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Andrew Sherwood

Professor Emeritus in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
Box 3119 Med Ctr, Durham, NC 27710
4571 Hosp South, Durham, NC 27710

Featured Works


The effect of job strain on nighttime blood pressure dipping among men and women with high blood pressure.

Journal article Scand J Work Environ Health · January 2013 Featured Work OBJECTIVES: Blunted nighttime blood pressure dipping is an established cardiovascular risk factor. This study examined the effect of job strain on nighttime blood pressure dipping among men and women with high blood pressure. METHODS: The sample consisted ... Full text Link to item Cite

Nighttime blood pressure dipping in postmenopausal women with coronary heart disease.

Journal article Am J Hypertens · October 2012 Featured Work BACKGROUND: Blunted nighttime blood pressure (BP) dipping is prognostic of cardiovascular morbidity and mortality. This relationship may be stronger among women than men. The present study hypothesized that coronary artery disease (CAD) and advancing age w ... Full text Link to item Cite

Exercise and pharmacological treatment of depressive symptoms in patients with coronary heart disease: results from the UPBEAT (Understanding the Prognostic Benefits of Exercise and Antidepressant Therapy) study.

Journal article J Am Coll Cardiol · September 18, 2012 Featured Work OBJECTIVES: The aim of this study was to assess the efficacy of exercise and antidepressant medication in reducing depressive symptoms and improving cardiovascular biomarkers in depressed patients with coronary heart disease. BACKGROUND: Although there is ... Full text Link to item Cite

Sex differences in the endothelial function of untreated hypertension.

Journal article J Clin Hypertens (Greenwich) · April 2012 Featured Work Vascular endothelial dysfunction is associated with increased risk for adverse cardiovascular (CV) events. However, less is known about sex differences in the endothelial function of untreated hypertensive individuals. The purpose of this study was to asse ... Full text Link to item Cite

Ethnic differences in the effects of the DASH diet on nocturnal blood pressure dipping in individuals with high blood pressure.

Journal article Am J Hypertens · December 2011 Featured Work BACKGROUND: Ethnic differences in nocturnal blood pressure (BP) dipping may contribute to the increased risk for adverse cardiovascular events noted in African Americans (AAs). The DASH (Dietary Approaches to Stop Hypertension) diet has been shown to be ef ... Full text Link to item Cite

Blood pressure dipping: ethnicity, sleep quality, and sympathetic nervous system activity.

Journal article Am J Hypertens · September 2011 Featured Work BACKGROUND: Blunted blood pressure (BP) dipping is an established predictor of adverse cardiovascular outcomes. Although blunted BP dipping is more common in African Americans than whites, the factors contributing to this ethnic difference are not well und ... Full text Link to item Cite

Association of vascular health and neurocognitive performance in overweight adults with high blood pressure.

Journal article J Clin Exp Neuropsychol · June 2011 Featured Work The relationship between vascular health--including flow-mediated dilation (FMD) and intima medial thickness (IMT)--and neurocognitive performance was examined in a sample of 124 sedentary, middle-aged adults with high blood pressure (systolic blood pressu ... Full text Link to item Cite

Coping effectively with heart failure (COPE-HF): design and rationale of a telephone-based coping skills intervention.

Journal article J Card Fail · March 2011 Featured Work BACKGROUND: Coping Effectively with Heart Failure (COPE-HF) is an ongoing randomized clinical trial funded by the National Institutes of Health to evaluate if a coping skills training (CST) intervention will result in improved health status and quality of ... Full text Link to item Cite

Worsening depressive symptoms are associated with adverse clinical outcomes in patients with heart failure.

Journal article J Am Coll Cardiol · January 25, 2011 Featured Work OBJECTIVES: The purpose of this study was to assess the impact of changes in symptoms of depression over a 1-year period on subsequent clinical outcomes in heart failure (HF) patients. BACKGROUND: Emerging evidence shows that clinical depression, which is ... Full text Link to item Cite

Effects of the dietary approaches to stop hypertension diet alone and in combination with exercise and caloric restriction on insulin sensitivity and lipids.

Journal article Hypertension · May 2010 Featured Work This study examined the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on insulin sensitivity and lipids. In a randomized control trial, 144 overweight (body mass index: 25 to 40) men (n=47) and women (n=97) with high blood pressure (13 ... Full text Link to item Cite

Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women.

Journal article Menopause · March 2010 Featured Work OBJECTIVE: After menopause, women are at an increased risk of cardiovascular disease. The present study assessed cardiovascular hemodynamics in premenopausal versus postmenopausal women, with a focus on systemic vascular resistance (SVR) at rest and during ... Full text Link to item Cite

Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence.

Journal article Ann Behav Med · February 2010 Featured Work BACKGROUND: Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease. PURPOSE: The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk ... Full text Link to item Cite

Effects of the DASH diet alone and in combination with exercise and weight loss on blood pressure and cardiovascular biomarkers in men and women with high blood pressure: the ENCORE study.

Journal article Arch Intern Med · January 25, 2010 Featured Work BACKGROUND: Although the DASH (Dietary Approaches to Stop Hypertension) diet has been shown to lower blood pressure (BP) in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiova ... Full text Link to item Cite

Cardiovascular disease risk, vascular health and erectile dysfunction among middle-aged, clinically depressed men.

Journal article Int J Impot Res · 2010 Featured Work Erectile dysfunction (ED) is especially common in men with major depressive disorder (MDD). This study examined the extent to which risk factors for cardiovascular disease (CVD) and vascular endothelial dysfunction were associated with ED severity in MDD p ... Full text Link to item Cite

Coping styles in heart failure patients with depressive symptoms.

Journal article J Psychosom Res · October 2009 Featured Work OBJECTIVE: Elevated depressive symptoms have been linked to poorer prognosis in heart failure (HF) patients. Our objective was to identify coping styles associated with depressive symptoms in HF patients. METHODS: A total of 222 stable HF patients (32.75% ... Full text Link to item Cite

Intima-media thickness and age of first depressive episode.

Journal article Biol Psychol · March 2009 Featured Work BACKGROUND: Late life depression, including patients with vascular depression, has been associated with higher levels of intima-media thickness (IMT). Although individuals with vascular depression tend to report a later onset of depression, the relationshi ... Full text Link to item Cite

Age moderates the short-term effects of transdermal 17beta-estradiol on endothelium-dependent vascular function in postmenopausal women.

Journal article Arterioscler Thromb Vasc Biol · August 2007 Featured Work OBJECTIVE: We evaluated age and coronary heart disease (CHD) as potential moderators of the effects of 17beta-estradiol on vascular endothelial function in postmenopausal women. METHODS AND RESULTS: In a double-blind crossover design, 100 postmenopausal wo ... Full text Link to item Cite

Relationship of depression to death or hospitalization in patients with heart failure.

Journal article Arch Intern Med · February 26, 2007 Featured Work BACKGROUND: Depression is widely recognized as a risk factor in patients with coronary heart disease. However, patients with heart failure (HF) have been less frequently studied, and the effect of depression on prognosis, independent of disease severity, i ... Full text Link to item Cite

Impaired endothelial function in coronary heart disease patients with depressive symptomatology.

Journal article J Am Coll Cardiol · August 16, 2005 Featured Work OBJECTIVES: The purpose of this study was to assess whether depressive symptomatology was associated with vascular endothelial dysfunction in patients with coronary heart disease (CHD). BACKGROUND: In patients with CHD, the presence of depression is associ ... Full text Link to item Cite

Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women.

Journal article J Psychosom Res · October 2004 Featured Work OBJECTIVE: Depression is a risk factor for morbidity and mortality in a variety of populations, and anxiety has also been associated with risk of mortality among cardiac patients. Dysfunction of the autonomic nervous system may be involved in this risk. Th ... Full text Link to item Cite

Ethnic differences in left ventricular structure: relations to hemodynamics and diurnal blood pressure variation.

Journal article Am J Hypertens · January 2004 Featured Work BACKGROUND: Previous studies have suggested that African Americans have a greater left ventricular relative wall thickness than whites with similar levels of blood pressure (BP), whereas other investigators have documented an attenuated nocturnal decline i ... Full text Link to item Cite

Hostility is related to blunted beta-adrenergic receptor responsiveness among middle-aged women.

Journal article Psychosom Med · 2004 Featured Work OBJECTIVE: Based on previous findings in men, the hypothesis that hostility would be associated with blunted responsiveness of cardiovascular beta-adrenergic receptors was tested in a study sample of middle-aged women. The roles of the sympathetic nervous ... Full text Link to item Cite

Ethnic differences in the hemodynamic mechanisms of ambulatory blood pressure regulation.

Journal article Am J Hypertens · April 2003 Featured Work BACKGROUND: African Americans typically exhibit greater systemic vascular resistance (SVR) than do white individuals in response to laboratory challenges that raise blood pressure (BP). However, ethnic differences in ambulatory blood pressure (ABP) regulat ... Full text Link to item Cite

Effects of perceived racism and anger inhibition on ambulatory blood pressure in African Americans.

Journal article Psychosom Med · 2003 Featured Work OBJECTIVE: Hypertension is more prevalent in African Americans compared with Americans of European descent. Preliminary evidence indicates that perceived racism may play a role in elevated blood pressure in African Americans. The present study examined whe ... Full text Link to item Cite

Changes in hemodynamics and left ventricular structure after menopause.

Journal article Am J Cardiol · April 1, 2002 Featured Work To evaluate the cardiovascular changes associated with menopause, we studied hemodynamics at rest, ambulatory blood pressure, and left ventricular structure in a biracial cohort of pre- and postmenopausal women of similar age, race, weight, and blood press ... Full text Link to item Cite

Nighttime blood pressure dipping: the role of the sympathetic nervous system.

Journal article Am J Hypertens · February 2002 Featured Work There is a marked diurnal variation in blood pressure (BP), with BP dipping to its lowest levels during nighttime sleep. A day-night dip in systolic BP (SBP) of <10% has been used to characterize individuals as nondippers, and is associated with an increas ... Full text Link to item Cite

Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressure.

Journal article Psychosom Med · 2002 Featured Work OBJECTIVE: This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP m ... Full text Link to item Cite

Blunted nighttime blood pressure dipping in postmenopausal women.

Journal article Am J Hypertens · August 2001 Featured Work Blunting of the normal drop in blood pressure (BP) from day to night is emerging as a strong prognostic indicator of cardiovascular morbidity and mortality. This study evaluated the effects of natural menopause on BP dipping in African American and white w ... Full text Link to item Cite

Religious coping, ethnicity, and ambulatory blood pressure.

Journal article Psychosom Med · 2001 Featured Work OBJECTIVE: To investigate the relationship between religious coping, ethnicity, and ambulatory blood pressure (ABP) measured during daily life. METHODS: A 24-hour ABP was obtained from 155 men and women (78 African American and 77 white) on a typical workd ... Full text Link to item Cite

Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning.

Journal article Arch Intern Med · July 10, 2000 Featured Work BACKGROUND: Lifestyle modifications have been recommended as the initial treatment strategy for lowering high blood pressure (BP). However, evidence for the efficacy of exercise and weight loss in the management of high BP remains controversial. METHODS: O ... Full text Link to item Cite

Hemodynamic and sympathetic nervous system responses to stress during the menstrual cycle.

Journal article AACN Clin Issues · May 2000 Featured Work In this study, the impact of menstrual cycle phase on hemodynamic and sympathetic nervous system responses was examined during exposure to a battery of laboratory stressors. Participants were 40 healthy premenopausal women, aged 26 to 51. Impedance cardiog ... Full text Link to item Cite

Emotional responsivity during daily life: relationship to psychosocial functioning and ambulatory blood pressure.

Journal article Int J Psychophysiol · April 2000 Featured Work Emotional responsivity refers to acute changes in affective states. This study examined the relationship of emotional responsivity during daily life with ambulatory blood pressure (ABP) and psychosocial functioning. Subjects were 162 employed men and women ... Full text Link to item Cite

Ambulatory blood pressure and marital distress in employed women.

Journal article Behav Med · 2000 Featured Work In this investigation, the relationship between marital distress and blood pressure during daily life in a sample of married employed women was examined. It was hypothesized that greater marital distress would be associated with elevated blood pressure in ... Full text Link to item Cite

Endothelial function and hemodynamic responses during mental stress.

Journal article Psychosom Med · 1999 Featured Work OBJECTIVE: The hemodynamic basis of blood pressure responses during psychological stress shows striking individual differences that share an interesting similarity with risk for cardiovascular disease. Factors accounting for these individual differences ar ... Full text Link to item Cite

Ambulatory impedance cardiography: a feasibility study.

Journal article J Appl Physiol (1985) · December 1998 Featured Work A wearable, ambulatory impedance monitor (AIM) has been developed to permit impedance cardiographic measurements while patients and volunteers engage in normal daily activities. The AIM system was developed for use with a new hybrid tetrapolar spot-band el ... Full text Link to item Cite

Psychosocial influences on blood pressure during daily life.

Journal article Int J Psychophysiol · March 1998 Featured Work Ambulatory blood pressure (ABP) monitoring allows frequent non-invasive blood pressure (BP) recordings in a variety of settings. Emerging evidence suggests that ABP is a better predictor of cardiovascular morbidity than clinic BP. Ambulatory blood pressure ... Full text Link to item Cite

High anxiety and white coat hypertension.

Journal article JAMA · January 21, 1998 Featured Work Full text Link to item Cite

Blood pressure reactivity and marital distress in employed women.

Journal article Psychosom Med · 1998 Featured Work OBJECTIVE: The impact of marital distress on cardiovascular responses to an "ecologically valid" laboratory stressor (a marital conflict recall task) was examined in maritally distressed and non-distressed women. It was hypothesized that the presence of hi ... Full text Link to item Cite

Ten-year stability of cardiovascular responses to laboratory stressors.

Journal article Psychophysiology · March 1997 Featured Work In this study, we examined test-retest stability of cardiovascular stress responses over a decade of the life span. Participants were 55 male college undergraduates, 19 years of age at initial testing, and 29 years of age at follow-up testing. Stressors we ... Full text Link to item Cite

Ethnic differences in hemodynamic responses to stress in hypertensive men and women.

Journal article Am J Hypertens · June 1995 Featured Work Hemodynamic response patterns to three laboratory stressors were compared in 63 mildly hypertensive black and white men and women. Ethnic groups were matched for age, body mass index, and casual blood pressures. Stressors included a mental arithmetic task, ... Full text Link to item Cite

Physiological determinants of hyperreactivity to stress in borderline hypertension.

Journal article Hypertension · March 1995 Featured Work Blood pressure hyperreactivity during stress is characteristic of borderline hypertension in white men. The present study evaluated the hemodynamic basis of this hyperreactivity and assessed its physiological basis in terms of sympathetic nervous system fu ... Full text Link to item Cite

Hemodynamic responses during psychological stress: implications for studying disease processes.

Journal article Int J Behav Med · 1995 Featured Work Investigation of the physiological correlates of psychological stress is of interest in relation to the putative impact of stress in the etiology of cardiovascular disease. Although the assessment of blood pressure and heart rate responses to psychological ... Full text Link to item Cite

Comparison of impedance cardiographic measurements using band and spot electrodes.

Journal article Psychophysiology · November 1992 Featured Work The comprehensive assessment of cardiac function using impedance cardiography has led to increasingly widespread use of the technique in psychophysiology. Disposable adhesive band electrodes have been the most widely used electrode type, but spot electrode ... Full text Link to item Cite

Cardiovascular reactivity assessment: effects of choice of difficulty on laboratory task responses.

Journal article Int J Psychophysiol · January 1992 Featured Work This laboratory study of cardiovascular reactivity was designed to examine how a choice of difficulty element in a mental arithmetic task would affect cardiovascular responses. 20 healthy male subjects were tested on a computer-controlled mental arithmetic ... Full text Link to item Cite

Cardiac output by impedance cardiography: two alternative methodologies compared with thermodilution.

Journal article Aviat Space Environ Med · February 1991 Featured Work One critical component of the Kubicek (8) stroke volume equation, used to measure cardiac output by impedance cardiography, is dZ/dt(max). The present study, conducted on six anesthetized dogs, compared impedance cardiac output derived using two alternativ ... Link to item Cite

Hemodynamics of blood pressure responses during active and passive coping.

Journal article Psychophysiology · November 1990 Featured Work This laboratory study was designed to address a number of interrelated issues regarding cardiovascular reactivity to psychological stress. One objective was to extend the previous research comparing cardiovascular responses during active versus passive cop ... Full text Link to item Cite

Methodological guidelines for impedance cardiography.

Journal article Psychophysiology · January 1990 Featured Work Impedance cardiography was introduced over 20 years ago as a noninvasive and unobtrusive technique for measuring systolic time intervals and cardiac output. Although our understanding of the physiological events reflected in the impedance cardiogram has be ... Full text Link to item Cite

Motor preparation aspects of cardiovascular reactivity to psychological challenge.

Journal article Int J Psychophysiol · November 1988 Featured Work Neural control of the circulation has evolved in such a way that behavioral responses to psychological stress may be accompanied by a dramatic activation of the cardiovascular system. This study was designed to address the hypothesis that such instances of ... Full text Link to item Cite