Scholars@Duke
Anna Kristina Strasma

Anna Kristina Strasma

Assistant Professor of Medicine
Medicine, Nephrology

Scholarly Works

Pediatric kidney health outcomes in communities impacted by chronic kidney disease of unknown etiology (CKDu): a systematic review.

Journal article Pediatr Nephrol · May 2026 BACKGROUND: Chronic kidney disease of unknown etiology (CKDu) is a tubulointerstitial disease that disproportionately affects young, primarily male, agricultural workers in Mesoamerica and South Asia who lack traditional risk factors for kidney disease. Ex ... Full text Link to item Cite

Taking the "unknown" out of CKDu-optimizing approaches to uncover the cause(s) of epidemic-level kidney disease in low- and middle-income settings: a report from the ISN's International Consortium of CKDu Collaborators (ISN i3C).

Journal article Kidney Int · April 2026 Chronic kidney disease of undetermined etiology (CKDu) is a major cause of mortality that affects communities, health systems, and national economies. Despite 2 decades of descriptive and analytical research, the causes of CKDu epidemics remain unclear. In ... Full text Link to item Cite

Automated methods for multi-isotopic analysis of major cations in biological samples: application to chronic kidney disease of unknown etiology.

Journal article Anal Bioanal Chem · March 2026 Natural variability in stable isotope ratios provides critical constraints on elemental cycling in nature without the need for the introduction of artificial tracers. While such data are widely used in environmental studies, they are not as widely employed ... Full text Link to item Cite

Chronic Kidney Disease of Unknown Etiology (CKDu) as an Underappreciated Cause of Emergent Hemodialysis Utilization in the United States

Preprint · 2025 ABSTRACTIntroduction End stage kidney disease (ESKD) affects an estimated 5500 persons living in the United States without legal residency documentation. One likely, but underappreciated cause of ESKD in the Hispanic migrant population, ... Full text Cite

Regional hotspots for chronic kidney disease: A multinational study from the ISN-GKHA.

Journal article PLOS Glob Public Health · 2024 Chronic kidney disease (CKD) disproportionately affects certain populations as demonstrated by well-established subnational geographic hotspots of CKD in Central America and South Asia. Using data from the third iteration of the International Society of Ne ... Full text Link to item Cite

Kidney disease characteristics, prevalence, and risk factors in León, Nicaragua: a population-based study.

Journal article BMC Nephrol · November 12, 2023 BACKGROUND: CKD of unknown etiology (CKDu) disproportionately affects young people in Central America who lack traditional CKD risk factors (diabetes and hypertension) and has instead been variably linked to heat stress, occupational and environmental expo ... Full text Link to item Cite

The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu).

Journal article Am J Physiol Renal Physiol · April 1, 2023 Chronic kidney disease (CKD) of uncertain etiology (CKDu) is a global health concern affecting tropical farming communities. CKDu is not associated with typical risk factors (e.g., diabetes) and strongly correlates with environmental drivers. To gain poten ... Full text Link to item Cite

Global Dialysis Perspective: Nicaragua.

Journal article Kidney360 · January 1, 2023 Full text Link to item Cite