Scholars@Duke
Andrew Darrell Krystal

Andrew Darrell Krystal

Professor Emeritus of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
andrew.krystal@duke.edu
Box 3309 Med Ctr, Durham, NC 27710
54221 Hosp South, Durham, NC 27710

Scholarly Works - Conferences

Leveraging convenient wearable technology to assess adolescent sleep: physical and behavioral health correlates of single-channel sleep electroencephalogram in a community sample of youth.

Conference J Clin Sleep Med · July 13, 2026 STUDY OBJECTIVES: Sleep disturbances during adolescence heighten risk for physical and behavioral health problems, yet sleep physiological markers critical to health outcomes are rarely assessed in pediatric care. Wearable single-channel electroencephalogr ... Full text Link to item Cite

Identification of Neural Biomarkers of Major Depressive Disorder Symptom Severity Using Computerized Linguistic Analysis

Conference International IEEE EMBS Conference on Neural Engineering Ner · January 1, 2023 Although numerous treatments are available for major depressive disorder (MDD), patients can be refractory to sequential treatment regimens. Experimental studies have demonstrated promising results implementing deep brain stimulation (DBS) as a therapy for ... Full text Cite

0983 Sleep Associated With Executive Functioning Among Adolescents Across The Adhd Continuum

Conference Sleep · May 27, 2020 AbstractIntroductionExecutive functioning (EF) deficits are a key feature of ADHD, and sleep disturbances may be an important contribu ... Full text Cite

0472 Do the Subjective Effects of Hypnotic Medications Result in Unblinding of Treatment Assignment in Hypnotic Randomized Clinical Trials?

Conference Sleep · May 27, 2020 AbstractIntroductionSome hypnotic medications have obvious subjective effects, including therapeutic effects (i.e., anti-insomnia effe ... Full text Cite

0774 Factors Associated With The Continuous Use Of Psychotropic Treatments For Narcolepsy

Conference Sleep · May 27, 2020 AbstractIntroductionNarcolepsy is a debilitating disorder characterized by excessive sleepiness and cataplexy episodes. There is no cu ... Full text Cite

SLEEP IMPACTS OF NOCTURIA IN A LONGITUDINAL STUDY

Conference SLEEP MEDICINE · December 2019 Link to item Cite

Shedding light to sleep studies

Conference Proceedings of SPIE the International Society for Optical Engineering · January 1, 2017 This paper presents our efforts in the development of a small wireless, flexible bandage sized near-infrared spectroscopy (NIRS) system for sleep analysis. The current size of the system is 2.8 cm × 1.7 cm × 0.6 cm. It is capable of performing NIRS with 66 ... Full text Cite

Efficacy of Cognitive-Behavioral Therapy for Insomnia Combined With Antidepressant Pharmacotherapy in Patients With Comorbid Depression and Insomnia: A Randomized Controlled Trial.

Conference J Clin Psychiatry · October 2016 OBJECTIVES: The Treatment of Insomnia and Depression (TRIAD) study evaluated the efficacy of combining depression pharmacotherapy (using MED, an ecologically valid and generalizable antidepressant medication algorithm) with cognitive-behavioral therapy for ... Full text Link to item Cite

Can We Use Brain Oscillations to Guide Treatment of MDD?

Conference BIOLOGICAL PSYCHIATRY · May 1, 2015 Link to item Cite

Towards injectable biophotonic sensors for physiological monitoring of animals

Conference Proceedings of IEEE Sensors · December 12, 2014 We present a novel subcutaneous biophotonics sensor system for continuous monitoring of hemodynamic parameters in animals. This sensor incorporates surface-mount light sources and photodetectors in the form factors of glass capsules used for microchip impl ... Full text Cite

Topography of seizures induced by electroconvulsive therapy and magnetic seizure therapy

Conference International IEEE EMBS Conference on Neural Engineering Ner · December 1, 2013 We present the first topographical characterization of seizures induced by ultrabrief pulse width right unilateral electroconvulsive therapy (ECT) and magnetic seizure therapy (MST). Topographical electroencephalogram (EEG) was acquired during treatments i ... Full text Cite

SLEEP PATTERNS OF INDIVIDUALS WITH SCHIZOPHRENIA

Conference SCHIZOPHRENIA BULLETIN · March 1, 2011 Link to item Cite

MR1 abnormalities and circadian rhythm disturbances in persons with dementia

Conference JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2008 Link to item Cite

Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group.

Conference Neurology · March 14, 2000 OBJECTIVE: This is one of two separate clinical trials to evaluate the efficacy and safety of modafinil, a novel wake-promoting agent, in patients with excessive daytime sleepiness (EDS) associated with narcolepsy. METHODS: In this 9-week, randomized, plac ... Full text Link to item Cite

Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy

Conference Annals of Neurology · January 1998 AbstractNarcolepsy is a central nervous system disorder characterized by excessive daytime sleepiness and cataplexy. This placebocontrolled, double‐blind, randomized, parallel‐group, 18‐center study assessed the efficacy an ... Full text Cite

THE LARGEST LYAPUNOV EXPONENT OF THE EEG IN ECT SEIZURES

Conference PROCEEDINGS OF THE CONFERENCE ON MEASURING CHAOS IN THE HUMAN BRAIN · January 1, 1991 Link to item Cite