1311–17. https://doi.org/10.1016/j.steroids.2008.07.003.
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    • Sam, Susan, Andrea D. Coviello, Yeon-Ah Sung, Richard S. Legro, and Andrea Dunaif. “Metabolic phenotype in the brothers of women with polycystic ovary syndrome.” Diabetes Care 31, no. 6 (June 2008): 1237–41. https://doi.org/10.2337/dc07-2190.
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    • Coviello, Andrea D., Beth Kaplan, Kishore M. Lakshman, Tai Chen, Atam B. Singh, and Shalender Bhasin. “Effects of graded doses of testosterone on erythropoiesis in healthy young and older men.” J Clin Endocrinol Metab 93, no. 3 (March 2008): 914–19. https://doi.org/10.1210/jc.2007-1692.
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    • Amory, John K., Andrea D. Coviello, Stephanie T. Page, Bradley D. Anawalt, Alvin M. Matsumoto, and William J. Bremner. “Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin.” Fertil Steril 89, no. 2 (February 2008): 380–86. https://doi.org/10.1016/j.fertnstert.2007.02.059.
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    • Amory, John K., Stephanie T. Page, Bradley D. Anawalt, Andrea D. Coviello, Alvin M. Matsumoto, and William J. Bremner. “Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraception.” J Androl 28, no. 4 (July 2007): 548–54. https://doi.org/10.2164/jandrol.106.002345.
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    • Bhasin, Shalender, Paul Enzlin, Andrea Coviello, and Rosemary Basson. “Sexual dysfunction in men and women with endocrine disorders.” Lancet 369, no. 9561 (February 17, 2007): 597–611. https://doi.org/10.1016/S0140-6736(07)60280-3.
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    • Coviello, Andrea D., Kishore Lakshman, Norman A. Mazer, and Shalender Bhasin. “Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone.” J Clin Endocrinol Metab 91, no. 11 (November 2006): 4669–75. https://doi.org/10.1210/jc.2006-0822.
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    • Coviello, Andrea D., Richard S. Legro, and Andrea Dunaif. “Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance.” J Clin Endocrinol Metab 91, no. 2 (February 2006): 492–97. https://doi.org/10.1210/jc.2005-1666.
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    • Anawalt, Bradley D., John K. Amory, Karen L. Herbst, Andrea D. Coviello, Stephanie T. Page, William J. Bremner, and Alvin M. Matsumoto. “Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial.” J Androl 26, no. 3 (May 2005): 405–13. https://doi.org/10.2164/jandrol.04135.
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    • Coviello, Andrea D., Alvin M. Matsumoto, William J. Bremner, Karen L. Herbst, John K. Amory, Bradley D. Anawalt, Paul R. Sutton, et al. “Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.” J Clin Endocrinol Metab 90, no. 5 (May 2005): 2595–2602. https://doi.org/10.1210/jc.2004-0802.
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    • Page, Stephanie T., Karen L. Herbst, John K. Amory, Andrea D. Coviello, Bradley D. Anawalt, Alvin M. Matsumoto, and William J. Bremner. “Testosterone administration suppresses adiponectin levels in men.” J Androl 26, no. 1 (January 2005): 85–92.
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    • Herbst, Karen L., Andrea D. Coviello, Stephanie Page, John K. Amory, Bradley D. Anawalt, and William J. Bremner. “A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men.” J Clin Endocrinol Metab 89, no. 12 (December 2004): 5959–65. https://doi.org/10.1210/jc.2003-032123.
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    • Coviello, Andrea D., William J. Bremner, Alvin M. Matsumoto, Karen L. Herbst, John K. Amory, Bradley D. Anawalt, Xiaohua Yan, et al. “Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen.” J Androl 25, no. 6 (November 2004): 931–38. https://doi.org/10.1002/j.1939-4640.2004.tb03164.x.
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    • Nusbaum, Neil J. “Intensive insulin therapy in critically ill patients.” N Engl J Med 346, no. 20 (May 16, 2002): 1586–88.
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    • Feldman, Henry A., Christopher Longcope, Carol A. Derby, Catherine B. Johannes, Andre B. Araujo, Andrea D. Coviello, William J. Bremner, and John B. McKinlay. “Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study.” J Clin Endocrinol Metab 87, no. 2 (February 2002): 589–98. https://doi.org/10.1210/jcem.87.2.8201.
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    • Goldstein, L. B., and A. Coviello. “Post-lesion administration of the NMDA receptor antagonist MK-801 does not impair motor recovery after unilateral sensorimotor cortex injury in the rat.” Brain Res 580, no. 1–2 (May 15, 1992): 129–36. https://doi.org/10.1016/0006-8993(92)90936-4.
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    • Goldstein, L. B., A. Coviello, G. D. Miller, and J. N. Davis. “Norepinephrine depletion impairs motor recovery following sensorimotor cortex injury in the rat.” Restor Neurol Neurosci 3, no. 1 (January 1, 1991): 41–47. https://doi.org/10.3233/RNN-1991-3105.
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  • Conference Papers

    • Ohlsson, Claes, Henri Wallaschofski, Kathryn L. Lunetta, Lisette Stolk, John R. B. Perry, Annemarie Koster, Ann-Kristin Petersen, et al. “Genetic determinants of serum testosterone concentrations in men.” In Plos Genet, 7:e1002313, 2011. https://doi.org/10.1371/journal.pgen.1002313.
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    • Zhai, Guangju, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, Andrea D. Coviello, Annemarie Koster, et al. “Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.” In Plos Genet, 7:e1002025, 2011. https://doi.org/10.1371/journal.pgen.1002025.
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    • Coviello, A. D., W. V. Zhuang, K. L. Lunetta, J. Ulloor, A. Zhang, D. Karasik, D. P. Kiel, S. Bhasin, R. S. Vasan, and J. M. Murabito. “Heritability of Circulating Testosterone and SHBG in Adult Women from the Framingham Heart Study.” In Endocrine Reviews, 31:S41–S41, 2010.
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