Scholars@Duke
Anne Frances Buckley

Anne Frances Buckley

Associate Professor of Pathology
Pathology
anne.buckley@duke.edu
Dept of Pathology, BOX_3712, Durham, NC 27710

Featured Works

An animal model of MYC-driven medulloblastoma.

Journal article Cancer Cell · February 14, 2012 Featured Publication Medulloblastoma (MB) is the most common malignant brain tumor in children. Patients whose tumors exhibit overexpression or amplification of the MYC oncogene (c-MYC) usually have an extremely poor prognosis, but there are no animal models of this subtype of ... Full text Link to item Cite

Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.

Journal article Nucl Med Biol · January 2012 Featured Publication INTRODUCTION: Malignant glioma remains a significant therapeutic challenge, and immunotherapeutics might be a beneficial approach for these patients. A monoclonal antibody (MAb) specific for multiple molecular targets could expand the treatable patient pop ... Full text Link to item Cite

Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report.

Journal article Neurosurgery · May 2008 Featured Publication OBJECTIVE: A vestibular schwannoma (VS) is a benign tumor of the VIIIth cranial nerve that can often be treated by microsurgery or radiosurgery and demonstrates high tumor control rates. Radiosurgery is typically performed as gamma knife surgery (GKS), alt ... Full text Link to item Cite

Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma.

Journal article Am J Clin Pathol · February 2008 Featured Publication Epidermal growth factor receptor (EGFR) is frequently overexpressed in hepatocellular carcinoma, but its relationship with EGFR gene copy number has not been studied. This study examined EGFR expression and gene copy number in hepatocellular carcinoma and ... Full text Link to item Cite

Comparison of the Dako EGFR pharmDx kit and Zymed EGFR antibody for assessment of EGFR status in colorectal adenocarcinoma.

Journal article Appl Immunohistochem Mol Morphol · September 2007 Featured Publication Immunohistochemistry is widely used to assess epidermal growth factor receptor (EGFR) expression on colorectal carcinomas to select patients for treatment with cetuximab, an anti-EGFR antibody. The data comparing different commercial EGFR antibodies is lim ... Full text Link to item Cite

Epidermal growth factor receptor expression and gene copy number in fibrolamellar hepatocellular carcinoma.

Journal article Hum Pathol · April 2006 Featured Publication Increased expression of epidermal growth factor receptor (EGFR), a transmembrane tyrosine kinase, is associated with tumor progression in many carcinomas. Epidermal growth factor receptor inhibitors have shown promise in treating some of these tumors. Fibr ... Full text Link to item Cite

Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway.

Journal article Nat Immunol · August 2001 Featured Publication T lymphocytes circulate in a quiescent state until they encounter cognate antigen bound to the surface of an antigen-presenting cell. The molecular pathways that regulate T cell quiescence remain largely unknown. Here we show that forced expression of the ... Full text Link to item Cite