Andrzej Stanislaw Kosinski

Journal article Stat Med · March 15, 2013 Featured Publication Positive and negative predictive values are important measures of a medical diagnostic test performance. We consider testing equality of two positive or two negative predictive values within a paired design in which all patients receive two diagnostic test ... Full text Link to item Cite

Effect of improving the quality of radiographic interpretation on the ability to predict pulmonary tuberculosis relapse.

Journal article Acad Radiol · February 2010 Featured Publication RATIONALE AND OBJECTIVES: Chest radiographic findings are important for diagnosis and management of tuberculosis. The reliability of these findings is therefore of interest. We sought to describe interobserver reliability of chest radiographic findings in ... Full text Link to item Cite

Design and rationale of the Evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) trial.

Journal article Am Heart J · November 2009 Featured Publication BACKGROUND: Currently recommended anticoagulant agents used in the setting of percutaneous coronary intervention (PCI) inhibit, with varying degrees of intensity, 2 critical targets (factor Xa and/or IIa) of the coagulation cascade, yet they carry signific ... Full text Link to item Cite

Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials.

Journal article Lancet · April 4, 2009 Featured Publication BACKGROUND: Coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) are alternative treatments for multivessel coronary disease. Although the procedures have been compared in several randomised trials, their long-term effects on mo ... Full text Link to item Cite

Reperfusion ventricular arrhythmia 'bursts' predict larger infarct size despite TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction.

Journal article Eur Heart J · April 2009 Featured Publication Aims Successful epicardial reperfusion with primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) can paradoxically evoke myocardial reperfusion injury, which may be signalled by temporally associated ventricular a ... Full text Link to item Cite

Reperfusion ventricular arrhythmia 'bursts' in TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction: a more precise definition of reperfusion arrhythmias.

Journal article Europace · August 2008 Featured Publication AIMS: We sought to define reperfusion-induced ventricular arrhythmias (VAs) more precisely through simultaneous angiography, continuous ST-segment recovery, and beat-to-beat Holter analyses in subjects with anterior ST-elevation myocardial infarction (STEM ... Full text Link to item Cite

Computer programs for the concordance correlation coefficient.

Journal article Comput Methods Programs Biomed · October 2007 Featured Publication The CCC macro is presented for computation of the concordance correlation coefficient (CCC), a common measure of reproducibility. The macro has been produced in both SAS and R, and a detailed presentation of the macro input and output for the SAS program i ... Full text Link to item Cite

Decreasing CD4+ T-cell count during suppressed or low-level viraemia in patients with HIV infection.

Journal article Antivir Ther · 2007 Featured Publication BACKGROUND: Suboptimal improvement in CD4+ T-cell count is not uncommon in HIV-infected patients with suppressed plasma HIV RNA levels, and a decrease in CD4+ T-cell count in patients with suppressed or low-level viraemia has been observed. METHODS: Our ob ... Link to item Cite

Comparison of concordance correlation coefficient and coefficient of individual agreement in assessing agreement.

Journal article J Biopharm Stat · 2007 Featured Publication In method comparison and reliability studies, it is often important to assess agreement between multiple measurements made by different methods, devices, laboratories, observers, or instruments. For continuous data, the concordance correlation coefficient ... Full text Link to item Cite

Assessing individual agreement.

Journal article J Biopharm Stat · 2007 Featured Publication Evaluating agreement between measurement methods or between observers is important in method comparison studies and in reliability studies. Often we are interested in whether a new method can replace an existing invasive or expensive method, or whether mul ... Full text Link to item Cite

The weighted generalized estimating equations approach for the evaluation of medical diagnostic test at subunit level.

Journal article Biom J · August 2006 Featured Publication Sensitivity and specificity are common measures used to evaluate the performance of a diagnostic test. A diagnostic test is often administrated at a subunit level, e.g. at the level of vessel, ear or eye of a patient so that the treatment can be targeted a ... Full text Link to item Cite

A global sensitivity analysis of performance of a medical diagnostic test when verification bias is present.

Journal article Stat Med · September 15, 2003 Featured Publication Current advances in technology provide less invasive or less expensive diagnostic tests for identifying disease status. When a diagnostic test is evaluated against an invasive or expensive gold standard test, one often finds that not all patients undergo t ... Full text Link to item Cite

Evaluating medical diagnostic tests at the subunit level in the presence of verification bias.

Journal article Stat Med · July 15, 2003 Featured Publication We advocate that medical diagnostic tests should be evaluated at the subunit level instead of the patient level if a disease can occur in multiple parts/units within a patient, for example, vessels, segments, ears, eyes etc. When a non-invasive test is com ... Full text Link to item Cite

Accounting for nonignorable verification bias in assessment of diagnostic tests.

Journal article Biometrics · March 2003 Featured Publication A "gold" standard test, providing definitive verification of disease status, may be quite invasive or expensive. Current technological advances provide less invasive, or less expensive, diagnostic tests. Ideally, a diagnostic test is evaluated by comparing ... Full text Link to item Cite

Prediction of native coronary artery disease progression following PTCA or CABG in the Emory Angioplasty Versus Surgery Trial.

Journal article Med Sci Monit · February 2003 Featured Publication BACKGROUND: The natural history of atherosclerosis progression following revascularization procedures (PTCA or CABG) limits the long-term benefits of these procedures and requires continuation of risk management. MATERIAL/METHODS: Of 392 patients with mult ... Link to item Cite

Cost and cost-effectiveness of an early invasive vs conservative strategy for the treatment of unstable angina and non-ST-segment elevation myocardial infarction.

Journal article JAMA · October 16, 2002 Featured Publication CONTEXT: In the Treat Angina with Aggrastat and Determine Cost of Therapy with an Invasive or Conservative Strategy (TACTICS)-Thrombolysis in Myocardial Infarction (TIMI) 18 trial, patients with either unstable angina or non-ST-segment elevation myocardial ... Full text Link to item Cite

Intravascular radiation therapy after balloon angioplasty of narrowed femoropopliteal arteries to prevent restenosis: results of the PARIS feasibility clinical trial.

Journal article J Vasc Interv Radiol · August 2001 Featured Publication PURPOSE: To conduct a feasibility study to assess the feasibility, safety, and outcome of endoluminal gamma radiation therapy after balloon angioplasty of superficial femoral artery (SFA) lesions. MATERIALS AND METHODS: Forty patients with claudication wer ... Full text Link to item Cite

Costs of revascularization over eight years in the randomized and eligible patients in the Emory Angioplasty versus Surgery Trial (EAST).

Journal article Am J Cardiol · October 1, 2000 Featured Publication The Emory Angioplasty versus Surgery Trial (EAST) was a randomized trial that compared, by intention to treat, the clinical outcome and costs of percutaneous transluminal coronary angioplasty (PTCA) and coronary bypass grafting (CABG) for multivessel coron ... Full text Link to item Cite

Targeting patients undergoing angioplasty for thrombus inhibition: a cost-effectiveness and decision support model.

Journal article Circulation · July 25, 2000 Featured Publication BACKGROUND: In recent clinical trials, glycoprotein IIb/IIIa blockers have demonstrated effectiveness in preventing adverse events after angioplasty in high-risk patients. However, uncertainty exists regarding the cost-effective selection of patients to re ... Full text Link to item Cite

Eight-year mortality in the Emory Angioplasty versus Surgery Trial (EAST).

Journal article J Am Coll Cardiol · April 2000 Featured Publication OBJECTIVES: To evaluate the long-term outcome of patients randomized to coronary bypass surgery or coronary angioplasty. BACKGROUND: The Emory Angioplasty versus Surgery Trial (EAST) is a single center randomized comparison of a strategy of initial coronar ... Full text Link to item Cite

Applying the resource-based relative value scale to the Emory angioplasty versus surgery trial.

Journal article Am J Cardiol · March 15, 2000 Featured Publication The resource-based relative value scale developed for use in the Medicare fee schedule can also be very useful in profiling and comparing physicians' cardiovascular utilization across different medical activities. This article applies relative value units ... Full text Link to item Cite

Prognostic value of thallium-201 single-photon emission computed tomography for patients with multivessel coronary artery disease after revascularization (the Emory Angioplasty versus Surgery Trial [EAST]).

Journal article Am J Cardiol · December 15, 1999 Featured Publication The aim of this study was to investigate the relation between reversible thallium single-photon emission computed tomography (SPECT) myocardial perfusion defects at 1-year after revascularization and quantitative indexes in Emory Angioplasty versus Surgery ... Full text Link to item Cite

Evaluating the exposure and disease relationship with adjustment for different types of exposure misclassification: a regression approach.

Journal article Stat Med · October 30, 1999 Featured Publication Misclassification of exposure can lead to biased results in the epidemiologic research. Available methods accounting for misclassification often require the use of a gold standard or assume non-differential misclassification of exposure. We present a regre ... Full text Link to item Cite

Economic impact of GPIIB/IIIA blockade after high-risk angioplasty: results from the RESTORE trial. Randomized Efficacy Study of Tirofiban for Outcomes and Restenosis.

Journal article J Am Coll Cardiol · October 1999 Featured Publication OBJECTIVE: This study was conducted to assess the impact of GPIIb/IIIa blockade with tirofiban on costs during the initial hospitalization and at 30 days among patients undergoing high-risk coronary angioplasty. BACKGROUND: GPIIb/IIIa blockers are a new cl ... Full text Link to item Cite

A comparison of the Charlson comorbidity index derived from medical record data and administrative billing data.

Journal article J Clin Epidemiol · February 1999 Featured Publication The objective of this article is to compare the Charlson comorbidity index derived from medical record data (Chart Index) with the same index derived from billing data (ICD-9 Index) to determine how well each predicted inpatient and 30-day mortality, lengt ... Full text Link to item Cite

A regression model for multivariate random length data.

Journal article Stat Med · January 30, 1999 Featured Publication Multivariate random length data occur when we observe multiple measurements of a quantitative variable and the variable number of these measurements is also an observed outcome for each experimental unit. For example, for a patient with coronary artery dis ... Full text Link to item Cite

Prospective, randomized trial comparing blood and oxygenated crystalloid cardioplegia in reoperative coronary artery bypass grafting.

Journal article J Thorac Cardiovasc Surg · May 1998 Featured Publication OBJECTIVES: Reoperative coronary artery bypass grafting presents unique challenges for myocardial preservation. The purpose of this study was to compare oxygenated blood cardioplegia with oxygenated crystalloid cardioplegia during reoperative coronary arte ... Full text Link to item Cite

Concomitant aortic and renal artery reconstruction in patients on an intensive antihypertensive medical regimen: long-term outcome.

Journal article Ann Vasc Surg · May 1998 Featured Publication A beneficial effect in blood pressure control is presumed for patients on an intensive preoperative antihypertensive regimen who undergo empiric renal revascularization. Nonetheless, a noticeable decline in surgical cure rates for hypertension has been rec ... Full text Link to item Cite

Power considerations when a continuous outcome variable is dichotomized.

Journal article J Biopharm Stat · May 1998 Featured Publication An investigator can compare two groups with respect to a continuous outcome variable, Y, by comparing the means of Y or by collapsing that variable into categories. For example, antihypertensive treatments can be compared on the basis of blood pressure mea ... Full text Link to item Cite

Angiogenesis as a predictor of survival after surgical resection for stage I non-small-cell lung cancer.

Journal article J Thorac Cardiovasc Surg · March 1998 Featured Publication OBJECTIVES: Some patients with surgically resected stage I non-small-cell lung cancer eventually have metastatic disease. A histologic marker of metastatic potential and diminished survival for stage I non-small-cell lung cancer may distinguish this patien ... Full text Link to item Cite

Aggressive lipid lowering in postcoronary angioplasty patients with elevated cholesterol (the Lovastatin Restenosis Trial).

Journal article Am J Cardiol · March 1, 1998 Featured Publication A substudy of the Lovastatin Restenosis Trial in patients with elevated cholesterol (>200 mg/dl) showed no evidence of an effect of aggressive lipid lowering on restenosis, confirming the results of the main trial. ... Full text Link to item Cite

Late survival after valve operation in patients with left ventricular dysfunction.

Journal article Ann Thorac Surg · October 1997 Featured Publication BACKGROUND: Left ventricular dysfunction is a predictor of hospital mortality after cardiac valve operation. We evaluated late survival in a large cohort of these patients. METHODS: From 1980 to 1993, 257 patients with a preoperative ejection fraction of 0 ... Full text Link to item Cite

Angioplasty or surgery for multivessel coronary artery disease: comparison of eligible registry and randomized patients in the EAST trial and influence of treatment selection on outcomes. Emory Angioplasty versus Surgery Trial Investigators.

Journal article Am J Cardiol · June 1, 1997 Featured Publication The Emory Angioplasty versus Surgery Trial (EAST) showed that multivessel patients eligible for both percutaneous transluminal coronary angioplasty (PTCA) and coronary bypass surgery (CABG) had equivalent 3-year outcomes regarding survival, myocardial infa ... Full text Link to item Cite

Tubal ligation and fatal ovarian cancer in a large prospective cohort study.

Journal article Am J Epidemiol · February 15, 1997 Featured Publication Several studies suggest that tubal sterilization may decrease the risk of ovarian cancer. Data from the Cancer Prevention Study II were analyzed to examine the relation between tubal ligation and ovarian cancer mortality in a large prospective study. A tot ... Full text Link to item Cite

Is there a bias against performing coronary revascularization in women?

Journal article Am J Cardiol · November 15, 1996 Featured Publication This study compares referral to coronary revascularization after diagnostic cardiac catheterization in 8,133 women and 25,785 men. Although gender played a role, angiographic severity of coronary disease was the most important determinant of the selection ... Link to item Cite

Empirical reconstruction of the renal artery: long-term outcome.

Journal article J Vasc Surg · September 1996 Featured Publication PURPOSE: Unequivocal indications for renal artery reconstruction remain the presence of significant underlying renal insufficiency or severe hypertension. Thus surgical intervention for renal artery stenosis in the absence of this clinical picture may well ... Full text Link to item Cite

Relation of lumen size to restenosis after percutaneous transluminal coronary balloon angioplasty. Lovastatin Restenosis Trial Group.

Journal article Am J Cardiol · July 15, 1996 Featured Publication The relation between post-percutaneous transluminal balloon angioplasty (post-PTCA) and angiography indexes were investigated in the Lovastatin Restenosis Trial. Post-PTCA percent diameter measured by the operator was found to be a weak predictor of angiog ... Link to item Cite

The importance of work-up (verification) bias correction in assessing the accuracy of SPECT thallium-201 testing for the diagnosis of coronary artery disease.

Journal article J Clin Epidemiol · July 1996 Featured Publication Noninvasive testing is often evaluated by the sensitivity and specificity in comparison with a more invasive, but more definitive "gold" standard. However, work-up or verification bias, which occurs when the results of a noninvasive test impact the decisio ... Full text Link to item Cite

Effectiveness of revascularization in the Emory angioplasty versus surgery trial. A randomized comparison of coronary angioplasty with bypass surgery.

Journal article Circulation · June 1, 1996 Featured Publication BACKGROUND: The Emory Angioplasty Versus Surgery Trial (EAST) was designed to determine whether percutaneous transluminal coronary angioplasty (PTCA) is as effective as coronary artery bypass graft surgery (CABG) in restoring arterial perfusion capacity in ... Full text Link to item Cite

A comparison of the costs of and quality of life after coronary angioplasty or coronary surgery for multivessel coronary artery disease. Results from the Emory Angioplasty Versus Surgery Trial (EAST).

Journal article Circulation · November 15, 1995 Featured Publication BACKGROUND: The Emory Angioplasty Versus Surgery Trial (EAST) is a randomized trial that compares, by intention to treat, the clinical outcome and costs of percutaneous transluminal coronary angioplasty (PTCA) and coronary surgery for multivessel coronary ... Full text Link to item Cite

Percutaneous transluminal coronary angioplasty as a first revascularization procedure in single-, double- and triple-vessel coronary artery disease.

Journal article J Am Coll Cardiol · July 1995 Featured Publication OBJECTIVES: We sought to compare in-hospital and long-term outcome after angioplasty in patients with single-, double- and triple-vessel disease. BACKGROUND: Coronary angioplasty is increasingly used in patients with multivessel disease. METHODS: The sourc ... Full text Link to item Cite

Emory Angioplasty Versus Surgery Trial (EAST): design, recruitment, and baseline description of patients.

Journal article Am J Cardiol · March 23, 1995 Featured Publication In patients with multivessel coronary artery disease who require revascularization there is uncertainty as to the selection of the appropriate patients for percutaneous transluminal coronary angioplasty (PTCA) as opposed to coronary artery bypass grafting ... Link to item Cite

Methodology to correct for differential misclassification.

Journal article Epidemiology · March 1995 Featured Publication Misclassification of exposure is a serious problem in epidemiology. Methods for addressing misclassification are available, but most are based on limiting assumptions such as availability of a "gold standard" measure of true exposure, or availability of tw ... Full text Link to item Cite

Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease.

Journal article N Engl J Med · February 23, 1995 Featured Publication BACKGROUND: Impaired endothelium-mediated relaxation contributes to vasospasm and myocardial ischemia in patients with coronary artery disease. We hypothesized that cholesterol-lowering therapy with the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhib ... Full text Link to item Cite

Lack of effect of lovastatin on restenosis after coronary angioplasty. Lovastatin Restenosis Trial Study Group.

Journal article N Engl J Med · November 17, 1994 Featured Publication BACKGROUND: Experimental and clinical observations suggest that lowering serum lipid levels may reduce the risk of restenosis after coronary angioplasty. We report the results of a prospective, randomized, double-blind trial evaluating whether lowering lip ... Full text Link to item Cite

A randomized trial comparing coronary angioplasty with coronary bypass surgery. Emory Angioplasty versus Surgery Trial (EAST).

Journal article N Engl J Med · October 20, 1994 Featured Publication BACKGROUND: The clinical benefit of percutaneous transluminal coronary angioplasty (PTCA) as compared with coronary-artery bypass grafting (CABG) for patients with multivessel coronary artery disease has not been established. To determine the outcomes of t ... Full text Link to item Cite

Percutaneous transluminal coronary angioplasty in women compared with men.

Journal article J Am Coll Cardiol · July 1994 Featured Publication OBJECTIVES: This study compares in-hospital and long-term outcome after angioplasty in women and men. BACKGROUND: The recognition that coronary artery disease is the most common cause of death in women has increased interest in outcome studies of coronary ... Full text Link to item Cite

A prospective evaluation of surgically treated groin complications following percutaneous cardiac procedures.

Journal article Am Surg · February 1994 Featured Publication During an 18-month study period, 100 noncardiac surgical complications of a percutaneous cardiac interventional procedure were treated at Emory University Hospital. These were predominantly pseudoaneurysms (61.2%), groin hematomas (11.2%) arteriovenous fis ... Link to item Cite

Ischemic nephropathy and concomitant aortic disease: a ten-year experience.

Journal article J Vasc Surg · January 1994 Featured Publication PURPOSE: The durability of renal preservation after surgical intervention has not been well defined, particularly in patients with associated aortic disease. A review of all patients at the Emory University Hospital with renal insufficiency (creatinine lev ... Full text Link to item Cite

Acute lower extremity ischemia after cardiac surgery.

Journal article Am J Surg · August 1993 Featured Publication A retrospective review during a 5-year period (1987 to 1992) was conducted of all patients manifesting leg ischemia after major cardiac surgery. There were 7,620 procedures performed, and 65 (0.85%) patients (mean age: 65 years) were identified with acute ... Full text Link to item Cite

Use of two data sources to estimate odds ratios in case-control studies.

Journal article Epidemiology · July 1993 Featured Publication Information bias is among the most serious and common problems in epidemiology. Approaches have been developed to reduce information bias by correcting for known amounts of misclassification. Unfortunately, in most studies, the extent of exposure misclassi ... Full text Link to item Cite

Can restenosis after coronary angioplasty be predicted from clinical variables?

Journal article J Am Coll Cardiol · January 1993 Featured Publication OBJECTIVES: The purpose of this study was to determine whether variables shown to correlate with restenosis in one group (learning group) could be shown to predict recurrent stenosis in a second group (validation group). BACKGROUND: Restenosis remains a cr ... Full text Link to item Cite

Early mortality of acute myocardial infarction in patients with and without prior coronary revascularization surgery. A Coronary Artery Surgery Study Registry Study.

Journal article Circulation · June 1992 Featured Publication BACKGROUND: The Coronary Artery Surgery Study (CASS) Registry is used to evaluate the effect of various baseline clinical and angiographic factors on mortality after acute out-of-hospital myocardial infarction (MI) in patients with and without prior corona ... Full text Link to item Cite

Analysing the relationship between change in a risk factor and risk of disease.

Journal article Stat Med · April 1992 Featured Publication There are numerous examples in the epidemiologic literature of analyses that relate the change in a risk factor, such as serum cholesterol, to the risk of an adverse outcome, such as heart disease. Many of these analyses fit some type of regression model ( ... Full text Link to item Cite

The relationship between cholesterol level and myocardial infarction or mortality risk in patients with coronary artery disease. A report from the Coronary Artery Surgery Study (CASS) registry.

Journal article Ann Epidemiol · 1992 Featured Publication Using data from the Coronary Artery Surgery Study (CASS) registry, we evaluated the relationship between cholesterol levels measured at enrollment and the following events: all-cause mortality, cardiac death, fatal myocardial infarction (MI), and nonfatal ... Full text Link to item Cite

Improved survival of surgically treated patients with triple vessel coronary artery disease and severe angina pectoris. A report from the Coronary Artery Surgery Study (CASS) registry.

Journal article J Thorac Cardiovasc Surg · April 1989 Featured Publication We examined survival rates during a 6-year follow-up of patients in the registry of the Coronary Artery Surgery Study who had three vessel coronary artery disease and Canadian Cardiovascular Society class III-IV angina pectoris. All patients had a stenosis ... Link to item Cite

Anomalous coronary arteries: location, degree of atherosclerosis and effect on survival--a report from the Coronary Artery Surgery Study.

Journal article J Am Coll Cardiol · March 1, 1989 Featured Publication Limited information is available about clinical presentation, degree of atherosclerosis and effect on overall survival in a large series of patients with coronary artery anomalies. From the National Heart, Lung, and Blood Institute Multicenter Coronary Art ... Full text Link to item Cite

Prevalence and significance of atrial fibrillation in coronary artery disease (CASS Registry).

Journal article Am J Cardiol · April 1, 1988 Featured Publication Estimates of the prevalence of atrial fibrillation (AF) in patients with coronary artery disease have varied from "frequent" to less than 2%. Data on 18,343 patients with angiographically demonstrated CAD in the Coronary Artery Surgery Study (CASS) registr ... Full text Link to item Cite