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Angel V Peterchev

Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
40 Duke Medicine Circle, Box 3620 DUMC, Durham, NC 27710

Featured Works


Controllable pulse parameter transcranial magnetic stimulator with enhanced circuit topology and pulse shaping.

Journal article J Neural Eng · October 2014 Featured Publication OBJECTIVE: This work aims at flexible and practical pulse parameter control in transcranial magnetic stimulation (TMS), which is currently very limited in commercial devices. APPROACH: We present a third generation controllable pulse parameter device (cTMS ... Full text Link to item Cite

Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

Journal article Nat Neurosci · August 2014 Featured Publication Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of ... Full text Open Access Link to item Cite

Pulse width dependence of motor threshold and input-output curve characterized with controllable pulse parameter transcranial magnetic stimulation.

Journal article Clin Neurophysiol · July 2013 Featured Publication OBJECTIVE: To demonstrate the use of a novel controllable pulse parameter TMS (cTMS) device to characterize human corticospinal tract physiology. METHODS: Motor threshold and input-output (IO) curve of right first dorsal interosseus were determined in 26 a ... Full text Link to item Cite

Electric field depth-focality tradeoff in transcranial magnetic stimulation: simulation comparison of 50 coil designs.

Journal article Brain Stimul · January 2013 Featured Publication BACKGROUND: Various transcranial magnetic stimulation (TMS) coil designs are available or have been proposed. However, key coil characteristics such as electric field focality and attenuation in depth have not been adequately compared. Knowledge of the coi ... Full text Link to item Cite

Analysis and optimization of pulse dynamics for magnetic stimulation.

Journal article PLoS One · 2013 Featured Publication Magnetic stimulation is a standard tool in brain research and has found important clinical applications in neurology, psychiatry, and rehabilitation. Whereas coil designs and the spatial field properties have been intensively studied in the literature, the ... Full text Link to item Cite

Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices.

Journal article Brain Stimul · October 2012 Featured Publication BACKGROUND: The growing use of transcranial electric and magnetic (EM) brain stimulation in basic research and in clinical applications necessitates a clear understanding of what constitutes the dose of EM stimulation and how it should be reported. METHODS ... Full text Link to item Cite

Regional electric field induced by electroconvulsive therapy in a realistic finite element head model: influence of white matter anisotropic conductivity.

Journal article Neuroimage · February 1, 2012 Featured Publication We present the first computational study investigating the electric field (E-field) strength generated by various electroconvulsive therapy (ECT) electrode configurations in specific brain regions of interest (ROIs) that have putative roles in the therapeu ... Full text Link to item Cite

Repetitive transcranial magnetic stimulator with controllable pulse parameters.

Journal article J Neural Eng · June 2011 Featured Publication The characteristics of transcranial magnetic stimulation (TMS) pulses influence the physiological effect of TMS. However, available TMS devices allow very limited adjustment of the pulse parameters. We describe a novel TMS device that uses a circuit topolo ... Full text Link to item Cite

Electric field strength and focality in electroconvulsive therapy and magnetic seizure therapy: a finite element simulation study.

Journal article J Neural Eng · February 2011 Featured Publication We present the first computational study comparing the electric field induced by various electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) paradigms. Four ECT electrode configurations (bilateral, bifrontal, right unilateral, and focal elec ... Full text Link to item Cite

Electroconvulsive therapy stimulus parameters: rethinking dosage.

Journal article J ECT · September 2010 Featured Publication In this article, we review the parameters that define the electroconvulsive therapy (ECT) electrical stimulus and discuss their biophysical roles. We also present the summary metrics of charge and energy that are conventionally used to describe the dose of ... Full text Link to item Cite

A transcranial magnetic stimulator inducing near-rectangular pulses with controllable pulse width (cTMS).

Journal article IEEE Trans Biomed Eng · January 2008 Featured Publication A novel transcranial magnetic stimulation (TMS) device with controllable pulse width (PW) and near-rectangular pulse shape (cTMS) is described. The cTMS device uses an insulated gate bipolar transistor (IGBT) with appropriate snubbers to switch coil curren ... Full text Link to item Cite

Quantization resolution and limit cycling in digitally controlled PWM converters

Journal article IEEE Transactions on Power Electronics · 2003 Featured Publication This paper discusses the presence of steady-state limit cycles in digitally controlled pulse-width modulation (PWM) converters, and suggests conditions on the control law and the quantization resolution for their elimination. It then introduces single-phas ... Full text Cite